389 results on '"Cools A"'
Search Results
2. Heart failure related to adult congenital heart disease: prevalence, outcome and risk factors
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Stijn Arnaert, Pieter De Meester, Els Troost, Walter Droogne, Lucas Van Aelst, Johan Van Cleemput, Gabor Voros, Marc Gewillig, Bjorn Cools, Philip Moons, Filip Rega, Bart Meyns, Zhenyu Zhang, Werner Budts, and Alexander Van De Bruaene
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Congenital ,Heart failure ,ACHD ,All‐cause mortality ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Abstract Aims Information on the prevalence, outcome and factors associated with heart failure in patients with adult congenital heart disease (CHD) (ACHD‐HF) is lacking. We aimed at assessing the prevalence and outcome of ACHD‐HF, the variables associated with ACHD‐HF, and the differences between major anatomical/pathophysiological ACHD subgroups. Methods and results We included 3905 patients (age 35.4 ± 13.2 years) under active follow‐up in our institution (last visit >2010). Outcome of ACHD‐HF cases was compared with sex‐ and age‐matched cases. Univariable and multivariable binary logistic regression with ACHD‐HF diagnosis as a dependent variable was performed. Overall prevalence of ACHD‐HF was 6.4% (mean age 49.5 ± 16.7 years), but was higher in patients with cyanotic CHD (41%), Fontan circulation (30%), and a systemic right ventricle (25%). All‐cause mortality was higher in ACHD‐HF cases when compared with controls (mortality rate ratio 4.67 (2.36–9.27); P = 0.0001). In multivariable logistic regression analysis, age at latest follow‐up [per 10 years; odds ratio (OR) 1.52; 95% confidence interval (CI) 1.31–1.77], infective endocarditis (OR 4.11; 95%CI 1.80–9.38), history of atrial arrhythmia (OR 3.52; 95%CI 2.17–5.74), pacemaker implantation (OR 2.66; 95% CI 1.50–4.72), end‐organ dysfunction (OR 2.41; 95% CI 1.03–5.63), New York Heart Association class (OR 9.28; 95% CI 6.04–14.25), heart rate (per 10 bpm; OR 1.27; 95% CI 1.08–1.50), ventricular dysfunction (OR 3.62; 95% CI 2.54–5.17), and pulmonary hypertension severity (OR 1.66; 95% CI 1.21–2.30) were independently related to the presence of ACHD‐HF. Some variables (age, atrial arrhythmia, pacemaker, New York Heart Association, and ventricular dysfunction) were related to ACHD‐HF in all anatomical/physiological subgroups, whereas others were not. Conclusions ACHD‐HF is prevalent especially in complex CHD and is associated with poor prognosis. Our data provide insight in the factors related to ACHD‐HF including differences between specific anatomical and physiological subgroups.
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- 2021
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3. The Updated European Hematology Association Research Roadmap
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Andreas Engert, Francesco Cerisoli, and Jan Cools
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Diseases of the blood and blood-forming organs ,RC633-647.5 - Published
- 2022
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4. Monitoring of Leukemia Clones in B-cell Acute Lymphoblastic Leukemia at Diagnosis and During Treatment by Single-cell DNA Amplicon Sequencing
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Sarah Meyers, Llucia Alberti-Servera, Olga Gielen, Margot Erard, Toon Swings, Jolien De Bie, Lucienne Michaux, Barbara Dewaele, Nancy Boeckx, Anne Uyttebroeck, Kim De Keersmaecker, Johan Maertens, Heidi Segers, Jan Cools, and Sofie Demeyer
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Diseases of the blood and blood-forming organs ,RC633-647.5 - Abstract
Acute lymphoblastic leukemia (ALL) is characterized by the presence of chromosomal changes, including numerical changes, translocations, and deletions, which are often associated with additional single-nucleotide mutations. In this study, we used single cell–targeted DNA sequencing to evaluate the clonal heterogeneity of B-ALL at diagnosis and during chemotherapy treatment. We designed a custom DNA amplicon library targeting mutational hotspot regions (in 110 genes) present in ALL, and we measured the presence of mutations and small insertions/deletions (indels) in bone marrow or blood samples from 12 B-ALL patients, with a median of 7973 cells per sample. Nine of the 12 cases showed at least 1 subclonal mutation, of which cases with PAX5 alterations or high hyperdiploidy (with intermediate to good prognosis) showed a high number of subclones (1 to 7) at diagnosis, defined by a variety of mutations in the JAK/STAT, RAS, or FLT3 signaling pathways. Cases with RAS pathway mutations had multiple mutations in FLT3, NRAS, KRAS, or BRAF in various clones. For those cases where we detected multiple mutational clones at diagnosis, we also studied blood samples during the first weeks of chemotherapy treatment. The leukemia clones disappeared during treatment with various kinetics, and few cells with mutations were easily detectable, even at low frequency (2 subclones at diagnosis and that even very rare mutant cells can be detected at diagnosis or during treatment by single cell–targeted DNA sequencing.
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- 2022
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5. Non-pharmacological interventions for the prevention of pain during endotracheal suctioning in ventilated neonates
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Pirlotte, Sofie, additional, Beeckman, Katrien, additional, Ooms, Isabel, additional, and Cools, Filip, additional
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- 2024
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6. P348: MRK-560 AND DEXAMETHASONE ARE SYNERGISTIC IN THE TREATMENT OF T-CELL ACUTE LYMPHOBLASTIC LEUKEMIA
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C. Vandersmissen, C. Prieto Fernàndez, O. Gielen, K. Jacobs, I. Govaerts, J. Maertens, H. Segers, and J. Cools
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Diseases of the blood and blood-forming organs ,RC633-647.5 - Published
- 2022
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7. P347: COOPERATION OF TLX3 AND FLT3-ITD IN T-CELL ACUTE LYMPHOBLASTIC LEUKEMIA IS ENHANCED BY TLE4 INACTIVATION
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Q. Van Thillo, L. Lauwereins, S. Demeyer, S. Provost, N. Mentens, C. de Bock, and J. Cools
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Diseases of the blood and blood-forming organs ,RC633-647.5 - Published
- 2022
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8. P462: IDENTIFICATION OF TARGETED THERAPIES DIRECTED TO ACUTE MYELOID LEUKEMIA MINIMAL RESIDUAL DISEASE
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N. van Gils, F. Kessler, M. Broux, F. Denkers, S. Demeyer, J. Cools, D. C. De Leeuw, J. Janssen, and L. Smit
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Diseases of the blood and blood-forming organs ,RC633-647.5 - Published
- 2022
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9. P1297: ABERRANT MYCN EXPRESSION DRIVES ONCOGENIC HIJACKING OF EZH2 AS A TRANSCRIPTIONAL ACTIVATOR IN PERIPHERAL T CELL LYMPHOMA
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M. Vanden Bempt, K. Debackere, S. Demeyer, Q. Van Thillo, N. Meeuws, J. Cools, and D. Dierickx
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Diseases of the blood and blood-forming organs ,RC633-647.5 - Published
- 2022
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10. Oncogenic Cooperation Between IL7R-JAK-STAT Pathway Mutations
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Inge Lodewijckx, Nicole Mentens, Kris Jacobs, and Jan Cools
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Diseases of the blood and blood-forming organs ,RC633-647.5 - Published
- 2021
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11. Multiplexed Surface Electrode Arrays Based on Metal Oxide Thin‐Film Electronics for High‐Resolution Cortical Mapping
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Londoño‐Ramírez, Horacio, primary, Huang, Xiaohua, additional, Cools, Jordi, additional, Chrzanowska, Anna, additional, Brunner, Clément, additional, Ballini, Marco, additional, Hoffman, Luis, additional, Steudel, Soeren, additional, Rolin, Cédric, additional, Mora Lopez, Carolina, additional, Genoe, Jan, additional, and Haesler, Sebastian, additional
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- 2023
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12. Working towards convergence of the clinical management of differences of sex development/intersex conditions and the human rights framework: A case study
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Cools, Martine, primary, Verhagen, Emmanuelle, additional, Hoebeke, Piet, additional, Van Hoecke, Eline, additional, and Cannoot, Pieter, additional
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- 2023
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13. Evaluation of a smartphone‐operated point‐of‐care device using loop‐mediated isothermal amplification technology for rapid and remote detection of SARS‐CoV‐2
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Meyers, Eline, primary, Park, JeongHo, additional, Coen, Anja, additional, Raman, Leen, additional, Heytens, Stefan, additional, Rhee, Joowon, additional, Padalko, Elizaveta, additional, and Cools, Piet, additional
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- 2023
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14. The Fifth Year of HemaSphere
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Jan Cools and Andreas Engert
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Diseases of the blood and blood-forming organs ,RC633-647.5 - Published
- 2021
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15. Open Access is the Plan S Way Forward in Hematology Research
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Jan Cools, Andreas Engert, John Gribben, and Elizabeth Macintyre
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Diseases of the blood and blood-forming organs ,RC633-647.5 - Published
- 2020
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16. Tumour extracellular vesicles induce neutrophil extracellular traps to promote lymph node metastasis
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Su, Xin, primary, Brassard, Ariane, additional, Bartolomucci, Alexandra, additional, Dhoparee‐Doomah, Iqraa, additional, Qiu, Qian, additional, Tsering, Thupten, additional, Rohanizadeh, Ramin, additional, Koufos, Olivia, additional, Giannias, Betty, additional, Bourdeau, France, additional, Feng, Lixuan, additional, Messina‐Pacheco, Julia, additional, Leo, Sabrina, additional, Sangwan, Veena, additional, Quail, Daniela, additional, Tankel, James, additional, Spicer, Jonathan, additional, Burnier, Julia Valdemarin, additional, Bailey, Swneke Donovan, additional, Ferri, Lorenzo, additional, and Cools‐Lartigue, Jonathan, additional
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- 2023
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17. Stent expansion of restrictive Fontan conduits to nominal diameter and beyond
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Thomas Salaets, Bjorn Cools, Pieter De Meester, Ruth Heying, Derize Boshoff, Benedicte Eyskens, Stephen Brown, Bart Meyns, Filip Rega, Joeri Van Puyvelde, Werner Budts, and Marc Gewillig
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Heart Defects, Congenital ,Treatment Outcome ,Humans ,Stents ,Radiology, Nuclear Medicine and imaging ,General Medicine ,Fontan Procedure ,Cardiology and Cardiovascular Medicine ,Retrospective Studies - Abstract
Mechanical factors may cause bottlenecks in a Fontan circuit. Extracardiac conduits (ECC) are placed at a young age, but the materials do not allow growth. Restriction in ECC dimensions may deteriorate the function of the circuit.This study aimed to evaluate the feasibility and safety of stent expansion of an ECC to the nominal dimension at the time of implant and, if possible, beyond nominal.Retrospective, single-center observational review of all ECC Fontan patients who received a stent to expand a previously placed surgical conduit.A total of 44 restrictive conduits were stented over a 14-year study period with a median of 11.8 (interquartile ranges [IQR]: 9.1-13.8) years after ECC placement. Cross-sectional areas were a median of 30% (IQR: 21-42) smaller than the originally placed ECC; there was no gradient in 23/44 patients and in 21/44, a minimal gradient of 1.3 ± 0.5 (range 1-3 mmHg). All conduits could be enlarged with a significant (p 0.0001) increase in diameter from 13.6 ± 1.8 to 19.2 ± 1.2 mm, corresponding to a median cross-sectional area increase of 171% (IQR: 153-220). In three patients where the conduits were not contracted, expansion of between 127% and 165% was obtained. There were no conduit ruptures and only one minor complication.ECC in some Fontan patients become smaller than nominal over time, usually without overt symptoms. The dimensions of ECC's can be safely and significantly increased to nominal or even beyond employing stenting. It allows adjustment of ECC dimensions to compensate for somatic growth.
