113 results on '"F. Martins"'
Search Results
2. Semaglutide (GLP‐1 receptor agonist) stimulates browning on subcutaneous fat adipocytes and mitigates inflammation and endoplasmic reticulum stress in visceral fat adipocytes of obese mice
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Fabiane F. Martins, Thatiany S. Marinho, Luiz E. M. Cardoso, Sandra Barbosa‐da‐Silva, Vanessa Souza‐Mello, Marcia B. Aguila, and Carlos A. Mandarim‐de‐Lacerda
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Clinical Biochemistry ,Cell Biology ,General Medicine ,Biochemistry - Abstract
Semaglutide (GLP-1 agonist) was approved for treating obesity. Although the effects on weight loss and metabolism are known, the responses of adipocytes to semaglutide are yet limited. C57BL/6 male mice (n = 20/group) were fed a control diet (C) or a high-fat (HF) diet for 16 weeks and then separated into four groups (n = 10/group) for an additional four weeks: C, C diet and semaglutide, HF, and HF diet and semaglutide. Epididymal white adipose tissue (eWAT) and subcutaneous white adipose tissue (sWAT) fat pads were studied with biochemistry, immunohistochemistry/fluorescence, stereology, and reverse transcription-quantitative polymerase chain reaction. In obese mice, semaglutide reduced the fat pad masses (eWAT, -55%; sWAT, -40%), plasmatic cytokines, and proinflammatory gene expressions: tumor necrosis factor-alpha (-60%); interleukin (IL)-6 (-55%); IL-1 beta (-40%); monocyte chemoattractant protein-1 (-90%); and leptin (-80%). Semaglutide also lessened endoplasmic reticulum (ER) stress genes of activating transcription factor-4 (-85%), CCAAT enhancer-binding protein homologous protein (-55%), and growth arrest and DNA damage-inducible gene 45 (-45%). The obese mice's adipocyte hypertrophy and macrophage infiltration were equally reduced by semaglutide. Semaglutide enhanced multiloculation and uncoupled protein 1 (UCP1) labeling in obese mice: peroxisome proliferator-activated receptor-alpha (+560%) and gamma (+150%), fibronectin type III domain-containing protein 5 (+215%), peroxisome proliferator-activated receptor-alpha coactivator (+110%), nuclear respiratory factor 1 (+260%), and mitochondrial transcription factor A (+120%). Semaglutide also increased thermogenetic gene expressions for the browning phenotype maintenance: beta-3 adrenergic receptor (+520%), PR domain containing 16 (+90%), and Ucp1 (+110%). In conclusion, semaglutide showed significant beneficial effects beyond weight loss, directly on fat pads and adipocytes of obese mice, remarkably anti-inflammatory, and reduced adipocyte size and ER stress. Besides, semaglutide activated adipocyte browning, improving UCP1, mitochondrial biogenesis, and thermogenic marker expressions help weight loss.
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- 2022
3. Polycardanol's potential to deasphalt crude oil: Influence of polymer conversion degree, molar mass, and structure
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Maximiliano F. Martins, Thiago M. Aversa, and Elizabete F. Lucas
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General Chemical Engineering - Published
- 2023
4. Author response for 'Polycardanol's potential to deasphalt crude oil: Influence of polymer conversion degree, molar mass, and structure'
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null Maximiliano F. Martins, null Thiago M. Aversa, and null Elizabete F. Lucas
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- 2023
5. Quasistatic and fatigue behavior of an AISI H13 steel obtained by additive manufacturing and conventional method
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Wojciech Macek, Rui F. Martins, Zbigniew Marciniak, Ricardo Branco, C.M.S.B. Pereira, José F. Garcias, and Cyril Santos
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Materials science ,Mechanics of Materials ,Mechanical Engineering ,General Materials Science ,Composite material ,Quasistatic process - Published
- 2021
6. Quantitative easing and economic growth in Japan: A meta‐analysis
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Luis F. Martins, Pedro Linhares, Tiago Neves Sequeira, and Alexandra Ferreira-Lopes
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Meta-probit ,Macroeconomics ,Economics and Econometrics ,Monetary policy ,Meta-analysis ,Quantitative easing ,Economics ,Bank of Japan ,Economic growth ,Ciências Sociais::Economia e Gestão [Domínio/Área Científica] - Abstract
We present an original meta-probit analysis for the effect of the Bank of Japan monetary policy on economic growth for the period 2001-2020, using 45 studies. We use impulse response functions in VAR type models to assess if the effects on output of unconventional monetary policies are significant (positive or negative) or not. Funnel asymmetry and precision effect tests do not provide a striking evidence of publication bias. Additionally, we do not find a consensus regarding the output growth effects during the quantitative easing years. Besides variables linked with the studies’ methodological features, other variables such as industrial production and the price level have a greater effect on the probability of reporting statistically significant (positive) effects of quantitative easing on output growth. However, one of the most important (policy) implications of our study is that the evidence for a significant real effect of unconventional monetary policy is weak. info:eu-repo/semantics/acceptedVersion
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- 2021
7. Probing the Catalytically Active Species in POM‐Catalysed DNA‐Model Hydrolysis**
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Frederico F. Martins, Jose Lanuza, Adrià Gil, Xabier Lopez, Haralampos N. Miras, Ángel Sánchez-González, and Nuno A. G. Bandeira
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Models, Molecular ,Spectrometry, Mass, Electrospray Ionization ,Molecular model ,010405 organic chemistry ,Chemistry ,Hydrolysis ,Organic Chemistry ,DNA ,General Chemistry ,010402 general chemistry ,01 natural sciences ,Decomposition ,Catalysis ,0104 chemical sciences ,Metal ,Computational chemistry ,visual_art ,Phosphodiester bond ,Polyoxometalate ,visual_art.visual_art_medium ,Density functional theory - Abstract
Phosphoester hydrolysis is an important chemical step in DNA repair. One archetypal molecular model of phosphoesters is para-nitrophenylphosphate (pNPP). It has been shown previously that the presence of molecular metal oxide [Mo7 O24 ]6- may catalyse the hydrolysis of pNPP through the partial decomposition of polyoxomolybdate framework resulting in a [(PO4 )2 Mo5 O15 ]6- product. Real-time monitoring of the catalytic system using electrospray ionisation mass spectrometry (ESI-MS) provided a glance into the species present in the reaction mixture and identification of potential catalytic candidates. Following up on the obtained spectrometric data, Density Functional Theory (DFT) calculations were carried out to characterise the hypothetical intermediate [Mo5 O15 (pNPP)2 (H2 O)6 ]6- that would be required to form under the hypothesised transformation. Surprisingly, our results point to the dimeric [Mo2 O8 ]4- anion resulting from the decomposition of [Mo7 O24 ]6- as the active catalytic species involved in the hydrolysis of pNPP rather than the originally assumed {Mo5 O15 } species. A similar study was carried out involving the same species but substituting Mo by W. The mechanism involving W species showed a higher barrier and less stable products in agreement with the non-catalytic effect found in experimental results.
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- 2021
8. Report on fetal mummification in the scalloped hammerhead shark<scp>Sphyrna lewini</scp>
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Fernanda A. Rolim, Mariana F. Martins, Otto Bismarck Fazzano Gadig, Univ Fed Rio Grande FURG, and Universidade Estadual Paulista (Unesp)
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Male ,0106 biological sciences ,animal structures ,hematic mummification ,Uterus ,embryo ,Zoology ,Aquatic Science ,010603 evolutionary biology ,01 natural sciences ,Critically endangered ,Hammerhead shark ,Carcharhiniformes ,medicine ,Animals ,Sphyrnidae ,Fetal Death ,Ecology, Evolution, Behavior and Systematics ,Sphyrna lewini ,biology ,010604 marine biology & hydrobiology ,Endangered Species ,Embryogenesis ,Embryo ,biology.organism_classification ,Mummification ,medicine.anatomical_structure ,embryonic structures ,Sharks ,Female ,Ovoviviparity ,umbilical torsion ,Brazil - Abstract
Made available in DSpace on 2020-12-10T19:59:25Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-05-20 Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) This study describes the fetal mummification process in two embryos of a 310 cm total length scalloped hammerhead shark Sphyrna lewini caught in southeastern Brazil, in December 2017. Fourteen embryos were observed in total, in which two males in the left uterus presented different stages of mummification. Both mummified embryos were covered by an exudate (i.e., a mucous substance), indicating a hematic mummification process. All embryos were at the placentotrophic stage of development, indicating that they were close to parturition. An intrinsic characteristic is suggested as possible etiology for this condition, such as umbilical torsion, because both embryos were at different sizes and, therefore, at different development stages. In addition, the sample size did not allow the authors to presume any pollution effect once only one female was observed. Finally, fetal mummification and other embryonic development disorders might have populational impacts due to reduction in embryo survival and, consequently, recruitment. For this reason and considering that S. lewini is categorized as a critically endangered species, this study's results have conservational relevance. Univ Fed Rio Grande FURG, Programa Posgrad Ciencias Fisiol, Inst Ciencias Biol, Ave Italia Km 8, BR-96203900 Rio Grande, RS, Brazil Univ Estadual Paulista, Lab Pesquisas Elasmobranquios, Inst Biociencias, Sao Vicente, Brazil Univ Estadual Paulista, Programa Posgrad Ciencias Biol Zool, Inst Biociencias, Rio Claro, Brazil Univ Estadual Paulista, Lab Pesquisas Elasmobranquios, Inst Biociencias, Sao Vicente, Brazil Univ Estadual Paulista, Programa Posgrad Ciencias Biol Zool, Inst Biociencias, Rio Claro, Brazil CAPES: 001 CNPq: 308430/2015-8
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- 2020
9. Enhanced hemocompatibility and antibacterial activity on titania nanotubes with tanfloc/heparin polyelectrolyte multilayers
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Ketul C. Popat, Alessandro F. Martins, Liszt Y.C. Madruga, Kirsten Kauk, Matt J. Kipper, and Roberta M. Sabino
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Staphylococcus aureus ,Materials science ,Biocompatibility ,Nitrogen ,Surface Properties ,0206 medical engineering ,Biomedical Engineering ,Biocompatible Materials ,Microbial Sensitivity Tests ,02 engineering and technology ,Biomaterials ,Contact angle ,Platelet Adhesiveness ,medicine ,Humans ,Titanium ,Nanotubes ,Heparin ,Photoelectron Spectroscopy ,Metals and Alloys ,Biofilm ,Fibrinogen ,Water ,Biomaterial ,Adhesion ,021001 nanoscience & nanotechnology ,Polyelectrolytes ,020601 biomedical engineering ,Polyelectrolyte ,Anti-Bacterial Agents ,Chemical engineering ,Factor XII ,Pseudomonas aeruginosa ,Ceramics and Composites ,Adsorption ,0210 nano-technology ,Antibacterial activity ,medicine.drug - Abstract
Biomaterial-associated thrombus formation and bacterial infection remain major challenges for blood-contacting devices. For decades, titanium-based implants have been largely used for different medical applications. However, titanium can neither suppress blood coagulation, nor prevent bacterial infections. To address these challenges, tanfloc/heparin polyelectrolyte multilayers on titania nanotubes array surfaces (NT) were developed. The surfaces were characterized by scanning electron microscopy (SEM), X-ray photoelectron spectroscopy (XPS), and water contact angle measurements. To evaluate the hemocompatibility of the surfaces, fibrinogen adsorption, Factor XII activation, and platelet adhesion and activation were analyzed. The antibacterial activity was investigated against Gram-negative P. aeruginosa and Gram-positive S. aureus. Bacterial adhesion and morphology, as well as biofilm formation, were analyzed using fluorescence microscopy and SEM. The anti-thrombogenic properties of the surfaces were demonstrated by significant decreases in fibrinogen adsorption, Factor XII activation, and platelet adhesion and activation. Modifying NT with tanfloc/heparin also reduces the adhesion and proliferation of P. aeruginosa and S. aureus bacteria after 24 hr of incubation, with no biofilm formation. The modified NT surfaces with tanfloc/heparin polyelectrolyte multilayers are a promising biomaterial for use on implant surfaces because of their enhanced blood biocompatibility and antibacterial properties.
