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Your search keyword '"Devlin, Gerard"' showing total 10 results
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10 results on '"Devlin, Gerard"'

1. Titration of medications and outcomes in multi‐ethnic heart failure cohorts (with reduced ejection fraction) from Singapore and New Zealand

Author

Teng, Tiew‐Hwa Katherine, primary, Tay, Wan Ting, additional, Ouwerkerk, Wouter, additional, Tromp, Jasper, additional, Richards, A. Mark, additional, Gamble, Greg, additional, Greene, Stephen J., additional, Yiu, Kai‐Hang, additional, Poppe, Katrina, additional, Ling, Lieng Hsi, additional, Lund, Mayanna, additional, Sim, David, additional, Devlin, Gerard, additional, Loh, Seet Yoong, additional, Troughton, Richard, additional, Ren, Qing‐wen, additional, Jaufeerally, Fazlur, additional, Lee, Shao Guang Sheldon, additional, Tan, Ru San, additional, Soon, Dinna Kar Nee, additional, Leong, Gerald, additional, Ong, Hean Yee, additional, Yeo, Daniel P.S., additional, Lam, Carolyn S.P., additional, and Doughty, Rob N., additional

Published
2023
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4. Angiographic and clinical outcomes of drug-eluting versus bare metal stent deployment in the Occluded Artery Trial

Author

Dz̆avík, Vladimír, primary, Buller, Christopher E., additional, Devlin, Gerard, additional, Carere, Ronald G., additional, Mancini, G.B. John, additional, Cantor, Warren J., additional, Buszman, Pawel E., additional, Rankin, James M., additional, Vozzi, Carlos, additional, Ross, John R., additional, Forman, Sandra, additional, Barton, Bruce A., additional, Lamas, A. Gervasio A., additional, and Hochman, Judith S., additional

Published
2009
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10. Plasma soluble fms-like tyrosine kinase-1, placental growth factor, and vascular endothelial growth factor system gene variants as predictors of survival in heart failure.

Author

Paterson MA, Pilbrow AP, Frampton CM, Cameron VA, Troughton RW, Pemberton CJ, Lund M, Devlin GP, Richards AM, Doughty RN, and Palmer BR

Subjects
Humans, Female, Male, Aged, Middle Aged, Prognosis, Vascular Endothelial Growth Factor A blood, Vascular Endothelial Growth Factor A genetics, Natriuretic Peptide, Brain blood, Peptide Fragments blood, Genotype, Enzyme-Linked Immunosorbent Assay, Heart Failure blood, Heart Failure genetics, Heart Failure mortality, Vascular Endothelial Growth Factor Receptor-1 blood, Vascular Endothelial Growth Factor Receptor-1 genetics, Placenta Growth Factor blood, Polymorphism, Single Nucleotide, Pregnancy Proteins blood, Pregnancy Proteins genetics, Biomarkers blood
Abstract

Aims: Soluble fms-like tyrosine kinase-1 (sFlt-1) and placental growth factor (PlGF), components of the vascular endothelial growth factor (VEGF) system, play key roles in angiogenesis. Reports of elevated plasma levels of sFlt-1 and PlGF in coronary heart disease and heart failure (HF) led us to investigate their utility, and VEGF system gene single nucleotide polymorphisms (SNPs), as prognostic biomarkers in HF., Methods and Results: ELISA assays for sFlt-1, PlGF and N-terminal pro-B-type natriuretic peptide (NT-proBNP) were performed on baseline plasma samples from the PEOPLE cohort (n = 890), a study of outcomes among patients after an episode of acute decompensated HF. Eight SNPs potentially associated with sFlt-1 or PlGF levels were genotyped. sFlt-1 and PlGF were assayed in 201 subjects from the Canterbury Healthy Volunteers Study (CHVS) matched to PEOPLE participants. All-cause death was the major endpoint for clinical outcome considered. In PEOPLE participants, mean plasma levels for both sFlt-1 (125 ± 2.01 pg/ml) and PlGF (17.5 ± 0.21 pg/ml) were higher (both p < 0.044) than in the CHVS cohort (81.2 ± 1.31 pg/ml and 15.5 ± 0.32 pg/ml, respectively). sFlt-1 was higher in HF with reduced ejection fraction compared to HF with preserved ejection fraction (p = 0.005). The PGF gene SNP rs2268616 was univariately associated with death (p = 0.016), and was also associated with PlGF levels, as was rs2268614 genotype. Cox proportional hazards modelling (n = 695, 246 deaths) showed plasma sFlt-1, but not PlGF, predicted survival (hazard ratio 6.44, 95% confidence interval 2.57-16.1; p < 0.001) in PEOPLE, independent of age, NT-proBNP, ischaemic aetiology, diabetic status and beta-blocker therapy., Conclusions: Plasma sFlt-1 concentrations have potential as an independent predictor of survival and may be complementary to established prognostic biomarkers in HF., (© 2024 The Author(s). European Journal of Heart Failure published by John Wiley & Sons Ltd on behalf of European Society of Cardiology.)

Published
2024
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