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- 2022
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18. Convolution Quadrature Time Domain Integral Equation Methods for Electromagnetic Scattering
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Dély, Alexandre, Merlini, Adrien, Cools, Kristof, and Andriulli, Francesco P.
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- 2022
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19. Is neurally adjusted ventilatory assist feasible and safe in the extremely preterm infant?
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Julie Lefevere, Filip Cools, Growth and Development, Faculty of Medicine and Pharmacy, Neonatology, UZB Other, and Clinical sciences
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Preterm infant ,Pediatrics, Perinatology and Child Health ,Pediatrics, Perinatology, and Child Health ,General Medicine ,neurally adjusted ventilatory assist - Abstract
N/A
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- 2023
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20. Mechanisms underlying transcription factor deregulation in acute lymphoblastic leukemia
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Jan Cools
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Diseases of the blood and blood-forming organs ,RC633-647.5 - Published
- 2018
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21. Ruxolitinib Synergizes With Dexamethasone for the Treatment of T-cell Acute Lymphoblastic Leukemia
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Delphine Verbeke, Olga Gielen, Kris Jacobs, Nancy Boeckx, Kim De Keersmaecker, Johan Maertens, Anne Uyttebroeck, Heidi Segers, and Jan Cools
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Diseases of the blood and blood-forming organs ,RC633-647.5 - Published
- 2019
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22. JAK/STAT Pathway Mutations in T-ALL, Including the STAT5B N642H Mutation, are Sensitive to JAK1/JAK3 Inhibitors
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Inge Govaerts, Kris Jacobs, Roel Vandepoel, and Jan Cools
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Diseases of the blood and blood-forming organs ,RC633-647.5 - Published
- 2019
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23. Pulmonary endarterectomy in a 12-year-old boy with multiple comorbidities
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Tom Verbelen, Bjorn Cools, Zina Fejzic, Raf Van Den Eynde, Geert Maleux, Marion Delcroix, and Bart Meyns
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Diseases of the circulatory (Cardiovascular) system ,RC666-701 ,Diseases of the respiratory system ,RC705-779 - Abstract
A 10-year-old boy, with multiple comorbidities presented with fever, exertional dyspnea, fatigue and an obliterated brachiocephalic and inferior caval vein. Chronic thromboembolic pulmonary hypertension (CTEPH) was diagnosed. Nadroparine, antibiotics and supplemental oxygen were successfully started. Aged 12 years, supplemental oxygen was permanently needed with progressive exertional dyspnea and fatigue. In the country of residence the patient was considered as inoperable. The right ventricle was severely dilated, hypocontractile and hypertrophic. Mean pulmonary artery pressure (mPAP) was 79 mmHg and cardiac output 2.2 L/min. Pulmonary endarterectomy was uneventful. Four days later, mPAP was 33 mmHg and cardiac output 6.4 L/min. Three months later the boy restarted his education without supplemental oxygen. Six months after surgery right ventricular size and function and mPAP (14 mmHg) were normal. We demonstrated that pulmonary endarterectomy in young aged children is feasible and well-tolerated, even in the presence of severe co-morbidities. CTEPH should be an important diagnostic consideration in symptomatic children with a known hypercoaguable state, a history of thrombo-embolism or venous catheter placement, and/or a diagnosis of pulmonary hypertension. Hesitating to refer children for surgical consideration, or attempting to treat them by medication, only postpones the single potentially curable treatment and may worsen their prognosis.
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- 2019
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24. Introducing the HemaSphere Controversies Series
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Dennis A. Eichenauer, Jan Cools, and Andreas Engert
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Diseases of the blood and blood-forming organs ,RC633-647.5 - Published
- 2019
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25. TESTOSTERONE RESTORES BODY COMPOSITION, BONE MASS AND BONE STRENGTH FOLLOWING EARLY PUBERTY SUPPRESSION IN A MOUSE MODEL MIMICKING THE CLINICAL STRATEGY IN TRANS BOYS
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Vanessa Dubois, Silvia Ciancia, Stefanie Doms, Sarah El Kharraz, Vera Sommers, Na Ri Kim, Karel David, Jolien Van Dijck, Roger Valle Tenney, Christa Maes, Leen Antonio, Brigitte Decallonne, Geert Carmeliet, Frank Claessens, Martine Cools, and Dirk Vanderschueren
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Endocrinology, Diabetes and Metabolism ,Orthopedics and Sports Medicine - Published
- 2023
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26. Is neurally adjusted ventilatory assist feasible and safe in the extremely preterm infant?
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Lefevere, Julie, primary and Cools, Filip, additional
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- 2023
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27. Helicobacter pylori‐derived outer membrane vesicles contribute to Alzheimer's disease pathogenesis via C3‐C3aR signalling
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Xie, Junhua, primary, Cools, Lien, additional, Van Imschoot, Griet, additional, Van Wonterghem, Elien, additional, Pauwels, Marie J., additional, Vlaeminck, Ine, additional, De Witte, Chloë, additional, EL Andaloussi, Samir, additional, Wierda, Keimpe, additional, De Groef, Lies, additional, Haesebrouck, Freddy, additional, Van Hoecke, Lien, additional, and Vandenbroucke, Roosmarijn E., additional
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- 2023
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28. Electromyographic Muscle Activity and <scp>Three‐Dimensional</scp> Scapular Kinematics in Patients With Multidirectional Shoulder Instability: A Study in the Hypermobile Type of the <scp>Ehlers‐Danlos</scp> Syndrome and the Hypermobility Spectrum Disorders
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Kelly Berckmans, Valentien Spanhove, Fransiska Malfait, Inge De Wandele, Ann Cools, Patrick Calders, and Tanneke Palmans
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musculoskeletal diseases ,Posterior deltoid ,medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,Electromyography ,musculoskeletal system ,Statistical parametric mapping ,Rheumatology ,body regions ,Physical medicine and rehabilitation ,Scapular kinematics ,Internal medicine ,medicine ,Shoulder instability ,In patient ,Muscle activity ,business - Abstract
Objective To investigate differences in EMG muscle activity and scapular kinematics during elevation in the scapular plane between healthy controls, participants with multidirectional shoulder laxity (MDL), and patients with multidirectional shoulder instability (MDI) who are diagnosed with hypermobile Ehlers-Danlos syndrome (hEDS) or Hypermobility Spectrum Disorder (HSD). Methods Twenty-seven women with hEDS/HSD and MDI, 27 female healthy control subjects, and 28 female subjects with MDL participated in this study. Scapular 3D kinematic data were obtained using 8 Oqus Qualisys cameras. Simultaneously, surface electromyography (EMG) was used to measure muscle activity of the upper, middle, and lower trapezius, infraspinatus, latissimus dorsi, serratus anterior, posterior deltoid, and pectoralis major during arm elevation in the scapular plane. Group differences were assessed using statistical parametric mapping. Results Regarding scapular kinematics, significantly less upward rotation was observed in hEDS/HSD patients with MDI compared to both healthy controls and MDL subjects. Significantly less posterior tilt was seen in hEDS/HSD patients compared to MDL subjects. Furthermore, significantly higher EMG activity of the infraspinatus, middle trapezius, and posterior deltoid was found in hEDS/HSD patients with MDI. Conclusion hEDS/HSD patients with MDI demonstrate altered scapular kinematics and increased EMG muscle activity compared to subjects without MDI. These findings could serve as stepping stone for future research regarding treatment strategies in patients belonging to the hypermobility spectrum.
