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32 results on '"Donnan, Peter T."'

1. Recruitment strategies for sarcopenia trials: lessons from the LACE randomized controlled trial

Author

Witham, Miles D., primary, Achison, Marcus, additional, Aspray, Terry J., additional, Avenell, Alison, additional, Band, Margaret M., additional, Donnan, Peter T., additional, George, Jacob, additional, Hapca, Adrian, additional, Hume, Cheryl, additional, Kemp, Paul, additional, Pilvinyte, Kristina, additional, Sayer, Avan A., additional, Smith, Karen T., additional, Struthers, Allan D., additional, and Sumukadas, Deepa, additional

Published
2021
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4. Texting to Reduce Alcohol Misuse (TRAM): main findings from a randomized controlled trial of a text message intervention to reduce binge drinking among disadvantaged men

Author

Crombie, Iain K, Irvine, Linda, Williams, Brian, Sniehotta, Falko F, Petrie, Dennis, Jones, Claire, Norrie, John, Evans, Josie M M, Emslie, Carol, Rice, Peter M, Slane, Peter W, Humphris, Gerry, Ricketts, Ian W, Melson, Ambrose J, Donnan, Peter T, and Hapca, Simona M

Subjects
narrative, text message intervention, men, Binge drinking, community based, deprivation
Abstract

Aims To test the effectiveness of a theoretically based text‐message intervention to reduce binge drinking among socially disadvantaged men. Design A multi‐centre parallel group, pragmatic, individually randomized controlled trial. Setting Community‐based study conducted in four regions of Scotland. Participants A total of 825 men aged 25–44 years recruited from socially disadvantaged areas who had two or more episodes of binge drinking (> 8 UK units on a single occasion) in the preceding 28 days: 411 men were randomized to the intervention and 414 to the control. Intervention and comparator A series of 112 interactive text messages was delivered by mobile phone during a 12‐week period. The intervention was structured around the Health Action Process Approach, a comprehensive model which allows integration of a range of evidence‐based behaviour change techniques. The control group received 89 texts on general health, with no mention of alcohol or use of behaviour change techniques. Measurements The primary outcome measure was the proportion of men consuming > 8 units on three or more occasions (in the previous 28 days) at 12 months post‐intervention. Findings The proportion of men consuming > 8 units on three or more occasions (in the previous 28 days) was 41.5% in the intervention group and 47.8% in the control group. Formal analysis showed that there was no evidence that the intervention was effective [odds ratio (OR) = 0.79, 95% confidence interval (CI) = 0.57–1.08; absolute reduction 5.7%, 95% CI = −13.3 to 1.9]. The Bayes factor for this outcome was 1.3, confirming that the results were inconclusive. The retention was high and similar in intervention (84.9%) and control (86.5%) groups. Most men in the intervention group engaged with the text messages: almost all (92%) replied to text messages and 67% replied more than 10 times. Conclusions A theoretically based text‐messaging intervention aimed at reducing binge drinking in disadvantaged men was not found to reduce prevalence of binge drinking at 12‐month follow‐up.

Published
2018

23. Early Treatment with Prednisolone or Acyclovir in Bell’s Palsy

Author

Sullivan, Frank M., primary, Swan, Iain R.C, additional, Donnan, Peter T., additional, Morrison, Jillian M., additional, Smith, Blair H., additional, McKinstry, Brian, additional, Davenport, Richard J., additional, Vale, Luke D., additional, Ciarkson, Janet E., additional, Hammersley, Victoria, additional, Hayavi, Sima, additional, McAteer, Anne, additional, Stewart, Ken, additional, and Daly, Fergus, additional

Published
2007
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31. Development and preliminary testing of a brief clinical tool to enable daily monitoring of chemotherapy toxicity: The Daily Chemotherapy Toxicity self-Assessment Questionnaire.

