1. Baseline characteristics of patients in the Reduction of Events with Darbepoetin alfa in Heart Failure trial (RED-HF)
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McMurray, J.J.V., Anand, I. S., Diaz, R., Maggioni, A. P., O'Connor, C., Pfeffer, M. A., Solomon, S. D., Tendera, M., van Veldhuisen, D. J., Albizem, M., Cheng, S., Scarlata, D., Swedberg, K., Young, J. B., Amuchastegui, M., Belziti, C., Bluguermann, J., Caccavo, M., Cartasegna, L., Colque, R., Cuneo, C., Fernandez, A., Gabito, A., Goicochea, R., Gonzalez, M., Gorosito, V., Grinfeld, L., Hominal, M., Kevorkian, R., Litvak Bruno, M., Llanos, J., Mackinnon, I., Manuale, O., Marzetti, E., Nul, D., Perna, E., Riccitelli, M., Sanchez, A., Santos, D., Schygiel, P., Toblli, J., Vogel, D., Aggarwal, A., Amerena, J., De Looze, F., Fletcher, P., Hare, D., Ireland, M., Krum, H., Lattimore, J., Marwick, T., Sindone, A., Thompson, P., Waites, J., Altenberger, J., Ebner, C., Lenz, K., Pacher, R., Poelzl, G., Charlier, F., de Ceuninck, M., De Keulenaer, G., Dendale, P., Marechal, P., Mullens, W., Thoeng, J., Vanderheyden, M., Vanhaecke, J., Weytjens, C., Wollaert, B., Albuquerque, D., Almeida, D., Aspe y Rosas, J., Bocchi, E., Bordignon, S., Clausell, N., Kaiser, S., Leaes, P., Martins Alves, S., Montera, M., Moura, L., Pereira de Castro, R., Rassi, S., Reis, A., Saraiva, J., Simoes, M., Souza Neto, J., Teixeira, M., Benov, H., Chompalova, B., Donova, T., Georgiev, P., Gotchev, D., Goudev, A., Grigorov, M., Guenova, D., Hergeldjieva, V., Ivanov, D., Kostova, E., Manolova, A., Marchev, S., Nikolov, F., Popov, A., Raev, D., Tzekova, M., Czarnecki, W., Giannetti, N., Haddad, H., Heath, J., Huynh, T., Lepage, S., Liu, P., Lonn, E., Ma, P., Manyari, D., Moe, G., Parker, J., Pesant, Y., Rajda, M., Ricci, J., Roth, S., Sestier, F., Sluzar, V., Sussex, B., Vizel, S., Antezana, G., Bugueno, C., Castro, P., Conejeros, C., Manriquez, L., Martinez, D., Potthoff, S., Stockins, B., Vukasovic, J., Gregor, P., Herold, M., Jerabek, O., Jirmar, R., Kuchar, R., Linhart, A., Podzemska, B., Soucek, M., Spac, J., Spacek, R., Vodnansky, P., Bronnum-Schou, J., Clemmensen, K., Egstrup, K., Jensen, G., Kjoller-Hansen, L., Kober, L., Markenvard, J., Rokkedal, J., Skagen, K., Torp-Pedersen, C., Tuxen, C., Videbak, L., Laks, T., Vahula, V., Harjola, V., Kettunen, R., Kotila, M., Bauer, F., Cohen Solal, A., Coisne, D., Davy, J., De Groote, P., Dos Santos, P., Funck, F., Galinier, M., Gibelin, P., Isnard, R., Neuder, Y., Roul, G., Sabatier, R., Trochu, J., Anker, S., Denny, S., Dreykluft, T., Flesch, M., Genth-Zotz, S., Hambrecht, R., Hein, J., Jeserich, M., John, M., Kreider-Stempfle, H., Laufs, U., Muellerleile, K., Natour, M., Sandri, M., Schaufele, T., von Hodenberg, E., Weyland, K., Winkelmann, B., Tse, H., Yan, B., Barsi, B., Csikasz, J., Dezsi, C., Edes, I., Forster, T., Karpati, P., Kerekes, C., Kis, E., Kosa, I., Lupkovics, G., Nagy, A., Preda, I., Ronaszeki, A., Tomcsanyi, J., Zamolyi, K., Agarwal, D., Bahl, V., Bordoloi, A., Chockalingam, K., Chopda, M., Chopra, V., Dugal, J., Ghaisas, N., Ghosh, S., Grant, P., Hiremath, S., Iyengar, S., Jagadeesa