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Your search keyword '"Drummer, Heidi E."' showing total 10 results
Start Over Author "Drummer, Heidi E." Publisher wiley
10 results on '"Drummer, Heidi E."'

1. Serological assays to measure dimeric IgA antibodies in SARS‐CoV‐2 infections

Author

Wei, Zihui, primary, Angrisano, Fiona, additional, Eriksson, Emily M, additional, Mazhari, Ramin, additional, Van, Huy, additional, Zheng, Shuning, additional, Center, Rob J, additional, McMahon, James, additional, Lau, Jillian, additional, Kiernan‐Walker, Nicholas, additional, Ruybal‐Pesántez, Shazia, additional, Mueller, Ivo, additional, Robinson, Leanne J, additional, Anderson, David A, additional, and Drummer, Heidi E, additional

Published
2023
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2. Validation of a novel point‐of‐care test for alanine aminotransferase measurement: A pilot cohort study

Author

Howell, Jessica, primary, Van, Huy, additional, Pham, Minh D., additional, Sawhney, Rohit, additional, Li, Fan, additional, Bhat, Purnima, additional, Lubel, John, additional, Kemp, William, additional, Bloom, Stephen, additional, Majumdar, Avik, additional, McCaughan, Geoffrey W., additional, Hall, Samuel, additional, Spelman, Timothy, additional, Doyle, Joseph S., additional, Hellard, Margaret, additional, Visvanathan, Kumar, additional, Thompson, Alexander, additional, Drummer, Heidi E., additional, and Anderson, David, additional

Published
2023
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6. T CD8 response in diverse outcomes of recurrent exposure to hepatitis C virus

Author

Bharadwaj, Mandvi, primary, Thammanichanond, Duangtawan, additional, Aitken, Campbell Kynoch, additional, Moneer, Sarah, additional, Drummer, Heidi E, additional, Tracy, Samantha, additional, Holdsworth, Rhonda, additional, Bowden, Scott, additional, Jackson, David, additional, Hellard, Margaret, additional, Torresi, Joseph, additional, and McCluskey, James, additional

Published
2009
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10. TCD8 response in diverse outcomes of recurrent exposure to hepatitis C virus.

Author

Bharadwaj M, Thammanichanond D, Aitken CK, Moneer S, Drummer HE, Tracy S, Holdsworth R, Bowden S, Jackson D, Hellard M, Torresi J, and McCluskey J

Subjects
Adolescent, Adult, CD8-Positive T-Lymphocytes immunology, CD8-Positive T-Lymphocytes pathology, Cell Proliferation, Drug Users, Environmental Exposure, Female, HLA Antigens metabolism, Hepacivirus pathogenicity, Hepatitis C pathology, Hepatitis C prevention & control, Hepatitis C transmission, Humans, Interferon-gamma metabolism, Male, Middle Aged, Remission, Spontaneous, Secondary Prevention, Tumor Necrosis Factor-alpha metabolism, CD8-Positive T-Lymphocytes metabolism, Hepacivirus immunology, Hepatitis C immunology
Abstract

To analyse the immune correlates in a setting of recurrent exposure to hepatitis C virus (HCV), we studied T(CD8) responses in injecting drug users (IDUs) with different disease outcomes. Ex vivo HCV-specific T(CD8) responses assessed by interferon-gamma (IFNgamma) enzyme-linked immunospot (ELISPOT) were comparable in human lymphocyte antigen (HLA)-matched IDUs with spontaneous HCV clearance or persistent infection. A detailed characterization of these T(CD8) cells in age and HLA-matched IDUs demonstrated that HCV clearance and protection from reinfection correlated with HCV-specific T(CD8) cells that could proliferate in vitro, possessed cytotoxic potential and produced IFNgamma and tumour-necrosis factor-alpha, rather than with the circulating frequency of responding T(CD8) cells determined ex vivo. While validating the importance of multifunctional T(CD8) in mediating protection in IDUs with recurrent exposure to HCV our findings highlight that the magnitude and/or breadth of HCV-specific T(CD8) determined in ex vivo ELISPOT may not be the sole determinant of protection especially in a setting of recurrent exposure.

Published
2009
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