Author

Maguire R, Kotronoulas G, Donnan PT, Paterson C, McCann L, Connaghan J, Di Domenico DGG, and Kearney N

Subjects
Adult, Aged, Constipation chemically induced, Constipation diagnosis, Diarrhea chemically induced, Diarrhea diagnosis, Fatigue chemically induced, Fatigue diagnosis, Feasibility Studies, Female, Humans, Male, Middle Aged, Nausea chemically induced, Nausea diagnosis, Patient Acceptance of Health Care, Reproducibility of Results, Self Report, Sensation Disorders chemically induced, Sensation Disorders diagnosis, Surveys and Questionnaires, Vomiting chemically induced, Vomiting diagnosis, Antineoplastic Combined Chemotherapy Protocols adverse effects, Breast Neoplasms drug therapy, Colorectal Neoplasms drug therapy, Drug Monitoring methods
Abstract

Close monitoring of chemotherapy toxicity can be instrumental in ensuring prompt symptom management and quality care. Our aim was to develop a brief clinical tool to enable daily assessment of chemotherapy toxicity and investigate/establish its content validity, feasibility/applicability, internal consistency and stability. Development of the Daily Chemotherapy Toxicity self-Assessment Questionnaire (DCTAQ) was based on an initial item pool created from two scoping reviews. Expert panel review (n = 15) and cognitive debriefing with patients with cancer (n = 7) were used to establish content validity. Feasibility/acceptability, applicability (self-report vs. interview-like administration), internal consistency (KR-20) and test-retest reliability (at 1-hr intervals) of the DCTAQ were field-tested with 82 patients with breast or colorectal cancer receiving active chemotherapy at eight hospitals. Initial development/content validity stages enabled item revisions and re-wording that led to a final, 11-item DCTAQ version with 10 core symptom items plus one open-ended "any other symptom" item. Feasibility and acceptability were demonstrated through the absence of participant withdrawals, absence of missing data and no complaints about tool length. The DCTAQ was found to have modest internal consistency (KR-20 = 0.56), but very good test-retest reliability. The DCTAQ is a brief clinical tool that allows for rapid and accurate daily assessments of chemotherapy toxicity in clinical practice., (© 2018 John Wiley & Sons Ltd.)

Published
2018
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32. Surgical interventions for the early management of Bell's palsy.

Author

McAllister K, Walker D, Donnan PT, and Swan I

Subjects
Facial Nerve surgery, Humans, Randomized Controlled Trials as Topic, Bell Palsy surgery, Decompression, Surgical methods
Abstract

Background: Bell's palsy is an acute paralysis of one side of the face of unknown aetiology. Bell's palsy should only be used as a diagnosis in the absence of all other pathology. As the proposed pathophysiology is swelling and entrapment of the nerve, some surgeons suggest surgical decompression of the nerve as a possible management option., Objectives: The objective of this review was to assess the effectiveness of surgery in the management of Bell's palsy and to compare this to outcomes of medical management., Search Strategy: We searched the Cochrane Neuromuscular Disease Group Specialized Register (23 November 2010). We also searched the Cochrane Central Register of Controlled Trials (CENTRAL) (23 November in The Cochrane Library, Issue 4 2010). We adapted this strategy to search MEDLINE (January 1966 to November 2010) and EMBASE (January 1980 to November 2010)., Selection Criteria: We included all randomised or quasi-randomised controlled trials involving any surgical intervention for Bell's palsy., Data Collection and Analysis: Two review authors independently assessed whether trials identified from the search strategy were eligible for inclusion. Two review authors assessed trial quality and extracted data independently., Main Results: Two trials with a total of 69 participants met the inclusion criteria. The first study considered the treatment of 403 patients but only included 44 in their surgical study. These were randomised into a surgical and non surgical group. The second study had 25 participants which they randomly allocated into surgical or control groups.The nerves of all the surgical group participants in both studies were decompressed using a retroauricular approach. The primary outcome was recovery of facial palsy at 12 months. The first study showed that both the operated and non operated groups had comparable facial nerve recovery at nine months. This study did not statistically compare the groups but the scores and size of the groups suggested that statistically significant differences are unlikely. The second study reported no statistically significant differences between their operated and control groups. One operated patient in the first study had 20 dB sensorineural hearing loss and persistent vertigo., Authors' Conclusions: There is only very low quality evidence from randomised controlled trials and this is insufficient to decide whether surgical intervention is beneficial or harmful in the management of Bell's palsy.Further research into the role of surgical intervention is unlikely to be performed because spontaneous recovery occurs in most cases.

Published
2011
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