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- 2020
10. Extract from Opuntia ficus‐indica cladode delays the Aedes aegypti larval development by inducing an axenic midgut environment
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Isabella C. V. Nova, Welton A. de Almeida, Thamara F. Procópio, Raquel S. M. Godoy, Franciane R. Miranda, Renata C. Barbosa, Jéssica da Silva Nascimento, Patrícia M. G. Paiva, Magda R. A. Ferreira, Luiz A. L. Soares, Paulo F. P. Pimenta, Gustavo F. Martins, Daniela Maria do Amaral F. Navarro, Thiago H. Napoleão, and Emmanuel V. Pontual
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Physiology ,Insect Science ,General Medicine ,Biochemistry - Abstract
This study evaluated the effects of acute exposure of Aedes aegypti third instar (L
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- 2022
11. Severe Early‐Onset Parkinsonian Syndrome Caused by <scp> PLA2G6 </scp> Heterozygous Variants
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Alessandra Ferreira, Francisco Cardoso, Vinícius Viana Abreu Montanaro, Pérola de Oliveira, Bernardo J. A. F. Martins, and Daniel C. Carvalho
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Pathology ,medicine.medical_specialty ,Neurology ,business.industry ,Neurodegeneration with brain iron accumulation ,Akinetic mutism ,Medicine ,Neurology (clinical) ,business ,medicine.disease ,Early onset - Published
- 2021
12. Higher probability of tick infestation reveals a hidden cost of army ant‐following in Amazonian birds
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Alan Fecchio, Fabio Schunck, Raphael Igor Dias, Maria Ogrzewalska, Jason D. Weckstein, and Thiago F. Martins
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Tick infestation ,Army ant ,Feeding behavior ,Amazonian ,medicine ,Zoology ,Animal Science and Zoology ,Biology ,medicine.disease ,biology.organism_classification ,Ecology, Evolution, Behavior and Systematics ,Ixodidae - Published
- 2021
13. Empagliflozin Downregulates Renal NHE3 Activity and NaPi‐2 Expression and Reduces Blood Pressure in Hypertensive Rats
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Adriana C. C. Girardi, Renato O. Crajoinas, F. Martins, and Thiago Matheus Santos Rios
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medicine.medical_specialty ,Endocrinology ,Blood pressure ,business.industry ,Internal medicine ,Genetics ,Empagliflozin ,Medicine ,business ,Molecular Biology ,Biochemistry ,Biotechnology - Published
- 2021
14. Author response for 'Higher probability of tick infestation reveals a hidden cost of army ant‐following in Amazonian birds'
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null Alan Fecchio, null Thiago F. Martins, null Maria Ogrzewalska, null Fabio Schunck, null Jason. D. Weckstein, and null Raphael I. Dias
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- 2021
15. Author response for 'Higher probability of tick infestation reveals a hidden cost of army ant‐following in Amazonian birds'
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Jason D. Weckstein, Raphael Igor Dias, Fabio Schunck, Thiago F. Martins, Alan Fecchio, and Maria Ogrzewalska
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Army ant ,Tick infestation ,biology ,Amazonian ,medicine ,Zoology ,biology.organism_classification ,medicine.disease - Published
- 2021
16. Safety of hospital discharge before return of bowel function after elective colorectal surgery
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J Chapman, S, Blanco-Colino, R, Pérez-Ajates, S, O Anabitarte Bautista, Hodson, J, C Glasbey, J, Pata, F, Pellino, G, Sgrò, A, Soares, A, T van Elst, S Van Straten, Nepogodiev, D, Borakati, A, F Bath, M, H Yasin, I, Mclean, K, Arthur, T, Kovacevic, M, Delibegovic, S, Karamanliev, M, Swamad, M, Žebrák, R, Paramasivam, R, Martensen, A, M Larsen, H, Rädeker, L, E Frey, P, Kechagias, A, Venara, A, Duchalais, E, Ioannidis, A, Pasquali, S, Simioni, A, Farina, V, Podda, M, Lorenzon, L, Schaeff, V, Otto, A, Jakubauskas, M, R van Elst, T, Chu, M, Pvb, Fagan, I Wells, C, A Alagoa João, Juloski, J, Y El Kasmy El Kasmi, Espin-Basany, E, Clerc, D, Ciubotaru, C, Popescu, S, Yanishev, A, Lee, S, B Ozkan, B, A Yagız Sen, K Aktas, M, E Baki, B, Yüksek, B, Kamarajah, S, A Khaw, R, Mills, E, Goodson, R, Thakral, N, D Ablett, A, Adra, M, Kwek, I, M Khan, S, Quinn, P, R Manley, L, Badran, A, Ramjeeawon, A, Campbell, A, L Tan, H, S Rye, D, Rajaraman, N, G Norman, J, Vutipongsatorn, K, Solomou, G, Akhbari, M, Ali, A, Murray, V, M Baker, D, D Brandao, B, Stainer, B, Thavayogan, R, Jones, D, O Onafowokan, O, Gharooni, A, Dabab, N, Carlton-Carew, S, Kungwengwe, G, Gabriel, M, Sewart, E, C Shortland, T, Lawday, S, Pockney, P, Dawson, A, D Brumfitt, C, Stewart, P, B, Ng, K Luong, J, Ivanov, V, Borisova, A, Neykov, V, Kunčarová, K, Kološová, B, Antonova, T, Farkašová, M, L Harbjerg, J, Brandsborg, S, Brinck, S, D Kjaer, M, Mark-Christensen, A, P Unbehaun, K, Dalsgaard, P, D Lycke, K, Lenaoures, P, Brigand, C, Dumange, E, Gout, M, Moehwald, C, Prem, M, Alhalabi, O, Sliwinski, S, Krupp, J, Gablenz, E, Schmitzer, L, Kopp, A, Steinle, J, Gsenger, J, J Pohl, L, Riccardi, M, M Christodoulou, I, Konstantinidis, M, Machairas, N, Zoikas, A, Balalis, D, K Manatakis, D, L Aguilera, M, Marano, L, Fleres, F, Lovisetto, F, Sasia, D, Segalini, E, Pata, G, Lucchi, A, Sagnotta, A, Campagnaro, T, Petrelli, F, Gallo, G, Papandrea, M, Testa, V, Sinibaldi, G, F Di Candido, Colombo, F, Perrone, G, Aresu, S, Biancafarina, A, Canonico, G, Pagnanelli, M, Curletti, G, Bini, R, A de Manzoni Garberini, Impellizzeri, H, Cillara, N, Tutino, R, Picciariello, A, Coletta, D, Savino, G, Ferrara, F, Tamini, N, Talamo, G, Parini, D, Giamundo, P, A Lo Conte, Pagano, G, Ripetti, V, Pesce, A, Menduni, N, Giudicissi, R, Goldin, E, Rega, D, Belli, A, Andriola, V, Gordini, L, Foppa, C, Piccolo, G, Birindelli, A, Ferrari, C, Ballarini, Z, Tirelli, F, Milone, M, M De Rosa, S Pipitone Federico, N, Molteni, B, L Tilocca, P, Sancini, G, N Piozzi, G, Lauretta, A, Poillucci, G, Mulas, S, Simcikas, D, Portelli, L, Jwm van Wijnbergen, L Dinger, T, Sfh Ten Doesschate, Ashm van Dalen, D van den Bos, D, Hansmann, M, J Medina Feliz, Z Kuiper, S, Abdulrahman, Z, R Pruijssers, S, Farik, S, M Elliott, B, P Geneta, V, Wilton, S, Kandelaki, H, L Peng, S, Campbell, S, K Lim, Y, S Yassaie, S, Murray, M, Haran, C, Tan, J, Castro, J, Laranjeira, A, Catarino, S, Neves-Marques, C, G Correia, J, N Vieira, B, C Quintela, A, L Serra, M, Maciel, J, Cunha, M, J Aparício, D, Neves, J, Azevedo, J, Romano, M, Eiró, F, Romano, J, Monteiro, C, Claro, M, R Almeida, M, Peyroteo, M, D Machado, N, Capote, H, Ferreira, M, Sousa, X, Devesa, H, Cavadas, D, Guerreiro, I, Costa, M, Rosete, M, Salman, M, English, C, Mohammed, N, Litvin, A, V Ćuk, V, Mészárosová, K, Jaich, R, H De Lima, Brooks, S, Marx, M, M Nshalati Salvation, J García Cardo, Mora-Guzmán, I, J Sancho Muriel, U de Andres Olabarria, Muriel, P, C Jimenez Viñas, Alconchel, F, O Esteban Sinovas, C Fairén Oro, M López Otero, S Figueroa Jiménez, O Claramonte Bellmunt, J Martínez Caballero, Rubio-Pérez, I, M Aguilar-Martínez, M, J Segura-Sampedro, J, C Olmedo Moreno, D Negre Parra, M Estévez Diz, A, Martín-Balbuena, R, C Bustamante Recuenco, E Licardie Bolaños, R, Fernández, P, A Díaz Padillo, Forero-Torres, A, I Alberdi San Román, H Salvador Rosés, M Merayo Álvarez, P Villarejo Campos, C Lopes Moreira, C, P Uriol Peralta, M Serrano Navidad, Ripollés-Melchor, J, Garcea, A, H Gómez Facundo, P Troncoso Pereira, V Pérez Guarinos, C, Blaser, B, Piazza, G, Gagliardi, B, Serin, H, S Yurdaor, S, Arslan, E, Kopac, O, Uyanik, A, B Ozmen, B, Tiftik, E, Aksoy, B, Yalcinkaya, A, Ozoglu, F, D Kocer, M, Bilicen, G, N Cinar, E, Uslu, Ö, Kaya, Y, Demirci, K, Wong, J, Mmh, Farhan-Alanie, Suresh, G, Asif, A, J Finch, B, Bhahirathan, Y, Herron, J, Z Yi Tew, Obukofe, R, Russell, C, Suchett-Kay, I, Netke, T, Williams, L, Kisiel, A, Y Liu, F, Claireaux, H, James, P, Mondal, A, Kalderon, R, H Nadama, H, Al-Saraff, Z, Jph, Tam, Powell-Chandler, A, Wood, F, Rebecca, Gorgievska, Ragavoodoo, A, Thakrar, C, Rojoa, D, Palmer, C, Davidson, K, Giacci, L, Hale, J, W Gan, F, Makin-Taylor, R, Y Hey, C, Toh, C, M Findlay, J, Griffiths, N, Ganesananthan, S, Jasionowska, S, Poustie, M, Wong, C, Turner, T, Pyc, W, Sloper, W, Warner, C, Coey, J, Mason, D, Sait, S, Kowal, M, Owen, M, Saiyed, A, Ashworth, I, Akbari, K, Curran, M, Martin, P, Parker, D, Kwok, K, Lye, C, Ghaly, M, Sammour, T, Lewis, D, Mundasad, R, Wilkes, A, Ctercteko, G, Maslyankov, S, Dimov, R, Iliev, S, Dimitrov, D, Marek, F, Örhalmi, J, Skalický, P, Skalický, T, Chrz, K, Christensen, P, Worsøe, J, S Kristensen, E, J Emmertsen, K, S Loeve, U, L Mihaljevic, A, Herrle, F, M Konstantinidis, K, Korkolis, D, Karanikas, I, Vincenti, L, Anania, G, Borghi, F, Agresta, F, Maretto, I, Parisi, A, Bucci, L, G De Palma, Guglielmi, A, Cucinotta, E, F La Torre, Cianchi, F, Guerrieri, M, Trompetto, M, Persiani, R, Micheletto, G, Delrio, P, Cantafio, S, Ronconi, M, Pag, Bisagni, M De Prizio, Franceschi, A, Galleano, R, Cavallini, M, Brescia, A, D'Ambra, L, Benevento, A, Niolu, P, Calgaro, M, Colangelo, E, Grottola, T, F Altomare, D, Puleo, S, Salamone, G, Pietrabissa, A, Poggioli, G, Erdas, E, Ottonello, R, Tonini, V, Selvaggi, F, Sammarco, G, Ceccarelli, G, C De Nisco, Surgo, D, Taglietti, L, Ozolins, A, Sivinš, A, Poskus, T, Psaila, J, A Bemelman, W, J Graat, L, Langenhoff, B, Bpl, Wijnhoven, Ahw van de Ven, Poelman, M, Lps, Stassen, Slooter, G, Yiz, Acherman, Hoff, C, F