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2. Stroke prevention in patients from Latin American countries with non‐valvular atrial fibrillation: Insights from the GARFIELD‐AF registry
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Jerjes-Sanchez C., Corbalan R., Barretto A. C. P., Luciardi H. L., Allu J., Illingworth L., Pieper K. S., Kayani G., Fitzmaurice D. A., Goto S., Hacke W., Mantovani L. G., Turpie A. G. G., Gersh B. J., Gibbs H., Brodmann M., Cools F., Connolly S. J., Spyropoulos A., Eikelboom J., Hu D., Jansky P., Nielsen J. D., Ragy H., Raatikainen P., Le Heuzey J. -Y., Darius H., Keltai M., Kakkar S., Sawhney J. P. S., Agnelli G., Ambrosio G., Koretsune Y., Diaz C. J. S., ten Cate H., Atar D., Stepinska J., Panchenko E., Lim T. W., Jacobson B., Oh S., Vinolas X., Rosenqvist M., Steffel J., Angchaisuksiri P., Parkhomenko A., Al Mahmeed W., Chen K. N., Zhao Y. S., Zhang H. Q., Chen J. Z., Cao S. P., Wang D. W., Yang Y. J., Li W. H., Yin Y. H., Tao G. Z., Yang P., Chen Y. M., He S. H., Wang Y., Fu G. S., Li X., Wu T. G., Cheng X. S., Yan X. W., Zhao R. P., Chen M. S., Xiong L. G., Chen P., Jiao Y., Guo Y., Xue L., Wang F. Z., Li H., Yang Z. M., Bai C. L., Chen J., Chen J. Y., Chen X., Feng S., Fu Q. H., Gao X. J., Guo W. N., He R. H., He X. A., Hu X. S., Huang X. F., Li B., Li J., Li L., Li Y. H., Liu T. T., Liu W. L., Liu Y. Y., Lu Z. C., Luo X. L., Ma T. Y., Peng J. Q., Sheng X., Shi X. J., Sun Y. H., Tian G., Wang K., Wang L., Wu R. N., Xie Q., Xu R. Y., Yang J. S., Yang L. L., Yang Q., Ye Y., Yu H. Y., Yu J. H., Yu T., Zhai H., Zhan Q., Zhang G. S., Zhang Q., Zhang R., Zhang Y., Zheng W. Y., Zhou B., Zhou Z. H., Zhu X. Y., Jadhav P., Durgaprasad R., Ravi Shankar A. G., Rajput R. K., Bhargava K., Sarma R., Srinivas A., Roy D., Nagamalesh U. M., Chopda M., Kishore R., Kulkarni G., Chandwani P., Pothiwala R. A., Padinhare Purayil M., Shah S., Chawla K., Kothiwale V. A., Raghuraman B., Vijayaraghavan G., Vijan V. M., Bantwal G., Bisne V., Khan A., Gupta J. B., Kumar S., Jain D., Abraham S., Adak D., Barai A., Begum H., Bhattacharjee P., Dargude M., Davies D., Deshpande B., Dhakrao P., Dhyani V., Duhan S., Earath M., Ganatra A., Giradkar S., Jain V., Karthikeyan R., Kasala L., Kaur S., Krishnappa S., Lawande A., Lokesh B., Madarkar N., Meena R., More P., Naik D., Prashanth K., Rao M., Rao N. M., Sadhu N., Shah D., Sharma M., Shiva P., Singhal S., Suresh S., Vanajakshamma V., Panse S. 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H., Yoo K. M., Yoon E. J., Yun S. Y., Chawanadelert S., Mongkolwongroj P., Kanokphatcharakun K., Cheewatanakornkul S., Laksomya T., Pattanaprichakul S., Chantrarat T., Rungaramsin S., Silaruks S., Wongcharoen W., Siriwattana K., Likittanasombat K., Katekangplu P., Boonyapisit W., Cholsaringkarl D., Chatlaong B., Chattranukulchai P., Santanakorn Y., Hutayanon P., Khunrong P., Bunyapipat T., Jai-Aue S., Kaewsuwanna P., Bamungpong P., Gunaparn S., Hongsuppinyo S., Inphontan R., Khattaroek R., Khunkong K., Kitmapawanont U., Kongsin C., Naratreekoon B., Ninwaranon S., Phangyota J., Phrommintikul A., Phunpinyosak P., Pongmorakot K., Poomiphol S., Pornnimitthum N., Pumprueg S., Ratchasikaew S., Sanit K., Sawanyawisuth K., Silaruks B., Sirichai R., Sriwichian A., Suebjaksing W., Sukklad P., Suttana T., Tangsirira A., Thangpet O., Tiyanon W., Vorasettakarnkij Y., Wisaratapong T., Wongtheptien W., Wutthimanop A., Yawila S., Altun A., Ozdogru I., Ozdemir K., Yilmaz O., Aydinlar A., Yilmaz M. 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C., Costabel J. P., Costamagna O. J. A., Damonte A. A., De Urquiza I. N., Diez F., Eden M. F., Fanuele M., Voena F. F., Torres M. F., Funosas C., Giacomi M. P., Gimenez C. H., Gurfinkel E. P., Had M. D. L. M., Hansen V., Hrabar A. D., Ingratta M., Lopez A., Maehara G., Maffei L., Martinelli A., Martinelli C., Matkovich J., Mautner B., Meirino A., Munguia R., Navarro A., Novas V., Prados G. P., Pontoriero J., Potito R. N., Ricotti C., Rodriguez M. A., Rolandi F., Palladino M. E. S., Salinger M., Sanziani L. S., Schygiel P. O., Sossich A., Tinto J. F., Tonelli L., Tufare A. L., Vallejo M., Yunis M. E., Zillo M., Zurbrigk F. J., Filho D. C. S., Jaber J., Armaganijan D., Neto J. F., Steffens A., de Souza W. K. S. B., de Souza Neto J. D., Ribeiro J. M., Teixeira M. S., Rossi P. R. F., Pires L., Moreira D., Jorge J. C. M., Filho A. M. L., Bodanese L. C., Montera M. W., Del Carlo C. H., Rodrigues T. D. R., da Costa F. A. A., Lopes A., Lopes R., Araujo G. R., Manenti E. R. F., Saraiva J. F. K., Braga J. C. F., Negri A., Souto L., Moncada C., Precoma D. B., Roquette F., Reis G., Filho R. A. R., Figueiredo E. L., Botelho R. V., Tavares C. M. D. F., Frack C. R. C., Saad J. A., Finimundi H. C., Pisani C., Chemello D., Martins M. P., Franca C. C. B., Alban F., Rosito G. B. A., Moraes Junior J. B. M. X., Tumelero R. T., Maia L. N., de Almeida R. S., do Carmo Borges N. C., Ferreira L. G. G., Agliardi P., Gomes J. A. O., Araujo V., Nakazone M. A., Barbosa T., Barroso S., Falchetto E. B., Lopes H. B., Lemos M. A. B. T., Biazus G., Queiroz L. B., Camazzola F. E., Caporale M., Cardoso Boscato S., Chieza F., Chokr M. O., Mingireanov R. C., Goes N. C., Correa C., Costa M., Ortiz C. C., da Silva L. S., Paulitsch F. D. S., da Silveira J. A., Daros E., de Araujo G. R., Del Monaco M. I., Dias C., Dias M. A., Wainstein A. P. D., Pizzato P. E., Esteves D. C., Fabri P., Fonseca T. F. L., Fernandes E., Fonseca C., Costantini C. R. F., Ferraz R. 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M., Olguin V., Vergara M., Villan C., Diaz J. I., Cantu R. L., Zavala M. G. R., Jardines R. C., Zavaleta N. E., Umana S. V., Rosas E. L., Esperon G. L., Pozas G., Munoz E. C., Hernandez N. M., Rendon A. L., Hernandez N. G., Ibarra M. L. R., Carrillo L. V., Villezca D. L., Herrera C. H., Prieto J. J. L., Rodriguez R. G., Espinosa E. V., Martinez D. F., Barcena J. V., Yong R., Briones I. R., Pons J. L. L., Lopez H. A., Ruiz R. O., de la Vega C. D., Brito C. C., Valenzuela E. C., Reyes-Sanchez R., Ruiz A. B., Flores O. N., Gonzalez M. B., Nava R. A., Cerda J. D. M., Fierro O. F., Campos P. F., Alfaro T. A. A., Bellorin S. A., Avena R., Chavarria M., Espinosa I., Silva F. F., Nava R. H. G., Godoy K., Felix E. J. G., Garcia C. L. G., Salas L. G. G., Guajardo P., Gonzalez S. H., Izquierdo T., Ortiz M. C. M., Vasquez D. M., Mendoza N., Morales J., Nikitina N., Aybar S. O., Ortiz A., Macias P. P., Perez F., Sanchez J. A. P., Toledano S. P., Gonzalez M. R., Ramos C. R., Castro V. 