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- 2022
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29. Helicobacter pylori-derived outer membrane vesicles contribute to Alzheimer's disease pathogenesis via C3-C3aR signalling
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Junhua Xie, Lien Cools, Griet Van Imschoot, Elien Van Wonterghem, Marie J. Pauwels, Ine Vlaeminck, Chloë De Witte, Samir EL Andaloussi, Keimpe Wierda, Lies De Groef, Freddy Haesebrouck, Lien Van Hoecke, and Roosmarijn E. Vandenbroucke
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EXPRESSION ,Histology ,Helicobacter pylori ,outer membrane vesicles (OMVs) ,gut-brain axis ,Biology and Life Sciences ,BETA ,Cell Biology ,Alzheimer's disease ,BARRIER ,ASTROCYTES ,MICROGLIA ,MOUSE MODELS ,CROSS ,STOMACH ,Medicine and Health Sciences ,complement ,AXIS ,C3 ,bacterial extracellular vesicles (bEVs) - Abstract
The gut microbiota represents a diverse and dynamic population of microorganisms that can influence the health of the host. Increasing evidence supports the role of the gut microbiota as a key player in the pathogenesis of neurodegenerative diseases, including Alzheimer's disease (AD). Unfortunately, the mechanisms behind the interplay between gut pathogens and AD are still elusive. It is known that bacteria-derived outer membrane vesicles (OMVs) act as natural carriers of virulence factors that are central players in the pathogenesis of the bacteria. Helicobacter pylori (H. pylori) is a common gastric pathogen and H. pylori infection has been associated with an increased risk to develop AD. Here, we are the first to shed light on the role of OMVs derived from H. pylori on the brain in healthy conditions and on disease pathology in the case of AD. Our results reveal that H. pylori OMVs can cross the biological barriers, eventually reaching the brain. Once in the brain, these OMVs are taken up by astrocytes, which induce activation of glial cells and neuronal dysfunction, ultimately leading to exacerbated amyloid-β pathology and cognitive decline. Mechanistically, we identified a critical role for the complement component 3 (C3)-C3a receptor (C3aR) signalling in mediating the interaction between astrocytes, microglia and neurons upon the presence of gut H. pylori OMVs. Taken together, our study reveals that H. pylori has a detrimental effect on brain functionality and accelerates AD development via OMVs and C3-C3aR signalling. ispartof: JOURNAL OF EXTRACELLULAR VESICLES vol:12 issue:2 ispartof: location:United States status: published
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- 2023
30. The First Year of HemaSphere and Many More to Come
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Andreas Engert and Jan Cools
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Diseases of the blood and blood-forming organs ,RC633-647.5 - Published
- 2018
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31. BCR-ABL1 positive B-ALL can undergo T-cell lineage shift to become CD19 negative T-ALL
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Jolien De Bie, Sofie Demeyer, Olga Gielen, Heidi Segers, Lucienne Michaux, Peter Vandenberghe, Nancy Boeckx, Anne Uyttebroeck, and Jan Cools
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Diseases of the blood and blood-forming organs ,RC633-647.5 - Published
- 2018
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32. EML1–ABL1 Is Activated by Coiled-Coil-Mediated Oligomerization and Induces T-Cell Acute Lymphoblastic Leukemia or Myeloproliferative Disease in a Mouse Bone Marrow Transplant Model
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Marlies Vanden Bempt, Nicole Mentens, Peter Vandenberghe, Jan Cools, and Kim De Keersmaecker
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Diseases of the blood and blood-forming organs ,RC633-647.5 - Published
- 2018
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33. Unexpected Formation of 2,2‐Dichloro‐ N ‐(chloromethyl)acetamides during Attempted Staudinger 2,2‐Dichloro‐β‐lactam Synthesis
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Hannes Naeyaert, Lore Cools, Kristof Van Hecke, Matthias D'hooghe, Veronique Van Speybroeck, Daan Deturck, Elias Van Den Broeck, Sari Deketelaere, and Christian V. Stevens
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chemistry.chemical_compound ,chemistry ,Stereochemistry ,Organic Chemistry ,β lactams ,Lactam ,Staudinger synthesis ,Physical and Theoretical Chemistry - Published
- 2021
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34. Primary mediastinal large B-cell lymphoma is characterized by large-scale copy-neutral loss of heterozygosity
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Stefania Tuveri, Koen Debackere, Lukas Marcelis, Nicolas Dierckxsens, Jonas Demeulemeester, Eftychia Dimitriadou, Daan Dierickx, Pierre Lefesvre, Karen Deraedt, Carlos Graux, Lucienne Michaux, Jan Cools, Thomas Tousseyn, Joris Robert Vermeesch, Iwona Wlodarska, Brussels Heritage Lab, Supporting clinical sciences, Experimental Pathology, Pathology, UCL - SSS/IREC/MONT - Pôle Mont Godinne, and UCL - (MGD) Service d'hématologie
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CN-LOH ,Cancer Research ,Lymphoma, Large B-Cell, Diffuse/diagnosis ,driver genes ,primary mediastinal B-cell lymphoma ,Loss of Heterozygosity ,Genomics ,mutations ,SNPa ,Mediastinal Neoplasms ,Pathology and Forensic Medicine ,whole exom/genome sequencing ,Mediastinal Neoplasms/genetics ,Mutation ,Genetics ,genomics ,Humans ,loss of heterozygosity ,Lymphoma, Large B-Cell, Diffuse ,mutation - Abstract
Development of primary mediastinal B-cell lymphoma (PMBL) is driven by cumulative genomic aberrations. We discovered a unique copy-neutral loss of heterozygosity (CN-LOH) landscape of PMBL which distinguishes this tumor from other B-cell malignancies, including the biologically related diffuse large B-cell lymphoma. Using single nucleotide polymorphism array analysis we identified large-scale CN-LOH lesions in 91% (30/33) of diagnostic PMBLs and both investigated PMBL-derived cell lines. Altogether, the cohort showed 157 extra-large (25.3-248.4 Mb) CN-LOH lesions affecting up to 14 chromosomes per case (mean of 4.4) and resulting in a reduction of heterozygosity an average of 9.9% (range 1.3-51%) of the genome. Predominant involvement of terminal chromosomal segments suggests the implication of B-cell specific crossover events in the pathogenesis of PMBL. Notably, CN-LOH stretches non-randomly clustered on 6p (60%), 15 (37.2%), and 17q (40%), and frequently co-occurred with homozygous mutations in the MHC I (6p21), B2M (15q15), and GNA13 (17q23) genes, respectively, as shown by preliminary whole-exome/genome sequencing data. Altogether, our findings implicate CN-LOH as a novel and distinct mutational process contributing to the molecular pathogenesis of PMBL. The aberration acting as "second hit" in the Knudson hypothesis, ranks as the major mechanism converting to homozygosity the PMBL-related driver genes. Screening of the cohort of 199 B cell leukemia/lymphoma whole-genomes revealed significant differences in the CN-LOH landscape of PMBL and other B-cell malignancies, including the biologically related diffuse large B-cell lymphoma.
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- 2022
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35. Nursing students' attitudes regarding euthanasia due to unbearable mental suffering: Cross‐sectional study using the adapted and validated Euthanasia Attitude Scale