Gerhards, M, Mwj, Stommel, J Hazebroek, E, Aaw van Geloven, A Schasfoort, R, L van Leeuwen, B, B Tuynman, J, Mwa van Tilburg, G Boerma, E, Sharma, P, Jenkins, B, P Bissett, I, Herd, A, Gordon, A, Vernon, D, Omundsen, M, J, Ly, Reddy, A, Bonnet, G, Harmston, C, Morales, M, Francisco, V, Costa, S, Manso, A, Amorim, E, Pereira, J, Cardoso, J, Ourô, S, Caratão, M, Nascimento, C, B Ribeiro da Silva, Taranu, V, Dias, R, Mendes, J, Allen, M, Silva, A, Carlos, S, Barbosa, E, Carneiro, C, Ramos, L, Lencastre, L, Martins, R, Silva-Vaz, P, F Ridgway, P, A McNamara, D, Cahill, R, Hogan, A, Larkin, J, R O'Connell, P, Negoi, I, Abelevich, A, M Ćuk, V, Vician, M, Ede, C, Sardiwalla, I, Mulira, S, Montwedi, D, Oyomno, M, Sabia, D, V Portugal Porras, Vigorita, V, G Sanz Ortega, García, J, A Espí Macías, F Blanco Antona, A Luján Mompeán, J, S Salvans Ruiz, Villarejo-Campos, P, M Romero Simó, Sánchez-Guillén, L, M Jiménez-Gómez, L, A Sánchez López, Golda, T, D Julià Bergkvist, Nevado, C, F Noguera Aguilar, J, B Ricardo Felipe, Septiem, J, A Rodríguez Sánchez, Cañete-Gómez, J, I Ruiz Montesinos, Millán-Scheiding, M, Prieto-Nieto, I, Frasson, M, D García Olmo, Hübner, M, Petermann, D, O Sauvain, M, Ozben, V, E Geçim, I, Disçi, E, Rencuzogullari, A, Kurt, A, Bisgin, T, Pehlivan, M, Isik, A, Onur, E, Leventoglu, S, C Haksal, M, S Erturk, M, Keskin, M, Guner, A, S Tutcu Sahin, S Ozbalci, G, Pergel, A, Albayrak, D, Bruce, D, Fearnhead, N, Arthur, J, Harron, M, Beattie, G, Titu, L, Saunders, M, Phillips, J, Dindyal, S, Cresswell, B, Gercek, Y, Lee, J, Linn, T, Faulkner, G, Lockwood, S, Rees, J, Charalabopoulos, A, Campbell, B, Kontovounisios, C, Amarnath, T, Johnson, M, Epanomeritakis, E, Vigs, S, Nastro, P, Gilliam, A, Smolarek, S, Wilson, T, Orbell, J, Mcintyre, R, Agarwal, T, Hainsworth, P, Patel, P, Vijay, J, Liu, B, P Dhruva Rao, Roxburgh, C, Vipond, M, Youssef, H, Thorn, C, Schizas, A, Denley, S, Bowley, D, Das, K, Cuming, T, Saha, A, Chung, L, Pitt, J, Davis, P, Jones, O, Taylor, M, Bhargava, A, Haji, A, Watson, N, Bloom, I, Singh, B, Norwood, M, Gurjar, S, Stylianides, N, Mirza, S, Evans, M, Williams, G, Patil, P, Hernon, J, Finch, G, Green, S, Chapple, K, Fafemi, O, Warusavitarne, J, Samee, A, Carden, C, Ong, L, Verma, K, Joseph, A, Rawat, N, Pinkney, T, Oke, O, Glen, P, Maxwell-Armstrong, C, Oliphant, R, Garner, J, J Moug, S, Middleton, S, N Lund, J, J Smart, N, Osborn, G, Moore, T, Raymond, T, H Knowles, C, S Hany, T, Clarke, R, Khera, G, Brady, R, Sellahewa, C, Mason, C, Torrance, A, Lasithiotakis, K, Knight, J, Pullybank, A, Ainsworth, P, Reid, F, Ramwell, A, Maslekar, S, George, R, Skull, A, Holtham, S, Muhammad, K, Lal, R, Varcada, M, M Smith, F, Howlader, M, Defriend, D, Kirk, S, Richards, T, Evans, C, M Borg, C, Telford, K, Sarfraz, N, Busby, K, Hollingshead, J, Speake, D, Pawa, N, West, D, Chadwick, M, Komolafe, O, Richardson, S, Thornton, M, Goede, A, Osborne, C, Bandyopadhyay, D, Foong, J, J 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M., Oliveira, J., Velez, C., Borges, F., Simoes, J., Botelho, P., Cismasiu, B., Alves, D., Dias, B., Goncalves, J. P., Valente, P., Freire, L., Saraiva, R., Moreira, M., Fragoso, M., Guimaraes, J., Cruz, G., Ribeiro, J., da Ponte, I. B., Almeida, S., Martins, A. R., Louro, T., Morgado, M., Ferreira, A. S., Alves, M., Oliveira, N., Lerias, R., Estalagem, I., Botelho, C., Bartolo, J., Antunes, C. F., Cabral, F., Silva, F. B., Matos, A. D., Santos, M., Cunha, R., Sousa, M., Canotilho, R., Correia, A. M., Martins, P. C., Jardim, J. A. M., Domingos, S. P., Baiao, J. M., Gomes, J. R., Monteiro, R. G., Varghese, S., Boyle, E., Aljohmani, L., Alexander, J., Graziadei, V., Mccaughey, C., Jain, A., Ramanayake, H., Sabnani, R., Colon, L. F., Bansal, N., Stephens, I., Tan, R., Sharma, S., Doherty, G., Fenn, S., Mulhare, E., Walsh, M., Leavey, C., Costigan, O., Dervan, L., Kang, S. J., Dixon, O., Morrissey, E., Compton, M., Pentony, A. R., Piong, C. L., Nossier, R., Hanna, J., Sabir, K., Eow, S. Y., Ladak, N., Boersma, D., Kamath, P. J., Soh, T. B. W., Dyer, A. H., Chee, S. Y., Tan, I. X. H., Kelliher, A., Adeusi, L., Howarth, N., Mccawley, N., O'Neill, A., Jones, M. R., Saleh, R., Singh, A., Senaratne, R., Kakodkar, P., Subramanian, I., Al-Salihi, A., Vyas, V., Vedadi, A., Popescu, S. S., Piras, K., Ciubotaru, C. I., Romanova, E., Ponomarev, N., Savchenko, A., Luzan, R., Lutovinova, E., Gavrilina, A., Barkovskaya, A., Kudelkina, N., Topchubaev, D., Radulovic, R., Milosevic, K., Bojicic, J., Gencic, M., Jankovic, U., Zubowicz, M., Suchan, P. K., Gerstmeier, J., Brazitikou, K. M. E., Fytrou, E., Celik, M., Dubovsky, M., Schmalenbeck, J., Sautter, S. C., Ceyran, H., Fitchat, N., Mathebula, S., Chauke, J., Mculu, W., Ngwenya, Z., Withey, K., Piperidis, A., Toyi, Y., Nicolaides, A., Jaffer, T., Sparke, A., Van Staden, N., Mcduling, C. R., Claassen, L., Kruger, C., Weyers, J., Lecler, J., Yebes, A., Mana, O. C., Gomez, H., Riba, L., Perez, J., Cornejo, L. C., Rodriguez, I. V., Escovar, F. J., Fernandez, M. C., Martinez, A. P., Bergara, I. B., Olavarria, A. L., del Pozo Andres, E., Ortega, C., Arias-Camison, P. L., Arranz, J. M. N., Sexmero, M. J. M., Alonso, E. D., Moreno, A. I., Margarida, A., Pando, B., Marin, L. L., Calle, M. P., Cordero, M. J. R., Cuartango, A. S., Sanchez, E., Rodrigo, A. M., Diago, J. P., Lista, M. V., Terricabras, S. R., Sanz, L. B., Camprubi, E. A., Ferrandez, M. R., Lao, E. P., Miro, M. D. P., Alberca-Paramo, A., Verdejo, T. A., Canete-Manzanares, J., Molina-Florez, M., Hernandez, L. C. G., Nunez, S. O., Suarez-Sanchez, M., Martin-Fernandez, J., Liebana, M. M. S., Betancourth, C. F. C., Mico, S. S., Fernandez, A., Curtis, C., Bosch, M., Triguero, D., Ramirez, M. B., Diaz, N. R., Caraballo, I. G., Vicente, T. P., Orue-Echebarria, M. I., Sanchez-Calvo, L., Wang, D., Trueba-Collado, C., de Quiros, J. T. M. B., Jimenez, F. A. R., Ortega, A. P., Barbadillo, A. T., Pujana, E. R., Illera, M. V. F., Serralvo, A. D. L. 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J., Livie, V., Ibrahim, B., Khalil, M., Pooley, G., Shishkin, B., Docherty, J., Southgate, A., Coomes, A., Mcgee, F., Flanagan, S., Tan, Q. J., Anwar, H., Clough, R., Chrisp, B., Cassels, J., Cross, G. W. V., Mercer, L., Mercer, C., Refalo, A., Hadley, R., Mctighe, A., Farrow, F., Brodie, A., Davis, G., Shah, D. R., Bowers, C., Patel, S., Morice, O., Burzic, A., Cheung, J., Shashidhara, A., Theodoraki, G., Birk, J., Ong, A., Ng, M. P. E., Wong, R. T. W., Maese, S., Yeap, B., Iqbal, Z., Melaugh, T., Perchard, W., Scurr, T., Campbell, E., Kelk, L., Ghosh, A., Gibbins, A., Mala, D., Loizidou, A., Hall, O., Mecia, L., Hew, C., Varathan, K., Tong, L., Chandrasekar, B., Buchanan, E., O'Connell, M., Kwak, S. Y., Ong, E. H., Gardner, S., Lim, J., Maden, C., Illahi, M., Tan, Z. X., Edwards, S., Stahl, R., Stahl, J., Hickman, A., Collett, D., Goolam-Mahomed, Z., Allen, B., Atiyah, A., Ahmad, H., Jones, J., Mcgregor, O., Ogundiya, E., Boulbadaoui, A., Kirnon-Jackman, O., Lim, Q. 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J., Horner, C., Heybourne, A., Morgan, H., Wickstone, C., Panagiotou, D., O'Connell, E., Dean, K., Iqbal, R., Walsh, L., Yu, N., Rana, N., Massie, E., Ng, J., Jung, M., Lee, Y. D., Harris, M., White, S., Boev, B., Tonchev, P., Prochazka, V., Risko, J., Skalicky, A., Ravn, S., Ojakaar, A., Dorr-Harim, C., Koutserimpas, C., Giraudo, G., Armellini, A., Ruzzenente, A., Mazzeo, C., De Padua, C., Luc, A. R., Maroli, A., Vitali, M., Gusai, G. P., Quattromani, R., Virgilio, E., Berti, S., Di Mola, F. F., Papagni, V., Tuminello, F., Vittori, L., Longheu, A., Loche, G. A., Braccio, B., De Luca, E., Resta, G., Ancans, G., Tamosiunas, A., Petrulionis, M., Abdulrahman, N., van de Pas, K. G. H., Thomas, G., Brandsma, A. M., Davids, J., Rottier, S. J., de Roy van Zuidewijn, D., Hawkins, R., Ong, H. I., Li, Y., Desmond, B., Winstanley, J., Martins, M., Americano, M., Frade, S., Senhorinho, R., Peixoto, R., Alves-Vale, C., Lamas, M., O'Connor, D. B., Hoo, M., Gopaul, A., Scanlon, K., O'Dwyer, N., Jovanovic, M., Panyko, A., Van Vuuren, S., Centeno, A., Bernado, I. R., Senorans, M. P. G., Amor, L. G., Ramirez, A. C., Abrisqueta, J., Gomez, M. E., Arroyo, A., Cerdan, C., Romeu, N. G., Enriquez-Navascues, J. M., Collado-Roura, F., Curchod, P., Gaspar, S., Imadalou, L., Mutlu, D., Akyol, C., Uygur, F. A., Eray, I. C., Biyiklioglu, O., Cetin, M. F., Isik, A. E., Karip, B., Dogan, H., Sarigul, L., Tunc, E., Aydin, T., Bodur, S., Karabulut, K., Francis, A. A., Al-hadithi, A., Lau, I. S. F., Smith, E., Mahapatra, S., Mcauliffe, O., Imam, L., Akram, B., Hossaini, S., Davies, R., Ko, M., Collins, J., Pandya, A., Reilly, S., Archer, J., Livie, J., Chaudhry, F. A., Ntakomyti, E., Diallo, R., Bylinski, T., Wright, J., Masiha, E., Tung, J., Shirazi, B., Neilson, A., Epton, S., Patel, N., Trussell, S., Couldrey, A., and Donnelly, C.
- Subjects