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Y., De Cleen D., De Coninck M., de Vos M., de Weerdt N., Delforge M., Delvigne M., Denie D., Derycker K., Deweerd E., Dormal F., Drieghe S., Everaert M., Eykerman T., Feys E., Ghekiere M., Gits F., Hellemans S., Helvasto L., Jacobs C., Lips S., Mestdagh I., Nimmegeers J., Piamonte V., Pollet P., Postolache A., Raepers M., Raymenants E., Richa J., Rombouts H., Salembier J., Scheurwegs C., Semeraro O., Simons N., Smessaert C., Smolders W., Stockman I., Tahon S., Thyssen V., Tincani G., Van Durme F., Van Lier D., Vandekerckhove H., Vandekerckhove Y., Vandenbroeck D., Vandorpe A., Vanhalst E., Vanhauwaert B., Vantomme C., Vergauwen L., Verloove H., Vydt T., Weyn T., Reichert P., Spacek R., Machova V., Zidkova E., Ludka O., Olsr J., Kotik L., Plocova K., Racz B., Ferkl R., Hubac J., Kotik I., Monhart Z., Burianova H., Jerabek O., Pisova J., Petrova I., Dedek V., Honkova M., Podrazil P., Spinar J., Vitovec J., Novak M., Lastuvka J., Durdil V., Antonova P., Bockova L., Bultas J., Chlumsky J., Dastychova L., Drasnar T., Honek J., Horejsi M., Hubacova V., Janska L., Kopeckova I., Kratochvilova R., Krcova E., Labrova R., Lindourkova A., Lipoldova J., Lubanda H., Ludkova A., Mahdalikova L., Majernikova M., Michalik D., Potuznik P., Prochazkova E., Sulc A., Sveceny J., Valtova M., Zidek M., Zika J., Nielsen H., Husted S., Hintze U., Rasmussen S., Bremmelgaard A., Markenvard J., Boerger J., Solgaard J., Simonsen P., Loekkegaard T., Bruun M., Mertz J., Dominguez H., Skagen K., Egstrup K., Ibsen H., Raymond I., Bang-Hansen T., Ellervik C., Eriksen E., Jensen L., Jensen M., Leth M., Nygaard A., Park J., Schou M., Therkelsen A., Tilma J., Vesterager K., Airaksinen J., Arola O., Koistinen J., Nappila H., Peltomaki K., Rasanen V., Vasankari T., Galinier M., Gottwalles Y., Paganelli F., Loiselet P., Muller J. -J., Koujan M. B., Marquand A., Destrac S., Piot O., Delarche N., Cebron J. -P., Boveda S., Guenoun M., Guedj-Meynier D., Galley D., Ohayon J., Assouline S., Zuber M., Amarenco P., Ellie E., Kadouch J., Fournier P. -Y., Huberman J. -P., Lemaire M., Rodier G., Milandre L., Vandamme X., Sibon I., Neau J. -P., Mahagne M. H., Mielot A., Bonnefoy M., Churet J. -B., Navarre V., Sellem F., Monniot G., Boyes J. -P., Doucet B., Martelet M., Obadia D., Crousillat B., Mouallem J., Bearez E., Nazeyrollas P., Brugnaux J. P., Fedorowsky A., Casassus F., Berneau J. -B., Chemin F., Falvo N., Perron J. -M., Poulard J. -E., Barreau A., Beltra C., Corrihons E., Decarsin N., Dubois B., Ducasse E., Giry X., Kemmel A., Ledure S., Lemaire N., Robin F., Rosolin N., Sanchez D., Suissa A., Koniger G., Purr J., Gerbaulet U., Kellner B. -T., Kopf A., Schafer T., Zauzig H., Riegel P., Hohensee H., Eissfeller E., Eder W., Rehling G., Glatzel D., Zutz S., Heinz G. -U., Menke H., Pustelnik A., Sandow P., Ludwig N., Wiswedel H., Wildenauer W., Axthelm C., Schwarz T., Babyesiza A., Stuchlik G., Zimny H. -H., Kropp M., Kahl F., Caspar A., Omankowsky S., Lassig T., Hartmann H. -J., Lehmann G., Bindig H. -W., Hergdt G., Reimer D., Hauk J., Dorsch W., Dshabrailov J., Michel H., Rapp K. -A., Vormann R., Mayer P., Horstmeier U., Eissing V., Hey H., Leuchtgens H., Lilienweiss V., Kolitsch K., Schubert C., Lauer H., Buchner T., Brauer G., Kamin S., Muller K., Abdel-Qader M., Baumbach S., Ebert H. -H., Schwencke C., Schellong S., Bernhardt P., Karolyi L., Sievers B., Haverkamp W., Salbach P., Rohnisch J. -U., Schoen S., Erdle W., Mueller T., Mueller H., Mitrovic V., Babjakova Z., Bergner K., Boehme S., Bonin K., Buckert D., Busch F., Dichristin U., Diez S., Fleck A., Flint K., Floegel H., Fritz C., Frommhold R., Gehre J., Geyer J., Grytzmann A., Hahn M., Helgert K., Hubert K., Kirchner-Volker K., Klein V., Kroll D., Krueger A., Lehmann R., Mann L., Maselli A., Menken G., Mikes K., Mortan H., Nasser N., Nicolaus D., Plauskat A., Pomper L., Quietzsch A., Ravenhorst C., Reichelt C., Reimer C., Schaefer B., Scharrer S., Schirmer K., Schmidt K., Schoene R., Schulze J., Schuppe M., Simon S., Sommer S., Spranger K., Talkenberger A., Tauber K., Tetlak A., Toennishoff T., Voelkel-Babyesiza R., Voigts B., Weiser U., Wesendorf S., Wildenauer S., Wolf T., Wurziger J., Zak J., Zauzig H. -D., Ziefle S., Zincke S., Vangel S., Szalai G., Merkely B., Kancz S., Boda Z., Nagy A., Laszlo Z., Matoltsy A., Gaszner B., Polgar P., Habon T., Noori E., Juhasz G., Kanakaridisz N., Szentpeteri I., Juhasz F., Vertes A., Papp A., May Z., Ferenczi J., Egyutt M., Kis E., Engelthaler G., Szantai G., Fulop E., Gombos P., Gulyas D., Jen P., Kiralyhazine Gyorke E., Kovacs M., Kovacsne Levang S., Marianna S., Radics Z., Sydo N., Szalo R., Szilagyi A., Sztanyik F., Vandrus B., Tiraferri E., Santoro R., Testa S., Di Minno G., Moia M., Caimi T. 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C., Sabir A., Choudhary F., Khalaque S., Wilson A., Peters S., Coulson W., Roberts N., Heer A., Coates S., Ward B., Jackson D., Walton S., Shepherd D., Sterry M., Wong T., Boon M., Bunney R., Haria-Shah R., Baron R. T., Davies S., Schatzberger T., Hargreaves N., Stephenson T., Choi H., Batson R., Lucraft L., Myhill T., Estifano S., Geatch D., Wilkinson J., Veale R., Forshaw K., Davies T., Zaman K., Vinson P., Liley C., Bandrapalli M., McGinty P., Wastling R., McEleny P., Beattie A., Cooke P., Wong M., Gunasegaram J., Pugsley M., Ahmad S., A'Court C., Ayers J., Bennett J., Cartwright S., Dobson S., Dooldeniya C., Flynn A., Fox R., Goram J., Halpin A., Hay A., Jacobs P., Jeffers L., Lomax L., Munro I., Muvva R., Nadaph M., Powell K., Randfield S., Redpath D., Reed R., Rickenbach M., Rogers G., Saunders P. 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M., Singh R., Naguib A., Abu-Mahfouz M., Al Omairi M., Al Naeemi A., Maruthanayagam R., Bazargani N., Wassef A., Gupta R., Khan M., Subbaraman B., Abdul A., Al Mulla A., El Bardisy S., Haridas P., Jadhav S., Magdaluyo K., Makdad M., Maqsood I., Mohamed R., Sharma N., Sharma R., Thanzeel M., Canosa R., Rama P., Blumberg E., Garcia J., Mullen P., Wilson V., Quick A., Ferrick K., Kutayli W. M., Cox M., Franco M., Falkowski S., Mendelson R., Williams M., Miller S., Beach S., Alfieri A., Gutowski T., Haque I., Reddy R., Ahmed W., Delafontaine P., Diercks D., Theodoro D., Remmel K., Alberts M., Ison R., Noveck H., Duffy P., Pitta S., Nishijima D., Treasure C., Asafu-Adjaye N., Ball K., Bartlett M., Bentley M., Bowers S., Brown A., Browne A., Cameron-Watts J., Canova M., Cassidy D., Cervellione K., Congal S., DePauw J., Dickerson A., Eley M., Evans L., Felpel S., Ferdinand K., Fielder D., Gentry P., Haideri A., Hakimi F., Harbour T., Hartranft E., Hawkins B., Headlee M., Henson L., Herrick C., Hicks T., Jasinski S., Jones A., Jones L., Jones