1. Nanoparticle-Programmed Self-Destructive Neural Stem Cells for Glioblastoma Targeting and Therapy
- Author
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Yu Cheng, Chin-Tu Chen, Alex Tobias, Karen S. Aboody, Shih-Hsun Cheng, Atique U. Ahmed, Yu Han, Brenda Auffinger, Catherine Yunis, Derek A. Wainwright, Ramin A. Morshed, Leu Wei Lo, Lingjiao Zhang, and Maciej S. Lesniak
- Subjects
Programmed cell death ,Apoptosis ,Article ,Biomaterials ,Mice ,Drug Delivery Systems ,Microscopy, Electron, Transmission ,Neural Stem Cells ,Cell Movement ,In vivo ,Cell Line, Tumor ,Glioma ,medicine ,Animals ,Humans ,General Materials Science ,Doxorubicin ,reproductive and urinary physiology ,Clinical Trials as Topic ,Cell Death ,Brain Neoplasms ,Chemistry ,General Chemistry ,Hydrogen-Ion Concentration ,medicine.disease ,Neural stem cell ,nervous system diseases ,Nanomedicine ,Microscopy, Fluorescence ,nervous system ,Immunology ,Drug delivery ,Cancer research ,Nanoparticles ,biological phenomena, cell phenomena, and immunity ,Glioblastoma ,Lysosomes ,Neoplasm Transplantation ,Biotechnology ,medicine.drug - Abstract
A 3-step glioblastoma-tropic delivery and therapy method using nanoparticle programmed self-destructive neural stem cells (NSCs) is demonstrated in vivo: 1) FDA-approved NSCs for clinical trials are loaded with pH-sensitive MSN-Dox; 2) the nanoparticle conjugates provide a delayed drug-releasing mechanism and allow for NSC migration towards a distant tumor site; 3) NSCs eventually undergo cell death and release impregnated MSN-Dox, which subsequently induces toxicity towards surrounding glioma cells.
- Published
- 2013