operative ,Male ,postoperative discharge ,Postoperative Complications ,0302 clinical medicine ,Colostomy ,CRITERIA ,Prospective Studies ,Bowel function ,Colectomy ,IMAGINE ,stoma ,intestines ,Proctectomy ,Ileostomy ,digestive, oral, and skin physiology ,patient discharge ,colorectal surgery, hospital discharge, bowel function ,RECOVERY ,Middle Aged ,adult ,colostomy ,elective surgical procedures ,female ,follow-up studies ,humans ,ileostomy ,ileus ,male ,middle aged ,multivariate analysis ,patient readmission ,patient safety ,postoperative complications ,prospective studies ,recovery of function ,colectomy ,proctectomy ,Patient Discharge ,Colorectal surgery ,ileus - - discharge - bowel function - elective - colorectal surgery ,Elective Surgical Procedures ,030220 oncology & carcinogenesis ,Female ,030211 gastroenterology & hepatology ,Patient Safety ,Cohort study ,safety ,Adult ,medicine.medical_specialty ,Ileus ,Patient Readmission ,defecation ,03 medical and health sciences ,medicine ,Hospital discharge ,Humans ,colorectal surgery ,colorectal resection ,Colorectal resection ,defecation, postoperative complications, colorectal surgery, intestines, patient discharge, patient readmission, safety, surgical procedures, operative, colorectal resection, ileus ,business.industry ,Recovery of Function ,Odds ratio ,medicine.disease ,digestive system diseases ,surgical procedures ,Surgery ,Multivariate Analysis ,Defecation ,business ,Follow-Up Studies - Abstract
Ileus is common after colorectal surgery and is associated with an increased risk of postoperative complications. Identifying features of normal bowel recovery and the appropriateness for hospital discharge is challenging. This study explored the safety of hospital discharge before the return of bowel function.A prospective, multicentre cohort study was undertaken across an international collaborative network. Adult patients undergoing elective colorectal resection between January and April 2018 were included. The main outcome of interest was readmission to hospital within 30 days of surgery. The impact of discharge timing according to the return of bowel function was explored using multivariable regression analysis. Other outcomes were postoperative complications within 30 days of surgery, measured using the Clavien-Dindo classification system.A total of 3288 patients were included in the analysis, of whom 301 (9·2 per cent) were discharged before the return of bowel function. The median duration of hospital stay for patients discharged before and after return of bowel function was 5 (i.q.r. 4-7) and 7 (6-8) days respectively (P 0·001). There were no significant differences in rates of readmission between these groups (6·6 versus 8·0 per cent; P = 0·499), and this remained the case after multivariable adjustment for baseline differences (odds ratio 0·90, 95 per cent c.i. 0·55 to 1·46; P = 0·659). Rates of postoperative complications were also similar in those discharged before versus after return of bowel function (minor: 34·7 versus 39·5 per cent; major 3·3 versus 3·4 per cent; P = 0·110).Discharge before return of bowel function after elective colorectal surgery appears to be safe in appropriately selected patients.El íleo es frecuente tras la cirugía colorrectal y se asocia con un aumento del riesgo de las complicaciones postoperatorias. Identificar las características de una recuperación normal del tránsito y la idoneidad para el alta hospitalaria es una tarea difícil. Este estudio examinó la seguridad del alta hospitalaria antes del restablecimiento de la función intestinal. MÉTODOS: Se llevó a cabo un estudio de cohortes prospectivo y multicéntrico a través de una red de colaboración internacional. Se incluyeron pacientes adultos sometidos a resección electiva colorrectal entre enero y abril 2018. El objetivo principal fue el reingreso hospitalario durante los 30 primeros días tras la intervención. Se utilizó un análisis de regresión multivariable para evaluar el impacto del momento del alta en función del restablecimiento de la función intestinal. El objetivo secundario fue las complicaciones postoperatorias en los primeros 30 días después de la cirugía, valoradas mediante el sistema de clasificación de Clavien-Dindo.Se incluyeron en el análisis 3.288 pacientes, de los cuales 301 (9,2%) fueron dados de alta antes del restablecimiento de la función intestinal. La mediana de la estancia hospitalaria de los pacientes dados de alta antes y después del restablecimiento de la función intestinal fue 5 (rango intercuartílico: 4-7) y 7 (6-8) días, respectivamente (P 0,001). No hubo diferencias significativas en las tasas de reingreso entre estos grupos (6,6% versus 8,0%; P = 0,499), y este resultado se mantuvo en el análisis multivariable tras el ajuste por diferencias basales (razón de opotunidades, odds ratio, OR 0,90; i.c. del 95% 0,55-1,46, P = 0,659). Las tasas de complicaciones postoperarorias fueron similares en aquellos dados de alta antes o después del restablecimiento de la función intestinal (complicaciones menores: 34,7% versus 39,5%; complicaciones mayores 3,3% versus 3,4%; P = 0,110). CONCLUSIÓN: Dar de alta antes del restablecimiento de la función intestinal tras cirugía colorrectal electiva parece ser seguro en pacientes debidamente seleccionados.
- Published
- 2020
17. The relationship between tax rates and tax revenues in eurozone member countries - exploring the Laffer curve
- Author
-
Luis F. Martins, Alexandra Ferreira-Lopes, and Ruben Espanhol
- Subjects
Economics and Econometrics ,050208 finance ,Direct tax ,05 social sciences ,Monetary economics ,Business cycle ,Ciências Sociais::Economia e Gestão [Domínio/Área Científica] ,Tax rate ,Laffer curve ,Eurozone countries ,Tax revenue ,Value-added tax ,SUR models ,Income tax ,0502 economics and business ,Economics ,050207 economics ,Optimal tax ,Indirect tax - Abstract
We estimate Laffer Curves for direct and indirect taxes for each Eurozone country, using panel data from 1995 to 2011, by means of Seemingly Unrelated Regression (SUR) models. We choose the three taxes that contribute the most to the government tax revenue: the value added tax (VAT), the corporate income tax (CT), and the labour income tax (LT). From our estimated significant parameters, which have the expected signs according to the Laffer Curve theory, we obtained a maximum/optimal tax rate for VAT for Greece, Portugal, and Slovakia and for the majority of the Eurozone countries for direct taxes. We also take into consideration the business cycle. Many countries do not present differences in regime, and when they do, the optimal tax rate is higher during recessions. Finally, we compare the observed tax rates in 2012 to the estimated optimal tax rates, to assess if the 2012 policy was located at the prohibitive range of the Laffer Curve. Our results are important for the discussions about fiscal discipline and harmonization in the Eurozone, since they exhibit important disparities between countries and taxes. We can see that, especially for CT and LT, there is a strong divide between the values of the optimal maximum tax rates for Eastern European countries and Western European economies. Additionally, the economic and financial conditions of each country also influence the value for the tax rate. info:eu-repo/semantics/acceptedVersion
- Published
- 2020
18. Irreversible Magnetic Behaviour Caused by the Thermosalient Phenomenon in an Iron(III) Spin Crossover Complex
- Author
-
Frederico F. Martins, Hermínio P. Diogo, Sónia Barroso, Maria José Calhorda, Maria João Romão, Abhinav Joseph, Liliana P. Ferreira, Manuel E. Minas da Piedade, Paulo N. Martinho, and Maria Deus Carvalho
- Subjects
Inorganic Chemistry ,Condensed matter physics ,010405 organic chemistry ,Spin crossover ,Chemistry ,010402 general chemistry ,01 natural sciences ,0104 chemical sciences - Published
- 2018
19. A novel Bayesian approach to reliability modeling: The benefits of uncertainty evaluation in the model selection procedure
- Author
-
C. L. S. Figueirôa Filho, Daniel D. Santana, I. Sartori, and Márcio A. F. Martins
- Subjects
0209 industrial biotechnology ,021103 operations research ,020901 industrial engineering & automation ,Computer science ,Model selection ,Bayesian probability ,0211 other engineering and technologies ,02 engineering and technology ,Management Science and Operations Research ,Safety, Risk, Reliability and Quality ,Reliability (statistics) ,Reliability model ,Reliability engineering - Published
- 2018
20. Lanthanide-Based T2ex and CEST Complexes Provide Insights into the Design of pH Sensitive MRI Agents
- Author
-
André F. Martins, Piyu Zhao, Yunkou Wu, Gyula Tircsó, Lei Zhang, and A. Dean Sherry
- Subjects
Lanthanide ,Chemistry ,General Chemistry ,Bulk water ,010402 general chemistry ,01 natural sciences ,Medicinal chemistry ,Catalysis ,030218 nuclear medicine & medical imaging ,0104 chemical sciences ,03 medical and health sciences ,0302 clinical medicine ,Nuclear magnetic resonance ,Természettudományok ,T2 relaxation ,Bound water ,Amine gas treating ,Kémiai tudományok - Abstract
The CEST and T1 /T2 relaxation properties of a series of Eu3+ and Dy3+ DOTA-tetraamide complexes with four appended primary amine groups are measured as a function of pH. The CEST signals in the Eu3+ complexes show a strong CEST signal after the pH was reduced from 8 to 5. The opposite trend was observed for the Dy3+ complexes where the r2ex of bulk water protons increased dramatically from ca. 1.5 mm-1 s-1 to 13 mm-1 s-1 between pH 5 and 9 while r1 remained unchanged. A fit of the CEST data (Eu3+ complexes) to Bloch theory and the T2ex data (Dy3+ complexes) to Swift-Connick theory provided the proton-exchange rates as a function of pH. These data showed that the four amine groups contribute significantly to proton-catalyzed exchange of the Ln3+ -bound water protons even though their pKa 's are much higher than the observed CEST or T2ex effects. This demonstrated the utility of using appended acidic/basic groups to catalyze prototropic exchange for imaging tissue pH by MRI.
