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28 results on '"Cinca, Juan"'

1. Time course, factors related to, and prognostic impact of venoarterial extracorporeal membrane flow in cardiogenic shock

Author

Montero, Santiago, primary, Rivas‐Lasarte, Mercedes, additional, Huang, Florent, additional, Chommeloux, Juliette, additional, Demondion, Pierre, additional, Bréchot, Nicolas, additional, Hékimian, Guillaume, additional, Franchineau, Guillaume, additional, Persichini, Romain, additional, Luyt, Charles‐Édouard, additional, Garcia‐Garcia, Cosme, additional, Bayes‐Genis, Antoni, additional, Lebreton, Guillaume, additional, Cinca, Juan, additional, Leprince, Pascal, additional, Combes, Alain, additional, Alvarez‐Garcia, Jesus, additional, and Schmidt, Matthieu, additional

Published
2022
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2. β2‐adrenergic stimulation potentiates spontaneous calcium release by increasing signal mass and co‐activation of ryanodine receptor clusters

Author

Nolla‐Colomer, Carme, primary, Casabella‐Ramon, Sergi, additional, Jimenez‐Sabado, Veronica, additional, Vallmitjana, Alexander, additional, Tarifa, Carmen, additional, Herraiz‐Martínez, Adela, additional, Llach, Anna, additional, Tauron, Manel, additional, Montiel, Jose, additional, Cinca, Juan, additional, Chen, S. R. Wayne, additional, Benitez, Raul, additional, and Hove‐Madsen, Leif, additional

Published
2021
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3. Prognostic impact of hyponatraemia and hypernatraemia at admission and discharge in heart failure patients with preserved, mid‐range and reduced ejection fraction

Author

Vicent, Lourdes, primary, Alvarez‐Garcia, Jesús, additional, Gonzalez‐Juanatey, José Ramón, additional, Rivera, Miguel, additional, Segovia, Javier, additional, Worner, Fernando, additional, Bover, Ramón, additional, Pascual‐Figal, Domingo, additional, Vázquez, Rafael, additional, Cinca, Juan, additional, Fernandez‐Aviles, Francisco, additional, and Martinez‐Sellés, Manuel, additional

Published
2021
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4. Prevalence and prognostic impact of subclinical pulmonary congestion at discharge in patients with acute heart failure

Author

Rivas‐Lasarte, Mercedes, primary, Maestro, Alba, additional, Fernández‐Martínez, Juan, additional, López‐López, Laura, additional, Solé‐González, Eduard, additional, Vives‐Borrás, Miquel, additional, Montero, Santiago, additional, Mesado, Nuria, additional, Pirla, Maria J., additional, Mirabet, Sonia, additional, Fluvià, Paula, additional, Brossa, Vicens, additional, Sionis, Alessandro, additional, Roig, Eulàlia, additional, Cinca, Juan, additional, and Álvarez‐García, Jesús, additional

Published
2020
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5. Discharge treatment with angiotensin‐converting enzyme inhibitor/angiotensin receptor blocker after a heart failure hospitalisation is associated with a better prognosis irrespective of left ventricular ejection fraction

Author

Vicent, Lourdes, primary, Cinca, Juan, additional, Vazquez‐García, Rafael, additional, Gonzalez‐Juanatey, José R., additional, Rivera, Miguel, additional, Segovia, Javier, additional, Pascual‐Figal, Domingo, additional, Bover, Ramón, additional, Worner, Fernando, additional, Delgado‐Jiménez, Juan, additional, Fernández‐Avilés, Francisco, additional, and Martínez‐Sellés, Manuel, additional

Published
2019
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6. Lung ultrasound‐guided treatment in ambulatory patients with heart failure: a randomized controlled clinical trial (LUS‐HF study)

Author

Rivas‐Lasarte, Mercedes, primary, Álvarez‐García, Jesús, additional, Fernández‐Martínez, Juan, additional, Maestro, Alba, additional, López‐López, Laura, additional, Solé‐González, Eduard, additional, Pirla, Maria J., additional, Mesado, Nuria, additional, Mirabet, Sonia, additional, Fluvià, Paula, additional, Brossa, Vicens, additional, Sionis, Alessandro, additional, Roig, Eulàlia, additional, and Cinca, Juan, additional

Published
2019
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7. Influence of sex and pregnancy on survival in patients admitted with heart failure: Data from a prospective multicenter registry

Author

Martínez-Sellés, Manuel, primary, Díez-Villanueva, Pablo, additional, Álvarez Garcia, Jesús, additional, Ferrero-Gregori, Andreu, additional, Vives-Borrás, Miquel, additional, Worner, Fernando, additional, Bardají, Alfredo, additional, Delgado, Juan F., additional, Vázquez, Rafael, additional, González-Juanatey, José R., additional, Fernández-Aviles, Francisco, additional, and Cinca, Juan, additional

