8 results on '"Extended thymectomy"'
Search Results
2. Risk factors for developing post‐thymectomy myasthenia gravis in patients with thymoma
- Author
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Jung-Joon Sung, Yoon-Ho Hong, Je Young Shin, Chang Hyun Kang, Seonkyung Lee, Sung Min Kim, Jin Ah Kim, Ahwon Kim, Hyoshin Son, and Seok Jin Choi
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Adult ,Male ,0301 basic medicine ,medicine.medical_specialty ,Thymoma ,Physiology ,medicine.medical_treatment ,Extended thymectomy ,030105 genetics & heredity ,Gastroenterology ,World health ,03 medical and health sciences ,Cellular and Molecular Neuroscience ,0302 clinical medicine ,Risk Factors ,Physiology (medical) ,Internal medicine ,Myasthenia Gravis ,Humans ,Medicine ,Receptors, Cholinergic ,In patient ,Retrospective Studies ,business.industry ,Hazard ratio ,Thymus Neoplasms ,Middle Aged ,Thymectomy ,medicine.disease ,Myasthenia gravis ,Female ,Neurology (clinical) ,business ,030217 neurology & neurosurgery ,Partial thymectomy - Abstract
BACKGROUND Thymectomy is required for the treatment of thymoma-associated myasthenia gravis (MG). However, MG may develop only after thymectomy, a condition known as post-thymectomy MG. This study aimed to investigate the risk factors for post-thymectomy MG in patients with thymoma. METHODS We retrospectively identified 235 patients with thymoma who underwent thymectomy at a single hospital from January 2008 to December 2017: 44 with preoperatively diagnosed MG were excluded, leaving 191 patients in the final analysis. Univariable survival analyses using Cox proportional hazards regression model and Kaplan-Meier estimate were conducted to identify risk factors for post-thymectomy MG. RESULTS Post-thymectomy MG developed in 4.2% (8/191) of the patients with thymoma between 18 days and 108 mo after surgery. Hazard ratios (HRs) of pre- and postoperative anti-acetylcholine receptor antibody (AChR-Ab) titers were 2.267 (P = .002) and 1.506 (P
- Published
- 2021
3. Photochemotherapy for thymoma‐associated graft‐versus‐host disease‐like eruptions
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Asako Kogure, Yoshihiro Kuwano, and Taeko Goto
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medicine.medical_specialty ,Thymoma ,business.industry ,Immunology ,Graft vs Host Disease ,Extended thymectomy ,Thymus Neoplasms ,Dermatology ,General Medicine ,medicine.disease ,Myasthenia gravis ,Surgery ,Metastasis ,Graft-versus-host disease ,Photochemotherapy ,Humans ,Immunology and Allergy ,Medicine ,Ultraviolet Therapy ,Radiology, Nuclear Medicine and imaging ,business ,Scalp hair loss - Abstract
The patient presented to our hospital with systemic eruptions and scalp hair loss. Six years ago, he underwent extended thymectomy for a diagnosis of thymoma complicated by myasthenia gravis. Three years post-surgery, recurrence manifested as left-sided pleural dissemination and liver metastasis.
- Published
- 2021
4. Mediastinal venolymphatic malformations mimicking thymic carcinoma
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Ji Yeon Kim, Do Kyun Kang, Youn-Ho Hwang, and Min Kyun Kang
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0301 basic medicine ,Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,medicine.medical_treatment ,Extended thymectomy ,Case Report ,Case Reports ,lcsh:RC254-282 ,Asymptomatic ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Thymic carcinoma ,business.industry ,Mediastinum ,Clinical course ,Mediastinal mass ,General Medicine ,lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,medicine.disease ,030104 developmental biology ,medicine.anatomical_structure ,Oncology ,Median sternotomy ,030220 oncology & carcinogenesis ,Radiology ,medicine.symptom ,thymic carcinoma ,Complication ,business ,venolymphatic malformation - Abstract
This report was about a 60‐year‐old asymptomatic female patient who presented to our clinic with an anterior mediastinal mass found on routine chest computed tomography (CT). Chest CT revealed an irregular poorly enhanced anterior mediastinal mass which showed signs of infiltration to adjacent structures with sparse calcifications. The preliminary diagnosis was thymic carcinoma. The patient underwent extended thymectomy via median sternotomy and complete excision of the tumor. A small draining vein to the left brachiocephalic vein and phleboliths were identified in the tumor. A definitive diagnosis was made of mediastinal venolymphatic malformation (VLM). The patient had an uneventful clinical course and was discharged without further complication. This report highlights that it is possible to misdiagnose mediastinal VLM as thymic carcinoma and could serve as a useful reminder to physicians in the future.
