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10. Comparison of lente insulin and NPH insulin therapy for the treatment of newly diagnosed diabetic dogs: a randomised study

Author

Francesca Del Baldo, Ugo Bonfanti, Eleonora Malerba, Antonella Di Cunzolo, Federico Fracassi, Simona D'Angelo, G. Carotenuto, Guido Linari, Sara Corradini, Fracassi, Federico, Linari, Guido, Del Baldo, Francesca, Di Cunzolo, Antonella, D'Angelo, Simona, Malerba, Eleonora, Carotenuto, Gaia, Bonfanti, Ugo, and Corradini, Sara

Subjects
Male, medicine.medical_specialty, 040301 veterinary sciences, medicine.medical_treatment, Insulin, Isophane, canine, NPH insulin, Newly diagnosed, Gastroenterology, 0403 veterinary science, Dogs, Polyuria, Internal medicine, Diabetes mellitus, Diabetes Mellitus, medicine, Animals, Hypoglycemic Agents, Dog Diseases, Prospective Studies, glucose, General Veterinary, diabetes mellitu, business.industry, Medicine (all), Insulin, 0402 animal and dairy science, Lente insulin, 04 agricultural and veterinary sciences, General Medicine, medicine.disease, 040201 dairy & animal science, Serum fructosamine, Treatment Outcome, Female, Insulin, Lente, medicine.symptom, business, Polydipsia
Abstract

Clinical studies that compare lente insulin and neutral protamine Hagedorn (NPH) insulin in diabetic dogs are lacking. This is a prospective, randomised, controlled clinical study aimed to compare the efficacy and safety of lente insulin and NPH insulin in diabetic dogs. Thirty client-owned, newly diagnosed diabetic dogs were included. Animals were randomised into two groups and received lente insulin or NPH insulin administered every 12 hours. Follow-up re-evaluations were done at 1, 2, 4, 6, 8 and 12 weeks. At each re-evaluation, a physical exam, blood glucose curve, and serum fructosamine concentrations were performed. At the end of the study, the median insulin dose per injection was 0.61 U/kg (range, 0.34-0.92 U/kg) and 0.49 U/kg (range, 0.23-0.68 U/kg) in the lente and NPH groups, respectively. There was a significant improvement of polyuria and polydipsia and glucose concentrations in both groups. At the end of the study, the glycaemic control was considered good in 9/15 (60 per cent) and 11/15 (73 per cent) in the lente and NPH groups, respectively. These differences were not significant. Lente insulin and NPH insulin were similarly effective in the treatment of dogs with diabetes mellitus.

Published
2018

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