Published
2018
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8. Identification of new biophysical markers for pathological ventricular remodelling in tachycardia‐induced dilated cardiomyopathy

Author

Benitez‐Amaro, Aleyda, primary, Samouillan, Valerie, additional, Jorge, Esther, additional, Dandurand, Jany, additional, Nasarre, Laura, additional, Gonzalo‐Calvo, David, additional, Bornachea, Olga, additional, Amoros‐Figueras, Gerard, additional, Lacabanne, Colette, additional, Vilades, David, additional, Leta, Ruben, additional, Carreras, Francesc, additional, Gallardo, Alberto, additional, Lerma, Enrique, additional, Cinca, Juan, additional, Guerra, Jose M., additional, and Llorente‐Cortés, Vicenta, additional

Published
2018
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9. Sarcoplasmic reticulum and L-type Ca2+ channel activity regulate the beat-to-beat stability of calcium handling in human atrial myocytes

Author

Llach, Anna, Molina, Cristina E, Fernandes, Jacqueline, Padró, Josep, Cinca, Juan, and Hove-Madsen, Leif

Subjects
Sarcoplasmic Reticulum, Calcium Channels, L-Type, Heart Rate, Action Potentials, Humans, Myocytes, Cardiac, Heart Atria, Cardiovascular, Membrane Potentials
Abstract

Irregularities in intracellular calcium on a beat-to-beat basis can precede cardiac arrhythmia, but the mechanisms inducing such irregularities remain elusive. This study tested the hypothesis that sarcoplasmic reticulum (SR) and L-type calcium channel activity determine the beat-to-beat response and its rate dependency. For this purpose, patch-clamp technique and confocal calcium imaging was used to record L-type calcium current (I-Ca) and visualize calcium in human atrial myocytes subjected to increasing stimulation frequencies (from 0.2 to 2Hz). The beat-to-beat response was heterogeneous among a population of 133 myocytes, with 30 myocytes responding uniformly at all frequencies, while alternating and irregular responses were induced in 78 and 25 myocytes, respectively. Myocytes with uniform responses had the lowest frequency of calcium wave-induced transient inward currents (I-TI; 0.4 +/- 0.2 min(-1)), I-Ca density (1.8 +/- 0.3 pA pF(-1)) and caffeine-releasable calcium load (6.2 +/- 0.5 amol pF(-1)), while those with alternating responses had the highest I-TI frequency (1.8 +/- 0.3 min(-1), P = 0.003) and I-Ca density (2.4 +/- 0.2 pA pF(-1), P = 0.04). In contrast, the calcium load was highest in myocytes with irregular responses (8.5 +/- 0.7 amol pF(-1), P = 0.01). Accordingly, partial I-Ca inhibition reduced the incidence (from 78 to 44%, P < 0.05) and increased the threshold frequency for beat-to-beat alternation (from 1.3 +/- 0.2 to 1.9 +/- 0.2 Hz, P < 0.05). Partial inhibition of SR calcium release reduced the I-TI frequency, increased calcium loading and favoured induction of irregular responses, while complete inhibition abolished beat-to-beat alternation at all frequencies. In conclusion, the beat-to-beat response was heterogeneous among human atrial myocytes subjected to increasing stimulation frequencies, and the nature and stability of the response were determined by the SR and L-type calcium channel activities, suggesting that these mechanisms are key to controlling cardiac beat-to-beat stability.

Published
2011

13. Changes in myocardial electrical impedance in human heart graft rejection

Author

Cinca, Juan, primary, Ramos, Juan, additional, Garcia, Miguel A., additional, Bragos, Ramon, additional, Bayés-Genís, Antoni, additional, Salazar, Yolocuauhtli, additional, Bordes, Ramon, additional, Mirabet, Sonia, additional, Padró, Josep M., additional, Picart, Joan Garcia, additional, Viñolas, Xavier, additional, and Rosell-Ferrer, Javier, additional

Published
2008
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14. Idiopathic dilated cardiomyopathy exhibits defective vascularization and vessel formation

Author

Roura, Santiago, primary, Planas, Francesc, additional, Prat‐Vidal, Cristina, additional, Leta, Ruben, additional, Soler‐Botija, Carolina, additional, Carreras, Francesc, additional, Llach, Anna, additional, Hove‐Madsen, Leif, additional, Lladó, Guillem Pons, additional, Farré, Jordi, additional, Cinca, Juan, additional, and Bayes‐Genis, Antoni, additional

Published
2007
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16. Dynamics of Ventricular Repolarization in Patients with Dilated Cardiomyopathy Versus Healthy Subjects

Author

Alonso, Jose Luis, primary, Martinez, Pablo, additional, Vallverdu, Montserrat, additional, Cygankiewicz, Iwona, additional, Pitzalis, Maria Vittoria, additional, Genis, Antoni Bayes, additional, Cinca, Juan, additional, Rizzon, Paolo, additional, Caminal, Pere, additional, Zareba, Wojciech, additional, and de Luna, Antoni Bayes, additional

Published
2005
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25. A simple validated method for predicting the risk of hospitalization for worsening of heart failure in ambulatory patients: the Redin-SCORE.