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Demedts, Dennis, primary, Cools, Wilfried, additional, Fobelets, Maaike, additional, Tricas‐Sauras, Sandra, additional, and Bilsen, Johan, additional
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- 2022
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36. Stent expansion of restrictive Fontan conduits to nominal diameter and beyond
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Salaets, Thomas, primary, Cools, Bjorn, additional, De Meester, Pieter, additional, Heying, Ruth, additional, Boshoff, Derize, additional, Eyskens, Benedicte, additional, Brown, Stephen, additional, Meyns, Bart, additional, Rega, Filip, additional, Van Puyvelde, Joeri, additional, Budts, Werner, additional, and Gewillig, Marc, additional
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- 2022
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37. Cerebral oxygenation and body position in the preterm infant: A systematic review and meta‐analysis
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Maes, Eva, primary, Cools, Filip, additional, Dereymaeker, Anneleen, additional, Jansen, Katrien, additional, Naulaers, Gunnar, additional, and Thewissen, Liesbeth, additional
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- 2022
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38. Stroke prevention in patients from Latin American countries with non‐valvular atrial fibrillation: Insights from the GARFIELD‐AF registry
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Jerjes-Sanchez C., Corbalan R., Barretto A. C. P., Luciardi H. L., Allu J., Illingworth L., Pieper K. S., Kayani G., Fitzmaurice D. A., Goto S., Hacke W., Mantovani L. G., Turpie A. G. G., Gersh B. J., Gibbs H., Brodmann M., Cools F., Connolly S. J., Spyropoulos A., Eikelboom J., Hu D., Jansky P., Nielsen J. D., Ragy H., Raatikainen P., Le Heuzey J. -Y., Darius H., Keltai M., Kakkar S., Sawhney J. P. S., Agnelli G., Ambrosio G., Koretsune Y., Diaz C. J. S., ten Cate H., Atar D., Stepinska J., Panchenko E., Lim T. W., Jacobson B., Oh S., Vinolas X., Rosenqvist M., Steffel J., Angchaisuksiri P., Parkhomenko A., Al Mahmeed W., Chen K. N., Zhao Y. S., Zhang H. Q., Chen J. Z., Cao S. P., Wang D. W., Yang Y. J., Li W. H., Yin Y. H., Tao G. Z., Yang P., Chen Y. M., He S. H., Wang Y., Fu G. S., Li X., Wu T. G., Cheng X. S., Yan X. W., Zhao R. P., Chen M. S., Xiong L. G., Chen P., Jiao Y., Guo Y., Xue L., Wang F. Z., Li H., Yang Z. M., Bai C. L., Chen J., Chen J. Y., Chen X., Feng S., Fu Q. 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O., Oriso S., Ota A., Otaki E., Saito Y., Sakai H., Sakamoto N., Sakamoto Y., Samejima Y., Sasagawa Y., Sasaguri H., Sasaki A., Sasaki T., Sato K., Sawano M., Seki S., Sekine Y., Seta Y., Sezaki K., Shibata N., Shiina Y., Shimono H., Shimoyama Y., Shindo T., Shinohara H., Shinohe R., Shinozuka T., Shirai T., Shiraiwa T., Shozawa Y., Suga T., Sugimoto C., Suzuki K., Suzuki S., Suzuki Y., Tada M., Taguchi A., Takagi T., Takagi Y., Takahashi K., Takahashi S., Takai H., Takanaka C., Take S., Takeda H., Takei K., Takenaka K., Tana T., Tanabe G., Taya K., Teragawa H., Tohyo S., Toru S., Tsuchiya Y., Tsuji T., Tsuzaki K., Uchiyama H., Ueda O., Ueyama Y., Wakaki N., Wakiyama T., Washizuka T., Watanabe M., Yamada T., Yamagishi T., Yamaguchi H., Yamamoto T., Yamaura M., Yamazoe M., Yasui K., Yokoyama Y., Yoshida K., Ching C. K., Foo C. G., Chow J. H., Chen D. D., Jaufeerally F. R., Lee Y. M., Lim G., Lim W. T., Thng S., Yap S. Y., Yeo C., Pak H. N., Kim J. -B., Kim J. H., Jang S. -W., Kim D. 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H., Yoo K. M., Yoon E. J., Yun S. Y., Chawanadelert S., Mongkolwongroj P., Kanokphatcharakun K., Cheewatanakornkul S., Laksomya T., Pattanaprichakul S., Chantrarat T., Rungaramsin S., Silaruks S., Wongcharoen W., Siriwattana K., Likittanasombat K., Katekangplu P., Boonyapisit W., Cholsaringkarl D., Chatlaong B., Chattranukulchai P., Santanakorn Y., Hutayanon P., Khunrong P., Bunyapipat T., Jai-Aue S., Kaewsuwanna P., Bamungpong P., Gunaparn S., Hongsuppinyo S., Inphontan R., Khattaroek R., Khunkong K., Kitmapawanont U., Kongsin C., Naratreekoon B., Ninwaranon S., Phangyota J., Phrommintikul A., Phunpinyosak P., Pongmorakot K., Poomiphol S., Pornnimitthum N., Pumprueg S., Ratchasikaew S., Sanit K., Sawanyawisuth K., Silaruks B., Sirichai R., Sriwichian A., Suebjaksing W., Sukklad P., Suttana T., Tangsirira A., Thangpet O., Tiyanon W., Vorasettakarnkij Y., Wisaratapong T., Wongtheptien W., Wutthimanop A., Yawila S., Altun A., Ozdogru I., Ozdemir K., Yilmaz O., Aydinlar A., Yilmaz M. B., Yeter E., Ongen Z., Cayli M., Pekdemir H., Ozdemir M., Sucu M., Sayin T., Demir M., Yorgun H., Ersanli M., Okuyan E., Aras D., Abdelrahman H., Aktas O., Alpay D., Aras F., Bireciklioglu M. F., Budeyri S., Buyukpapuc M., Caliskan S., Esen M., Felekoglu M. A., Genc D., Ikitimur B., Karaayvaz E. B., Karatas S. K., Okutucu S., Ozcelik E., Quisi A., Sag H., Sahiner L., Sayin B. Y., Seker T., Alkan D. U., Yildirim E., Yildirim R., Yilmaz F., Yuksekdag V., Vensentini N., Ingaramo A. C., Sambadaro G. A., Caputi V. F., Berman S. G., Dragotto P., Kleiban A. J., Centurion N., Giacomi G., Guerrero R. A. A., Conde D., Zapata G., Di Paola L. A., Ramos J. L., Dran R. D., Egido J., Fernandez A. A., Fosco M. J., Sassone S., Sinisi V. A., Cartasegna L. R., Berli M. A., Vilamajo O. A. G., Ferroni F., Alaguibe E. D., D'Amelio A. A., Arabetti C., Arias L., Belardi J. A., Bergesio L., Berli F., Berli M., Borchowiec S., Buzzetti C., Cabrini R., Campisi V., Cappi A. L., Carrizo R., Berra F. 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K., Braga J. C. F., Negri A., Souto L., Moncada C., Precoma D. B., Roquette F., Reis G., Filho R. A. R., Figueiredo E. L., Botelho R. V., Tavares C. M. D. F., Frack C. R. C., Saad J. A., Finimundi H. C., Pisani C., Chemello D., Martins M. P., Franca C. C. B., Alban F., Rosito G. B. A., Moraes Junior J. B. M. X., Tumelero R. T., Maia L. N., de Almeida R. S., do Carmo Borges N. C., Ferreira L. G. G., Agliardi P., Gomes J. A. O., Araujo V., Nakazone M. A., Barbosa T., Barroso S., Falchetto E. B., Lopes H. B., Lemos M. A. B. T., Biazus G., Queiroz L. B., Camazzola F. E., Caporale M., Cardoso Boscato S., Chieza F., Chokr M. O., Mingireanov R. C., Goes N. C., Correa C., Costa M., Ortiz C. C., da Silva L. S., Paulitsch F. D. S., da Silveira J. A., Daros E., de Araujo G. R., Del Monaco M. I., Dias C., Dias M. A., Wainstein A. P. D., Pizzato P. E., Esteves D. C., Fabri P., Fonseca T. F. L., Fernandes E., Fonseca C., Costantini C. R. F., Ferraz R. 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M., Olguin V., Vergara M., Villan C., Diaz J. I., Cantu R. L., Zavala M. G. R., Jardines R. C., Zavaleta N. E., Umana S. V., Rosas E. L., Esperon G. L., Pozas G., Munoz E. C., Hernandez N. M., Rendon A. L., Hernandez N. G., Ibarra M. L. R., Carrillo L. V., Villezca D. L., Herrera C. H., Prieto J. J. L., Rodriguez R. G., Espinosa E. V., Martinez D. F., Barcena J. V., Yong R., Briones I. R., Pons J. L. L., Lopez H. A., Ruiz R. O., de la Vega C. D., Brito C. C., Valenzuela E. C., Reyes-Sanchez R., Ruiz A. B., Flores O. N., Gonzalez M. B., Nava R. A., Cerda J. D. M., Fierro O. F., Campos P. F., Alfaro T. A. A., Bellorin S. A., Avena R., Chavarria M., Espinosa I., Silva F. F., Nava R. H. G., Godoy K., Felix E. J. G., Garcia C. L. G., Salas L. G. G., Guajardo P., Gonzalez S. H., Izquierdo T., Ortiz M. C. M., Vasquez D. M., Mendoza N., Morales J., Nikitina N., Aybar S. O., Ortiz A., Macias P. P., Perez F., Sanchez J. A. P., Toledano S. P., Gonzalez M. R., Ramos C. R., Castro V. 