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Your search keyword '"Dilip K. Pandey"' showing total 4 results
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4 results on '"Dilip K. Pandey"'

1. Optimized Hemodynamic Assessment to Predict Stroke Risk in Vertebrobasilar Disease: Analysis From the VERiTAS Study

Author

Alfred P. See, Dilip K. Pandey, Xinjian Du, Linda Rose‐Finnell, Fady T. Charbel, Colin P. Derdeyn, and Sepideh Amin‐Hanjani

Subjects
blood flow, magnetic resonance angiography, magnetic resonance imaging, quantitative magnetic resonance angiography, stroke vertebrobasilar disease, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Background Atherosclerotic vertebrobasilar disease is a significant etiology of posterior circulation stroke. The prospective observational VERiTAS (Vertebrobasilar Flow Evaluation and Risk of Transient Ischemic Attack and Stroke) study demonstrated that distal hemodynamic status is a robust predictor of subsequent vertebrobasilar stroke risk. We sought to compare predictive models using thresholds for posterior circulation vessel flows standardized to age and vascular anatomy to optimize risk prediction. Methods and Results VERiTAS enrolled patients with recent vertebrobasilar transient ischemic attack or stroke and ≥50% atherosclerotic stenosis/occlusion in vertebral and/or basilar arteries. Quantitative magnetic resonance angiography measured large‐vessel vertebrobasilar territory flow, and patients were designated as low or normal flow based on a prespecified empiric algorithm considering distal territory regional flow and collateral capacity. For the present study, post hoc analysis was performed to generate additional predictive models using age‐specific normalized flow measurements. Sensitivity, specificity, and time‐to‐event analyses were compared between the algorithms. The original prespecified algorithm had 50% sensitivity and 79% specificity for future stroke risk prediction; using a predictive model based on age‐normalized flows in the basilar and posterior cerebral arteries, standardized to vascular anatomy, optimized flow status thresholds were identified. The optimized algorithm maintained sensitivity and increased specificity to 84%, while demonstrating a larger and more significant hazard ratio for stroke on time‐to‐event analysis. Conclusions These results indicate that flow remains a strong predictor of stroke across different predictive models, and suggest that prediction of future stroke risk can be optimized by use of vascular anatomy and age‐specific normalized flows.

Published
2020
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3. Self‐management for adults with epilepsy: Aggregate Managing Epilepsy Well Network findings on depressive symptoms

Author

Dilip K. Pandey, Rakale C. Quarells, Tanya M. Spruill, Erica K. Johnson, Hongyan Liu, Robert T. Fraser, Samantha S. Schmidt, Mary R. Janevic, Kristin A. Cassidy, Ross Shegog, Curtis Tatsuoka, Martha Sajatovic, Barbara C. Jobst, and Peter B Scal

Subjects
Adult, Male, 0301 basic medicine, medicine.medical_specialty, Neurology, Databases, Factual, Article, law.invention, 03 medical and health sciences, Epilepsy, 0302 clinical medicine, Randomized controlled trial, Quality of life, law, Adaptation, Psychological, Humans, Medicine, Prospective Studies, Depression (differential diagnoses), Self-management, Depression, business.industry, Self-Management, Middle Aged, medicine.disease, Patient Health Questionnaire, 030104 developmental biology, Quality of Life, Physical therapy, Marital status, Female, Neurology (clinical), business, 030217 neurology & neurosurgery
Abstract

OBJECTIVE To assess depressive symptom outcomes in a pooled sample of epilepsy self-management randomized controlled trials (RCTs) from the Managing Epilepsy Well (MEW) Network integrated research database (MEW DB). METHODS Five prospective RCTs involving 453 adults with epilepsy compared self-management intervention (n = 232) versus treatment as usual or wait-list control outcomes (n = 221). Depression was assessed with the nine-item Patient Health Questionnaire. Other variables included age, gender, race, ethnicity, education, income, marital status, seizure frequency, and quality of life. Follow-up assessments were collapsed into a visit 2 and a visit 3; these were conducted postbaseline. RESULTS Mean age was 43.5 years (SD = 12.6), nearly two-thirds were women, and nearly one-third were African American. Baseline sample characteristics were mostly similar in the self-management intervention group versus controls. At follow-up, the self-management group had a significantly greater reduction in depression compared to controls at visit 2 (P

Published
2019

4. Hypertension in Women: The Women Take Heart Project

Author

Alice Furumoto-Dawson, Roxanne H. Wicklund, Noel Camba, William J. Elliott, Carlos F. Mendes de Leon, Dilip K. Pandey, Henry R. Black, Steven Hollenberg, and Arfan J. Al-Hani

Subjects
Adult, Health Knowledge, Attitudes, Practice, medicine.medical_specialty, Heart disease, Endocrinology, Diabetes and Metabolism, Disease, Prehypertension, Risk Factors, Surveys and Questionnaires, Internal medicine, Prevalence, Internal Medicine, medicine, Humans, Mass Screening, Prospective Studies, Antihypertensive Agents, Aged, Aged, 80 and over, Chicago, African american, Chi-Square Distribution, business.industry, Public health, Mean age, Articles, Middle Aged, medicine.disease, Logistic Models, Blood pressure, Cardiovascular Diseases, Hypertension, Physical therapy, Female, Cardiology and Cardiovascular Medicine, business, Cohort study
Abstract

Hypertension is an important, modifiable risk for cardiovascular disease. The Women Take Heart study, a prospective, community-based cohort study of risk factors for heart disease, provides an opportunity to examine prevalence, awareness, and control of hypertension specifically in women. In 1992, 5932 women, age 35 and older (mean age, 52.9; 86% white, 9% African American, 5% other) and free of active heart disease symptoms for 3 months, were recruited through Chicago area public announcements, and their baseline examination data analyzed. Overall, 47.6% were hypertensive (systolic blood pressureor=140 mm Hg or diastolic blood pressureor=90 mm Hg, or self-report). Only 17.3% reported being hypertensive; in 63.2% of all hypertensive women, the hypertension was undetected or unacknowledged. Blood pressure was controlled to140/90 mm Hg in 24.1% of self-reported hypertensives. Results from this study and national surveys indicate that hypertension detection and control remain major public health challenges in preventing cardiovascular disease in older women.

Published
2003

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