Author

Álvarez-García J, Ferrero-Gregori A, Puig T, Vázquez R, Delgado J, Pascual-Figal D, Alonso-Pulpón L, González-Juanatey JR, Rivera M, Worner F, Bardají A, and Cinca J

Subjects
Acute Disease, Aged, Chronic Disease, Female, Heart Failure physiopathology, Humans, Male, Models, Statistical, Heart Failure therapy, Outpatients, Patient Readmission statistics & numerical data
Abstract

Aims: Prevention of hospital readmissions is one of the main objectives in the management of patients with heart failure (HF). Most of the models predicting readmissions are based on data extracted from hospitalized patients rather than from outpatients. Our objective was to develop a validated score predicting 1-month and 1-year risk of readmission for worsening of HF in ambulatory patients., Methods and Results: A cohort of 2507 ambulatory patients with chronic HF was prospectively followed for a median of 3.3 years. Clinical, echocardiographic, ECG, and biochemical variables were used in a competing risk regression analysis to construct a risk score for readmissions due to worsening of HF. Thereafter, the score was externally validated using a different cohort of 992 patients with chronic HF (MUSIC registry). Predictors of 1-month readmission were the presence of elevated natriuretic peptides, left ventricular (LV) HF signs, and estimated glomerular filtration rate (eGFR) <60 mL/min/m(2) . Predictors of 1-year readmission were elevated natriuretic peptides, anaemia, left atrial size >26 mm/m(2) , heart rate >70 b.p.m., LV HF signs, and eGFR <60 mL/min/m(2) . The C-statistics for the models were 0.72 and 0.66, respectively. The cumulative incidence function distinguished low-risk (<1% event rate) and high-risk groups (>5% event rate) for 1-month HF readmission. Likewise, low-risk (7.8%), intermediate-risk (15.6%) and high-risk groups (26.1%) were identified for 1-year HF readmission risk. The C-statistics remained consistent after the external validation (<5% loss of discrimination)., Conclusion: The Redin-SCORE predicts early and late readmission for worsening of HF using proven prognostic variables that are routinely collected in outpatient management of chronic HF., (© 2015 The Authors. European Journal of Heart Failure published by John Wiley & Sons Ltd on behalf of European Society of Cardiology.)

Published
2015
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26. Differential clinical characteristics and prognosis of intraventricular conduction defects in patients with chronic heart failure.

Author

Cinca J, Mendez A, Puig T, Ferrero A, Roig E, Vazquez R, Gonzalez-Juanatey JR, Alonso-Pulpon L, Delgado J, Brugada J, and Pascual-Figal D

Subjects
Aged, Aged, 80 and over, Bundle-Branch Block complications, Bundle-Branch Block mortality, Cardiomyopathy, Dilated complications, Case-Control Studies, Diabetes Complications, Female, Heart Failure complications, Heart Failure mortality, Humans, Hypertension complications, Male, Middle Aged, Myocardial Ischemia complications, Patient Readmission, Prognosis, Proportional Hazards Models, Stroke Volume, Ventricular Function, Left, Bundle-Branch Block diagnosis, Heart Failure diagnosis
Abstract

Aims: Intraventricular conduction defects (IVCDs) can impair prognosis of heart failure (HF), but their specific impact is not well established. This study aimed to analyse the clinical profile and outcomes of HF patients with LBBB, right bundle branch block (RBBB), left anterior fascicular block (LAFB), and no IVCDs., Methods and Results: Clinical variables and outcomes after a median follow-up of 21 months were analysed in 1762 patients with chronic HF and LBBB (n = 532), RBBB (n = 134), LAFB (n = 154), and no IVCDs (n = 942). LBBB was associated with more marked LV dilation, depressed LVEF, and mitral valve regurgitation. Patients with RBBB presented overt signs of congestive HF and depressed right ventricular motion. The LAFB group presented intermediate clinical characteristics, and patients with no IVCDs were more often women with less enlarged left ventricles and less depressed LVEF. Death occurred in 332 patients (interannual mortality = 10.8%): cardiovascular in 257, extravascular in 61, and of unknown origin in 14 patients. Cardiac death occurred in 230 (pump failure in 171 and sudden death in 59). An adjusted Cox model showed higher risk of cardiac death and pump failure death in the LBBB and RBBB than in the LAFB and the no IVCD groups., Conclusion: LBBB and RBBB are associated with different clinical profiles and both are independent predictors of increased risk of cardiac death in patients with HF. A more favourable prognosis was observed in patients with LAFB and in those free of IVCDs. Further research in HF patients with RBBB is warranted.

