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Your search keyword '"Dong, Hangming"' showing total 8 results
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8 results on '"Dong, Hangming"'

2. Variations in pleural microbiota and metabolic phenotype associated with malignant pleural effusion in human lung adenocarcinoma

Author

Huang, DanHui, primary, Zhuo, JinZhong, additional, Ye, CuiPing, additional, Su, XiaoFang, additional, Chen, YueHua, additional, Li, Cui, additional, Lin, LiSan, additional, Liu, LaiYu, additional, Zhao, Haijin, additional, Luo, Tingyue, additional, Ren, QianNan, additional, Wu, JianHua, additional, Cai, Shaoxi, additional, and Dong, Hangming, additional

Published
2023
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3. Extracellular HSP90α promotes cellular senescence by modulating TGF ‐β signaling in pulmonary fibrosis

Author

Zhong, Wenshan, primary, Chen, Weimou, additional, Liu, Yuanyuan, additional, Zhang, Jinming, additional, Lu, Ye, additional, Wan, Xuan, additional, Qiao, Yujie, additional, Huang, Haohua, additional, Zeng, Zhaojin, additional, Li, Wei, additional, Meng, Xiaojing, additional, Zhao, Haijin, additional, Zou, Mengchen, additional, Cai, Shaoxi, additional, and Dong, Hangming, additional

Published
2022
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4. HDM induce airway epithelial cell ferroptosis and promote inflammation by activating ferritinophagy in asthma

Author

Zeng, Zhaojin, primary, Huang, Haohua, additional, Zhang, Jinming, additional, Liu, Yuanyuan, additional, Zhong, Wenshan, additional, Chen, Weimou, additional, Lu, Ye, additional, Qiao, Yujie, additional, Zhao, Haijin, additional, Meng, Xiaojing, additional, Zou, Fei, additional, Cai, Shaoxi, additional, and Dong, Hangming, additional

Published
2022
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8. Tetrandrine Alleviates Pulmonary Fibrosis by Modulating Lung Microbiota-Derived Metabolism and Ameliorating Alveolar Epithelial Cell Senescence.

Author

Zhuo J, Chu L, Liu D, Zhang J, Chen W, Huang H, Yu Q, Meng X, Zou F, Cai S, and Dong H

Subjects
Animals, Mice, Male, RNA, Ribosomal, 16S genetics, Mice, Inbred C57BL, Stephania tetrandra chemistry, Humans, Cellular Senescence drug effects, Pulmonary Fibrosis drug therapy, Pulmonary Fibrosis chemically induced, Alveolar Epithelial Cells drug effects, Alveolar Epithelial Cells metabolism, Benzylisoquinolines pharmacology, Bleomycin, Lung drug effects, Microbiota drug effects
Abstract

Tetrandrine (TET) is a minimally toxic drug extracted from the root of Stephania tetrandra. We previously demonstrated that TET could ameliorate pulmonary fibrosis (PF) by modulating autophagy. However, the mechanism behind TET's protective effects on PF remains unclear. In this study, we utilized 16S rRNA gene sequencing, nontargeted metabolomic analysis, and network pharmacology to identify changes in lung microbiota and metabolites that mediate alveolar epithelial cell senescence in bleomycin (BLM)-induced PF in mice. Additionally, we employed Western blot analysis, RT-PCR, and immunofluorescence staining to investigate the in vitro and in vivo effects of TET and its influential bacterial metabolites on PF. The TET intervention alleviated PF by regulating the compositions of lung microbial communities (Streptococcus, Micrococcus, Acinetobacter, Altererythrobacter, Atopostipes, Candidatus Cloacimonas, Clostridium sensu stricto 1, Sphingomonas, Listeria, Blautia, and Pseudomonas) and metabolites (3,4-dihydroxyphenylpropionic acid (3,4-DHPPA), 6-Aminonicotinamide, N-acetyl-5-methoxykynuramine, and resiniferatoxin). Through network pharmacological analysis, it was determined that 3,4-DHPPA played a crucial role in alleviating PF by further inhibiting the senescence of alveolar epithelial cells, a finding further validated in ex vivo experiments. TET mitigated BLM-induced PF in murine models through the modulation of lung microbiota composition and metabolism. Specifically, TET augmented the level of the microbiota-derived metabolite, 3,4-DHPPA, which in turn attenuated alveolar epithelial cell senescence., (© 2024 John Wiley & Sons Ltd.)

Published
2025
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