P., Karl S., Keeling M., Kerr J., Knowles P., Langdon J., Lay M., Lee J. A., Lincoln T., Malone E., Merliss A., Merritt D., Minardo J., Mooso B., Orosco C., Palumbo V., Parker M., Parrott T., Paserchia S., Pearl G., Peterson J., Pickelsimer N., Purcell T., Raynor J., Raziano S., Richard C., Richardson T., Robertson C., Sage A., Sanghera T., Shaw P., Shoemaker J., Smith K., Stephanie B., Thatcher A., Theobald H., Thompson N., Treasure L., Tripti T., Verdi C., Worthy V., Jerjes-Sanchez, C, Corbalan, R, Barretto, A, Luciardi, H, Allu, J, Illingworth, L, Pieper, K, Kayani, G, Fitzmaurice, D, Goto, S, Hacke, W, Mantovani, L, Turpie, A, Gersh, B, Gibbs, H, Brodmann, M, Cools, F, Connolly, S, Spyropoulos, A, Eikelboom, J, Hu, D, Jansky, P, Nielsen, J, Ragy, H, Raatikainen, P, Le Heuzey, J, Darius, H, Keltai, M, Kakkar, S, Sawhney, J, Agnelli, G, Ambrosio, G, Koretsune, Y, Diaz, C, ten Cate, H, Atar, D, Stepinska, J, Panchenko, E, Lim, T, Jacobson, B, Oh, S, Vinolas, X, Rosenqvist, M, Steffel, J, Angchaisuksiri, P, Parkhomenko, A, Al Mahmeed, W, Chen, K, Zhao, Y, Zhang, H, Chen, J, Cao, S, Wang, D, Yang, Y, Li, W, Yin, Y, Tao, G, Yang, P, Chen, Y, He, S, Wang, Y, Fu, G, Li, X, Wu, T, Cheng, X, Yan, X, Zhao, R, Chen, M, Xiong, L, Chen, P, Jiao, Y, Guo, Y, Xue, L, Wang, F, Li, H, Yang, Z, Bai, C, Chen, X, Feng, S, Fu, Q, Gao, X, Guo, W, He, R, He, X, Hu, X, Huang, X, Li, B, Li, J, Li, L, Li, Y, Liu, T, Liu, W, Liu, Y, Lu, Z, Luo, X, Ma, T, Peng, J, Sheng, X, Shi, X, Sun, Y, Tian, G, Wang, K, Wang, L, Wu, R, Xie, Q, Xu, R, Yang, J, Yang, L, Yang, Q, Ye, Y, Yu, H, Yu, J, Yu, T, Zhai, H, Zhan, Q, Zhang, G, Zhang, Q, Zhang, R, Zhang, Y, Zheng, W, Zhou, B, Zhou, Z, Zhu, X, Jadhav, P, Durgaprasad, R, Ravi Shankar, A, Rajput, R, Bhargava, K, Sarma, R, Srinivas, A, Roy, D, Nagamalesh, U, Chopda, M, Kishore, R, Kulkarni, G, Chandwani, P, Pothiwala, R, Padinhare Purayil, M, Shah, S, Chawla, K, Kothiwale, V, Raghuraman, B, Vijayaraghavan, G, Vijan, V, Bantwal, G, Bisne, V, Khan, A, Gupta, J, Kumar, S, Jain, D, Abraham, S, Adak, D, Barai, A, Begum, H, Bhattacharjee, P, Dargude, M, Davies, D, Deshpande, B, Dhakrao, P, Dhyani, V, Duhan, S, Earath, M, Ganatra, A, Giradkar, S, Jain, V, Karthikeyan, R, Kasala, L, Kaur, S, Krishnappa, S, Lawande, A, Lokesh, B, Madarkar, N, Meena, R, More, P, Naik, D, Prashanth, K, Rao, M, Rao, N, Sadhu, N, Shah, D, Sharma, M, Shiva, P, Singhal, S, Suresh, S, Vanajakshamma, V, Panse, S, Kanamori, S, Yamamoto, K, Kumagai, K, Katsuda, Y, Sadamatsu, K, Toyota, F, Mizuno, Y, Misumi, I, Noguchi, H, Ando, S, Suetsugu, T, Minamoto, M, Oda, H, Shiraishi, K, Adachi, S, Chiba, K, Norita, H, Tsuruta, M, Koyanagi, T, Ando, H, Higashi, T, Okada, K, Azakami, S, Komaki, S, Kumeda, K, Murayama, T, Matsumura, J, Oba, Y, Sonoda, R, Goto, K, Minoda, K, Haraguchi, Y, Suefuji, H, Miyagi, H, Kato, H, Nakamura, T, Nandate, H, Zaitsu, R, Fujiura, Y, Yoshimura, A, Numata, H, Ogawa, J, Tatematsu, H, Kamogawa, Y, Murakami, K, Wakasa, Y, Yamasawa, M, Maekawa, H, Abe, S, Kihara, H, Tsunoda, S, Saito, K, Fudo, T, Obunai, K, Tachibana, H, Oba, I, Kuwahata, T, Higa, S, Gushiken, M, Eto, T, Yoshida, H, Ikeda, D, Ishizawa, M, Nakatsuka, M, Murata, K, Ogurusu, C, Shimoyama, M, Akutsu, M, Takamura, I, Hoshino, F, Yokota, N, Iwao, T, Tsuchida, K, Takeuchi, M, Hatori, Y, Kitami, Y, Nakamura, Y, Oyama, R, Ageta, M, Go, Y, Mishima, K, Unoki, T, Morii, S, Shiga, Y, Sumi, H, Nagatomo, T, Sanno, K, Fujisawa, K, Atsuchi, Y, Nagoshi, T, Seto, T, Tabuchi, T, Kameko, M, Nii, K, Oshiro, K, Takezawa, H, Nagano, S, Miyamoto, N, Iwaki, M, Fujii, M, Okawa, M, Abe, M, Saito, T, Mito, T, Nagao, K, Minami, J, Mita, T, Sakuma, I, Taguchi, T, Marusaki, S, Doi, H, Tanaka, M, Fujito, T, Matsuta, M, Kusumoto, T, Kakinoki, S, Ashida, K, Yoshizawa, N, Agata, J, Arasaki, O, Manita, M, Ikemura, M, Fukuoka, S, Murakami, H, Matsukawa, S, Hata, Y, Taniguchi, T, Ko, T, Kubo, H, Imamaki, M, Akiyama, M, Inagaki, M, Odakura, H, Ueda, T, Katsube, Y, Nakata, A, Watanabe, H, Techigawara, M, Igarashi, M, Taga, K, Kimura, T, Tomimoto, S, Shibuya, M, Nakano, M, Ito, K, Seo, T, Hiramitsu, S, Hosokawa, H, Hoshiai, M, Hibino, M, Miyagawa, K, Horie, H, Sugishita, N, Soma, A, Neya, K, Yoshida, T, Mizuguchi, M, Ishiguro, M, Minagawa, T, Wada, M, Mukawa, H, Okuda, F, Nagasaka, S, Abe, Y, Adachi, T, Akahane, K, Amano, T, Aoki, K, Aoyama, T, Arai, H, Arima, S, Arino, T, Asano, H, Asano, T, Azuma, J, Baba, T, Betsuyaku, T, Chibana, H, Date, H, Doiuchi, J, Emura, Y, Endo, M, Fujii, Y, Fujiki, R, Fujisawa, A, Fujisawa, Y, Fukuda, T, Fukui, T, Furukawa, N, Furukawa, T, Furumoto, W, Goto, T, Hamaoka, M, Hanazono, N, Hasegawa, K, Hatsuno, T, Hayashi, Y, Higuchi, K, Hirasawa, K, Hirayama, H, Hirose, M, Hirota, S, Honda, M, Ido, T, Iiji, O, Ikeda, H, Ikeda, K, Ikeoka, K, Imaizumi, M, Inaba, H, Inoue, T, Iseki, F, Ishihara, A, Ishioka, N, Ito, N, Iwase, T, Kakuda, H, Kamata, J, Kanai, H, Kanda, H, Kaneko, M, Kano, H, Kasai, T, Kato, T, Kato, Y, Kawada, Y, Kawai, K, Kawakami, K, Kawakami, S, Kawamoto, T, Kawano, S, Kim, J, Kira, T, Kitazawa, H, Kitazumi, H, Kito, T, Kobayashi, T, Koeda, T, Kojima, J, Komatsu, H, Komatsu, I, Koshibu, Y, Kotani, T, Kozuka, T, Kumai, Y, Kumazaki, T, Maeda, I, Maeda, K, Maruyama, Y, Matsui, S, Matsushita, K, Matsuura, Y, Mineoi, K, Mitsuhashi, H, Miura, N, Miyaguchi, S, Miyajima, S, Miyamoto, H, Miyashita, A, Miyata, S, Mizuguchi, I, Mizuno, A, Mori, T, Moriai, O, Morishita, K, Murai, O, Nagai, S, Nagata, E, Nagata, H, Nakagomi, A, Nakahara, S, Nakamura, M, Nakamura, R, Nakanishi, N, Nakayama, T, Nakazato, R, Nanke, T, Nariyama, J, Niijima, Y, Niinuma, H, Nishida, Y, Nishihata, Y, Nishino, K, Nishioka, H, Nishizawa, K, Niwa, I, Nomura, K, Nomura, S, Nozoe, M, Ogawa, T, Ohara, N, Okada, M, Okamoto, K, Okita, H, Okuyama, M, Ono, H, Ono, T, Pearce, Y, Oriso, S, Ota, A, Otaki, E, Saito, Y, Sakai, H, Sakamoto, N, Sakamoto, Y, Samejima, Y, Sasagawa, Y, Sasaguri, H, Sasaki, A, Sasaki, T, Sato, K, Sawano, M, Seki, S, Sekine, Y, Seta, Y, Sezaki, K, Shibata, N, Shiina, Y, Shimono, H, Shimoyama, Y, Shindo, T, Shinohara, 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J., Watson, E., Sarai, B., Ahmad, N., Willcock, W., Cairns, J., Sathananthan, S., de