Subramania, B., Jain, P., Joshi, A., Khan, A., Mullasari, A., Naik, S., Oomman, A., Pai, V., Pareppally Gopal, R., Parikh, K., Patel, T., Prakash, V., Sastry, B., Sathe, S., Sinha, N., Srikanthan, V., Subburamakrishnan, P., Thacker, H., Wander, G., Admon, D., Katz, A., Klainman, E., Lewis, B., Marmor, A., Moriel, M., Mosseri, M., Shotan, A., Weinstein, J., Zimlichman, R., Agostoni, P., Albanese, M., Alunni, G., Bini, R., Boccanelli, A., Bolognese, L., Campana, C., Carbonieri, E., Carpino, C., Checco, L., Cosmi, F., D'Angelo, G., De Cristofaro, M., Floresta, A., Fucili, A., Galvani, M., Ivleva, A., Marra, S., Musca, G., Peccerillo, N., Perrone Filardi, P., Picchio, E., Russo, T., Scelsi, L., Senni, M., Tavazzi, L., Erglis, A., Jasinkevica, I., Kakurina, N., Veze, I., Volans, E., Bagdonas, A., Berukstis, E., Celutkiene, J., Dambrauskaite, A., Jarasuniene, D., Luksiene, D., Rudys, A., Sakalyte, G., Sliaziene, S., Aguilar-Romero, R., Cardona-Munoz, E., Castro-Jimenez, J., Chavez-Herrera, J., Chuquiure Valenzuela, E., De la Pena, G., Herrera, E., Leiva-Pons, J., Lopez Alvarado, A., Mendez Machado, G., Ramos-Lopez, G., Basart, D., Buijs, E., Cornel, J., de Leeuw, M., Dijkgraaf, R., Dunselman, P., Freericks, M., Hamraoui, K., Lenderlink, T., Linssen, G., Lodewick, P., Lodewijks, C., Lok, D., Nierop, P., Ronner, E., Somsen, A., van Dantzig, J., van der Burgh, P., van Kempen, L., van Vlies, B., Voors, A., Wardeh, A., Willems, F., Dickstein, K., Gundersen, T., Hole, T., Thalamus, J., Westheim, A., Dabrowski, M., Gorski, J., Korewicki, J., Kuc, K., Miekus, P., Musial, W., Niegowska, J., Piotrowski, W., Podolec, P., Polonski, L., Ponikowski, P., Rynkiewicz, A., Szelemej, R., Trusz-Gluza, M., Ujda, M., Wojciechowski, D., Wysokinski, A., Camacho, A., Fonseca, C., Monteiro, P., Apetrei, E., Bruckner, I., Carasca, E., Coman, I., Datcu, M., Dragulescu, S., Ionescu, P., Iordachescu-Petica, D., Manitiu, I., Popa, V., Pop-Moldovan, A., Radoi, M., Stamate, S., Tomescu, M., Vita, I., Aroutiounov, G., Ballyuzek, M., Bart, B., Churina, S., Glezer, M., Goloshchekin, B., Kobalava, Z., Kostenko, V., Lopatin, Y., Martynov, A., Orlov, V., Semernin, E., Shogenov, Z., Sidorenko, B., Skvortsov, A., Storzhakov, G., Sulimov, V., Talibov, O., Tereshenko, S., Tsyrline, V., Zadionchenko, V., Zateyshchikov, D., Dzupina, A., Hranai, M., Kmec, J., Micko, K., Murin, J., Pella, D., Sojka, G., Spisak, V., Vahala, P., Vinanska, D., Badat, A., Bayat, J., Dawood, S., Delport, E., Ellis, G., Garda, R., Klug, E., Mabin, T., Naidoo, D., Pretorius, M., Ranjith, N., Van Zyl, L., Weich, H., Anguita, M., Berrazueta, J., Bruguera i Cortada, J., de Teresa, E., Gomez Sanchez, M., Gonzalez Juanatey, J., Gonzalez-Maqueda, I., Jordana, R., Lupon, J., Manzano, L., Pascual Figal, D., Pulpon, L., Recio, J., Ridocci Soriano, F., Rodriguez Lambert, J., Roig