Published
2013
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27. Left atrial enlargement and NT-proBNP as predictors of sudden cardiac death in patients with heart failure.

Author

Bayes-Genis A, Vazquez R, Puig T, Fernandez-Palomeque C, Fabregat J, Bardají A, Pascual-Figal D, Ordoñez-Llanos J, Valdes M, Gabarrús A, Pavon R, Pastor L, Gonzalez Juanatey JR, Almendral J, Fiol M, Nieto V, Macaya C, Cinca J, and Bayes de Luna A

Subjects
Aged, Cardiomegaly blood, Female, Heart Failure blood, Humans, Male, Middle Aged, Multivariate Analysis, Predictive Value of Tests, Risk Assessment, Sensitivity and Specificity, Cardiomegaly epidemiology, Death, Sudden, Cardiac epidemiology, Heart Atria, Heart Failure epidemiology, Natriuretic Peptide, Brain blood, Peptide Fragments blood
Abstract

Aims: The identification of valuable markers of sudden cardiac death (SCD) in patients with established HF remains a challenge. We sought to assess the value of clinical, echocardiographic and biochemical variables to predict SCD in a consecutive cohort of patients with heart failure (HF) due to systolic dysfunction., Methods: A cohort of 494 patients with established HF had baseline echocardiographic and NT-proBNP measurements and were followed for 942+/-323 days., Results: Fifty patients suffered SCD. Independent predictors of SCD were indexed LA size>26 mm/m2 (HR 2.8; 95% CI 1.5-5.0; p=0.0007), NT-proBNP>908 ng/L (HR 3.1; 95% CI 1.5-6.7; p=0.003), history of myocardial infarction (HR 2.3; 95% CI 1.3-4.1; p=0.007), peripheral oedema (HR 2.1; 95% CI 1.1-3.9; p=0.02), and diabetes mellitus (HR 1.9; 95% CI 1.1-3.3; p=0.03). NYHA functional class, left ventricular ejection fraction and glomerular filtration rate were not independent predictors of SCD in this cohort. Notably, the combination of both LA size>26 mm/m2 and NT-proBNP>908 ng/L increased the risk of SCD (HR 4.3; 95% CI 2.5-7.6; p<0.0001). At 36 months, risk of SCD in patients with indexed LA size26 mm/m2 and NT-proBNP>908 ng/L reached 25% (p<0.0001)., Conclusions: Among HF patients, indexed LA size and NT-proBNP levels are more useful to stratify risk of SCD than other clinical, echocardiographic or biochemical variables. The combination of these two parameters should be considered for predicting SCD in patients with HF.

Published
2007
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28. Effect of aging on the pluripotential capacity of human CD105+ mesenchymal stem cells.

Author

Roura S, Farré J, Soler-Botija C, Llach A, Hove-Madsen L, Cairó JJ, Gòdia F, Cinca J, and Bayes-Genis A

Subjects
Adult, Aged, Humans, In Vitro Techniques, Aging physiology, Antigens, CD blood, Cell Differentiation physiology, Cellular Senescence physiology, Mesenchymal Stem Cells physiology, Receptors, Cell Surface blood, Telomere physiology
Abstract

Background: Whether aging modifies mesenchymal stem cell (MSC) properties is unknown., Aim: To compare the differentiation capacity of human CD105(+) MSCs obtained from young and elderly donors., Methods and Results: Cells were obtained from young (n=10, 24+/-6.4 years) and elderly (n=9, 77+/-8.4 years) donors. Cell senescence was assessed by telomere length assays and lipofuscin accumulation. Cell pluripotentiality was analysed by adipogenic and osteogenic induction media, and myocyte phenotype was attempted with 5-azacytidine (5-AZ). Immunofluorescence, Western blot, transmission electron microscopy and fluo-4 confocal imaging were used to analyse the sarcomere, gap junctions and Ca(2+) dynamics. Cells obtained from young and elderly donors showed no significant differences in relative telomere length (40.1+/-6.4% and 40.3+/-3.6%, p=0.9) and lipofuscin accumulation. Adipogenic and osteogenic potential of CD105(+) MSCs was demonstrated. 5-AZ induced increased expression of sarcomeric proteins without complete sarcomere organization. Treated cells also showed increased presence of connexin-43 both in young and old donor-derived cells. Intercellular communications were verified by the observation of gap junctions and passage of Ca(2+) between neighbouring cells. Spontaneous Ca(2+) raises did not significantly increase after 5-AZ treatment in both age groups., Conclusion: Age does not influence the adipogenic and myogenic differentiation potential of human CD105(+) MSCs.

Published
2006
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