Kare-Silver, N., Gilliland, A., Strieder, E., Howitt, A., Vishwanathan, B., Bird, N., Gray, D., Clark, M., Bisatt, J., Litchfield, J., Fisher, E., Fooks, T., Kelsall, A. R., Alborough, E., Wakeling, J., Parfitt, M., Milne, K., Rogers, S., Priyadharshan, R., Oliver, J. L., Davies, E., Abushal, S., Jacobs, M., Hutton, C., Walls, N. I., Thompson, R., Chigbo, C., Zaidi, S. M. A., Howard, M., Butter, K. C., Barrow, S., Little, H., Haq, I. U., Gibbons, L., Glencross, S., Mcleod, A. J., Poland, K., Mulholland, C., Warke, A., Conn, P., Burns, G., Smith, R. N., Lowe, S., Kamath, R., Dau, H. S., Webster, J., Hodgins, I., Vercoe, S., Roome, P. C., Pinnock, H., Patel, J. R. A., Ali, A., Hart, N., Davies, R., Stuart, E., Neden, C. A., Danielsen, M., Heath, R., Sharma, P., Galloway, S., Hawkins, C., Oliver, R., Aylward, M., Mannion, S., Braddick, M., Edwards, D., Rothwell, A. C., Sabir, A., Choudhary, F., Khalaque, S., Wilson, A., Peters, S., Coulson, W., Roberts, N., Heer, A., Coates, S., Ward, B., Jackson, D., Walton, S., Shepherd, D., Sterry, M., Wong, T., Boon, M., Bunney, R., Haria-Shah, R., Baron, R. T., Davies, S., Schatzberger, T., Hargreaves, N., Stephenson, T., Choi, H., Batson, R., Lucraft, L., Myhill, T., Estifano, S., Geatch, D., Wilkinson, J., Veale, R., Forshaw, K., Davies, T., Zaman, K., Vinson, P., Liley, C., Bandrapalli, M., Mcginty, P., Wastling, R., Mceleny, P., Beattie, A., Cooke, P., Wong, M., Gunasegaram, J., Pugsley, M., Ahmad, S., A'Court, C., Ayers, J., Bennett, J., Cartwright, S., Dobson, S., Dooldeniya, C., Flynn, A., Fox, R., Goram, J., Halpin, A., Hay, A., Jacobs, P., Jeffers, L., Lomax, L., Munro, I., Muvva, R., Nadaph, M., Powell, K., Randfield, S., Redpath, D., Reed, R., Rickenbach, M., Rogers, G., Saunders, P. B., Seamark, C., Shewring, J., Simmons, P., Simper, H., Stoddart, H., Sword, A., Thomas, N., Thomson, A., Blenkhorn, A., Singh, B., Van Gaal, W., Abhayaratna, W., Lehman, R., Roberts-Thomson, P., Kilian, J., Coulshed, D., Catanchin, A., Colquhoun, D., Kiat, H., Eccleston, D., French, J., Zimmett, L., Ayres, B., Phan, T., Blombery, P., Crimmins, D., O'Donnell, D., Choi, A., Astridge, P., Arstall, M., Jepson, N., Binnekamp, M., Lee, A., Rogers, J., Starmer, G., Carroll, P., Faunt, J., Aggarwala, A., Barry, L., Batta, C., Beveridge, R., Black, A., Bonner, M., Boys, J., Buckley, E., Campo, M., Carlton, L., Connelly, A., Conway, B., Cresp, D., Dimitri, H., Dixon, S., Dolman, M., Duroux, M., Eskandari, M., Eslick, R., Ferreira-Jardim, A., Fetahovic, T., Fitzpatrick, D., Geraghty, R., Gibbs, J., Grabek, T., Modi, M. H., Hayes, K., Hegde, M. 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M., Jean, C., Jethoo, G., Kahlon, R., Kelly, S., Kim, R., Korley, V., Kornder, J., Kwan, L., Largy, J., Lewis, C., Lewis, S., Mangat, I., Moor, R., Navratil, J., Neas, I., Otis, J., Otis, R., Pandey, M., Petrie, F., Pinter, A., Raines, M., Roberts, P., Robinson, M., Sas, G., Schulman, S., Snell, L., Spearson, S., Stevenson, J., Trahey, T., Wong, S., Wright, D., El-Aziz, A. A., Seif, S. K. A., El Din, M. 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M., Singh, R., Naguib, A., Abu-Mahfouz, M., Al Omairi, M., Al Naeemi, A., Maruthanayagam, R., Bazargani, N., Wassef, A., Gupta, R., Khan, M., Subbaraman, B., Abdul, A., Al Mulla, A., El Bardisy, S., Haridas, P., Jadhav, S., Magdaluyo, K., Makdad, M., Maqsood, I., Mohamed, R., Sharma, N., Sharma, R., Thanzeel, M., Canosa, R., Rama, P., Blumberg, E., Garcia, J., Mullen, P., Wilson, V., Quick, A., Ferrick, K., Kutayli, W. 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A., Lincoln, T., Malone, E., Merliss, A., Merritt, D., Minardo, J., Mooso, B., Orosco, C., Palumbo, V., Parker, M., Parrott, T., Paserchia, S., Pearl, G., Peterson, J., Pickelsimer, N., Purcell, T., Raynor, J., Raziano, S., Richard, C., Richardson, T., Robertson, C., Sage, A., Sanghera, T., Shaw, P., Shoemaker, J., Smith, K., Stephanie, B., Thatcher, A., Theobald, H., Thompson, N., Treasure, L., Tripti, T., Verdi, C., and Worthy, V.
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Registrie ,Male ,Latin Americans ,030204 cardiovascular system & hematology ,outcomes ,0302 clinical medicine ,Drug Prescription ,Retrospective Studie ,Risk Factors ,Atrial Fibrillation ,Antithrombotic ,Prospective Studies ,Registries ,030212 general & internal medicine ,Practice Patterns, Physicians' ,Stroke ,Anticoagulant ,Atrial fibrillation ,General Medicine ,Middle Aged ,Treatment Outcome ,Stroke prevention ,outcome ,Female ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,Human ,medicine.medical_specialty ,medicine.drug_class ,Clinical Investigations ,Hemorrhage ,antithrombotic treatment ,Drug Prescriptions ,03 medical and health sciences ,Internal medicine ,medicine ,Humans ,Mexico ,Aged ,Retrospective Studies ,Fibrillation ,business.industry ,Risk Factor ,Anticoagulants ,South America ,medicine.disease ,Drug Utilization ,Clinical trial ,Prospective Studie ,Latin American ,antithrombotic treatment, atrial fibrillation, Latin American, outcomes ,business - Abstract
Author(s): Jerjes-Sanchez, Carlos; Corbalan, Ramon; Barretto, Antonio CP; Luciardi, Hector L; Allu, Jagan; Illingworth, Laura; Pieper, Karen S; Kayani, Gloria; GARFIELD-AF Investigators | Abstract: BackgroundAtrial fibrillation (AF) is an important preventable cause of stroke. Anticoagulation (AC) therapy can reduce this risk. However, prescribing patterns and outcomes in patients with non-valvular AF (NVAF) from Latin American countries are poorly described.MethodsUsing data from the Global Anticoagulant Registry in the FIELD-AF (GARFIELD-AF), we examined the stroke prevention strategies and the 1-year outcomes in patients from four Latin American countries: Argentina, Brazil, Chile, and Mexico.ResultsA total of 4162 patients (2010-2014) were included in this analysis. At the time of AF diagnosis, 39.9% of patients were prescribed vitamin K antagonists (VKA) ± antiplatelet (AP) therapy, 21.8% non-VKA oral anticoagulant (NOAC) ± AP, 24.1% AP only and 14.1% no antithrombotic treatment. The proportion of moderate-high risk patients receiving no AC therapy at participating centers was highest in Mexico (46.4%) and lowest in Chile (14.3%). During 1-year follow-up, the rates of all-cause mortality, stroke/SE and major bleeding were: 5.77 (95% CI) (5.06-6.56), 1.58 (1.23-2.02), and 0.99 (0.72-1.36) and per 100 person-years, respectively, which are higher than the global rates across all countries in GARFIELD-AF. Unadjusted rates of all-cause mortality were highest in Argentina, 6.95 (5.43-8.90), and lowest in Chile, 4.01 (2.92-5.52).ConclusionsGARFIELD-AF results describes the marked variation in the baseline characteristics and patterns of antithrombotic treatments in patients with NVAF in four Latin American countries. Over one-third of patients with a moderate-to-high risk of stroke received no AC therapy, highlighting the need for improved management of patients according to national guideline. CLINICAL TRIAL REGISTRATION-URL: http://www.clinicaltrials.gov. Unique identifier: NCT01090362.