- Published
- 2017
21. Lanthanide-Based T2ex and CEST Complexes Provide Insights into the Design of pH Sensitive MRI Agents
- Author
-
Lei Zhang, André F. Martins, Piyu Zhao, Yunkou Wu, Gyula Tircsó, and A. Dean Sherry
- Subjects
03 medical and health sciences ,0302 clinical medicine ,General Medicine ,010402 general chemistry ,01 natural sciences ,030218 nuclear medicine & medical imaging ,0104 chemical sciences - Published
- 2017
22. Cover Feature: Probing the Catalytically Active Species in POM‐Catalysed DNA‐Model Hydrolysis (Chem. Eur. J. 35/2021)
- Author
-
Frederico F. Martins, Xabier Lopez, Jose Lanuza, Adrià Gil, Haralampos N. Miras, Ángel Sánchez-González, and Nuno A. G. Bandeira
- Subjects
Hydrolysis ,chemistry.chemical_compound ,chemistry ,Feature (computer vision) ,Stereochemistry ,Organic Chemistry ,Polyoxometalate ,Molecular models of DNA ,Cover (algebra) ,General Chemistry ,Catalysis ,DNA - Published
- 2021
23. Reproductive biology of Psammobatis rutrum (Chondrichthyes: Arhynchobatidae) in south Brazil, south-west Atlantic
- Author
-
Mariana F. Martins and Maria Cristina Oddone
- Subjects
0106 biological sciences ,Morphometrics ,biology ,Ecology ,010604 marine biology & hydrobiology ,Zoology ,Aquatic Science ,biology.organism_classification ,Fecundity ,010603 evolutionary biology ,01 natural sciences ,Chondrichthyes ,Reproductive biology ,Arhynchobatidae ,Vitellogenesis ,Psammobatis ,Oviparity ,Ecology, Evolution, Behavior and Systematics - Abstract
This study presents information on the reproductive biology of Psammobatis rutrum based on 55 males and 53 females obtained as by-catch from bottom trawlers off southern Brazil during July 2013 and September 2014 and includes a detailed description of the egg capsule. Total lengths (LT) ranged from 22·3 to 31·6 cm and most of the sample comprised larger individuals, although there were no sexual differences in length-frequency distributions. Significant sexual differences were found for total length-disc width, LT–body mass and LT–eviscerated body mass relationships, with females being heavier and larger. Males started to mature at 25·5 cm LT and females, at 25·9 cm LT, while LT at maturity was calculated in 26·67 and 26·81 cm, respectively. Attaining larger sizes and mass may represent a reproductive investment for females, as observed in other rajoid species. Egg bearing females were first observed over 27·1 cm LT and ovarian fecundity was 1–12 vitellogenic follicles. The egg capsules were 2·22–2·62 cm length and had attaching fibrils on both lateral sides. Microscopically, the ventral face of the egg capsule was rougher than the dorsal face.
- Published
- 2017
24. Chitin and Chitosan‐Based (NANO) Composites
- Author
-
Antonio G.B. Pereira, Alexandre Tadeu Paulino, Alessandro F. Martins, André R. Fajardo, You-Lo Hsieh, and Edvani C. Muniz
- Subjects
Materials science ,Nano composites ,02 engineering and technology ,Advanced materials ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,0104 chemical sciences ,Chitosan ,chemistry.chemical_compound ,chemistry ,Chemical engineering ,Chitin ,0210 nano-technology - Published
- 2017
25. Temporal overexpression of SIRT1 in skeletal muscle of adult mice does not improve insulin sensitivity or markers of mitochondrial biogenesis
- Author
-
Samuel LaBarge, Kristoffer Svensson, Simon Schenk, and Vitor F. Martins
- Subjects
Blood Glucose ,0301 basic medicine ,medicine.medical_specialty ,Physiology ,medicine.medical_treatment ,Mice, Transgenic ,Mitochondrion ,Article ,Mice ,03 medical and health sciences ,Insulin resistance ,Sirtuin 1 ,Internal medicine ,medicine ,Animals ,Homeostasis ,Respiratory function ,RNA, Messenger ,Muscle, Skeletal ,biology ,Insulin ,Skeletal muscle ,medicine.disease ,Mitochondria ,Insulin receptor ,Glucose ,030104 developmental biology ,medicine.anatomical_structure ,Endocrinology ,Mitochondrial biogenesis ,biology.protein ,Insulin Resistance ,Biomarkers ,Signal Transduction - Abstract
Aims Activation of the NAD+ dependent protein deacetylase SIRT1 has been proposed as a therapeutic strategy to treat mitochondrial dysfunction and insulin resistance in skeletal muscle. However, life-long overexpression of SIRT1 in skeletal muscle does not improve parameters of mitochondrial function and insulin sensitivity. In this study we investigated whether temporal overexpression of SIRT1 in muscle of adult mice would affect skeletal muscle mitochondrial function and insulin sensitivity. Methods To circumvent potential effects of germline SIRT1 overexpression, we utilized an inducible model of SIRT1 overexpression in skeletal muscle of adult mice (i-mOX). Insulin sensitivity was assessed by 2-deoxyglucose uptake, muscle maximal respiratory function by high-resolution respirometry and systemic energy expenditure was assessed by whole body calorimetry. Results Although SIRT1 was highly, and specifically, overexpressed in skeletal muscle of i-mOX compared to WT mice, glucose tolerance and skeletal muscle insulin sensitivity were comparable between genotypes. Additionally, markers of mitochondrial biogenesis, muscle maximal respiratory function and whole body oxygen consumption were also unaffected by SIRT1 overexpression. Conclusion These results support previous work demonstrating that induction of SIRT1 in skeletal muscle, either at birth or in adulthood, does not impact muscle insulin action or mitochondrial function. This article is protected by copyright. All rights reserved.
- Published
- 2017
26. Incorporation of conjugated fatty acids into Nile tilapia (Oreochromis niloticus)
- Author
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Luana Caroline Figueiredo, Alessandro F. Martins, Elton Guntendorfer Bonafé, Oscar Os Junior, Johny P. Monteiro, Swami Arêa Maruyama, Edmilson Antonio Canesin, and Jesuí Vergílio Visentainer
- Subjects
0301 basic medicine ,Muscle tissue ,030109 nutrition & dietetics ,Nutrition and Dietetics ,biology ,Linolenic acid ,010401 analytical chemistry ,Nutritional quality ,Conjugated system ,biology.organism_classification ,01 natural sciences ,0104 chemical sciences ,03 medical and health sciences ,chemistry.chemical_compound ,Oreochromis ,Nile tilapia ,medicine.anatomical_structure ,Biochemistry ,Biosynthesis ,chemistry ,medicine ,Ingestion ,Agronomy and Crop Science ,Food Science ,Biotechnology - Abstract
The aim of this work was to improve the nutritional quality of Nile tilapia meat through enriched diets with conjugated isomers of linolenic acid from tung oil. The transfer process of conjugated fatty acids (CFAs) into fish muscle tissue was evaluated by gas chromatography-flame ionization detection (GC-FID) and easy ambient sonic-spray ionization mass spectrometry (EASI-MS).; Results: The results showed that conjugated fatty acids were transferred from enriched diet for muscle tissue of Nile tilapia. Conjugated linoleic acids biosynthesis from conjugated linolenic acids was also observed after 10 days. Other important fatty acids such as docosahexaenoic (DHA), eicosapentaenoic (EPA) and arachidonic (AA) acids were also identified over time; however, DHA showed the highest concentration when compared with EPA and AA compounds.; Conclusion: Therefore, the nutritional quality of Nile tilapia was improved through feeding with enriched diets. The ingestion of these fish may contribute to reaching adequate levels of daily CFA consumption. Furthermore, other important substances which play an important role in human metabolism, such as EPA, DHA and AA, can also be ingested together with CFA. © 2016 Society of Chemical Industry.; © 2016 Society of Chemical Industry.
- Published
- 2017
27. Imaging Extracellular Lactate In Vitro and In Vivo Using CEST MRI and a Paramagnetic Shift Reagent
- Author
-
Yuyan Mai, André F. Martins, Lei Zhang, A. Dean Sherry, Piyu Zhao, Alexander M. Funk, Veronica Clavijo Jordan, Wei Chen, Yunkou Wu, and Shanrong Zhang
- Subjects
medicine.diagnostic_test ,010405 organic chemistry ,Chemistry ,Organic Chemistry ,Magnetic resonance imaging ,General Chemistry ,010402 general chemistry ,01 natural sciences ,Article ,Catalysis ,In vitro ,0104 chemical sciences ,Tissue culture ,Nuclear magnetic resonance ,In vivo ,Reagent ,Cancer cell ,medicine ,Extracellular ,Intracellular - Abstract
Overproduction of lactate is a hallmark of cancer, yet a method to quantitatively measure lactate production by cancer cells is not straight-forward. Chemical exchange saturation transfer magnetic resonance imaging (CEST MRI) can potentially be used to image lactate but the small difference in chemical shift of the lactate -OH proton and water proton resonances make it challenging. Like other spectroscopic methods, CEST MRI cannot discriminate intracellular lactate from extracellular lactate. Herein, we demonstrate a relatively simple way to shift the lactate -OH proton resonance far away from water by addition of the paramagnetic shift reagent, EuDO3A, while retaining the CEST properties of lactate itself. The potential of the method was demonstrated by imaging extracellular lactate excreted from lung cancer cells in tissue culture without interference from other components in the culture media and by imaging excess lactate excreted into the bladder of a mouse.
