1. Clinical outcomes and patterns of population‐based management of urachal carcinoma of the bladder: An analysis of the National Cancer Database
- Author
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Furkan Dursun, Kelvin Lim, Robert S. Svatek, Jiaqiong Xu, Ziad M. El‐Zaatari, Evan P. Wenker, Zachary W. Klaassen, Ahmed M. Mansour, Taliah Muhammad, Eleni Efstathiou, Guru P. Sonpavde, Christopher J. D. Wallis, and Raj Satkunasivam
- Subjects
partial cystectomy ,perioperative chemotherapy ,survival outcome ,radical cystectomy ,urachal carcinoma ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Background Given the low incidence of urachal carcinoma of the bladder (UCB), there is limited published data from contemporary population‐based cohorts. This study aimed to describe demographic, clinicopathological features, and survival outcomes of patients diagnosed with UCB. Methods The National Cancer Database (2004–2016) was queried for UCB patients. Descriptive analyses characterized demographics and clinicopathologic features. We assessed 5‐year overall survival (OS) rates of the entire cohort and subgroups of localized/locally advanced and metastatic disease. We utilized Cox proportional hazards models to assess the association between covariates of interest and all‐cause mortality and to examine the impact of surgical technique and chemotherapy. Results We identified 841 patients with UCB. The most common histologic subtype was non‐mucinous adenocarcinoma (39.6%). Approximately 50% had ≥cT2 disease, and 14.3% were metastatic at diagnosis. Altogether, partial cystectomy (60%) was most performed, and lymph node dissection was performed in 377 patients (44.8%), with specific temporal increase in utilization over the study period (p
- Published
- 2022
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