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- 2019
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3. Ultrafilter extensions do not preserve elementary equivalence
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Denis I. Saveliev and Saharon Shelah
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Mathematics::Operator Algebras ,Logic ,Mathematics::Rings and Algebras ,010102 general mathematics ,Ultrafilter ,Elementary equivalence ,0102 computer and information sciences ,01 natural sciences ,Combinatorics ,Mathematics::Group Theory ,Mathematics::Logic ,010201 computation theory & mathematics ,Astrophysics::Solar and Stellar Astrophysics ,Beta (velocity) ,0101 mathematics ,Mathematics - Abstract
We show that there exist models $\mathcal M_1$ and $\mathcal M_2$ such that $\mathcal M_1$ elementarily embeds into $\mathcal M_2$ but their ultrafilter extensions $\beta(\mathcal M_1)$ and $\beta(\mathcal M_2)$ are not elementarily equivalent.
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- 2019
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4. Satellite telemetry reveals population specific winter ranges of beluga whales in the Bering Sea
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Gregory O'Corry-Crowe, Kathryn J. Frost, Helen Aderman, Denis I. Litovka, Robert Suydam, Ben Tinker, Marianne Marcoux, Lori T. Quakenbush, Tom Gray, Lloyd F. Lowry, Roderick C. Hobbs, Pierre Richard, John J. Citta, Jack Orr, and Matthew L. Druckenmiller
- Subjects
0106 biological sciences ,geography ,education.field_of_study ,geography.geographical_feature_category ,Satellite telemetry ,010604 marine biology & hydrobiology ,Population ,Beaufort sea ,Aquatic Science ,01 natural sciences ,010601 ecology ,Fishery ,Population specific ,Beluga Whale ,education ,Bay ,Ecology, Evolution, Behavior and Systematics ,Sound (geography) - Abstract
At least five populations (stocks) of beluga whales (Delphinapterus leucas) are thought to winter in the Being Sea, including the Bristol Bay, Eastern Bering Sea (Norton Sound), Anadyr, Eastern Chukchi Sea, and Eastern Beaufort Sea (Mackenzie) populations. Belugas from each population have been tagged with satellite-linked transmitters, allowing us to describe their winter (January–March) distribution. The objectives of this paper were to determine: (1) If each population winters in the Bering Sea, and if so, where? (2) Do populations return to the same area each year (i.e., are wintering areas traditional)? (3) To what extent do the winter ranges of different populations overlap? Tagged belugas from all five populations either remained in, or moved into, the Bering Sea and spent the winter there. Each population wintered in a different part of the Bering Sea and populations with multiple years of data (four of five) returned to the same regions in multiple years. When data were available from two populations that overlapped in the same year, they did not occupy the shared area at the same time. Although our sample sizes were small, the evidence suggests belugas from different populations have traditional winter ranges that are mostly exclusive to each population.
- Published
- 2016
- Full Text
- View/download PDF
5. On the set-theoretic strength of the existence of disjoint cofinal sets in posets without maximal elements
- Author
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Eleftherios Tachtsis, Paul E. Howard, and Denis I. Saveliev
- Subjects
Combinatorics ,Discrete mathematics ,Set (abstract data type) ,Cofinal ,Star product ,010102 general mathematics ,0103 physical sciences ,010307 mathematical physics ,Disjoint sets ,0101 mathematics ,01 natural sciences ,Maximal element ,Mathematics - Published
- 2016
- Full Text
- View/download PDF
6. Ultrafilter extensions do not preserve elementary equivalence
- Author
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Saveliev, Denis I., primary and Shelah, Saharon, additional
- Published
- 2019
- Full Text
- View/download PDF
7. Band Alignment in As‐Transferred and Annealed Graphene/MoS 2 Heterostructures
- Author
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Romanov, Roman I., primary, Slavich, Aleksandr S., additional, Kozodaev, Maxim G., additional, Myakota, Denis I., additional, Lebedinskii, Yuri Y., additional, Novikov, Sergey M., additional, and Markeev, Andrey M., additional
- Published
- 2019
- Full Text
- View/download PDF
8. Arcicella
- Author
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Wolf‐Rainer Abraham, Alexandre J. Macedo, Heinrich Lünsdorf, and Denis I. Nikitin
- Published
- 2015
- Full Text
- View/download PDF
9. Band Alignment in As‐Transferred and Annealed Graphene/MoS 2 Heterostructures
- Author
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Denis I. Myakota, Roman I. Romanov, Maxim G. Kozodaev, Andrey M. Markeev, Sergey M. Novikov, Aleksandr S. Slavich, and Yuri Lebedinskii
- Subjects
Materials science ,Annealing (metallurgy) ,business.industry ,Graphene ,Heterojunction ,Electronic structure ,Condensed Matter Physics ,law.invention ,chemistry.chemical_compound ,symbols.namesake ,chemistry ,X-ray photoelectron spectroscopy ,law ,symbols ,Optoelectronics ,General Materials Science ,business ,Raman spectroscopy ,Electronic band structure ,Molybdenum disulfide - Published
- 2019
- Full Text
- View/download PDF
10. ChemInform Abstract: Protonation and Transformations of α-Diazo-β-dicarbonyl Compounds in Superacids: Generation of the Strongest Carbon-Centered Cationic Electrophiles at the Protonation of Diazomalonates in Friedel-Crafts Reactions
- Author
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Eugeniy T. Satumov, Maria A. Sandzhieva, Aleksander V. Vasilyev, Denis I. Nilov, Irina A. Boyarskaya, Jury J. Medvedev, and Valerij A. Nikolaev
- Subjects
chemistry.chemical_compound ,chemistry ,Electrophile ,Cationic polymerization ,Protonation ,Diazo ,General Medicine ,Carbon-13 NMR ,Benzene ,Toluene ,Friedel–Crafts reaction ,Medicinal chemistry - Abstract
Protonation of diazodiketones N2C(COR)2 in Bronsted superacids (TfOH, FSO3H, TfOH–SbF5) gives rise to stable and non-reactive O,O-diprotonated at carbonyl oxygens species N2C(C( OH+)R)2, which were studied by means of 1H and 13C NMR. Diazomalonates N2C(CO2Alk)2, contrary to diazodiketones, react with TfOH or HF, releasing nitrogen and producing triflates of oxymalonates TfOCH(CO2Alk)2 or fluoromalonates FCH(CO2Alk)2, respectively. Diazoketoesters N2C(COR)(CO2Alk) react in the same way only with TfOH, but not with HF. The reactions of diazomalonates with arenes ArH (benzene, toluene, xylenes) in TfOH solution yield corresponding Friedel–Crafts reaction products ArCH(CO2Alk)2. According to performed DFT calculations, trication +CH(C( OH+)OMe)2, a possible intermediate, which is derived from protonation of dimethyl diazomalonate, should be the strongest cationic carbon-centered electrophile known up to date.
- Published
- 2016
- Full Text
- View/download PDF
11. ChemInform Abstract: Reactions of N,3-Diarylpropiolamides with Arenes under Superelectrophilic Activation: Synthesis of 4,4-Diaryl-3,4-dihydroquinolin-2(1H)-ones and Their Derivatives
- Author
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Dmitry S. Ryabukhin, Aleksander V. Vasilyev, Larisa Yu. Gurskaya, Irina A. Boyarskaya, Denis I. Nilov, and Diana S. Belyanskaya
- Subjects
chemistry.chemical_compound ,chemistry ,Aryl ,General Medicine ,Benzene ,Medicinal chemistry - Abstract
The reaction of 3-aryl-N-(aryl)propiolamides with arenes in TfOH at room temperature for 0.5 h led to 4,4-diaryl-3,4-dihydroquinolin-2-(1H)-ones in yields of 44-98%. The obtained dihydroquinolinones were further transformed into the corresponding N-acyl or N-formyl derivatives. For the latter, the superelectrophilic activation of the N-formyl group by TfOH in the reaction with benzene resulted in the formation of N-(diphenylmethyl)-substituted dihydroquinolinones.
- Published
- 2016
- Full Text
- View/download PDF
12. ChemInform Abstract: One-Pot Tandem Hydrophenylation and Ionic Hydrogenation of 3-Phenylpropynoic Acid Derivatives under Superelectrophilic Activation
- Author
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Denis I. Nilov and Aleksander V. Vasilyev
- Subjects
chemistry.chemical_compound ,chemistry ,Cascade reaction ,Cyclohexane ,Tandem ,Acetylene ,Yield (chemistry) ,Ionic bonding ,General Medicine ,Lewis acids and bases ,Benzene ,Medicinal chemistry - Abstract
The reactions of esters and amides of 3-phenylpropynoic acid with strong Lewis acids AlX 3 (X = Cl, Br) or conjugate Bronsted–Lewis superacids HX-AlX 3 (X = Cl, Br) in benzene and cyclohexane at room temperature afforded 3,3-diphenylpropanoic acid derivatives in up to 94% yield. This tandem reaction of the acetylene bond proceeded by hydrophenylation followed by ionic hydrogenation.