- Published
- 2017
28. Improved Tests for Forecast Comparisons in the Presence of Instabilities
- Author
-
Luis F. Martins and Pierre Perron
- Subjects
Statistics and Probability ,Applied Mathematics ,05 social sciences ,Autocorrelation ,Scale (descriptive set theory) ,Monotonic function ,Variance (accounting) ,01 natural sciences ,Power (physics) ,010104 statistics & probability ,0502 economics and business ,Econometrics ,A priori and a posteriori ,0101 mathematics ,Statistics, Probability and Uncertainty ,Null hypothesis ,Reversal test ,050205 econometrics ,Mathematics - Abstract
Of interest is comparing the out-of-sample forecasting performance of two competing models in the presence of possible instabilities. To that effect, we suggest using simple structural change tests, sup-Wald and UDmax as proposed by Andrews (1993) and Bai and Perron (1998), for changes in the mean of the loss-differences. Giacomini and Rossi (2010) proposed a Aiuctuations test and a one-time reversal test also applied to the loss-differences. When properly constructed to account for potential serial correlation under the null hypothesis to have a pivotal limit distribution, it is shown that their tests have undesirable power properties, power that can be low and non-increasing as the alternative gets further from the null hypothesis. The good power properties they reported is simply an artifact of imposing a priori that the loss di§erentials are serially uncorrelated and using the simple sample variance to scale the tests. On the contrary, our statistics are shown to have higher monotonic power, especially the UDmax version. We use their empirical examples to show the practical relevance of the issues raised.
- Published
- 2016
29. Monetary Developments and Expansionary Fiscal Consolidations: Evidence from the EMU
- Author
-
Luis F. Martins and António Afonso
- Subjects
Macroeconomics ,Economics and Econometrics ,Final consumption expenditure ,050208 finance ,05 social sciences ,Probit ,Fiscal union ,Order (exchange) ,Accounting ,Quantitative easing ,0502 economics and business ,Economics ,Economic and monetary union ,media_common.cataloged_instance ,050207 economics ,European union ,Finance ,Panel data ,media_common - Abstract
This paper provides new insights about the existence of expansionary fiscal consolidations in the Economic and Monetary Union, using annual panel data for 14 European Union countries over the period 1970-2012. Different measures for assessing fiscal consolidations based on the changes in the cyclically adjusted primary balance were calculated. A similar ad-hoc approach was used to compute monetary expansions, in order to include them in the assessment of non-Keynesian effects for different budgetary components. Panel Fixed Effects estimations for private consumption show that, in some cases, when fiscal consolidations are coupled with monetary expansions, the traditional Keynesian signals are reversed in the cases of general government final consumption expenditure, social transfers and taxes. Keynesian effects prevail when fiscal consolidations are not matched by monetary easing. Panel probit estimations suggest that longer and expenditure-based consolidations contribute positively for its success, whilst the opposite is the case for tax-based ones.
- Published
- 2015
30. TAMIS and ERUS in the treatment of a para-rectal tumor - a video vignette
- Author
-
Sandra F. Martins, Maria Lígia Sousa, Nuno Figueiredo, André Goulart, F Nogueira, C Viana, Pedro Leão, J P Pinto, and Universidade do Minho
- Subjects
medicine.medical_specialty ,Science & Technology ,business.industry ,General surgery ,Gastroenterology ,MEDLINE ,Video-Audio Media ,3. Good health ,03 medical and health sciences ,0302 clinical medicine ,Vignette ,030220 oncology & carcinogenesis ,Ciências Médicas::Medicina Básica ,Medicine ,030211 gastroenterology & hepatology ,business - Abstract
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- Published
- 2018
31. Letrozole Treatment of Pubertal Female Mice Results in Impaired Insulin Action in Skeletal Muscle
- Author
-
Varykina G. Thackray, Angelina Hernandez-Carretero, Matthew Riopel, Bryan Ho, Vitor F. Martins, and Simon Schenk
- Subjects
medicine.medical_specialty ,business.industry ,Letrozole ,Insulin ,medicine.medical_treatment ,Skeletal muscle ,Biochemistry ,medicine.anatomical_structure ,Endocrinology ,Action (philosophy) ,Internal medicine ,Genetics ,medicine ,business ,Molecular Biology ,Biotechnology ,medicine.drug - Published
- 2018
32. Basic MR relaxation mechanisms and contrast agent design
- Author
-
Neil M. Rofsky, Luis M. De León-Rodríguez, Dean Sherry, André F. Martins, and Marco Da Cunha Pinho
- Subjects
medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,MRI contrast agent ,Contrast resolution ,Magnetic resonance imaging ,Context (language use) ,Mr contrast ,Contrast (music) ,Human–computer interaction ,medicine ,Radiology, Nuclear Medicine and imaging ,Medical physics ,business - Abstract
The diagnostic capabilities of magnetic resonance imaging (MRI) have undergone continuous and substantial evolution by virtue of hardware and software innovations and the development and implementation of exogenous contrast media. Thirty years since the first MRI contrast agent was approved for clinical use, a reliance on MR contrast media persists, largely to improve image quality with higher contrast resolution and to provide additional functional characterization of normal and abnormal tissues. Further development of MR contrast media is an important component in the quest for continued augmentation of diagnostic capabilities. In this review we detail the many important considerations when pursuing the design and use of MR contrast media. We offer a perspective on the importance of chemical stability, particularly kinetic stability, and how this influences one's thinking about the safety of metal-ligand-based contrast agents. We discuss the mechanisms involved in MR relaxation in the context of probe design strategies. A brief description of currently available contrast agents is accompanied by an in-depth discussion that highlights promising MRI contrast agents in the development of future clinical and research applications. Our intention is to give a diverse audience an improved understanding of the factors involved in developing new types of safe and highly efficient MR contrast agents and, at the same time, provide an appreciation of the insights into physiology and disease that newer types of responsive agents can provide.
- Published
- 2015
33. Rickettsial Infection in Animals, Humans and Ticks in Paulicéia, Brazil
- Author
-
E Guedes, Marcelo Bahia Labruna, Cassio Peterka, Iara Silveira, Maria Marlene Martins Olegário, Thiago F. Martins, and Fernando Ferreira
- Subjects
Male ,Veterinary medicine ,Epidemiology ,Tick ,Polymerase Chain Reaction ,Amblyomma cajennense ,Dogs ,Ticks ,Blood serum ,Risk Factors ,parasitic diseases ,Animals ,Humans ,Horses ,Rickettsia ,Antigens, Bacterial ,General Veterinary ,General Immunology and Microbiology ,biology ,Public Health, Environmental and Occupational Health ,Blastocerus dichotomus ,Amblyomma ,Agriculture ,Rickettsia Infections ,Opossums ,bacterial infections and mycoses ,biology.organism_classification ,FEBRE MACULOSA ,Spotted fever ,Infectious Diseases ,Tick-Borne Diseases ,Multivariate Analysis ,Rhipicephalus microplus ,Arachnid Vectors ,Female ,Brazil - Abstract
A previous study in Paulicéia Municipality, south-eastern Brazil, reported 9.7% of the Amblyomma triste ticks to be infected by Rickettsia parkeri, a bacterial pathogen that causes spotted fever in humans. These A. triste ticks were shown to be associated with marsh areas, where the marsh deer Blastocerus dichotomus is a primary host for this tick species. During 2008-2009, blood serum samples were collected from 140 horses, 41 dogs, 5 opossums (Didelphis albiventris) and 26 humans in farms from Pauliceia Municipality. Ticks were collected from these animals, from vegetation and from additional wildlife in these farms. Overall, 25% (35/140) of the horses, 7.3% (3/41) of the dogs, 3.8% (1/26) of the humans and 100% (5/5) of the opossums were seroreactive (titre ≥64) to spotted fever group (SFG) Rickettsia spp. Multivariate statistical analysis indicated that horses that were allowed to forage in the marsh were 4.8 times more likely to be seroreactive to spotted fever group (SFG) Rickettsia spp than horses that did not forage in the marsh. In addition, horses that had been living in the farm for more than 8.5 years were 2.8 times more likely to be seroreactive to SFG Rickettsia spp than horses that were living for ≤8.5 years. Ticks collected from domestic animals or from vegetation included Amblyomma cajennense, Amblyomma coelebs, Amblyomma dubitatum, Dermacentor nitens and Rhipicephalus microplus. By PCR analyses, only one pool of A. coelebs ticks from the vegetation was shown to be infected by rickettsiae, for which DNA sequencing revealed to be Rickettsia amblyommii. Ticks (not tested by PCR) collected from wildlife encompassed A. cajennense and Amblyomma rotundatum on lizards (Tupinambis sp), and A. cajennense and A. triste on the bird Laterallus viridis. Our results indicate that the marsh area of Paulicéia offers risks of infection by SFG rickettsiae.
- Published
- 2015
34. Comparative analysis of the male reproductive accessory glands of bat species from the five Brazilian Subfamilies of the family Phyllostomidae (Chiroptera)
- Author
-
Mateus R. Beguelini, Eliana Morielle-Versute, Sebastião Roberto Taboga, Cintia C. I. Puga, Patricia S.L. Vilamaior, and Fabiane F. Martins
- Subjects
Desmodus ,biology ,Glossophaga ,Zoology ,Carollia ,Stenodermatinae ,biology.organism_classification ,Bulbourethral gland ,medicine.anatomical_structure ,Platyrrhinus ,medicine ,Animal Science and Zoology ,Phyllostominae ,Developmental Biology ,Glossophaginae - Abstract
This study aimed to morphologically characterize and compare the male reproductive acces- sory glands (RAGs) of bats belonging to the five Brazil- ian subfamilies of the family Phyllostomidae (Carollia perspicillata—Carollinae; Desmodus rotundus—Desmo- dontinae; Glossophaga soricina—Glossophaginae; Phyl- lostomus discolor—Phyllostominae and Platyrrhinus lineatus—Stenodermatinae). The study demonstrated that the RAGs of phyllostomid bats were comprised of a pair of extra-abdominal bulbourethral glands and an intra-abdominal complex, composed of paraurethral glands and a prostate with two (Desmodontinae and Stenodermatinae) or three (Carollinae, Glossophaginae and Phyllostominae) different regions, with the absence of the seminal vesicles; this pattern possibly evolved from a process of compaction of the prostatic regions from an ancestor with three regions. J. Morphol.
