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Your search keyword '"Crimi E"' showing total 12 results
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12 results on '"Crimi E"'

1. Nonspecific provocation of target organs in allergic diseases: EAACI‐GA2LEN consensus report

Author

Bonini, S., primary, Rasi, G., additional, Brusasco, V., additional, Carlsen, K.‐H., additional, Crimi, E., additional, Popov, T., additional, Schultze‐Werninghaus, G., additional, Gramiccioni, C., additional, Bonini, M., additional, Passali, D., additional, Bachert, C., additional, Van Cauwenberge, P. B., additional, Bresciani, M., additional, Bonini, S., additional, Calonge, M., additional, Montan, P. G., additional, Serapiao Dos Santos, M., additional, Belfort, R., additional, Lambiase, A., additional, and Sacchetti, M., additional

Published
2007
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12. Functional impairment of hematopoietic progenitor cells in patients with coronary heart disease

Author

Louis J. Ignarro, Giuseppe Bruzzese, Ettore Crimi, Claudio Napoli, Pellegrino Biagio Minucci, Alfonso Giovane, Linda Sommese, Maria Luisa Balestrieri, Sharon Williams-Ignarro, Carmela Fiorito, A. Liguori, Maurizio D’Amora, Vincenzo Grimaldi, Bartolomeo Farzati, Liguori, A., Fiorito, C., Balestrieri, Maria Luisa, Crimi, E., Bruzzese, G., WILLIAMS IGNARRO, S., D'Amora, M., Sommese, L., Grimaldi, V., Minucci, Pellegrino Biagio, Giovane, Alfonso, Farzati, B., Ignarro, L., and Napoli, Claudio

Subjects
Male, Vascular Endothelial Growth Factor A, Cardiac function curve, medicine.medical_specialty, CD34, Bone Marrow Cells, Coronary Disease, Peripheral blood mononuclear cell, Colony-Forming Units Assay, Cell Movement, Internal medicine, medicine, Humans, cardiovascular diseases, coronary heart disease, Progenitor cell, Cells, Cultured, Aged, Aged, 80 and over, business.industry, Hematology, General Medicine, Middle Aged, Hematopoietic Stem Cells, Haematopoiesis, Vascular endothelial growth factor A, medicine.anatomical_structure, Immunology, Leukocytes, Mononuclear, cardiovascular system, Cardiology, hematopoietic progenitor cell, Endothelium, Vascular, Bone marrow, Stem cell, business
Abstract

The circulating form of endothelial progenitors cells (EPCs) are derived from bone marrow (BM)-derived hematopoietic stem cells (HSCs). Enhanced mobilization of EPCs was shown to be linked to cardiac diseases. This study investigated whether reduced EPC levels in advanced coronary heart disease (CHD) are secondary to a functional exhaustion of HSCs in the BM or to reduced mobilization. Number and functional properties of EPCs were assessed in 15 healthy controls, and 40 patients with CHD. The colony-forming unit (CFU) capacity of BM-derived mononuclear cells and the CD34+ HSC number were examined in four healthy volunteers, and 15 CHD patients. EPC number was reduced in CHD patients (P < 0.01 vs. controls). Moreover, the migratory capacity was significantly impaired in EPCs of CHD patients (P < 0.05 vs. controls). On multivariate analysis, CHD was an independent predictor of functional EPC impairment. CFUs were reduced in CHD patients (59.6 +/- 21.2 vs. 75.4 +/- 25.8 in controls, P < 0.05). CHD was also predictor of impaired CFU capacity. In this small clinical study, CHD is associated with selective impairment of HSC function in the BM and in the peripheral blood, which may contribute to impairment of cardiac function.

Published
2008

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