Minguell, E., Romero, J., Valdovinos, P., Klintberg, L., Kronvall, T., Lycksell, M., Morner, S., Rydberg, E., Timberg, I., Wikstrom, G., Moccetti, T., Ashok, J., Banerjee, P., Carr-White, G., Cleland, J., Connolly, E., Francis, M., Greenbaum, R., Kadr, H., Lindsay, S., McMurray, J., Megarry, S., Memon, A., Murdoch, D., Senior, R., Squire, I., Tan, L., Witte, K., Adams, K., Adamson, P., Adler, A., Altschul, L., Altschuller, A., Amirani, H., Anand, I., Andreou, C., Ansari, M., Antonishen, M., Banchs, H., Banerjee, S., Banish, D., Bank, A., Barbagelata, A., Barnard, D., Bellinger, R., Benn, A., Berk, M., Berry, B., Bethala, V., Bilazarian, S., Bisognano, J., Bleyer, F., Blum, M., Boehmer, J., Bouchard, A., Boyle, A., Bozkurt, B., Brown, C., Burlew, B., Burnham, K., Butler, J., Call, J., Cambier, P., Cappola, T., Carlson, R., Chandler, B., Chandra, R., Chandraratna, P., Chernick, R., Colan, D., Colfer, H., Colucci, W., Connelly, T., Costantini, O., Dadkhah, S., Dauber, I., Davis, J., Davis, S., Denning, S., Drazner, M., Dunlap, S., Egbujiobi, L., Elkayam, U., Elliott, J., El-Shahawy, M., Essandoh, L., Ewald, G., Fang, J., Farhoud, H., Felker, G., Fernandez, J., Festin, R., Fishbein, G., Florea, V., Flores, E., Floro, J., Gabris, M., Garg, M., Gatewood, R., Geller, M., Ghali, J., Ghumman, W., Gibbs, G., Gillespie, E., Gilmore, R., Gogia, H., Goldberg, L., Gradus-Pizlo, I., Grainger, T., Gudmundsson, G., Gunawardena, D., Gupta, D., Hack, T., Hall, S., Hamroff, G., Hankins, S., Hanna, M., Hargrove, J., Haught, W., Hauptman, P., Hazelrigg, M., Herzog, C., Heywood, J., Hill, T., Hilton, T., Hirsch, H., Hunter, J., Ibrahim, H., Imburgia, M., Iteld, B., Jackson, B., Jaffrani, N., Jain, D., Jain, A., James, M., Jimenez, J., Johnson, E., Kale, P., Kaneshige, A., Kapadia, S., Karia, D., Karlsberg, R., Katholi, R., Kerut, E., Khoury, W., Kipperman, R., Klapholz, M., Kosinski, E., Kozinn, M., Kraus, D., Krueger, S., Kumar, S., Lader, E., Lee, C., Levy, W., Lewis, E., Light-McGroary, K., Loh, I., Lombardi, W., Machado, C., Maislos, F., Mancini, D., Markus, T., Mather, P., McCants, K., McGrew, F., McLaurin, B., McMillan, E., McNamara, D., Meyer, T., Meymandi, S., Miller, A., Minami, E., Modi, M., Mody, F., Mohanty, P., Moscoso, R., Moskowitz, R., Moustafa, M., Mullen, M., Naz, T., Noonan, T., O'Brien, T., Oellerich, W., Oren, R., Pamboukian, S., Pereira, N., Pitt, W., Porter, C., Prabhu, S., Promisloff, S., Ratkovec, R., Richardson, R., Ross, A., Saleh, N., Saltzberg, M., Sarkar, S., Schmedtje, J., Schneider, R., Schuyler, G., Shanes, J., Sharma, A., Siegel, C., Siegel, R., Silber, D., Singh, V., Singh, N., Singh, J., Sklar, J., Small, R., Smith, A., Smith, E., Smull, D., Sotolongo, R., Staniloae, C., Stapleton, D., Steele, P., Stehlik, J., Stein, M., Tang, W., Thadani, U., Torre-Amoine, G., Trichon, B., Tsai, C., Tummala, R., Van Bakel, A., Vicari, R., Vijay, N., Vijayaraghavan, K., Vittorio, T., Vossler, M., Wagoner, L., Wallis, D., Ward, N., Widmer, M., Wight, J., Wilkins, C., Williams, C., Williams, G., Winchester, M., Winkel, E., Wittmer, B., Wood, D., Wormer, D., Wright, R., Xu, Z., Yasin, M., Zolty, R., J. J. V., Mcmurray, I. S., Anand, R., Diaz, A. P., Maggioni, C., O'Connor, M. A., Pfeffer, S. D., Solomon, M., Tendera, D. J., van