- Published
- 2016
- Full Text
- View/download PDF
13. GABA<scp>a</scp>receptor α-subunit proteins in human chronic alcoholics
- Author
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Peter R. Dodd, Flavia Huygens, Joanne Marie Lewohl, and Denis I. Crane
- Subjects
Gene isoform ,medicine.medical_specialty ,GABAA receptor ,Central nervous system ,Brain damage ,Biochemistry ,Pathogenesis ,Cellular and Molecular Neuroscience ,Endocrinology ,medicine.anatomical_structure ,Cerebral cortex ,Internal medicine ,Toxicity ,medicine ,medicine.symptom ,Psychology ,Motor cortex - Abstract
Antibodies were raised against specific peptides from N-terminal regions of the α1 and α3 isoforms of the GABAA receptor, and used to assess the relative expression of these proteins in the superior frontal and primary motor cortices of 10 control, nine uncomplicated alcoholic and six cirrhotic alcoholic cases were matched for age and post-mortem delay. The regression of expression on post-mortem delay was not statistically significant for either isoform in either region. In both cortical areas, the regression of α1 expression on age differed significantly between alcoholic cases, which showed a decrease, and normal controls, which did not. Age had no effect on α3 expression. The α1 and α3 isoforms were found to be expressed differentially across cortical regions and showed a tendency to be expressed differentially across case groups. In cirrhotic alcoholics, α1 expression was greater in superior frontal than in motor cortex, whereas this regional difference was not significant in controls or uncomplicated alcoholics. In uncomplicated alcoholics, α3 expression was significantly lower in superior frontal than in motor cortex. Expression of α1 was significantly different from that of α3 in the superior frontal cortex of alcoholics, but not in controls. In motor cortex, there were no significant differences in expression between the isoforms in any case group.
- Published
- 2001
- Full Text
- View/download PDF
14. Satellite telemetry reveals population specific winter ranges of beluga whales in the Bering Sea
- Author
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Citta, John J., primary, Richard, Pierre, additional, Lowry, Lloyd F., additional, O'Corry-Crowe, Gregory, additional, Marcoux, Marianne, additional, Suydam, Robert, additional, Quakenbush, Lori T., additional, Hobbs, Roderick C., additional, Litovka, Denis I., additional, Frost, Kathryn J., additional, Gray, Tom, additional, Orr, Jack, additional, Tinker, Ben, additional, Aderman, Helen, additional, and Druckenmiller, Matthew L., additional
- Published
- 2016
- Full Text
- View/download PDF
15. ChemInform Abstract: Protonation and Transformations of α-Diazo-β-dicarbonyl Compounds in Superacids: Generation of the Strongest Carbon-Centered Cationic Electrophiles at the Protonation of Diazomalonates in Friedel-Crafts Reactions.
- Author
-
Satumov, Eugeniy T., primary, Medvedev, Jury J., additional, Nilov, Denis I., additional, Sandzhieva, Maria A., additional, Boyarskaya, Irina A., additional, Nikolaev, Valerij A., additional, and Vasilyev, Aleksander V., additional
- Published
- 2016
- Full Text
- View/download PDF
16. ChemInform Abstract: Reactions of N,3-Diarylpropiolamides with Arenes under Superelectrophilic Activation: Synthesis of 4,4-Diaryl-3,4-dihydroquinolin-2(1H)-ones and Their Derivatives.
- Author
-
Gurskaya, Larisa Yu., primary, Belyanskaya, Diana S., additional, Ryabukhin, Dmitry S., additional, Nilov, Denis I., additional, Boyarskaya, Irina A., additional, and Vasilyev, Aleksander V., additional
- Published
- 2016
- Full Text
- View/download PDF
17. On the set‐theoretic strength of the existence of disjoint cofinal sets in posets without maximal elements
- Author
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Howard, Paul, primary, Saveliev, Denis I., additional, and Tachtsis, Eleftherios, additional
- Published
- 2016
- Full Text
- View/download PDF
18. A Corn Oil-Based Diet Protects Against Combined Ethanol and Iron-Induced Liver Injury in a Mouse Model of Hemochromatosis
- Author
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Darrell H. G. Crawford, Gregory J. Anderson, V. Nathan Subramaniam, N. Santrampurwala, Lesley Jaskowski, Denis I. Crane, Andrew D. Clouston, T. L. Murphy, Terrence C. H. Tan, and Linda M. Fletcher
- Subjects
Male ,Alcoholic liver disease ,Pathology ,medicine.medical_specialty ,Iron ,Medicine (miscellaneous) ,Physiology ,Alcohol ,Toxicology ,Mice ,Random Allocation ,chemistry.chemical_compound ,medicine ,Animals ,Hemochromatosis ,Mice, Knockout ,Liver injury ,Ethanol ,business.industry ,medicine.disease ,Dietary Fats ,Mice, Inbred C57BL ,Disease Models, Animal ,Psychiatry and Mental health ,chemistry ,Toxicity ,Corn Oil ,business ,Corn oil ,Chronic liver injury - Abstract
Combined iron overload and alcohol may promote synergistic chronic liver injury and toxicity. The role of specific dietary fats in influencing the development of co-toxic alcoholic liver disease needs further evaluation and is investigated in this study.Wild-type (WT) and the iron-loaded Hfe-null (Hfe(-/-) ) mice were fed chow (CC), a AIN-93G standard control (SC), or a corn oil-modified, AIN-93G-based (CO) diet with or without the addition of 20% ethanol (EtOH) in the drinking water for 8 weeks and assessed for liver injury.WT mice on CC, SC, and CO diets had no liver injury, although mild steatosis developed in the SC and CO groups. The addition of EtOH resulted in mild steatohepatitis in WT mice fed SC but not those on a CO diet. EtOH administration in Hfe(-/-) animals on the CC and SC diets caused marked oxidative stress, inflammatory activity, and subsinusoidal and portal-portal tract linkage fibrosis with significant up-regulation of genes involved in cellular stress signaling and fibrogenic pathways. These effects were abrogated in the CO-fed mice, despite elevated serum EtOH levels and hepatic iron concentrations, reduced hepatic glutathione and mitochondrial superoxide dismutase activities. Feeding with the CO diet led to increased hepatic glutathione peroxidase and catalase activities and attenuated alcohol-induced hepatic steatosis in the Hfe(-/-) animals. Iron and EtOH feeding markedly reduced p-STAT3 and p-AMPK protein levels, but this effect was significantly attenuated when a CO diet was consumed.A CO-based diet is protective against combined EtOH- and iron-induced liver toxicity, likely via attenuation of hepatic steatosis and oxidative stress and may have a role in the prevention of fibrosis development in chronic liver disease.
- Published
- 2013
- Full Text
- View/download PDF
19. ChemInform Abstract: One-Pot Tandem Hydrophenylation and Ionic Hydrogenation of 3-Phenylpropynoic Acid Derivatives under Superelectrophilic Activation.
- Author
-
Nilov, Denis I., primary and Vasilyev, Aleksander V., additional
- Published
- 2016
- Full Text
- View/download PDF
20. ChemInform Abstract: Synthesis and Structural/Physical Properties of U3Fe2Ge7: A Single-Crystal Study.
- Author
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Henriques, Margarida S., primary, Gorbunov, Denis I., additional, Waerenborgh, Joao C., additional, Pasturel, Mathieu, additional, Andreev, Alexander V., additional, Dusek, Michal, additional, Skourski, Yurii, additional, Havela, Ladislav, additional, and Goncalves, Antonio P., additional
- Published
- 2015
- Full Text
- View/download PDF
21. Arcicella
- Author
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Abraham, Wolf‐Rainer, primary, Macedo, Alexandre J., additional, Lünsdorf, Heinrich, additional, and Nikitin, Denis I., additional
- Published
- 2015
- Full Text
- View/download PDF
22. ChemInform Abstract: Unexpected Reaction of 2-(Cyclopent-2-enyl)aniline Hydrochloride with Dimethyldioxirane
- Author
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N. N. Kabal'nova, Abdrakhmanov Ildus B, Denis I. D’yachenko, V. P. Kazakov, Akhat G. Mustafin, V. V. Shereshovets, and Tolstikov Genrikh A
- Subjects
chemistry.chemical_compound ,Chemistry ,Aniline hydrochloride ,Organic chemistry ,General Medicine ,Dimethyldioxirane - Published
- 2010
- Full Text
- View/download PDF
23. ChemInform Abstract: Ozonolysis of N-Acetyl-2-(cyclopent-2-enyl)aniline
- Author
-
Gumer Yu. Ishmuratov, Abdrakhmanov Ildus B, Akhat G. Mustafin, T. V. Khakimova, Tolstikov Genrikh A, Denis I. D’yachenko, and Leonid V. Spirikhin
- Subjects
Indole test ,chemistry.chemical_compound ,Aniline ,Ozonolysis ,chemistry ,General Medicine ,Medicinal chemistry - Abstract
Double cyclization of N-acetyl-2-(cyclopent-2-enyl)aniline initiated by ozonolysis resulted in 9-acetyl-2-hydroxy-2,3,4,4a,9,9a-hexahydropyrano[2,3-b]indole.
