1. Pragmatic Weight Management Program for Patients With Obesity and Heart Failure With Preserved Ejection Fraction
- Author
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Elia C. El Hajj, Milad C. El Hajj, Brandon Sykes, Melissa Lamicq, Michael R. Zile, Robert Malcolm, Patrick M. O’Neil, and Sheldon E. Litwin
- Subjects
exercise ,heart failure with preserved ejection fraction ,left ventricular hypertrophy ,obesity ,quality of life ,weight loss ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Background Obesity is associated with heart failure with preserved ejection fraction (HFpEF). Weight loss can improve exercise capacity in HFpEF. However, previously reported methods of weight loss are impractical for widespread clinical implementation. We tested the hypothesis that an intensive lifestyle modification program would lead to relevant weight loss and improvement in functional status in patients with HFpEF and obesity. Methods and Results Patients with ejection fraction >45%, at least 1 objective criteria for HFpEF, and body mass index ≥30 kg/m2 were offered enrollment in an established 15‐week weight management program that included weekly visits for counseling, weight checks, and provision of meal replacements. At baseline, 15 weeks, and 26 weeks, Minnesota Living With Heart Failure score, 6‐minute walk distance, echocardiography, and laboratory variables were assessed. A total of 41 patients completed the study (mean body mass index, 40.8 kg/m2), 74% of whom lost >5% of their baseline body weight following the 15‐week program. At 15 weeks, mean 6‐minute walk distance increased from 223 to 281 m (P=0.001) and then decreased to 267 m at 26 weeks. Minnesota Living With Heart Failure score improved from 59.9 to 37.3 at 15 weeks (P
- Published
- 2021
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