Veldhuisen, M., Albizem, S., Cheng, D., Scarlata, K., Swedberg, J. B., Young, M., Amuchastegui, C., Belziti, J., Bluguermann, M., Caccavo, L., Cartasegna, R., Colque, C., Cuneo, A., Fernandez, A., Gabito, R., Goicochea, M., Gonzalez, V., Gorosito, L., Grinfeld, M., Hominal, R., Kevorkian, M., Litvak Bruno, J., Llano, I., Mackinnon, O., Manuale, E., Marzetti, D., Nul, E., Perna, M., Riccitelli, A., Sanchez, D., Santo, P., Schygiel, J., Toblli, D., Vogel, A., Aggarwal, J., Amerena, F., De Looze, P., Fletcher, D., Hare, M., Ireland, H., Krum, J., Lattimore, T., Marwick, A., Sindone, P., Thompson, J., Waite, J., Altenberger, C., Ebner, K., Lenz, R., Pacher, G., Poelzl, F., Charlier, M., de Ceuninck, G., De Keulenaer, P., Dendale, P., Marechal, W., Mullen, J., Thoeng, M., Vanderheyden, J., Vanhaecke, C., Weytjen, B., Wollaert, D., Albuquerque, D., Almeida, J. Aspe y., Rosa, E., Bocchi, S., Bordignon, N., Clausell, S., Kaiser, P., Leae, S., Martins Alve, M., Montera, L., Moura, R., Pereira de Castro, S., Rassi, A., Rei, J., Saraiva, M., Simoe, J., Souza Neto, M., Teixeira, H., Benov, B., Chompalova, T., Donova, P., Georgiev, D., Gotchev, A., Goudev, M., Grigorov, D., Guenova, V., Hergeldjieva, D., Ivanov, E., Kostova, A., Manolova, S., Marchev, F., Nikolov, A., Popov, D., Raev, M., Tzekova, W., Czarnecki, N., Giannetti, H., Haddad, J., Heath, T., Huynh, S., Lepage, P., Liu, E., Lonn, P., Ma, D., Manyari, G., Moe, J., Parker, Y., Pesant, M., Rajda, J., Ricci, S., Roth, F., Sestier, V., Sluzar, B., Sussex, S., Vizel, G., Antezana, C., Bugueno, P., Castro, C., Conejero, L., Manriquez, D., Martinez, S., Potthoff, B., Stockin, J., Vukasovic, P., Gregor, M., Herold, O., Jerabek, R., Jirmar, R., Kuchar, A., Linhart, B., Podzemska, M., Soucek, J., Spac, R., Spacek, P., Vodnansky, J., Bronnum Schou, K., Clemmensen, K., Egstrup, G., Jensen, L., Kjoller Hansen, L., Kober, J., Markenvard, J., Rokkedal, K., Skagen, C., Torp Pedersen, C., Tuxen, L., Videbak, T., Lak, V., Vahula, V., Harjola, R., Kettunen, M., Kotila, F., Bauer, A., Cohen Solal, D., Coisne, J., Davy, P., De Groote, P., Dos Santo, F., Funck, M., Galinier, P., Gibelin, R., Isnard, Y., Neuder, G., Roul, R., Sabatier, J., Trochu, S., Anker, S., Denny, T., Dreykluft, M., Flesch, S., Genth Zotz, R., Hambrecht, J., Hein, M., Jeserich, M., John, H., Kreider Stempfle, U., Lauf, K., Muellerleile, M., Natour, M., Sandri, T., Schaufele, E., von Hodenberg, K., Weyland, B., Winkelmann, H., Tse, B., Yan, B., Barsi, J., Csikasz, C., Dezsi, I., Ede, T., Forster, P., Karpati, C., Kereke, E., Ki, I., Kosa, G., Lupkovic, A., Nagy, I., Preda, A., Ronaszeki, J., Tomcsanyi, K., Zamolyi, D., Agarwal, V., Bahl, A., Bordoloi, K., Chockalingam, M., Chopda, V., Chopra, J., Dugal, N., Ghaisa, S., Ghosh, P., Grant, S., Hiremath, S., Iyengar, B., Jagadeesa Subramania, P., Jain, A., Joshi, A., Khan, A., Mullasari, S., Naik, A., Oomman, V., Pai, R., Pareppally