- Published
- 2010
- Full Text
- View/download PDF
24. ChemInform Abstract: Oxidation of N-Acyl-2-(cycloalk-1-enyl)anilines with Ozone and Hydrogen Peroxide
- Author
-
M. F. Nasyrov, L. V. Spirikhin, O. V. Shitikova, Rail R. Gataullin, Denis I. D’yachenko, A. A. Fatykhov, and Abdrakhmanov Ildus B
- Subjects
chemistry.chemical_compound ,Ozone ,chemistry ,Organic chemistry ,General Medicine ,Photochemistry ,Hydrogen peroxide - Published
- 2010
- Full Text
- View/download PDF
25. Conditional inactivation of the peroxisome biogenesisPex13 gene by Cre-loxP excision
- Author
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Megan Maxwell, Graham F. Kay, Jonas Carl-Otto Bjorkman, Ian D. Tonks, Carol Paterson, and Denis I. Crane
- Subjects
Male ,Integrases ,Membrane Proteins ,Mice, Transgenic ,Cell Biology ,Peroxisome ,Biology ,Cell biology ,Mice ,Viral Proteins ,Endocrinology ,Peroxisomes ,Genetics ,Animals ,Female ,Gene Silencing ,Cre-Lox recombination ,Gene ,Biogenesis - Published
- 2002
- Full Text
- View/download PDF
26. ChemInform Abstract: Ozonolysis of N-Acetyl-2-(cyclopent-2-enyl)aniline.
- Author
-
Mustafin, Akhat G., primary, D'yachenko, Denis I., additional, Khakimova, Tat'yana V., additional, Spirikhin, Leonid V., additional, Ishmuratov, Gumer Yu., additional, Abdrakhmanov, Il'dus B., additional, and Tolstikov, Genrikh A., additional
- Published
- 2010
- Full Text
- View/download PDF
27. Corrigendum to “Small heat shock protein Hsp27 protects myosin S1 from heat‐induced aggregation, but not from thermal denaturation and ATPase inactivation” [FEBS Lett. 582 (2008) 1407–1412]
- Author
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Markov, Denis I., primary, Pivovarova, Anastasia V., additional, Chernik, Ivan S., additional, Gusev, Nikolai B., additional, and Levitsky, Dmitrii I., additional
- Published
- 2009
- Full Text
- View/download PDF
28. α-Synuclein abnormalities in mouse models of peroxisome biogenesis disorders
- Author
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Yakunin, Eugenia, primary, Moser, Ann, additional, Loeb, Virginie, additional, Saada, Ann, additional, Faust, Phyllis, additional, Crane, Denis I., additional, Baes, Myriam, additional, and Sharon, Ronit, additional
- Published
- 2009
- Full Text
- View/download PDF
29. Small heat shock protein Hsp27 protects myosin S1 from heat‐induced aggregation, but not from thermal denaturation and ATPase inactivation
- Author
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Markov, Denis I., primary, Pivovarova, Anastasia V., additional, Chernik, Ivan S., additional, Gusev, Nikolai B., additional, and Levitsky, Dmitrii I., additional
- Published
- 2008
- Full Text
- View/download PDF
30. Corrigendum to 'Small heat shock protein Hsp27 protects myosin S1 from heat-induced aggregation, but not from thermal denaturation and ATPase inactivation' [FEBS Lett. 582 (2008) 1407-1412]
- Author
-
Anastasia V. Pivovarova, Ivan S. Chernik, Denis I. Markov, Nikolai B. Gusev, and Dmitrii I. Levitsky
- Subjects
Thermal denaturation ,Heat induced ,ATPase ,Biophysics ,Cell Biology ,Biology ,medicine.disease_cause ,Biochemistry ,law.invention ,Hsp27 ,Structural Biology ,law ,Heat shock protein ,Myosin ,Genetics ,medicine ,biology.protein ,Recombinant DNA ,Molecular Biology ,Escherichia coli - Abstract
B-crystallin(isolated from bovine lens) prevents both thermal aggregationand inactivation of chicken skeletal myosin, whereas our data indi-cate that recombinant human Hsp27 (expressed in Escherichia coli)effectively prevents aggregation, but does not affect thermal dena-turation of rabbit skeletal myosin S1 and inactivation of its ATPase.In order to solve this discrepancy we analyzed the effect of recom-binant human
- Published
- 2009
- Full Text
- View/download PDF
31. An Efficient Synthesis of Novel Heterocycle-Fused Derivatives of 1-Oxo-1,2,3,4-tetrahydropyrazine Using Ugi Condensation.
- Author
-
Ilyn, Alexey P., primary, Kuzovkova, Julia A., additional, Potapov, Victor V., additional, Shkirando, Alexandre M., additional, Kovrigin, Denis I., additional, Tkachenko, Sergey E., additional, and Ivachtchenko, Alexandre V., additional
- Published
- 2005
- Full Text
- View/download PDF
32. RhoA is highly up‐regulated in the process of early heart development of the chick and important for normal embryogenesis
- Author
-
Kaarbø, Mari, primary, Crane, Denis I., additional, and Murrell, Wayne G., additional
- Published
- 2003
- Full Text
- View/download PDF
33. Double Addition of Diphenylcyclopropenone to Azomethine Imines Generated from 6-Aryl-1,5-diazabicyclo[3.1.0]hexanes
- Author
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Molchanov, Alexander P., primary, Sipkin, Denis I., additional, Koptelov, Yuri B., additional, and Kostikov, Rafael R., additional
- Published
- 2002
- Full Text
- View/download PDF
34. Conditional inactivation of the peroxisome biogenesisPex13 gene by Cre-loxP excision
- Author
-
Bjorkman, Jonas, primary, Tonks, Ian, additional, Maxwell, Megan A., additional, Paterson, Carol, additional, Kay, Graham F., additional, and Crane, Denis I., additional
- Published
- 2002
- Full Text
- View/download PDF
35. GABAareceptor α-subunit proteins in human chronic alcoholics
- Author
-
Lewohl, Joanne M., primary, Huygens, Flavia, additional, Crane, Denis I., additional, and Dodd, Peter R., additional
- Published
- 2001
- Full Text
- View/download PDF
36. ChemInform Abstract: Reaction of 6‐Aryl‐1,5‐diazabicyclo[3.1.0]hexanes with Aryl Isocyanates and Aryl Isothiocyanates.
- Author
-
Molchanov, Alexander P., primary, Sipkin, Denis I., additional, Koptelov, Yuri B., additional, and Kostikov, Rafael R., additional
- Published
- 2001
- Full Text
- View/download PDF
37. Cerebral blood flow requirement for brain viability in newborn infants is lower than in adults
- Author
-
William J. Powers, Jeffrey M. Perlman, Denis I. Altman, Sara L. Volpe, Joseptemberh J. Volpe, and Peter Herscovitch
- Subjects
Pediatrics ,medicine.medical_specialty ,Resuscitation ,Ischemia ,Gestational Age ,Neurological examination ,Bayley Scales of Infant Development ,Spastic diplegia ,medicine ,Humans ,Brain Diseases ,medicine.diagnostic_test ,business.industry ,Infant, Newborn ,Brain ,Infant ,medicine.disease ,nervous system ,Neurology ,Cerebral blood flow ,Term Infant ,Positron emission tomography ,Cerebrovascular Circulation ,Child, Preschool ,Anesthesia ,Neurology (clinical) ,business ,Infant, Premature ,Tomography, Emission-Computed ,circulatory and respiratory physiology - Abstract
Measurements of regional cerebral blood flow (CBF) with positron emission tomography in adult humans with cerebrovascular disease have demonstrated consistently that values below 10 ml/(100 gm · min) occur only in infarcted brain. Although experimental data suggest that the newborn brain may be more resistant to ischemic injury than the adult brain, the minimum CBF necessary to sustain neuronal viability in newborn infants is unknown. We have measured CBF with positron emission tomography in 16 preterm and 14 term newborn infants and have determined the relationship between CBF and subsequent brain function as assessed by neurological examination and developmental assessment. The range of mean CBF in the preterm infants was 4.9 to 23 ml/(100 gm · min) and the range of mean CBF in the term infants was 9.0 to 73 ml/(100 gm · min). Five preterm infants and one term infant with mean CBF less than 10 ml/(100 gm · min) survived. Three of these 5 preterm infants, with mean CBF of 4.9, 5.2, and 9.3 ml/ (100 gm · min, respectively, have normal neurological examinations and Bayley Scales of 80 or greater at 6, 6, and 24 months of age, respectively. One (mean CBF 6.9) has normal cognitive development (Bayley 103) and a mild spastic diplegia at age 19 months, and one infant (mean CBF 6.2) has a left hemiparesis and a Binet IQ score of 70 at age 33 months. The term infant, with a mean CBF of 9.0 ml/(100 gm · min), was developing normally when he died of Septembersis at age 5 months. These data indicate that mean CBF as low as 5 ml/(100 gm · min) in newborn infants can be associated with normal subsequent neurological development and therefore with preservation of a substantial number of cortical/ neurons. Since the minimal CBF below this value necessary to maintain neuronal viability in newborn infants remains to be determined, measurements of CBF in the newborn period should not be used in determination of brain death.
