Search

Your search keyword '"Chenyao Nie"' showing total 4 results
Start Over Author "Chenyao Nie" Publisher wiley
4 results on '"Chenyao Nie"'

2. Preparation of Reactive Oligo( p ‐Phenylene Vinylene) Materials for Spatial Profiling of the Chemical Reactivity of Intracellular Compartments

Author

Shu Wang, Fengting Lv, Libing Liu, Shengliang Li, Chenyao Nie, Zhihui Dai, Rong Hu, Hui Chen, and Bing Wang

Subjects
Materials science, Mechanical Engineering, 02 engineering and technology, 010402 general chemistry, 021001 nanoscience & nanotechnology, 01 natural sciences, Fluorescence, Small molecule, Combinatorial chemistry, 0104 chemical sciences, Mechanics of Materials, Phenylene, General Materials Science, Reactivity (chemistry), 0210 nano-technology, Intracellular, Macromolecule
Abstract

An oligo(p-phenylene vinylene) derivative (OPV-pfp) functionalized with pentafluorophenol active ester is designed and synthesized. The high reactivity of OPV-pfp with biological small molecules or macromolecules containing amino groups under physiological conditions leads to spectral changes of OPV-pfp; thus, spatial reactivity discrimination for different subcellular structures inside cells is realized by triggering and imaging the fluorescence signal change of the OPV-pfp.

Published
2016

3. Conjugated Polymer Nanoparticles for Cell Membrane Imaging

Author

Meng Li, Shu Wang, Liheng Feng, Libing Liu, Huanxiang Yuan, Chenyao Nie, and Fengting Lv

Subjects
Benzylamines, Biocompatibility, Polymers, Surface Properties, Nanoparticle, Nanotechnology, Conjugated system, Cyclams, Endocytosis, Biochemistry, Polyethylene Glycols, Cell membrane, Heterocyclic Compounds, medicine, Humans, Polyglactin 910, Fluorescent Dyes, chemistry.chemical_classification, Drug Carriers, Chemistry, Cell Membrane, Organic Chemistry, General Chemistry, Polymer, Fluorescence, medicine.anatomical_structure, Microscopy, Fluorescence, Reagent, MCF-7 Cells, Nanoparticles, HT29 Cells, HeLa Cells
Abstract

The outstanding optical properties and biocompatibility of fluorescent conjugated polymer nanoparticles (CPNs) make them favorable for bioimaging application. However, few CPNs could achieve stable cell membrane labeling due to cell endocytosis. In this work, conjugated polymer nanoparticles (PFPNP-PLE) encapsulated with PFP and PLGA-PEG-N3 in the matrix and functionalized with the small-molecule drug plerixafor (PLE) on the surface were prepared by a mini-emulsion method. PFPNP-PLE exhibits excellent photophysical properties, low cytotoxicity, and specific cytomembrane location, which makes it a potential cell membrane labeling reagent with blue fluorescence emission, an important component for multilabel/multicolor bioimaging.

Published
2014

4. Multicellular Assembly and Light-Regulation of Cell-Cell Communication by Conjugated Polymer Materials

Author

Fengting Lv, Bing Wang, Libing Liu, Huanxiang Yuan, Chenyao Nie, Jinzhao Song, and Shu Wang

Subjects
Cell signaling, Materials science, Light, Polymers, Cell, Biotin, chemistry.chemical_element, Cell Communication, Thiophenes, Conjugated system, Oxygen, Jurkat Cells, Immune system, Polymer chemistry, medicine, Humans, General Materials Science, chemistry.chemical_classification, Reactive oxygen species, Microscopy, Confocal, Mechanical Engineering, Killer Cells, Natural, Multicellular organism, medicine.anatomical_structure, chemistry, Mechanics of Materials, Biophysics, Surface modification, Streptavidin, Protein Binding
Abstract

Using cell-surface modification and biotin-streptavidin interactions, immune cells and target tumor cells are made to form multicellular assemblies. A polythiophene derivative can undergo cellular uptake, allowing the sensitization of oxygen under light irradiation. The subsequent generation of reactive oxygen species (ROS) regulates cell-cell communication in time and space.

Published
2013

Catalog

Books, media, physical & digital resources
See catalog results