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Start Over Author "Cheng, Chi-Yuan" Publisher wiley
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6. HLA associations and clinical implications in T-cell mediated drug hypersensitivity reactions: an updated review.

Author

Cheng CY, Su SC, Chen CH, Chen WL, Deng ST, and Chung WH

Subjects
Alleles, Allopurinol adverse effects, Carbamazepine adverse effects, Dideoxynucleosides adverse effects, Drug Hypersensitivity Syndrome etiology, Drug Hypersensitivity Syndrome immunology, Drug Hypersensitivity Syndrome pathology, Gene Expression, HLA Antigens immunology, Humans, Stevens-Johnson Syndrome etiology, Stevens-Johnson Syndrome immunology, Stevens-Johnson Syndrome pathology, T-Lymphocytes drug effects, T-Lymphocytes pathology, Drug Hypersensitivity Syndrome genetics, Genetic Predisposition to Disease, HLA Antigens genetics, Stevens-Johnson Syndrome genetics, T-Lymphocytes immunology
Abstract

T-cell mediated drug hypersensitivity reactions may range from mild rash to severe fatal reactions. Among them, drug reaction with eosinophilia and systemic symptoms (DRESS) or drug-induced hypersensitivity syndrome (DIHS), Stevens-Johnson syndrome/ toxic epidermal necrolysis (SJS/TEN), are some of the most life-threatening severe cutaneous adverse reactions (SCARs). Recent advances in pharmacogenetic studies show strong genetic associations between human leukocyte antigen (HLA) alleles and susceptibility to drug hypersensitivity. This review summarizes the literature on recent progresses in pharmacogenetic studies and clinical application of pharmacogenetic screening based on associations between SCARs and specific HLA alleles to avoid serious conditions associated with drug hypersensitivity.

Published
2014
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