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C., Sabir A., Choudhary F., Khalaque S., Wilson A., Peters S., Coulson W., Roberts N., Heer A., Coates S., Ward B., Jackson D., Walton S., Shepherd D., Sterry M., Wong T., Boon M., Bunney R., Haria-Shah R., Baron R. T., Davies S., Schatzberger T., Hargreaves N., Stephenson T., Choi H., Batson R., Lucraft L., Myhill T., Estifano S., Geatch D., Wilkinson J., Veale R., Forshaw K., Davies T., Zaman K., Vinson P., Liley C., Bandrapalli M., McGinty P., Wastling R., McEleny P., Beattie A., Cooke P., Wong M., Gunasegaram J., Pugsley M., Ahmad S., A'Court C., Ayers J., Bennett J., Cartwright S., Dobson S., Dooldeniya C., Flynn A., Fox R., Goram J., Halpin A., Hay A., Jacobs P., Jeffers L., Lomax L., Munro I., Muvva R., Nadaph M., Powell K., Randfield S., Redpath D., Reed R., Rickenbach M., Rogers G., Saunders P. 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M., Singh R., Naguib A., Abu-Mahfouz M., Al Omairi M., Al Naeemi A., Maruthanayagam R., Bazargani N., Wassef A., Gupta R., Khan M., Subbaraman B., Abdul A., Al Mulla A., El Bardisy S., Haridas P., Jadhav S., Magdaluyo K., Makdad M., Maqsood I., Mohamed R., Sharma N., Sharma R., Thanzeel M., Canosa R., Rama P., Blumberg E., Garcia J., Mullen P., Wilson V., Quick A., Ferrick K., Kutayli W. M., Cox M., Franco M., Falkowski S., Mendelson R., Williams M., Miller S., Beach S., Alfieri A., Gutowski T., Haque I., Reddy R., Ahmed W., Delafontaine P., Diercks D., Theodoro D., Remmel K., Alberts M., Ison R., Noveck H., Duffy P., Pitta S., Nishijima D., Treasure C., Asafu-Adjaye N., Ball K., Bartlett M., Bentley M., Bowers S., Brown A., Browne A., Cameron-Watts J., Canova M., Cassidy D., Cervellione K., Congal S., DePauw J., Dickerson A., Eley M., Evans L., Felpel S., Ferdinand K., Fielder D., Gentry P., Haideri A., Hakimi F., Harbour T., Hartranft E., Hawkins B., Headlee M., Henson L., Herrick C., Hicks T., Jasinski S., Jones A., Jones L., Jones P., Karl S., Keeling M., Kerr J., Knowles P., Langdon J., Lay M., Lee J. A., Lincoln T., Malone E., Merliss A., Merritt D., Minardo J., Mooso B., Orosco C., Palumbo V., Parker M., Parrott T., Paserchia S., Pearl G., Peterson J., Pickelsimer N., Purcell T., Raynor J., Raziano S., Richard C., Richardson T., Robertson C., Sage A., Sanghera T., Shaw P., Shoemaker J., Smith K., Stephanie B., Thatcher A., Theobald H., Thompson N., Treasure L., Tripti T., Verdi C., Worthy V., Jerjes-Sanchez, C, Corbalan, R, Barretto, A, Luciardi, H, Allu, J, Illingworth, L, Pieper, K, Kayani, G, Fitzmaurice, D, Goto, S, Hacke, W, Mantovani, L, Turpie, A, Gersh, B, Gibbs, H, Brodmann, M, Cools, F, Connolly, S, Spyropoulos, A, Eikelboom, J, Hu, D, Jansky, P, Nielsen, J, Ragy, H, Raatikainen, P, Le Heuzey, J, Darius, H, Keltai, M, Kakkar, S, Sawhney, J, Agnelli, G, Ambrosio, G, Koretsune, Y, Diaz, C, ten Cate, H, Atar, D, Stepinska, J, Panchenko, E, Lim, T, Jacobson, B, Oh, S, Vinolas, X, Rosenqvist, M, Steffel, J, Angchaisuksiri, P, Parkhomenko, A, Al Mahmeed, W, Chen, K, Zhao, Y, Zhang, H, Chen, J, Cao, S, Wang, D, Yang, Y, Li, W, Yin, Y, Tao, G, Yang, P, Chen, Y, He, S, Wang, Y, Fu, G, Li, X, Wu, T, Cheng, X, Yan, X, Zhao, R, Chen, M, Xiong, L, Chen, P, Jiao, Y, Guo, Y, Xue, L, Wang, F, Li, H, Yang, Z, Bai, C, Chen, X, Feng, S, Fu, Q, Gao, X, Guo, W, He, R, He, X, Hu, X, Huang, X, Li, B, Li, J, Li, L, Li, Y, Liu, T, Liu, W, Liu, Y, Lu, Z, Luo, X, Ma, T, Peng, J, Sheng, X, Shi, X, Sun, Y, Tian, G, Wang, K, Wang, L, Wu, R, Xie, Q, Xu, R, Yang, J, Yang, L, Yang, Q, Ye, Y, Yu, H, Yu, J, Yu, T, Zhai, H, Zhan, Q, Zhang, G, Zhang, Q, Zhang, R, Zhang, Y, Zheng, W, Zhou, B, Zhou, Z, Zhu, X, Jadhav, P, Durgaprasad, R, Ravi Shankar, A, Rajput, R, Bhargava, K, Sarma, R, Srinivas, A, Roy, D, Nagamalesh, U, Chopda, M, Kishore, R, Kulkarni, G, Chandwani, P, Pothiwala, R, Padinhare Purayil, M, Shah, S, Chawla, K, Kothiwale, V, Raghuraman, B, Vijayaraghavan, G, Vijan, V, Bantwal, G, Bisne, V, Khan, A, Gupta, J, Kumar, S, Jain, D, Abraham, S, Adak, D, Barai, A, Begum, H, Bhattacharjee, P, Dargude, M, Davies, D, Deshpande, B, Dhakrao, P, Dhyani, V, Duhan, S, Earath, M, Ganatra, A, Giradkar, S, Jain, V, Karthikeyan, R, Kasala, L, Kaur, S, Krishnappa, S, Lawande, A, Lokesh, B, Madarkar, N, Meena, R, More, P, Naik, D, Prashanth, K, Rao, M, Rao, N, Sadhu, N, Shah, D, Sharma, M, Shiva, P, Singhal, S, Suresh, S, Vanajakshamma, V, Panse, S, Kanamori, S, Yamamoto, K, Kumagai, K, Katsuda, Y, Sadamatsu, K, Toyota, F, Mizuno, Y, Misumi, I, Noguchi, H, Ando, S, Suetsugu, T, Minamoto, M, Oda, H, Shiraishi, K, Adachi, S, Chiba, K, Norita, H, Tsuruta, M, Koyanagi, T, Ando, H, Higashi, T, Okada, K, Azakami, S, Komaki, S, Kumeda, K, Murayama, T, Matsumura, J, Oba, Y, Sonoda, R, Goto, K, Minoda, K, Haraguchi, Y, Suefuji, H, Miyagi, H, Kato, H, Nakamura, T, Nandate, H, Zaitsu, R, Fujiura, Y, Yoshimura, A, Numata, H, Ogawa, J, Tatematsu, H, Kamogawa, Y, Murakami, K, Wakasa, Y, Yamasawa, M, Maekawa, H, Abe, S, Kihara, H, Tsunoda, S, Saito, K, Fudo, T, Obunai, K, Tachibana, H, Oba, I, Kuwahata, T, Higa, S, Gushiken, M, Eto, T, Yoshida, H, Ikeda, D, Ishizawa, M, Nakatsuka, M, Murata, K, Ogurusu, C, Shimoyama, M, Akutsu, M, Takamura, I, Hoshino, F, Yokota, N, Iwao, T, Tsuchida, K, Takeuchi, M, Hatori, Y, Kitami, Y, Nakamura, Y, Oyama, R, Ageta, M, Go, Y, Mishima, K, Unoki, T, Morii, S, Shiga, Y, Sumi, H, Nagatomo, T, Sanno, K, Fujisawa, K, Atsuchi, Y, Nagoshi, T, Seto, T, Tabuchi, T, Kameko, M, Nii, K, Oshiro, K, Takezawa, H, Nagano, S, Miyamoto, N, Iwaki, M, Fujii, M, Okawa, M, Abe, M, Saito, T, Mito, T, Nagao, K, Minami, J, Mita, T, Sakuma, I, Taguchi, T, Marusaki, S, Doi, H, Tanaka, M, Fujito, T, Matsuta, M, Kusumoto, T, Kakinoki, S, Ashida, K, Yoshizawa, N, Agata, J, Arasaki, O, Manita, M, Ikemura, M, Fukuoka, S, Murakami, H, Matsukawa, S, Hata, Y, Taniguchi, T, Ko, T, Kubo, H, Imamaki, M, Akiyama, M, Inagaki, M, Odakura, H, Ueda, T, Katsube, Y, Nakata, A, Watanabe, H, Techigawara, M, Igarashi, M, Taga, K, Kimura, T, Tomimoto, S, Shibuya, M, Nakano, M, Ito, K, Seo, T, Hiramitsu, S, Hosokawa, H, Hoshiai, M, Hibino, M, Miyagawa, K, Horie, H, Sugishita, N, Soma, A, Neya, K, Yoshida, T, Mizuguchi, M, Ishiguro, M, Minagawa, T, Wada, M, Mukawa, H, Okuda, F, Nagasaka, S, Abe, Y, Adachi, T, Akahane, K, Amano, T, Aoki, K, Aoyama, T, Arai, H, Arima, S, Arino, T, Asano, H, Asano, T, Azuma, J, Baba, T, Betsuyaku, T, Chibana, H, Date, H, Doiuchi, J, Emura, Y, Endo, M, Fujii, Y, Fujiki, R, Fujisawa, A, Fujisawa, Y, Fukuda, T, Fukui, T, Furukawa, N, Furukawa, T, Furumoto, W, Goto, T, Hamaoka, M, Hanazono, N, Hasegawa, K, Hatsuno, T, Hayashi, Y, Higuchi, K, Hirasawa, K, Hirayama, H, Hirose, M, Hirota, S, Honda, M, Ido, T, Iiji, O, Ikeda, H, Ikeda, K, Ikeoka, K, Imaizumi, M, Inaba, H, Inoue, T, Iseki, F, Ishihara, A, Ishioka, N, Ito, N, Iwase, T, Kakuda, H, Kamata, J, Kanai, H, Kanda, H, Kaneko, M, Kano, H, Kasai, T, Kato, T, Kato, Y, Kawada, Y, Kawai, K, Kawakami, K, Kawakami, S, Kawamoto, T, Kawano, S, Kim, J, Kira, T, Kitazawa, H, Kitazumi, H, Kito, T, Kobayashi, T, Koeda, T, Kojima, J, Komatsu, H, Komatsu, I, Koshibu, Y, Kotani, T, Kozuka, T, Kumai, Y, Kumazaki, T, Maeda, I, Maeda, K, Maruyama, Y, Matsui, S, Matsushita, K, Matsuura, Y, Mineoi, K, Mitsuhashi, H, Miura, N, Miyaguchi, S, Miyajima, S, Miyamoto, H, Miyashita, A, Miyata, S, Mizuguchi, I, Mizuno, A, Mori, T, Moriai, O, Morishita, K, Murai, O, Nagai, S, Nagata, E, Nagata, H, Nakagomi, A, Nakahara, S, Nakamura, M, Nakamura, R, Nakanishi, N, Nakayama, T, Nakazato, R, Nanke, T, Nariyama, J, Niijima, Y, Niinuma, H, Nishida, Y, Nishihata, Y, Nishino, K, Nishioka, H, Nishizawa, K, Niwa, I, Nomura, K, Nomura, S, Nozoe, M, Ogawa, T, Ohara, N, Okada, M, Okamoto, K, Okita, H, Okuyama, M, Ono, H, Ono, T, Pearce, Y, Oriso, S, Ota, A, Otaki, E, Saito, Y, Sakai, H, Sakamoto, N, Sakamoto, Y, Samejima, Y, Sasagawa, Y, Sasaguri, H, Sasaki, A, Sasaki, T, Sato, K, Sawano, M, Seki, S, Sekine, Y, Seta, Y, Sezaki, K, Shibata, N, Shiina, Y, Shimono, H, Shimoyama, Y, Shindo, T, Shinohara, 