1. Dissecting pain processing in adolescents with Non‐Suicidal Self Injury: Could suicide risk lurk among the electrodes?
- Author
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Arianna Terrinoni, Sofia Misuraca, Chiara Possidente, Cristina Mollica, Caterina Leone, Valeria Milone, Andrea Truini, Giorgio Cruccu, Serena Galosi, Luana Berillo, Mauro Ferrara, and Mattia Fortunato
- Subjects
Adolescent ,Laser-Evoked Potentials ,Pain ,Pain processing ,Suicidal Ideation ,03 medical and health sciences ,0302 clinical medicine ,Risk Factors ,Non-Suicidal Self Injury ,Laser-evoked potentials ,Suicide ,Humans ,Medicine ,030212 general & internal medicine ,Suicide Risk ,Electrodes ,Suicide attempt ,business.industry ,Original Articles ,Psychological evaluation ,Anesthesiology and Pain Medicine ,Nociception ,Conditioned pain modulation ,Biomarker (medicine) ,Original Article ,business ,Self-Injurious Behavior ,030217 neurology & neurosurgery ,Clinical psychology - Abstract
Background Although non-suicidal self-injury (NSSI) disorder is highly prevalent in adolescents, its relationship with pain system function and suicidality is still controversial. The present study was designed to assess the function of the nociceptive afferent pathways and the endogenous pain modulation in adolescent patients with NSSI and to longitudinally register any suicide attempt, describe its frequency and find a possible association between suicide, neurophysiological measures, and psychological measures. Methods We enrolled 30 adolescents suffering from NSSI and 20 age- and gender-matched healthy controls. Patients underwent a comprehensive psychological evaluation. Each participant underwent thermal-pain thresholds of the quantitative sensory testing, laser evoked potential recording to study the ascending nociceptive pathway and the conditioned pain modulation testing to test the endogenous pain modulation. Results We found that patients with NSSI had a reduced amplitude of the N2 component of laser evoked potentials and an abnormal conditioned pain modulation. The amplitude of the N2 was associated with suicidal risk. Conclusions The deficit of the endogenous pain modulation likely depends on a saturation due to continuous pain solicitation. The strong association of a reduced amplitude of the N2 component with suicide suggests it may serve as a possible biomarker in self-harming adolescents. Significance The present study, for the first time, identifies the N2 component of laser evoked potentials as a possible neurophysiological biomarker of suicidal risk in patients with non-suicidal self-injury, therefore raising the possibility for a non-invasive test to identify subjects at higher risk of suicide among self-harming patients.
- Published
- 2021