- Published
- 1988
- Full Text
- View/download PDF
38. Cerebral blood flow requirement for brain viability in newborn infants is lower than in adults
- Author
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Altman, Denis I., primary, Powers, William J., additional, Perlman, Jeffrey M., additional, Herscovitch, Peter, additional, Volpe, Sara L., additional, and Volpe, Joseptemberh J., additional
- Published
- 1988
- Full Text
- View/download PDF
39. Influence of resident involvement on fluoroscopy time and ionizing radiation exposure in fluoroscopy-guided spinal procedures.
- Author
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Soucy B, Lee D, Moreau-Bourbonnais A, Filiatrault M, Denis I, Chang MC, and Boudier-Revéret M
- Subjects
- Humans, Injections, Epidural methods, Lumbosacral Region, Fluoroscopy methods, Radiation, Ionizing, Radiation Dosage, Radiation Exposure
- Abstract
Background: Fluoroscopic guidance has become the standard for a variety of medical procedures. Mastering these techniques requires practice, which may entail additional radiation for patients and providers. Despite their widespread use, the literature examining factors influencing radiation exposure in fluoroscopically guided pain procedures is scarce., Objective: To evaluate the influence of resident involvement on radiation exposure during fluoroscopy-guided spinal interventions., Design: Single-center, observational study., Setting: Outpatient physiatry clinic in a teaching hospital., Patients: All patients who received cervical or lumbar facet block(s) (FBs), transforaminal epidural steroid injection(s) (TFESIs) without digital subtraction, or a caudal epidural (CE) during the study period were included., Interventions: Resident involvement in the procedures: absent, observing, or participating., Main Outcome Measures: Machine-indicated fluoroscopy time (seconds) and radiation dose (milligrays [mGy])., Results: Two hundred ninety six procedures were included: 188 FBs (58 cervical, 130 lumbar), 48 CEs, and 60 TFESIs. For lumbar FBs, fluoroscopy time and radiation dose increased significantly when residents performed them (mean
time = 24.5 s, confidence interval [CI] = 20.4-28.7; meandose = 3.53 mGy, CI = 2.57-4.49) compared to when they observed (meantime = 9.9 s, CI = 8.1-11.7; meandose = 1.28 mGy, CI = 0.98-1.59) (mean difference: time = 14.63 s, CI = 9.31-19.94; dose = 2.25 mGy, CI = 1.17-3.33) and were absent during the procedure (meantime = 12.9 s, CI = 11.1-14.6; meandose = 1.65 mGy, CI = 1.40-1.89) (mean difference: time = 11.67 s, CI = 7.35-15.98; dose = 1.88 mGy, CI = 1.01-2.76). In the case of TFESIs, time, but not dose, increased significantly when residents observed (meantime = 39.1 s, CI = 30.7-47.6; meandose = 6.73 mGy, CI = 3.39-10.07) compared to when they were absent (meantime = 27.1 s, CI = 22.4-31.8; meandose = 4.41 mGy, CI = 3.06-5.76 (mean difference: time = 11.99 s, CI = 1.37-22.61; dose = 2.32 mGy, CI = -1.20-5.84). Finally, resident involvement did not significantly affect the outcomes for CEs (ptime = .032, pdose = .74) and cervical FBs (ptime = .64, pdose = .68)., Conclusion: Resident participation affected lumbar FBs the most, with an increase in both fluoroscopy time and radiation dose., (© 2023 American Academy of Physical Medicine and Rehabilitation.)- Published
- 2024
- Full Text
- View/download PDF
40. Posttraumatic Stress Disorder Following Myocardial Infarction: A Systematic Review.
- Author
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Jacquet-Smailovic M, Tarquinio C, Alla F, Denis I, Kirche A, Tarquinio C, and Brennstuhl MJ
- Subjects
- Causality, Humans, Prevalence, Risk Factors, Stress Disorders, Post-Traumatic epidemiology, Myocardial Infarction psychology, Stress Disorders, Post-Traumatic psychology
- Abstract
The objective of the present review is to provide an overview of existing research that has reported on the association between posttraumatic stress disorder (PTSD) and ischemic heart disease. Specific focus is given to the incidence of PTSD following myocardial infarction (MI). A systematic review using Preferred Reporting Items for Systematic reviews and Meta-Analysis (PRISMA) guidelines was performed by searching four bibliographic databases: PubMed, PsychINFO, ScienceDirect, and ProQuest Dissertations and Theses. A total of 39 articles were included in this literature review. The results of these studies suggest that the occurrence of an acute cardiac event is likely to contribute to the development of PTSD. Not only is this type of psychiatric disorder associated with significant suffering and impaired quality of life, but it is also a predictor of an increased risk of recurrent adverse cardiovascular events and mortality. Screening, assessment, and treatment of PTSD and posttraumatic stress symptoms following a major cardiac event are critical for offsetting potential deleterious psychological and physical consequences., (© 2020 International Society for Traumatic Stress Studies.)
- Published
- 2021
- Full Text
- View/download PDF
41. RhoA regulation of cardiomyocyte differentiation.
- Author
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Kaarbø M, Crane DI, and Murrell WG
- Subjects
- Animals, Base Sequence, Cell Line, Chick Embryo, Cloning, Molecular, DNA Primers, Humans, Mice, Promoter Regions, Genetic, Real-Time Polymerase Chain Reaction, rhoA GTP-Binding Protein genetics, Cell Differentiation physiology, Myocytes, Cardiac cytology, rhoA GTP-Binding Protein physiology
- Abstract
Earlier findings from our laboratory implicated RhoA in heart developmental processes. To investigate factors that potentially regulate RhoA expression, RhoA gene organisation and promoter activity were analysed. Comparative analysis indicated strict conservation of both gene organisation and coding sequence of the chick, mouse, and human RhoA genes. Bioinformatics analysis of the derived promoter region of mouse RhoA identified putative consensus sequence binding sites for several transcription factors involved in heart formation and organogenesis generally. Using luciferase reporter assays, RhoA promoter activity was shown to increase in mouse-derived P19CL6 cells that were induced to differentiate into cardiomyocytes. Overexpression of a dominant negative mutant of mouse RhoA (mRhoAN19) blocked this cardiomyocyte differentiation of P19CL6 cells and led to the accumulation of the cardiac transcription factors SRF and GATA4 and the early cardiac marker cardiac α -actin. Taken together, these findings indicate a fundamental role for RhoA in the differentiation of cardiomyocytes.
- Published
- 2013
- Full Text
- View/download PDF
42. Preliminary investigation of the Panic Screening Score for emergency department patients with unexplained chest pain.
- Author
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Foldes-Busque G, Fleet R, Poitras J, Chauny JM, Belleville G, Denis I, Diodati JG, Pelland MÈ, Lessard MJ, and Marchand A
- Subjects
- Chest Pain diagnosis, Cross-Sectional Studies, Diagnosis, Differential, Female, Humans, Logistic Models, Male, Middle Aged, Panic Disorder psychology, Predictive Value of Tests, Quebec, ROC Curve, Sensitivity and Specificity, Chest Pain psychology, Emergency Service, Hospital, Mass Screening methods, Panic Disorder diagnosis
- Abstract
Objectives: The objective was to demonstrate the derivation and the preliminary validation of a brief screening score to improve recognition of panic-like anxiety in emergency department (ED) patients with unexplained chest pain., Methods: This cross-sectional study included 507 ED patients with unexplained chest pain randomly assigned to the derivation condition (n = 201) or the validation condition (n = 306). The Anxiety Disorders Interview Schedule for DSM-IV (ADIS-IV) acted as the criterion standard for panic diagnosis. Receiver operating characteristic (ROC) curves were used to determine which of the sociodemographic, medical, and questionnaire response variables best predicted the presence of panic-like anxiety in the derivation condition. The selected predictors were entered in a logistic regression analysis to determine variables to be included in the screening score. The predictive validity of the resulting score was evaluated in both conditions., Results: The four-item Panic Screening Score (PSS) identified panic-like anxiety with a sensitivity of 63% (95% confidence interval [CI] = 52% to 73%) and a specificity of 84% (95% CI = 76% to 90%) in the derivation phase. The positive predictive value was 74% (95% CI = 62% to 93%) and the negative predictive value was 76% (95% CI = 68% to 89%). In the validation phase, the sensitivity and specificity were 53% (95% CI = 44% to 62%) and 85% (95% CI = 78% to 89%), respectively. The positive predictive value was 72% (95% CI = 62% to 80%) and the negative predictive value was 71% (95% CI = 65% to 77%)., Conclusions: The PSS may be useful to identify patients with unexplained chest pain who could benefit from referral to mental health professionals or their primary care providers for evaluation of panic attack and panic disorder. Prospective studies to improve and validate the PSS, followed by impact analysis, are mandatory before clinical implementation., (© 2011 by the Society for Academic Emergency Medicine.)
- Published
- 2011
- Full Text
- View/download PDF
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