Search

Your search keyword '"Davis, Caroline"' showing total 25 results
Start Over Author "Davis, Caroline" Publisher wiley
25 results on '"Davis, Caroline"'

25. Sex differences in subjective and objective responses to a stimulant medication (methylphenidate): Comparisons between overweight/obese adults with and without binge-eating disorder.

Author

Davis C, Levitan RD, Kaplan AS, Carter-Major JC, and Kennedy JL

Subjects
Adult, Affect drug effects, Appetite drug effects, Binge-Eating Disorder complications, Central Nervous System Stimulants pharmacokinetics, Cross-Over Studies, Double-Blind Method, Female, Humans, Male, Methylphenidate pharmacokinetics, Middle Aged, Obesity complications, Obesity drug therapy, Overweight complications, Overweight drug therapy, Young Adult, Binge-Eating Disorder drug therapy, Central Nervous System Stimulants therapeutic use, Methylphenidate therapeutic use, Sex Characteristics
Abstract

Objective: The purpose of this study was to examine sex differences in response to a single dose of a psychomotor-stimulant medication (methylphenidate: MP) and to assess whether expected differences were moderated by binge-eating disorder (BED) status. It is anticipated that findings will shed light on factors that contribute to response variation in the use of stimulant pharmacotherapy to treat BED., Method: The study employed a double-blind, drug-placebo, cross-over design in overweight/obese adults with BED (n = 90) and without BED (n = 108). Emotional/mood ratings were assessed every 15 minutes after oral administration of the drug/placebo, and appetite, cravings, and consumption were assessed during a laboratory-based snack-food challenge., Results: Women reported earlier and more sustained "overall" effects of the drug-including "feeling high"-than the men. There was also a significantly greater suppression in appetite ratings, food cravings, and food consumption from the placebo to the drug condition among the women. Indeed, among men there were no significant differences between the two conditions on any of the food-related variables. BED status also did not moderate any of the drug-placebo differences., Discussion: These findings are relevant to the use of stimulant pharmacotherapy for BED, and raise the possibility that overweight/obese men may be relatively less responsive to this form of treatment. © 2015 Wiley Periodicals, Inc. (Int J Eat Disord 2016; 49:473-481)., (© 2015 Wiley Periodicals, Inc.)

Published
2016
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results