- Published
- 2014
35. Abstracts of the ESE Wladimir Adlivankine Research Prize and Original Scientific Posters
- Author
-
João Miguel Marques dos Santos, Katarzyna Olczak, Ana Moura teles, Sebastian Ortolani Seltenerich, Elisabetta Cotti, Sławomir Ledzion, Suzan Amin, Rui F. Martins, and Alexis Gaudin
- Subjects
medicine.medical_specialty ,Cone beam computed tomography ,Visual analogue scale ,business.industry ,medicine ,Medical physics ,Decision confidence ,business ,Endodontics ,General Dentistry - Abstract
16th ESE (European Society of Endodontology) Biennial Congress; Lisbon, Portugal; 12-14 September 2013
- Published
- 2013
36. Seed Treatment with Live or Dead Fusarium verticillioides Equivalently Reduces the Severity of Subsequent Stalk Rot
- Author
-
Jay Swerbilow, Shawn A. Christensen, Vitor F. Martins, James Sims, Alisa Huffaker, Eric A. Schmelz, Martha M. Vaughan, Peter E. A. Teal, Nicole D. Benda, and Hans T. Alborn
- Subjects
Fusarium ,biology ,Physiology ,fungi ,food and beverages ,Plant Science ,Fungus ,biology.organism_classification ,Endophyte ,Terpenoid ,chemistry.chemical_compound ,Agronomy ,chemistry ,Stalk ,Seed treatment ,Genetics ,Mycotoxin ,Agronomy and Crop Science ,Pathogen - Abstract
Fusarium verticillioides is a widely distributed fungus that can associate with maize as a deleterious pathogen and an advantageous endophyte. Here, we show that seed treatment with live F. verticillioides enhances maize resistance to secondary stalk rot infection and further demonstrate that dead F. verticillioides is sufficient to equivalently reduce F. verticillioides biomass. Seed treatment with live or dead F. verticillioides primes maize plants, and upon subsequent stalk infection, terpenoid phytoalexins accumulate faster than control-treated plants. Seed treatment did not constitutively activate plant defences nor did it impact plant growth. These results suggest that seed treatment with dead F. verticillioides can be used as a ‘vaccination’ method to decrease the severity of stalk rot and potentially pathogen infection throughout the plant.
- Published
- 2013
37. The Empirical Determinants of Credit Default Swap Spreads: a Quantile Regression Approach
- Author
-
João Pedro Pereira, Luis F. Martins, and Pedro Pires
- Subjects
Credit default swap index ,Leverage (finance) ,Credit default swap ,iTraxx ,Financial economics ,Accounting ,Econometrics ,Economics ,Implied volatility ,General Economics, Econometrics and Finance ,Credit risk ,Quantile ,Quantile regression - Abstract
We study the empirical determinants of Credit Default Swap (CDS) spreads through quantile regressions. In addition to traditional variables, such as implied volatility, put skew, historical stock return, leverage, profitability, and ratings, the results indicate that CDS premiums are strongly determined by CDS illiquidity costs, measured by absolute bid-ask spreads. The quantile regression approach reveals that high-risk firms are more sensitive to changes in the explanatory variables that low-risk firms. Furthermore, the goodness-of-fit of the model increases with CDS premiums, which is consistent with the credit spread puzzle.
- Published
- 2013
38. PDMS extraction bars for the determination of volatile aromatic hydrocarbons in water and wastewater
- Author
-
Daiane S. da Silva, Francieli M. Mayer, Carla G. B. Brenner, Ayrton F. Martins, and Sheila Montipó
- Subjects
chemistry.chemical_compound ,Chromatography ,chemistry ,Wastewater ,Extraction (chemistry) ,Xylene ,Filtration and Separation ,Benzene ,Effluent ,High-performance liquid chromatography ,Toluene ,Ethylbenzene ,Analytical Chemistry - Abstract
In this study, the preparation and application of extraction bars of PDMS were investigated to preconcentrate and determine benzene, toluene, ethylbenzene, and xylene in water and wastewater by means of HPLC with fluorescence detection. Aliquot samples from hospital wastewater were used as the model effluent. The independent variables for the sorptive extraction were as follows: ionic strength (added amounts of NaCl); pH; temperature and time of absorption; temperature and time of desorption. Under optimized conditions, by using a factorial design, the suspended extraction bars could allow the determination of benzene, toluene, ethylbenzene, and xylene (1.20 ± 0.05 μg/L; 10.40 ± 0.02 μg/L; 1.80 ± 0.04 μg/L; 15.9 ± 0.04 μg/L, respectively) in hospital effluent (fortified samples), by recoveries of 71.9 ± 4.9 to 74.8 ± 5.6%. This procedure represents an innovation that eliminates the time-consuming stage of vacuum microfiltration, and allows the determination of volatile organic compounds by HPLC. As far as we know, this procedure is original and represents an important contribution to the field.
- Published
- 2012
39. Convergence of the Economic Sentiment Cycles in the Eurozone: A Time-Frequency Analysis
- Author
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Maria Joana Soares, Luís Aguiar-Conraria, and Manuel M. F. Martins
- Subjects
Phase difference ,Economics and Econometrics ,050208 finance ,Financial economics ,05 social sciences ,Convergence (economics) ,Monetary economics ,General Business, Management and Accounting ,Currency ,8. Economic growth ,0502 economics and business ,Political Science and International Relations ,Synchronization (computer science) ,Business cycle ,Economics ,050207 economics ,Business and International Management ,European monetary union - Abstract
In this article, wavelet tools and economic sentiment indicators are used to study the similarity and synchronization of economic cycles in the eurozone. The time-varying and frequency-varying patterns of business cycles synchronization are assessed and the impact of the creation of the European monetary union (EMU) in 1999 is tested. Among several results, it is found that: the EMU is associated with a significant increase in the similarity and synchronization of the economic sentiment in the eurozone; and the hard-peg of its currency to the euro led to a comparable effect on Denmark's economic sentiment after 1999, different from what happened in the United Kingdom.
- Published
- 2012
40. Quantification of Diclofenac in Hospital Effluent and Identification of Metabolites and Degradation Products
- Author
-
Luciane Minetto, Francieli M. Mayer, Carlos A. Mallmann, and Ayrton F. Martins
- Subjects
Environmental Chemistry ,Pollution ,Water Science and Technology - Published
- 2012
41. TESTING FOR PARAMETER CONSTANCY USING CHEBYSHEV TIME POLYNOMIALS*
- Author
-
Luis F. Martins
- Subjects
Economics and Econometrics ,Sieve ,Stationary process ,Autoregressive model ,Simple (abstract algebra) ,law ,Sample size determination ,Econometrics ,Economics ,Regression analysis ,Chebyshev filter ,Bootstrapping (statistics) ,law.invention - Abstract
We propose a simple method of testing for parameter constancy in regression models with stationary data that allow for coefficients that vary smoothly over time. The method is shown to have good statistical properties. A sieve bootstrapping procedure is suggested to improve the finite sample size of the test for a large number of time polynomials in autoregressive models. We revisited Hansen's study (Journal of Economic Perspectives, Vol. 15 (2001), pp. 117–128) of structural breaks in a first-order autoregressive model of labor productivity in the US manufacturing/durables sector and found evidence of time-varying autoregressive parameter.
- Published
- 2012
42. Tris(phosphonomethyl)cyclen Derivatives: Thermodynamic Stability, Kinetics, Solution Structure, and Relaxivity of Ln 3+ Complexes
- Author
-
Carlos F. G. C. Geraldes, Petr Hermann, Rita Delgado, André F. Martins, Éva Tóth, Luís M. P. Lima, Přemysl Lubal, Henrique F. Carvalho, Radek Ševčík, Department of Prosthodontics, Semmelweis University [Budapest], Centre de biophysique moléculaire (CBM), and Université d'Orléans (UO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)
- Subjects
Lanthanide ,Lanthanide complexes ,Square antiprismatic molecular geometry ,010405 organic chemistry ,Stereochemistry ,Ligand ,010402 general chemistry ,01 natural sciences ,Medicinal chemistry ,Dissociation (chemistry) ,0104 chemical sciences ,Inorganic Chemistry ,Macrocyclic ligands ,Kinetics ,chemistry.chemical_compound ,chemistry ,Cyclen ,Thermodynamics ,Molecule ,[SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology ,Chemical stability ,Relaxivity ,Methylphosphonic acid - Abstract
International audience; The lanthanide (Ln3+) complexes of three cyclen-based ligands containing three methylphosphonate pendant arms were studied, the ligands being 1,4,7,10-tetraazacyclododecane-1,4,7-triyltris(methylphosphonic acid) (H6do3p), 3-[4,7,10-tris(phosphonomethyl)-1,4,7,10-tetraazacyclododec-1-yl]propanoic acid (H7do3p1pr), and 10-(3-hydroxypropyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyltris(methylphosphonic acid) (H6do3p1ol). The three macrocyclic ligands form complexes of very high thermodynamic stability with all studied Ln3+ ions. Kinetic studies showed that the acid-assisted dissociation of Ce3+ complexes of these ligands is much faster than for the complex of the related ligand H8dotp [1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrayltetrakis(methylphosphonic acid)]. The number of water molecules coordinated to the Eu3+ and Gd3+ complexes was estimated to be < 1 for the do3p1ol ligand but ca. 1 for the other two ligands, as obtained by time-resolved luminescence spectroscopy and by 1H and 17O relaxometric measurements. The NMR spectroscopic data indicate the existence of a considerable contribution from second-sphere water molecules to the relaxivity of all the Gd3+ complexes studied. The 1H and 31P NMR spectra of the Eu3+, Yb3+ and Lu3+ complexes showed that the propionate arm in the [Ln(do3p1pr)]4- complexes and the propanol arm in the [Ln(do3p1ol)]3- complexes are not bound to the Ln3+ ion. The [Ln(do3p)]3- and [Ln(do3p1pr)]4- complexes have a clear preference for the TSAP (twisted square antiprismatic) isomer, while both SAP (square antiprismatic) and TSAP isomers are present in solutions of the [Ln(do3p1ol)]3- complexes.
- Published
- 2012
43. Occurrence of the Antimicrobials Sulfamethoxazole and Trimethoprim in Hospital Effluent and Study of Their Degradation Products after Electrocoagulation
- Author
-
Daniel R. Arsand, Francieli M. Mayer, Ayrton F. Martins, Carla G. B. Brenner, and Carlos Augusto Mallmann
- Subjects
Aqueous solution ,Chromatography ,Chemistry ,Sulfamethoxazole ,medicine.medical_treatment ,Chemical oxygen demand ,bacterial infections and mycoses ,urologic and male genital diseases ,Pollution ,Trimethoprim ,female genital diseases and pregnancy complications ,Electrocoagulation ,Adsorption ,medicine ,Environmental Chemistry ,Response surface methodology ,Effluent ,Water Science and Technology ,medicine.drug - Abstract
In this study, an investigation was carried out into the occurrence of sulfamethoxazole (SMX) and trimethoprim (TMP) in the effluent of the university hospital (HUSM) of the UFSM. The degradation of these antimicrobials by the electrocoagulation (EC) process was also examined, in both the aqueous solution and hospital effluent, and a study was conducted in order to identify the subproducts formed. The experiments were optimized through factorial planning and, also, checked by response surface methodology. The best conditions for EC (achieving 58.0% of chemical oxygen demand (COD) reduction) were obtained by using 13 mA cm -2 , 500 mg L -1 of NaCl, and 30mm of interelectrode distance. The quantification of SMX (27.8 μg L -1 ) and TMP (6.65 μg L -1 ) in the hospital effluent, and the identification of the degradation products were carried out through liquid chromatography-mass spectrometry quadrupole linear and ion trapping with electrospray ionization (LC-ESI-MS/MS_QTrap). Removals of 88.0% (degradation only) and 33.0% (adsorption only) were achieved for aqueous solutions of SMX and TMP, respectively, under optimized conditions. In hospital effluent samples, fortified with additions of SMX and TMP, corresponding removals of 16.0% (degradation) and 28.0% (adsorption) were achieved. This suggests that the EC process is efficient in degrading SMX in aqueous solution, although the same was not the case with TMP. The degradation products of SMX were identified (m/z 256.0 and 288.5); however, only the latter is mentioned in the literature. Toxicological aspects were not considered in this study.