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J., Watson, E., Sarai, B., Ahmad, N., Willcock, W., Cairns, J., Sathananthan, S., de Kare-Silver, N., Gilliland, A., Strieder, E., Howitt, A., Vishwanathan, B., Bird, N., Gray, D., Clark, M., Bisatt, J., Litchfield, J., Fisher, E., Fooks, T., Kelsall, A. R., Alborough, E., Wakeling, J., Parfitt, M., Milne, K., Rogers, S., Priyadharshan, R., Oliver, J. L., Davies, E., Abushal, S., Jacobs, M., Hutton, C., Walls, N. I., Thompson, R., Chigbo, C., Zaidi, S. M. A., Howard, M., Butter, K. C., Barrow, S., Little, H., Haq, I. U., Gibbons, L., Glencross, S., Mcleod, A. J., Poland, K., Mulholland, C., Warke, A., Conn, P., Burns, G., Smith, R. N., Lowe, S., Kamath, R., Dau, H. S., Webster, J., Hodgins, I., Vercoe, S., Roome, P. C., Pinnock, H., Patel, J. R. A., Ali, A., Hart, N., Davies, R., Stuart, E., Neden, C. A., Danielsen, M., Heath, R., Sharma, P., Galloway, S., Hawkins, C., Oliver, R., Aylward, M., Mannion, S., Braddick, M., Edwards, D., Rothwell, A. C., Sabir, A., Choudhary, F., Khalaque, S., Wilson, A., Peters, S., Coulson, W., Roberts, N., Heer, A., Coates, S., Ward, B., Jackson, D., Walton, S., Shepherd, D., Sterry, M., Wong, T., Boon, M., Bunney, R., Haria-Shah, R., Baron, R. T., Davies, S., Schatzberger, T., Hargreaves, N., Stephenson, T., Choi, H., Batson, R., Lucraft, L., Myhill, T., Estifano, S., Geatch, D., Wilkinson, J., Veale, R., Forshaw, K., Davies, T., Zaman, K., Vinson, P., Liley, C., Bandrapalli, M., Mcginty, P., Wastling, R., Mceleny, P., Beattie, A., Cooke, P., Wong, M., Gunasegaram, J., Pugsley, M., Ahmad, S., A'Court, C., Ayers, J., Bennett, J., Cartwright, S., Dobson, S., Dooldeniya, C., Flynn, A., Fox, R., Goram, J., Halpin, A., Hay, A., Jacobs, P., Jeffers, L., Lomax, L., Munro, I., Muvva, R., Nadaph, M., Powell, K., Randfield, S., Redpath, D., Reed, R., Rickenbach, M., Rogers, G., Saunders, P. B., Seamark, C., Shewring, J., Simmons, P., Simper, H., Stoddart, H., Sword, A., Thomas, N., Thomson, A., Blenkhorn, A., Singh, B., Van Gaal, W., Abhayaratna, W., Lehman, R., Roberts-Thomson, P., Kilian, J., Coulshed, D., Catanchin, A., Colquhoun, D., Kiat, H., Eccleston, D., French, J., Zimmett, L., Ayres, B., Phan, T., Blombery, P., Crimmins, D., O'Donnell, D., Choi, A., Astridge, P., Arstall, M., Jepson, N., Binnekamp, M., Lee, A., Rogers, J., Starmer, G., Carroll, P., Faunt, J., Aggarwala, A., Barry, L., Batta, C., Beveridge, R., Black, A., Bonner, M., Boys, J., Buckley, E., Campo, M., Carlton, L., Connelly, A., Conway, B., Cresp, D., Dimitri, H., Dixon, S., Dolman, M., Duroux, M., Eskandari, M., Eslick, R., Ferreira-Jardim, A., Fetahovic, T., Fitzpatrick, D., Geraghty, R., Gibbs, J., Grabek, T., Modi, M. H., Hayes, K., Hegde, M. P., Hesketh, L., Hoffmann, B., Johnson, K., Juergens, C., Kassam, I., Lawlor, V., Lehman, M., Lehman, S., Leung, D., Mackay, S., Mackenzie, M., Mccarthy, C., Mcintosh, C., Mckeon, L., Morrison, H., Mussap, C., Myers, J. -D., Nagalingam, V., Oldfield, G., O'May, V., Palmer, J., Parsons, L., Patching, K., Patching, T., Paul, V., Plotz, M., Preston, S., Rashad, H., Ratcliffe, M., Raynes, S., Rose, J., Sanders, L., Seremetkoska, M., Setio, H., Shone, S., Shrestha, P., Singh, C., Singleton, C., Stoyanov, N., Sutcliffe, S., Swaraj, K., Tarrant, J., Thompson, S., Tsay, I. M., Vorster, M., Waldman, A., Wallis, L., Wilford, E., Wong, K., Luton, R., Gupta, M., Pandey, A. S., Cheung, S., Leader, R., Beaudry, P., Ayala-Paredes, F., Berlingieri, J., Heath, J., Poirier, G., Du Preez, M., Nadeau, R., Dresser, G., Dhillon, R., Hruczkowski, T., Schweitzer, B., Coutu, B., Angaran, P., Macdonald, P., Vizel, S., Fikry, S., Parkash, R., Lavoie, A., Cha, J., Ramjattan, B., Bonet, J., Ahmad, K., Aro, L., Aves, T., Beaudry, K., Bergeron, C., Bigcanoe, J., Bignell, N., Breakwell, L., Burke, E., Carroll, L., Clarke, B., Cleveland, T., Daheb, S., Dehghani, P., Denis, I., Djaidani, Z., Dorian, P., Douglass, S., Dunnigan, J., Ewert, A., Farquhar, D., Fearon, A., Ferleyko, L., Fournier, D., Fox, B., Grenier, M. -C., Gulliver, W., Haveman, K., Hines, C., Hines, K., Jackson, A. M., Jean, C., Jethoo, G., Kahlon, R., Kelly, S., Kim, R., Korley, V., Kornder, J., Kwan, L., Largy, J., Lewis, C., Lewis, S., Mangat, I., Moor, R., Navratil, J., Neas, I., Otis, J., Otis, R., Pandey, M., Petrie, F., Pinter, A., Raines, M., Roberts, P., Robinson, M., Sas, G., Schulman, S., Snell, L., Spearson, S., Stevenson, J., Trahey, T., Wong, S., Wright, D., El-Aziz, A. A., Seif, S. K. A., El Din, M. G., El Etriby, S., Elbahry, A., El-Etreby, A., Elkhadem, M., Katta, A., Khairy, T., Mowafy, A., Nawar, M., Ohanissian, A., Reda, A., Reda, M., Salem, H., Sami, N., Samir, S., Setiha, M., Sobhy, M., Soliman, A., Taha, N., Tawfik, M., Zaatout, E., Kettles, D., Bayat, J., Siebert, H., Horak, A., Kelfkens, Y., Garda, R., Pillay, T., Guerra, M., van Zyl, L., Theron, H., Murray, A., Louw, R., Greyling, D., Mntla, P., Ueckermann, V., Loghdey, R., Ismail, S., Ahmed, F., Engelbrecht, J., Ramdass, A., Maharajh, S., Oosthuysen, W., Angel, G., Bester, C., Booysen, M., Boshoff, C., Cannon, C., Cassimjee, S., Chami, C., Conway, G., Davids, A., de Meyer, L., Du Plessis, G., Ellis, T., Henley, L., Karsten, M., Loyd, E., Marks, J., Mavhusa, L., Mostert, M., Page, A., Rikhotso, L., Salie, M., Sasto, J., Shaik, F., Skein, A., Smith, L., Tarr, G., Tau, T., van Zyl, F., Yousef, G., Agrawal, A., Nathani, M., Ibrahim, M., Esheiba, E. M., Singh, R., Naguib, A., Abu-Mahfouz, M., Al Omairi, M., Al Naeemi, A., Maruthanayagam, R., Bazargani, N., Wassef, A., Gupta, R., Khan, M., Subbaraman, B., Abdul, A., Al Mulla, A., El Bardisy, S., Haridas, P., Jadhav, S., Magdaluyo, K., Makdad, M., Maqsood, I., Mohamed, R., Sharma, N., Sharma, R., Thanzeel, M., Canosa, R., Rama, P., Blumberg, E., Garcia, J., Mullen, P., Wilson, V., Quick, A., Ferrick, K., Kutayli, W. M., Cox, M., Franco, M., Falkowski, S., Mendelson, R., Williams, M., Miller, S., Beach, S., Alfieri, A., Gutowski, T., Haque, I., Reddy, R., Ahmed, W., Delafontaine, P., Diercks, D., Theodoro, D., Remmel, K., Alberts, M., Ison, R., Noveck, H., Duffy, P., Pitta, S., Nishijima, D., Treasure, C., Asafu-Adjaye, N., Ball, K., Bartlett, M., Bentley, M., Bowers, S., Brown, A., Browne, A., Cameron-Watts, J., Canova, M., Cassidy, D., Cervellione, K., Congal, S., Depauw, J., Dickerson, A., Eley, M., Evans, L., Felpel, S., Ferdinand, K., Fielder, D., Gentry, P., Haideri, A., Hakimi, F., Harbour, T., Hartranft, E., Hawkins, B., Headlee, M., Henson, L., Herrick, C., Hicks, T., Jasinski, S., Jones, A., Jones, L., Jones, P., Karl, S., Keeling, M., Kerr, J., Knowles, P., Langdon, J., Lay, M., Lee, J. A., Lincoln, T., Malone, E., Merliss, A., Merritt, D., Minardo, J., Mooso, B., Orosco, C., Palumbo, V., Parker, M., Parrott, T., Paserchia, S., Pearl, G., Peterson, J., Pickelsimer, N., Purcell, T., Raynor, J., Raziano, S., Richard, C., Richardson, T., Robertson, C., Sage, A., Sanghera, T., Shaw, P., Shoemaker, J., Smith, K., Stephanie, B., Thatcher, A., Theobald, H., Thompson, N., Treasure, L., Tripti, T., Verdi, C., and Worthy, V.
