1. Functional Iron Oxide Magnetic Nanoparticles with Hyperthermia-Induced Drug Release Ability by Using a Combination of Orthogonal Click Reactions
- Author
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Clément Guibert, Thomas P. Davis, Michael R. Whittaker, Sagrario Pascual, Véronique Montembault, Hien T. T. Duong, Jérôme Fresnais, Johan Sebastian Basuki, Cyrille Boyer, Laurent Fontaine, Thuy T T N'Guyen, Institut des Molécules et Matériaux du Mans (IMMM), Le Mans Université (UM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Australian center for Nanomedecine (Sydney), PHysicochimie des Electrolytes et Nanosystèmes InterfaciauX (PHENIX), Université Pierre et Marie Curie - Paris 6 (UPMC)-Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Monash Institute of Pharmaceutical Science, Le Mans Université (UM)-Centre National de la Recherche Scientifique (CNRS), and Université Pierre et Marie Curie - Paris 6 (UPMC)-ESPCI ParisTech-Centre National de la Recherche Scientifique (CNRS)
- Subjects
Iron oxide ,02 engineering and technology ,Photochemistry ,010402 general chemistry ,Ferric Compounds ,01 natural sciences ,Catalysis ,chemistry.chemical_compound ,Drug Delivery Systems ,[CHIM]Chemical Sciences ,Magnetite Nanoparticles ,ComputingMilieux_MISCELLANEOUS ,iron oxide nanoparticles ,General Chemistry ,Hyperthermia, Induced ,General Medicine ,equipment and supplies ,021001 nanoscience & nanotechnology ,Controlled release ,Combinatorial chemistry ,0104 chemical sciences ,Hyperthermia induced ,chemistry ,retro-Diels–Alder reaction ,Drug delivery ,click chemistry ,drug delivery ,Drug release ,Click chemistry ,Magnetic nanoparticles ,Nanoparticles ,controlled release ,0210 nano-technology ,human activities ,Iron oxide nanoparticles - Abstract
International audience; Click and drug: A combination of orthogonal click reactions is employed for the preparation of functional iron oxide nanoparticles (IONPs) that show unprecedented hyperthermia-induced drug release through a magnetically stimulated retro-Diels–Alder (rDA) process. Magnetic stimulation induces sufficient local energy in close proximity to the cycloadduct to initiate the rDA process.
- Published
- 2013
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