1. Review of bioanalytical assays for the quantitation of various HDAC inhibitors such as vorinostat, belinostat, panobinostat, romidepsin and chidamine.
- Author
-
Suresh PS, Devaraj VC, Srinivas NR, and Mullangi R
- Subjects
- Aminopyridines blood, Aminopyridines pharmacokinetics, Aminopyridines urine, Animals, Benzamides blood, Benzamides pharmacokinetics, Benzamides urine, Depsipeptides blood, Depsipeptides pharmacokinetics, Depsipeptides urine, Histone Deacetylase Inhibitors blood, Histone Deacetylase Inhibitors urine, Humans, Hydroxamic Acids blood, Hydroxamic Acids pharmacokinetics, Hydroxamic Acids urine, Indoles blood, Indoles pharmacokinetics, Indoles urine, Neoplasms drug therapy, Panobinostat, Sulfonamides blood, Sulfonamides pharmacokinetics, Sulfonamides urine, Vorinostat, Chromatography, High Pressure Liquid methods, Histone Deacetylase Inhibitors pharmacokinetics, Tandem Mass Spectrometry methods
- Abstract
Histone deacetylase inhibitors (HDAC inhibitors) are used to treat malignancies such as cutaneous T cell lymphoma and peripheral T cell lymphoma. Only four drugs are approved by the US Food and Drug Administration, namely vorinostat, romidepsin, panobinostat and belinostat, while chidamide has been approved in China. There are a number of bioanalytical methods reported for the measurement of HDAC inhibitors in clinical (human plasma and serum) and preclinical (mouse plasma, rat plasma, urine and tissue homogenates, etc.) studies. This review covers various HDAC inhibitors such as vorinostat, romidepsin, panobinostat, belinostat and chidamide. In addition to providing a comprehensive review of the available methods for the above mentioned HDAC inhibitors, it also provides case studies with perspectives for chosen drugs. Based on the review, it is concluded that the published methodologies using either HPLC or LC-MS/MS are well suited for the quantification of HDAC inhibitors in various biological fluids to delineate pharmacokinetic data., (Copyright © 2016 John Wiley & Sons, Ltd.)
- Published
- 2017
- Full Text
- View/download PDF