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The International Atomic Energy Agency conducted a Coordinated Research Project on 'Labelling of Small Biomolecules Using Novel Technetium-99m Cores' during 2003-2006. Thirteen research groups from Asia, Europe, North and South America participated in this program. The objective of the CRP was to generate know-how and expertise to develop high specific activity 99m Tc labelled biomolecules using the relatively new chemistries introduced in the recent past. The Technical Report Series 459, a fully edited publication of the IAEA, describes the work done by the different participating laboratories. This paper is a review of the publication, highlighting the important outputs from the CRP. The International Atomic Energy Agency (IAEA) Technical Report Series 459 on 'Labelling of Small Biomolecules Using Novel Technetium-99m Cores' is the outcome of an IAEA Coordinated Research Project (CRP) held during 2003-2006. 1 The CRP is a mechanism in which scientists from different member states (MS) come together to conduct research activity in a well-defined area. Through the CRP IAEA aims at effectively transferring the technologies from developed MS to developing MS. Thirteen research groups actively engaged in the development of 99m Tc radiopharmaceuticals participated in the above CRP (Table 1). The publication describes the work done by the different participating laboratories. Part I of the book, which is corporate authored, gives the background, objectives and important research outputs arising out of this CRP. Subsequent chapters describe the accomplishments in each participating laboratories. These chapters are written in the form of research papers as per the IAEA format. Following sections give the information about the CRP and the work reported in the book.

The reaction of pertechnetate with the S-methyl ester of dithiocarbazic acid, H2N–NR–C(S)SCH3(R = H or CH3), in the presence of HCl and triphenylphosphine, affords the technetium(V) nitrido complex [TcNCl2(PPh3)2] in high yield. Derivatives of S-methyl dithiocarbazate of the type R1(R2)CN–NR3–C(S)SCH3, where R1=o-C6H4OH, C6H5, or CH3, R2= H or CH3, and R3= H or CH3, behave as sources of N3– groups, giving rise to a variety of technetium complexes containing the TcN multiple bond. These reactions apply equally well to the preparation of technetium-99m radiopharmaceuticals containing the TcN group, at the non-carrier-added level of nuclear medicine.

An unusual, facile cleavage of C–N bonds of diethylenetriamine (H2NCH2CH2NHCH2CH2NH2= dien) promoted by the reaction with the rhenium(V) nitrido complex [ReNCl2(PPh3)2] to yield β-alanine (H2NCH2CH2CO2H =β-ala) is reported.

The synthesis, characterization and electrochemical behaviour of neutral [TcN(noet)2][noet = Et(EtO)N–CS2–], the first technetium(V) nitrido complex currently under preliminary clinical evaluation for myocardial perfusion, are reported.

Le (N-salicylidene-D-glucosimato)(salicylaldehydato) oxotechnetium(V) cristallise dans le systeme orthorhombique avec le groupe d'espace P2 1 2 1 2 1 . Affinement de la structure jusqu'a 0,054. L'atome Tc se trouve dans un environnement de coordination octaedrique deforme, les 3 atomes donneurs du coordinat base de Schiff occupant le plan normal a la liaison Tc=0

Some isomers of the ReOX2LPPh3 complexes [X = Cl or Br and L =N-methylsalicylideneiminate,N-phenylsalicylideneiminate, halfN,N∼'-ethylenebis(salicylideneiminate) or 8-hydroxyquinolinate] have been synthesized and characterized. Two different mechanisms for reaction of thetrans-ReOX3(PPh3)2 complexes (X = Cl or Br) with the Schiff bases are supported by qualitative studies on such parameters as the Schiff base ligand form, concentration of free triphenylphosphine ligand, reaction solvent and temperature.