- Published
- 2010
44. Determination of Sulfamethoxazole and Trimethoprim and Their Metabolites in Hospital Effluent
- Author
-
Ayrton F. Martins, Carlos Augusto Mallmann, Carla G. B. Brenner, Daniel R. Arsand, and Francieli M. Mayer
- Subjects
Detection limit ,Chromatography ,Calibration curve ,Chemistry ,Sulfamethoxazole ,Selected reaction monitoring ,Pollution ,Trimethoprim ,Linear range ,Liquid chromatography–mass spectrometry ,medicine ,Environmental Chemistry ,Ion trap ,Water Science and Technology ,medicine.drug - Abstract
In this work, an analytical methodological study was carried out to determine the antimicrobials sulfamethoxazole and trimethoprim, as well as their metabolites, in hospital effluent. The determinations were conducted by liquid chromatography tandem mass spectrometry using a hybrid triple quadrupole-linear ion trap mass spectrometer (LC-QqLIT-MS). The data acquisition was made in selected reaction monitoring (SRM) mode, in which two SRM transitions were monitored to ensure that the target compounds were accurately identified by the information dependent acquisition (IDA) function. The limits of detection (LOD) and quantification (LOQ) were 0.25 and 0.80 μgL -1 for sulfamethoxazole and 0.15 and 0.50 μg L -1 for trimethoprim. The linear range for the SMX was 0.8-100.0 μg L -1 and TMP was 0.5-100.0 μgL -1 on the basis of six-point calibration curves generated by means of linear regression analysis. The coefficients of the correlation were higher than 0.999, which ensured the linearity of the method. The average concentration of sulfamethoxazole and trimethoprim found in hospital effluent was 27.8 and 6.65 μgL -1 , respectively. The analytical methodology employed allowed two metabolites to be identified, N4-acetyl-sulfamethoxazole and α-hydroxy-trimethoprim. Fragmentation pathways were proposed.
- Published
- 2010
45. Chemical characterisation of Nephrops norvegicus from Portuguese coast
- Author
-
Maria Leonor Nunes, Patrícia Anacleto, Helena Lourenço, Maria Luísa Carvalho, Cláudia Afonso, A.R. Lino, and Maria F Martins
- Subjects
Cadmium ,Nutrition and Dietetics ,biology ,Chemistry ,Sodium ,Potassium ,chemistry.chemical_element ,biology.organism_classification ,Crustacean ,Nephrops norvegicus ,Environmental chemistry ,media_common.cataloged_instance ,European union ,Agronomy and Crop Science ,Shellfish ,Food Science ,Biotechnology ,media_common ,Food contaminant - Abstract
BACKGROUND: Among seafood products, crustaceans are an important group owing to their nutritional benefits and high market value. The aim of this study was to evaluate the proximate composition as well as essential and non-essential elements in the edible muscle of Nephrops norvegicus (Norway lobster). RESULTS: The studied crustacean showed a high protein level of about 210 g kg−1 and a mineral level of about 24 g kg−1. The pattern for the elements studied was Cl > Na > K > P > S > Ca > Mg > Br > Fe > Sr ≈ Zn > Cu > Mn > Rb > Se > Ni > Cr. Regarding non-essential elements, the average total Hg content was 0.40 mg kg−1, but two samples exceeded the legal limit set by the European Union (EU) for Hg in crustaceans (0.50 mg kg−1). The levels of Pb and Cd found in all samples were below the EU limits (0.50 mg kg−1 for both metals). CONCLUSION:Nephrops norvegicus is a good source of protein and contains most minerals at levels sufficient to satisfy the dietary reference intake. The amounts of Pb and Cd are not a concern. Hg levels indicate some contamination; however, taking into account the type of consumption of this species, it can be concluded that this does not represent a risk in terms of the human diet. Copyright © 2009 Society of Chemical Industry
- Published
- 2009
46. Genetic variability and phylogeny of the high-risk HPV-31, -33, -35, -52, and -58 in central Brazil
- Author
-
Daniela M. Cerqueira, Natália von Gal Milanezi, Patrícia Soares Wyant, Regina M.S. Amorim, Laura Sichero, Cláudia R. F. Martins, Tainá Raiol, and Marcelo M. Brigido
- Subjects
Risk ,Genetics ,Phylogenetic tree ,Sequence analysis ,Molecular Sequence Data ,Papillomavirus Infections ,Genetic Variation ,Oncogene Proteins, Viral ,Sequence Analysis, DNA ,Biology ,Genome ,Infectious Diseases ,Phylogenetics ,Virology ,GenBank ,DNA, Viral ,Genetic variation ,Humans ,Female ,Genetic variability ,Papillomaviridae ,Gene ,Brazil ,Phylogeny - Abstract
More than 100 HPV types have been described, 13 of which are classified as high-risk due to their association with the development of cervical cancer. The intratype genomic diversity of HPV-16 and -18 has been studied extensively, while little data have been generated for other less common high-risk types. The present study explores the nucleotide variability and phylogeny of the high-risk HPV-31, -33, -35, -52, and -58, in samples from Central Brazil. For this purpose, the LCR and the E6 and L1 genes were sequenced. Several variants of these HPV types were detected, some of which have been detected in other parts of the world. Furthermore, new variants of all types examined were characterized in a total of 13 new variants. Based on the E6 and L1 sequences, variants were described comprising conservative and non-conservative amino acid changes. For phylogenetic tree construction, samples characterized in this study were compared to others described and submitted to GenBank previously. The phylogenetic analysis of HPV-31, -33, -35, and -58 isolates did not reveal ethnic or geographical clustering as observed previously for HPV-16 and -18. HPV-35 analysis showed a dichotomic branching characteristic of viral subtypes. Interestingly, four clusters relative to the analysis of HPV-52 isolates were identified, two of which could be classified as Asian and European branches. The genomic characterization of HPV variants is crucial for understanding the intrinsic geographical relatedness and biological differences of these viruses and contributes further to studies on their infectivity and pathogenicity.
- Published
- 2009
47. A Study of Photocatalytic Processes Involving the Degradation of the Organic Load and Amoxicillin in Hospital Wastewater
- Author
-
Carla da S. Frank, Francieli M. Mayer, Ayrton F. Martins, and Eliza C. Confortin
- Subjects
Light intensity ,Chromatography ,Wastewater ,Chemistry ,Chemical oxygen demand ,Photocatalysis ,Environmental Chemistry ,Sewage treatment ,Response surface methodology ,Pollution ,Effluent ,High-performance liquid chromatography ,Water Science and Technology - Abstract
An investigation was carried out into the treatment of wastewater from the University Hospital of Santa Maria (HUSM) by means of a heterogeneous photocatalytic process (HPP) and a photo-Fenton process (PFP) using Response Surface Methodology (RSM) for maximizing the removal efficiency of the chemical oxygen demand, COD. The rates of COD reduction obtained by HPP and PFP were 44 and 64.6%, respectively. The toxicity (LC 50 values) of the hospital wastewater (pre- and post-treatment) were determined by means of the bioassay Artemia salina. During the treatment a toxicity inhibition of 43.5% was achieved by photo-Fenton and 46.3% by TiO 2 photocatalysis. Spiked samples of hospital effluent with amoxicillin were degraded by 100% after treatment by HPP for 30 min and 85% after treatment by PFP for 60 min, as measured by high performance liquid chromatography (HPLC). All the treatments were conducted on a bench scale using a batch recirculation 2 L Dewar-like photoreactor provided with a light intensity of 401 W/m 2 , which was irradiated by a 125 W medium pressure mercury vapor lamp. Ferrioxalate actinometry solution was used to measure the photon flux (q = 1.71·10 -5 ± 1.25 ·10 -7 ). The photonic efficiency was 30.00 ± 0.67% for PFP and 19.02 ± 0.88% for HPP.
- Published
- 2009
48. Study of Metal Distribution in Raw and Screened Swine Manure
- Author
-
Valderi L. Dressler, Ayrton F. Martins, Airton Kunz, Ricardo Luis Radis Steinmetz, and Erico M.M. Flores
- Subjects
Cadmium ,Waste management ,chemistry.chemical_element ,Sulfuric acid ,Pollution ,Manure ,chemistry.chemical_compound ,chemistry ,Wastewater ,Nitric acid ,Inductively coupled plasma atomic emission spectroscopy ,Environmental chemistry ,Environmental Chemistry ,Sample preparation ,Effluent ,Water Science and Technology - Abstract
The growth of industrial swine production over the last few years has led to a growth in concern over effluents generated by the activity. Several elements, mainly toxic metals, can be present in swine wastewater and can have a serious environmental impact. It is important, therefore, to know the metal concentration before the discharge of wastewater. In this work the temporal metal distribution in swine manure and its potential reduction using coarse (2 mm) and fine (
- Published
- 2009
49. COD Evaluation of Hospital Effluent by Means of UV-Spectral Deconvolution
- Author
-
Ayrton F. Martins, Daniel R. Arsand, Carla G. B. Brenner, and Luciane Minetto
- Subjects
MERCURE ,Pollutant ,Chemistry ,digestive, oral, and skin physiology ,Chemical oxygen demand ,chemistry.chemical_element ,Pollution ,Mercury (element) ,Absorbance ,Wastewater ,Environmental chemistry ,Environmental Chemistry ,Deconvolution ,Effluent ,Water Science and Technology - Abstract
The Chemical Oxygen Demand (COD) is an important parameter for the evaluation of the oxidizable matter in water and effluent in general. Although laborious and time-consuming, the Standard Method for COD determination employs very toxic pollutants, i. e., dichromate and mercury, which are now being gradually avoided or replaced. In general, the organic load of effluents usually shows absorbance in the UV-visible region, as a result of the presence of absorbing groups in its organic constituents, e. g., in the case of aromatic compounds, they show the well-known UV fingerprint. In this study, an attempt has been made to find a deconvolution correlation between the COD values of effluent samples from the Hospital of the Federal University of Santa Maria (HUSM) and their integrated UV-absorbances. Experimental procedures reveal a correlation of +0.567, classified as moderate positive and with a significancy of 0.0001, between the estimated and the determined values. Hence, a COD-estimation for hospital effluents is proposed, through a simple spectrophotometric measurement of the integrated absorbance in the 285–295 nm range.
- Published
- 2008
50. Modelling fatigue crack propagation in CT specimens
- Author
-
Fernando Antunes, Ricardo Branco, and Rui F. Martins
- Subjects
Materials science ,Computer simulation ,business.industry ,Mechanical Engineering ,Magnitude (mathematics) ,Fatigue testing ,Fracture mechanics ,Mechanics ,Structural engineering ,Physics::Classical Physics ,Physics::Geophysics ,Fatigue crack propagation ,Mechanics of Materials ,General Materials Science ,business ,Order of magnitude ,K-distribution - Abstract
Although there are a great number of numerical studies focused on the numerical simulation of crack shape evolution, a deeper understanding is required concerning the numerical parameters and the mathematical modelling. Therefore, the objectives of the paper are the study of the influence of numerical parameters, particularly the radial size of crack front elements and the magnitude of individual crack extensions, the mathematical modelling of crack propagation regimes, and the linking of crack shape changes with K distribution. A relatively simple through-crack geometry, the CT specimen, was studied and the numerical model was validated with experimental results with a good agreement. The K distribution along crack front was found to be the driving force for shape variations. Shape variations were found to be one order of magnitude lower than K variations.
- Published
- 2008
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