1. WAY-318068: a novel, potent and selective noradrenaline re-uptake inhibitor with activity in rodent models of pain and depression
- Author
-
G H Johnston, Eugene John Trybulski, John C. L. Erve, Brian W. Strassle, A. Adedoyin, Jeffrey D. Kennedy, James E. Harrison, Claudine Pulicicchio, Michael J. Piesla, Peimin Lu, Kathryn E. Rogers, Puwen Zhang, Brian J. Platt, Terri Cummons, Garth T. Whiteside, Liza Leventhal, Chad E. Beyer, Zoë A. Hughes, Darlene C. Deecher, L Manzino, Lilly Mark, and Jason M. Dwyer
- Subjects
Pharmacology ,medicine.medical_specialty ,business.industry ,Dopamine Plasma Membrane Transport Proteins ,Chronic pain ,medicine.disease ,Norepinephrine (medication) ,Endocrinology ,Adrenergic Uptake Inhibitors ,Internal medicine ,Medicine ,Norepinephrine Plasma Membrane Transport Proteins ,Serotonin ,business ,Serotonin Uptake Inhibitors ,5-HT receptor ,medicine.drug - Abstract
Background and purpose: Antidepressants, which raise the CNS concentrations of 5-HT and noradrenaline, are frequently used in the treatment of chronic pain; however, it is not known if increasing CNS noradrenaline levels alone is sufficient for efficacy, in part resulting from a lack of small molecules with sufficient selectivity.
- Published
- 2010
- Full Text
- View/download PDF