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Registrie ,Male ,Latin Americans ,030204 cardiovascular system & hematology ,outcomes ,0302 clinical medicine ,Drug Prescription ,Retrospective Studie ,Risk Factors ,Atrial Fibrillation ,Antithrombotic ,Prospective Studies ,Registries ,030212 general & internal medicine ,Practice Patterns, Physicians' ,Stroke ,Anticoagulant ,Atrial fibrillation ,General Medicine ,Middle Aged ,Treatment Outcome ,Stroke prevention ,outcome ,Female ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,Human ,medicine.medical_specialty ,medicine.drug_class ,Clinical Investigations ,Hemorrhage ,antithrombotic treatment ,Drug Prescriptions ,03 medical and health sciences ,Internal medicine ,medicine ,Humans ,Mexico ,Aged ,Retrospective Studies ,Fibrillation ,business.industry ,Risk Factor ,Anticoagulants ,South America ,medicine.disease ,Drug Utilization ,Clinical trial ,Prospective Studie ,Latin American ,antithrombotic treatment, atrial fibrillation, Latin American, outcomes ,business - Abstract
Author(s): Jerjes-Sanchez, Carlos; Corbalan, Ramon; Barretto, Antonio CP; Luciardi, Hector L; Allu, Jagan; Illingworth, Laura; Pieper, Karen S; Kayani, Gloria; GARFIELD-AF Investigators | Abstract: BackgroundAtrial fibrillation (AF) is an important preventable cause of stroke. Anticoagulation (AC) therapy can reduce this risk. However, prescribing patterns and outcomes in patients with non-valvular AF (NVAF) from Latin American countries are poorly described.MethodsUsing data from the Global Anticoagulant Registry in the FIELD-AF (GARFIELD-AF), we examined the stroke prevention strategies and the 1-year outcomes in patients from four Latin American countries: Argentina, Brazil, Chile, and Mexico.ResultsA total of 4162 patients (2010-2014) were included in this analysis. At the time of AF diagnosis, 39.9% of patients were prescribed vitamin K antagonists (VKA) ± antiplatelet (AP) therapy, 21.8% non-VKA oral anticoagulant (NOAC) ± AP, 24.1% AP only and 14.1% no antithrombotic treatment. The proportion of moderate-high risk patients receiving no AC therapy at participating centers was highest in Mexico (46.4%) and lowest in Chile (14.3%). During 1-year follow-up, the rates of all-cause mortality, stroke/SE and major bleeding were: 5.77 (95% CI) (5.06-6.56), 1.58 (1.23-2.02), and 0.99 (0.72-1.36) and per 100 person-years, respectively, which are higher than the global rates across all countries in GARFIELD-AF. Unadjusted rates of all-cause mortality were highest in Argentina, 6.95 (5.43-8.90), and lowest in Chile, 4.01 (2.92-5.52).ConclusionsGARFIELD-AF results describes the marked variation in the baseline characteristics and patterns of antithrombotic treatments in patients with NVAF in four Latin American countries. Over one-third of patients with a moderate-to-high risk of stroke received no AC therapy, highlighting the need for improved management of patients according to national guideline. CLINICAL TRIAL REGISTRATION-URL: http://www.clinicaltrials.gov. Unique identifier: NCT01090362.
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- 2019
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39. A multicenter real‐life study on the multiple reasons for uncontrolled allergic rhinitis
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Peter Hellings, Pauline Van Bulck, Leen Cools, Wytske Fokkens, Patricia Kabobo, Luo Zhang, Glenis Scadding, Elina Toskala, Mysore S Soumya, Brecht Steelant, Dieudonné T. Nyembue, Ear, Nose and Throat, and AII - Inflammatory diseases
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China ,medicine.medical_specialty ,India ,Physical examination ,Disease ,aeroallergens ,rhinitis ,Surveys and Questionnaires ,medicine ,Humans ,Immunology and Allergy ,Outpatient clinic ,allergens ,allergic rhinitis ,Medical treatment ,medicine.diagnostic_test ,business.industry ,University hospital ,Rhinitis, Allergic ,Chronic disease ,Otorhinolaryngology ,Emergency medicine ,Democratic Republic of the Congo ,Life study ,business ,chronic disease - Abstract
Background: : Recent data show uncontrolled disease in 35% of allergic rhinitis (AR) patients on medical treatment. The reasons for uncontrolled disease can arbitrarily be divided into disease-related, diagnosis-related, treatment-related, and patient-related factors. However, the relative importance of these factors in uncontrolled disease remains speculative. This explorative study aimed at determining the factors causing uncontrolled AR on four different continents worldwide, identifying the most common reasons for uncontrolled disease in AR. Methods: : Patients with uncontrolled AR (n = 430) were asked to fill out a questionnaire and underwent a clinical examination at the outpatient clinic in five university outpatient clinics (Leuven [Belgium], Beijing [China], Kinshasa [Congo], Bangalore [India], and Philadelphia [US]). Two independent physicians evaluated the reason or multiple reasons for uncontrolled disease. The study was coordinated from the University Hospital of Leuven. Results: : In uncontrolled AR patients, 76% of patients showed two or more reasons for uncontrolled disease according to the physicians’ evaluation. Disease-related factors (64%) were considered most often the reason for uncontrolled disease, followed by treatment- (56%), patient- (54%), and diagnosis-related (47%) factors. There is limited variability in observations across different centers worldwide. Conclusion: : We here define the multiple reasons for uncontrolled AR across different continents, with disease-related factors being most frequently associated with uncontrolled disease. A better understanding of uncontrolled disease will guide us in defining strategies to improve AR care.
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- 2021
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40. In memory of Tessa Holyoake and Her Work on Chronic Myeloid Leukemia Stem Cells
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Jan Cools
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Diseases of the blood and blood-forming organs ,RC633-647.5 - Published
- 2017
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41. Local Immigration and Support for Anti‐Immigration Parties: A Meta‐Analysis
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Ole Rogeberg, Sara Cools, and Henning Finseraas
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Sociology and Political Science ,Political science ,Meta-analysis ,media_common.quotation_subject ,Political Science and International Relations ,Immigration ,Criminology ,Anti immigration ,media_common - Abstract
Does the share of immigrants in a community influence whether people vote for anti-immigration parties? We conduct a systematic review of the causal inference literature studying this question. We collect estimates from 20 studies and develop a new Bayesian meta-analysis framework to account for both between-study heterogeneity in effect sizes and the possibility of reporting bias. Although meta-analysis methods that do not adjust for reporting bias suggest a moderate effect of local immigration, our Bayesian model finds that the effect of local immigration on far-right voting is on average negligible once we account for reporting bias. However, the analysis also reveals a large heterogeneity in effects across contexts, suggesting that local immigration may be important for anti-immigration vote shares in certain settings.
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- 2021
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42. Primary mediastinal large B‐cell lymphoma is characterized by large‐scale copy‐neutral loss of heterozygosity
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Tuveri, Stefania, primary, Debackere, Koen, additional, Marcelis, Lukas, additional, Dierckxsens, Nicolas, additional, Demeulemeester, Jonas, additional, Dimitriadou, Eftychia, additional, Dierickx, Daan, additional, Lefesvre, Pierre, additional, Deraedt, Karen, additional, Graux, Carlos, additional, Michaux, Lucienne, additional, Cools, Jan, additional, Tousseyn, Thomas, additional, Vermeesch, Joris Robert, additional, and Wlodarska, Iwona, additional
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- 2022
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43. Cells infected with human papilloma pseudovirus display nuclear reorganization and heterogenous infection kinetics
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Molenberghs, Freya, primary, Verschuuren, Marlies, additional, Barbier, Michaël, additional, Bogers, Johannes J., additional, Cools, Nathalie, additional, Delputte, Peter, additional, Schelhaas, Mario, additional, and De Vos, Winnok H., additional
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- 2022
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44. <scp>IOData</scp> : A python library for reading, writing, and converting computational chemistry file formats and generating input files
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Leila Pujal, Toon Verstraelen, Maarten Cools-Ceuppens, Michael Richer, Esteban Vöhringer-Martinez, Raymundo Hernández-Esparza, Taewon David Kim, Braden D. Kelly, Alireza Tehrani, Paul W. Ayers, Farnaz Heidar-Zadeh, William Adams, Matthew Chan, Valerii S. Chuiko, Fanwang Meng, Xiaotian Derrick Yang, and Luis Macaya
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Computer science ,basis set conversion ,Interoperability ,010402 general chemistry ,computer.software_genre ,01 natural sciences ,theoretical chemistry ,quantum chemistry ,Documentation ,Software ,input file generation ,0103 physical sciences ,computer.programming_language ,Package management ,Parsing ,010304 chemical physics ,Python library ,business.industry ,Programming language ,Software development ,chemistry software development ,file format conversion ,General Chemistry ,Python (programming language) ,File format ,computational chemistry ,molecular mechanics ,0104 chemical sciences ,Chemistry ,Computational Mathematics ,Physics and Astronomy ,JSON schema ,data parsing ,business ,computer - Abstract
IOData is a free and open-source Python library for parsing, storing, and converting various file formats commonly used by quantum chemistry, molecular dynamics, and plane-wave density-functional-theory software programs. In addition, IOData supports a flexible framework for generating input files for various software packages. While designed and released for stand-alone use, its original purpose was to facilitate the interoperability of various modules in the HORTON and ChemTools software packages with external (third-party) molecular quantum chemistry and solid-state density-functional-theory packages. IOData is designed to be easy to use, maintain, and extend; this is why we wrote IOData in Python and adopted many principles of modern software development, including comprehensive documentation, extensive testing, continuous integration/delivery protocols, and package management. This article is the official release note of the IOData library.