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- 2019
5. De novo thymic carcinoma or malignant transformation: a myasthenic patient presented with multiple mediastinal tumours
- Author
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Yi-Chen Yeh, Chien-Sheng Huang, Chih Ming Lin, Biing‐Shiun Huang, and Chu‐Pin Pai
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Pulmonary and Respiratory Medicine ,Pathology ,medicine.medical_specialty ,Thymoma ,Ocular myasthenia ,Extended thymectomy ,Case Report ,Computed tomography ,Case Reports ,Malignant transformation ,03 medical and health sciences ,0302 clinical medicine ,hemic and lymphatic diseases ,medicine ,Thymic carcinoma ,lcsh:RC705-779 ,myasthenia gravis ,medicine.diagnostic_test ,business.industry ,lcsh:Diseases of the respiratory system ,thymoma ,medicine.disease ,Myasthenia gravis ,030228 respiratory system ,030220 oncology & carcinogenesis ,Differential diagnosis ,thymic carcinoma ,business - Abstract
A 63‐year‐old man presented with bilateral ptosis, and detailed evaluation confirmed ocular myasthenia gravis with three anterior mediastinal masses on computed tomography (CT) of the chest. Extended thymectomy was performed, and pathology revealed two thymic carcinoma and one thymoma. After surgery, the patient is free from recurrence. Synchronous triple thymic carcinomas and thymoma have not been reported. The finding of this case report supports the hypothesis of malignant transformation of thymoma to thymic carcinoma. Thymic carcinoma should be considered in the differential diagnosis of multiple thymic tumours, and extended thymectomy should be the treatment of choice., Synchronous triple thymic carcinomas and thymoma have not been reported. The finding of this case report supports the hypothesis of malignant transformation of thymoma to thymic carcinoma.
- Published
- 2020
6. Experience with the 'da Vinci' robotic system for early-stage thymomas: Report of 23 cases
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Bo Ye, Heng Zhao, Yu Yang, Ping Huang, and Jicheng Tantai
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Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Thymoma ,business.industry ,medicine.medical_treatment ,Extended thymectomy ,General Medicine ,medicine.disease ,Surgery ,Masaoka Stage I ,Thymectomy ,Robotic systems ,Oncology ,medicine ,Operative time ,Stage (cooking) ,business ,Pathological - Abstract
Background The aim of this study was to report a single referral center experience in robotic extended thymectomy for clinical early stage thymomas, evaluating its safety, feasibility and efficacy, with special regard to oncological outcomes. Methods Between January 2009 and December 2012, we retrospectively selected patients who underwent robotic extended thymectomy for clinical early stage thymomas. Operative time, morbidity, mortality, duration of hospitalization, and overall and disease-free survival were analyzed. Results There were 23 patients (15 males, eight females) with a mean age of 49.3 years (range 20–66). There were no intra-operative complications, and no mortality. The mean operative time was 85.2 minutes (range 60–180). No patient underwent conversion to open surgery. All post-operative complications (4.3%) were conservatively treated. The mean post-operative stay was 3.6 days (range two to nine). The pathological analysis revealed Masaoka stage I (21 cases) and II (two cases). No disease recurrence occurred at a mean follow-up of 24.8 months. Conclusions Robotic thymectomy is a safe and feasible technique, with a short operative time and low morbidity. Even on a small series with short follow-up, robotic extended thymectomy for thymoma appeared to be an effective treatment for early-stage thymomas.
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- 2014
7. Analysis of Peripheral Blood Dendritic Cell Subtypes in Thymomatous MG
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Wenbo Wang, Qiushi Wang, Yunduo Liu, Linyou Zhang, and Y.-K. Feng
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medicine.medical_specialty ,medicine.drug_class ,business.industry ,Immunology ,Extended thymectomy ,hemic and immune systems ,macromolecular substances ,General Medicine ,Plasmacytoid dendritic cell ,Dendritic cell ,Monoclonal antibody ,medicine.disease ,Peripheral blood mononuclear cell ,Gastroenterology ,Myasthenia gravis ,Peripheral blood ,Internal medicine ,medicine ,In patient ,business - Abstract
The object of this work was to measure the levels of monocyte-derived dendritic cell precursors (pDC1) and plasmacytoid dendritic cell precursors (pDC2) in peripheral blood mononuclear cells (PBMC) of patients with thymomatous MG and to assess the ratio of pDC1/pDC2 in these patients. Three-colour monoclonal antibody labelling technology was used to detect the cell counts and ratio of pDC1 and pDC2 in PBMCs of 18 patients with myasthenia gravis (MG), nine thymomatous patients without MG, and 15 normal controls. The number of pDC and pDC subsets in peripheral blood of patients with thymomatous generalized MG was significantly lower than that in thymomatous controls before and after the treatment. After the treatment, patients with both generalized MG and ocular MG had significantly lower number of pDC compared with thymomatous controls. We found no significant differences in pDC1/pDC2 ratio among groups. Before the extended thymomatous treatment, the number of pDC in patients with generalized MG was significantly lower than that in patients with ocular MG (P
- Published
- 2010
8. Video-assisted Thoracoscopic Extended Thymectomy (VATET) in Myasthenia Gravis Two-Year Follow-up in 101 Patients and Comparison with the Transsternal Approach
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M. Porta, G. Pezzuoli, Lorenzo Novellino, Ferdinando Cornelio, Carlo Antozzi, Maria Teresa Ferrò, Renato Mantegazza, and P. Confalonieri
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Adult ,Male ,medicine.medical_specialty ,Time Factors ,Video Recording ,Extended thymectomy ,General Biochemistry, Genetics and Molecular Biology ,History and Philosophy of Science ,Myasthenia Gravis ,Humans ,Medicine ,Video assisted ,Age of Onset ,Retrospective Studies ,business.industry ,Thoracoscopy ,General Neuroscience ,Middle Aged ,Thymectomy ,medicine.disease ,Myasthenia gravis ,Surgery ,Female ,business ,Follow-Up Studies ,Transsternal approach - Published
- 1998
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