Gopal, K., Parikh, T., Patel, V., Prakash, B., Sastry, S., Sathe, N., Sinha, V., Srikanthan, P., Subburamakrishnan, H., Thacker, G., Wander, D., Admon, A., Katz, E., Klainman, B., Lewi, A., Marmor, M., Moriel, M., Mosseri, A., Shotan, J., Weinstein, R., Zimlichman, P., Agostoni, M., Albanese, G., Alunni, R., Bini, A., Boccanelli, L., Bolognese, C., Campana, E., Carbonieri, C., Carpino, L., Checco, F., Cosmi, G., D'Angelo, M., De Cristofaro, A., Floresta, A., Fucili, M., Galvani, A., Ivleva, S., Marra, G., Musca, N., Peccerillo, PERRONE FILARDI, Pasquale, E., Picchio, T., Russo, L., Scelsi, M., Senni, L., Tavazzi, A., Ergli, I., Jasinkevica, N., Kakurina, I., Veze, E., Volan, A., Bagdona, E., Beruksti, J., Celutkiene, A., Dambrauskaite, D., Jarasuniene, D., Luksiene, A., Rudy, G., Sakalyte, S., Sliaziene, R., Aguilar Romero, E., Cardona Munoz, J., Castro Jimenez, J., Chavez Herrera, E., Chuquiure Valenzuela, G., De la Pena, E., Herrera, J., Leiva Pon, A., Lopez Alvarado, G., Mendez Machado, G., Ramos Lopez, D., Basart, E., Buij, J., Cornel, M., de Leeuw, R., Dijkgraaf, P., Dunselman, M., Freerick, K., Hamraoui, T., Lenderlink, G., Linssen, P., Lodewick, C., Lodewijk, D., Lok, P., Nierop, E., Ronner, A., Somsen, J., van Dantzig, P., van der Burgh, L., van Kempen, B., van Vlie, A., Voor, A., Wardeh, F., Willem, K., Dickstein, T., Gundersen, T., Hole, J., Thalamu, A., Westheim, M., Dabrowski, J., Gorski, J., Korewicki, K., Kuc, P., Mieku, W., Musial, J., Niegowska, W., Piotrowski, P., Podolec, L., Polonski, P., Ponikowski, A., Rynkiewicz, R., Szelemej, M., Trusz Gluza, M., Ujda, D., Wojciechowski, A., Wysokinski, A., Camacho, C., Fonseca, P., Monteiro, E., Apetrei, I., Bruckner, E., Carasca, I., Coman, M., Datcu, S., Dragulescu, P., Ionescu, D., Iordachescu Petica, I., Manitiu, V., Popa, A., Pop Moldovan, M., Radoi, S., Stamate, M., Tomescu, I., Vita, G., Aroutiounov, M., Ballyuzek, B., Bart, S., Churina, M., Glezer, B., Goloshchekin, Z., Kobalava, V., Kostenko, Y., Lopatin, A., Martynov, V., Orlov, E., Semernin, Z., Shogenov, B., Sidorenko, A., Skvortsov, G., Storzhakov, V., Sulimov, O., Talibov, S., Tereshenko, V., Tsyrline, V., Zadionchenko, D., Zateyshchikov, A., Dzupina, M., Hranai, J., Kmec, K., Micko, J., Murin, D., Pella, G., Sojka, V., Spisak, P., Vahala, D., Vinanska, A., Badat, J., Bayat, S., Dawood, E., Delport, G., Elli, R., Garda, E., Klug, T., Mabin, D., Naidoo, M., Pretoriu, N., Ranjith, L., Van Zyl, H., Weich, M., Anguita, J., Berrazueta, J. Bruguera i., Cortada, E., de Teresa, M., Gomez Sanchez, J., Gonzalez Juanatey, I., Gonzalez Maqueda, R., Jordana, J., Lupon, L., Manzano, D., Pascual Figal, L., Pulpon, J., Recio, F., Ridocci Soriano, J., Rodriguez Lambert, E., Roig Minguell, J., Romero, P., Valdovino, L., Klintberg, T., Kronvall, M., Lycksell, S., Morner, E., Rydberg, I., Timberg, G., Wikstrom, T., Moccetti, J., Ashok, P., Banerjee, G., Carr