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- 2020
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45. Impact of different anticoagulation management strategies on outcomes in atrial fibrillation
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Seelig, Jaap, Hemels, Martin E W, Xhaet, Olivier, Bongaerts, Maarten C M, de Wolf, Axel, Groenemeijer, Björn E, Heyse, Alex, Hoogslag, Pieter, Voet, Joeri, Herrman, Jean-Paul R, Vervoort, Geert, Hermans, Walter, Wollaert, Bart, Boersma, Lucas V A, Hermans, Kurt, Lucassen, Andreas, Verstraete, Stefan, Adriaansen, Henk J, Mairesse, Georges H, Terpstra, Willem F, Faes, Dirk, Pieterse, Mathijs, Virdone, Saverio, Verheugt, Freek W A, Cools, Frank, Ten Cate, Hugo, GARFIELD-AF investigators, Interne Geneeskunde, MUMC+: HVC Trombosezorg (8), MUMC+: MA Alg Interne Geneeskunde (9), MUMC+: HVC Pieken Trombose (9), RS: Carim - B04 Clinical thrombosis and Haemostasis, Biochemie, Cardiology, ACS - Heart failure & arrhythmias, UCL - SSS/IREC/MONT - Pôle Mont Godinne, and UCL - (MGD) Service de cardiologie
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medicine.medical_specialty ,anticoagulants ,Vitamin K ,Anticoagulation management ,Administration, Oral ,030204 cardiovascular system & hematology ,THERAPY ,WARFARIN ,03 medical and health sciences ,0302 clinical medicine ,Belgium ,Risk Factors ,Internal medicine ,VENOUS THROMBOEMBOLIC DISEASE ,Atrial Fibrillation ,medicine ,Humans ,Risk factor ,Stroke ,METAANALYSIS ,Aged ,Netherlands ,ORAL ANTICOAGULANTS ,RISK ,business.industry ,INTENSITY ,Hazard ratio ,international normalized ratio ,Warfarin ,registries ,Atrial fibrillation ,Hematology ,Original Articles ,medicine.disease ,stroke ,Confidence interval ,THROMBOSIS ,DEFINITION ,SAFETY ,Cardiology ,Female ,Original Article ,hemorrhage ,business ,Major bleeding ,medicine.drug - Abstract
Background The uptake rate of non-vitamin K oral anticoagulants (NOAC) for the treatment of non-valvular atrial fibrillation (AF) was far lower in the Netherlands (NL) compared to Belgium (BE). Also, patients on VKA in NL were treated with a higher target international normalized ratio (INR) range of 2.5 to 3.5. Objectives To explore the effect of these differences on thromboembolism (TE) and bleeding. Methods Data from the GARFIELD-AF registry was used. Patients with new-onset AF and >= 1 investigator-determined risk factor for stroke were included between 2010 and 2016. Event rates from 2 years of follow-up were used. Results In NL and BE, 1186 and 1705 patients were included, respectively. Female sex (42.3% vs 42.2%), mean age (70.7 vs 71.3 years), CHA(2)DS(2)-VASc (3.1 vs 3.1), and HAS-BLED score (1.4 vs 1.5) were comparable between NL and BE. At diagnosis in NL vs BE, 72.1% vs 14.6% received vitamin K antagonists (VKA) and 17.8% vs 65.5% NOACs, varying greatly across cohorts. Mean INR was 2.9 (+/- 1.0) and 2.4 (+/- 1.0) in NL and BE, respectively. Event rates per 100 patient-years in NL and BE, respectively, of all-cause mortality (3.38 vs 3.90; hazard ratio [HR] 0.86, 95% confidence interval [CI] 0.65-1.15), ischemic stroke/TE (0.82 vs 0.72; HR 1.14, 95% CI 0.62-2.11), and major bleeding (2.06 vs 1.54; HR 1.33, 95% CI 0.89-1.99) did not differ significantly. Conclusions In GARFIELD-AF, despite similar characteristics, patients on anticoagulants were treated differently in NL and BE. Although the rate of major bleeding was 33% higher in NL, variations in bleeding, mortality, and TE rates were not statistically significant.
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- 2020
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46. Optimizing the diagnostic workflow for acute lymphoblastic leukemia by optical genome mapping
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Katrina Rack, Jolien Bie, Geneviève Ameye, Olga Gielen, Sofie Demeyer, Jan Cools, Kim Keersmaecker, Joris R. Vermeesch, Johan Maertens, Heidi Segers, Lucienne Michaux, and Barbara Dewaele
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Hematology - Abstract
Acute lymphoblastic leukemia (ALL) is a malignancy that can be subdivided into distinct entities based on clinical, immunophenotypic and genomic features, including mutations, structural variants (SVs), and copy number alterations (CNA). Chromosome banding analysis (CBA) and Fluorescent In-Situ Hybridization (FISH) together with Multiple Ligation-dependent Probe Amplification (MLPA), array and PCR-based methods form the backbone of routine diagnostics. This approach is labor-intensive, time-consuming and costly. New molecular technologies now exist that can detect SVs and CNAs in one test. Here we apply one such technology, optical genome mapping (OGM), to the diagnostic work-up of 41 ALL cases. Compared to our standard testing pathway, OGM identified all recurrent CNAs and SVs as well as additional recurrent SVs and the resulting fusion genes. Based on the genomic profile obtained by OGM, 32 patients could be assigned to one of the major cytogenetic risk groups compared to 23 with the standard approach. The latter identified 24/34 recurrent chromosomal abnormalities, while OGM identified 33/34, misinterpreting only 1 case with low hypodiploidy. The results of MLPA were concordant in 100% of cases. Overall, there was excellent concordance between the results. OGM increased the detection rate and cytogenetic resolution, and abrogated the need for cascade testing, resulting in reduced turnaround times. OGM also provided opportunities for better patient stratification and accurate treatment options. However, for comprehensive cytogenomic testing, OGM still needs to be complemented with CBA or SNP-array to detect ploidy changes and with BCR::ABL1 FISH to assign patients as soon as possible to targeted therapy. ispartof: AMERICAN JOURNAL OF HEMATOLOGY vol:97 issue:5 pages:548-561 ispartof: location:United States status: published
- Published
- 2022
47. Electromyographic Muscle Activity and Three‐Dimensional Scapular Kinematics in Patients With Multidirectional Shoulder Instability: A Study in the Hypermobile Type of the Ehlers‐Danlos Syndrome and the Hypermobility Spectrum Disorders
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Spanhove, Valentien, primary, Calders, Patrick, additional, Berckmans, Kelly, additional, Palmans, Tanneke, additional, Malfait, Fransiska, additional, Cools, Ann, additional, and De Wandele, Inge, additional
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- 2022
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48. Optimizing the diagnostic workflow for acute lymphoblastic leukemia by optical genome mapping
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Rack, Katrina, primary, Bie, Jolien, additional, Ameye, Geneviève, additional, Gielen, Olga, additional, Demeyer, Sofie, additional, Cools, Jan, additional, Keersmaecker, Kim, additional, Vermeesch, Joris R., additional, Maertens, Johan, additional, Segers, Heidi, additional, Michaux, Lucienne, additional, and Dewaele, Barbara, additional
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- 2022
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49. The effect of an air purifier on aerosol generation measurements during clinical motility testing
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Hideki Mori, Jolien Schol, Jan Tack, Herman Devriese, Louise Cools, Joran Toth, Florencia Carbone, Lien Timmermans, Wout Verbeure, Hannelore Geysen, Annelies Geeraerts, Tim Vanuytsel, I-Hsuan Huang, and Rico Haesaerts
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aerosol ,COVID19 ,Physiology ,medicine.medical_treatment ,nasogastric intubation ,Technical Note ,medicine ,Humans ,Air purifier ,Particle Size ,Air filter ,Aerosols ,Endocrine and Autonomic Systems ,business.industry ,air purifier ,Gastroenterology ,COVID-19 ,Aerosol ,Surgical mask ,Catheter ,Air Filters ,Particle ,Nasogastric intubation ,Technical Notes ,business ,Particle counter ,Biomedical engineering - Abstract
Background Aerosol spread is key to interpret the risk of viral contamination during clinical procedures such as esophageal high‐resolution manometry (HRM). Installing an air purifier seems a legitimate strategy, but this has recently been questioned. Methods Patients undergoing an HRM procedure at the Leuven University Hospital were included in this clinical study. All subjects had to wear a surgical mask which was only lowered beneath the nose during the placement and removal of the nasogastric catheter. The number of aerosol particles was measured by a Lasair® II Particle Counter to obtain data about different particles sizes: 0.3; 0.5; 1.0; 3.0; 5.0; and 10.0 µm. Measurements were done immediately before the placement and the removal of the HRM catheter, and one and 5 min after. A portable air purifier with high‐efficiency particle air filters was installed in the hospital room. Key Results Thirteen patients underwent a manometry examination. The amount of 0.3 µm‐sized particles was unaffected during the whole procedure. The larger particle sizes (1.0; 3.0; 5.0; and 10.0 µm) decreased when the catheter was positioned, but not 0.5 µm. During the HRM measurements itself, these numbers decreased further. Yet, 1 min after catheter removal a significant elevation of particles was seen, which did not recover within 5 min. Conclusions & Interferences Based on this study, there is no evidence that filtration systems reduce aerosol particles properly during a clinical investigation.
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- 2021
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50. Unexpected Formation of 2,2‐Dichloro‐N‐(chloromethyl)acetamides during Attempted Staudinger 2,2‐Dichloro‐β‐lactam Synthesis
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Deketelaere, Sari, primary, Van Den Broeck, Elias, additional, Cools, Lore, additional, Deturck, Daan, additional, Naeyaert, Hannes, additional, Van Hecke, Kristof, additional, Stevens, Christian V., additional, Van Speybroeck, Veronique, additional, and D'hooghe, Matthias, additional
- Published
- 2021
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