White, J., Cleland, E., Connolly, M., Franci, R., Greenbaum, H., Kadr, S., Lindsay, J., Mcmurray, S., Megarry, A., Memon, D., Murdoch, R., Senior, I., Squire, L., Tan, K., Witte, K., Adam, P., Adamson, A., Adler, L., Altschul, A., Altschuller, H., Amirani, I., Anand, C., Andreou, M., Ansari, M., Antonishen, H., Banch, S., Banerjee, D., Banish, A., Bank, A., Barbagelata, D., Barnard, R., Bellinger, A., Benn, M., Berk, B., Berry, V., Bethala, S., Bilazarian, J., Bisognano, F., Bleyer, M., Blum, J., Boehmer, A., Bouchard, A., Boyle, B., Bozkurt, C., Brown, B., Burlew, K., Burnham, J., Butler, J., Call, P., Cambier, T., Cappola, R., Carlson, B., Chandler, R., Chandra, P., Chandraratna, R., Chernick, D., Colan, H., Colfer, W., Colucci, T., Connelly, O., Costantini, S., Dadkhah, I., Dauber, J., Davi, S., Davi, S., Denning, M., Drazner, S., Dunlap, L., Egbujiobi, U., Elkayam, J., Elliott, M., El Shahawy, L., Essandoh, G., Ewald, J., Fang, H., Farhoud, G., Felker, J., Fernandez, R., Festin, G., Fishbein, V., Florea, E., Flore, J., Floro, M., Gabri, M., Garg, R., Gatewood, M., Geller, J., Ghali, W., Ghumman, G., Gibb, E., Gillespie, R., Gilmore, H., Gogia, L., Goldberg, I., Gradus Pizlo, T., Grainger, G., Gudmundsson, D., Gunawardena, D., Gupta, T., Hack, S., Hall, G., Hamroff, S., Hankin, M., Hanna, J., Hargrove, W., Haught, P., Hauptman, M., Hazelrigg, C., Herzog, J., Heywood, T., Hill, T., Hilton, H., Hirsch, J., Hunter, H., Ibrahim, M., Imburgia, B., Iteld, B., Jackson, N., Jaffrani, D., Jain, A., Jain, M., Jame, J., Jimenez, E., Johnson, P., Kale, A., Kaneshige, S., Kapadia, D., Karia, R., Karlsberg, R., Katholi, E., Kerut, W., Khoury, R., Kipperman, M., Klapholz, E., Kosinski, M., Kozinn, D., Krau, S., Krueger, S., Kumar, E., Lader, C., Lee, W., Levy, E., Lewi, K., Light McGroary, I., Loh, W., Lombardi, C., Machado, F., Maislo, D., Mancini, T., Marku, P., Mather, K., Mccant, F., Mcgrew, B., Mclaurin, E., Mcmillan, D., Mcnamara, T., Meyer, S., Meymandi, A., Miller, E., Minami, M., Modi, F., Mody, P., Mohanty, R., Moscoso, R., Moskowitz, M., Moustafa, M., Mullen, T., Naz, T., Noonan, T., O'Brien, W., Oellerich, R., Oren, S., Pamboukian, N., Pereira, W., Pitt, C., Porter, S., Prabhu, S., Promisloff, R., Ratkovec, R., Richardson, A., Ro, N., Saleh, M., Saltzberg, S., Sarkar, J., Schmedtje, R., Schneider, G., Schuyler, J., Shane, A., Sharma, C., Siegel, R., Siegel, D., Silber, V., Singh, N., Singh, J., Singh, J., Sklar, R., Small, A., Smith, E., Smith, D., Smull, R., Sotolongo, C., Staniloae, D., Stapleton, P., Steele, J., Stehlik, M., Stein, W., Tang, U., Thadani, G., Torre Amoine, B., Trichon, C., Tsai, R., Tummala, A., Van Bakel, R., Vicari, N., Vijay, K., Vijayaraghavan, T., Vittorio, M., Vossler, L., Wagoner, D., Walli, N., Ward, M., Widmer, J., Wight, C., Wilkin, C., William, G., William, M., Winchester, E., Winkel, B., Wittmer, D., Wood, D., Wormer, R., Wright, Z., Xu, M., Yasin, R., Zolty, Faculteit Medische Wetenschappen/UMCG, and Cardiovascular Centre (CVC)
- Subjects
Male ,CHRONIC KIDNEY-DISEASE ,Darbepoetin alfa ,medicine.medical_treatment ,heart failure ,Ciencias de la Salud ,Comorbidity ,Severity of Illness Index ,law.invention ,DOUBLE-BLIND ,Randomized controlled trial ,law ,Interquartile range ,Cause of Death ,Medicine ,Cause of death ,Aged, 80 and over ,Clinical Trials as Topic ,CARDIAC-RESYNCHRONIZATION THERAPY ,HEALTH-STATUS ,Ética Médica ,Middle Aged ,RANDOMIZED CONTROLLED-TRIAL ,Hospitalization ,IRON-DEFICIENCY ,Treatment Outcome ,purl.org/becyt/ford/3 [https] ,Female ,TREATMENT OPTIONS ,Cardiology and Cardiovascular Medicine ,medicine.drug ,medicine.medical_specialty ,CIENCIAS MÉDICAS Y DE LA SALUD ,Anemia ,Cardiac resynchronization therapy ,Heart failure ,Anaemia ,purl.org/becyt/ford/3.3 [https] ,Double-Blind Method ,Internal medicine ,Humans ,Clinical Trials ,ANEMIA ,Erythropoietin ,Aged ,Demography ,anaemia ,business.industry ,MORTALITY ,medicine.disease ,MORBIDITY CHARM PROGRAM ,Clinical trial ,Hematinics ,Physical therapy ,CAUSA DA MORTE ,business - Abstract
AIMS: This report describes the baseline characteristics of patients in the Reduction of Events with Darbepoetin alfa in Heart Failure trial (RED-HF) which is testing the hypothesis that anaemia correction with darbepoetin alfa will reduce the composite endpoint of death from any cause or hospital admission for worsening heart failure, and improve other outcomes. METHODS AND RESULTS: Key demographic, clinical, and laboratory findings, along with baseline treatment, are reported and compared with those of patients in other recent clinical trials in heart failure. Compared with other recent trials, RED-HF enrolled more elderly [mean age 70 (SD 11.4) years], female (41%), and black (9%) patients. RED-HF patients more often had diabetes (46%) and renal impairment (72% had an estimated glomerular filtration rate < 60 mL/min/1.73 m2). Patients in RED-HF had heart failure of longer duration [5.3 (5.4) years], worse NYHA class (35% II, 63% III, and 2% IV), and more signs of congestion. Mean EF was 30% (6.8%). RED-HF patients were well treated at randomization, and pharmacological therapy at baseline was broadly similar to that of other recent trials, taking account of study-specific inclusion/exclusion criteria. Median (interquartile range) haemoglobin at baseline was 112 (106-117) g/L. CONCLUSION: The anaemic patients enrolled in RED-HF were older, moderately to markedly symptomatic, and had extensive co-morbidity. Fil: McMurray, John J. V.. University of Glasgow; Reino Unido Fil: Anand, Inder S.. University of Minnesota; Estados Unidos Fil: Diaz, Rafael. Estudios Clínicos Latinoamérica; Argentina Fil: Maggioni, Aldo P.. Associazione Nazionale Medici Cardiologi Ospedalieri; Italia Fil: O'Connor, Christopher. University of Duke; Estados Unidos Fil: Pfeffer, Marc A.. Brigham and Women’s Hospita; Estados Unidos Fil: Solomon, Scott D.. Brigham and Women’s Hospital; Estados Unidos Fil: Tendera, Micha. Medical University of Silesia; Polonia Fil: van Veldhuisen, Dirk J.. University of Groningen; Países Bajos Fil: Moetaz, Albizem. Amgen Inc.; Estados Unidos Fil: Cheng, Sunfa. Amgen Inc.; Estados Unidos Fil: Scarlata, Debra. Amgen Inc.; Estados Unidos Fil: Swedberg, Karl. University of Gothenburg; Suecia Fil: Young, James B.. Cleveland Clinic. Endocrinology and Metabolism Institute; Estados Unidos Fil: Toblli, Jorge Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: RED-HF Committees Investigators. No especifíca
- Published
- 2013