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Intensive agriculture has led to a reduction of overall biodiversity and ecosystem services such as pollination and biological control. To offset these economic losses, many farmers are planting native wildflowers to enhance flowering plant diversity and augment pollinator and other beneficial arthropod populations on their farms. In this study, we examined arthropod communities in Florida (USA) within wildflower plots and fallow control plots, which were primarily composed of grasses. Significantly more herbivorous insects, predatory arthropods, and pollinators were found within wildflower plots than in fallow control plots. We also implemented pollinator surveys at flowering plants. These surveys highlighted numerous plant–pollinator interactions within wildflower plots, supporting the idea that some native wildflower species are more attractive to pollinators than are others. Nevertheless, utilizing diverse flowering plants for wildflower plots may support a wide diversity of beneficial arthropod species, including native bees. Our results suggest that wildflower plantings in Florida can be a successful management tool to harbor increased overall plant and arthropod diversity (including native pollinators and other beneficial arthropods) within intensive agricultural areas.

Objective Minority candidates for office must overcome numerous hurdles in order to win elective office, with one such hurdle being the racial resentment of voters. This article tests the impact racial resentment has on white support for a minority candidate in relation to a similar white candidate. Method This article employs a natural experiment provided by the 2014 South Carolina Senate elections. Examining these elections, this article examines what impact a voter's racial resentment has on his or her support for the two candidates. Results The results show that voters who score highly on the racial resentment scale are just as likely to support a minority Republican as they are to support a white Republican. Conclusion These findings indicate that racial resentment scores may not adequately measure a person's true feelings on race, particularly when the minority candidate is a Republican.

Key points Using whole-cell clamp methods, we characterized the temporal coding in each type of OFF bipolar cell. We found that type 2 and 3a cells are transient, type 1 and 4 cells are sustained, and type 3b cells are intermediate. The light-evoked excitatory postsynaptic potentials in some types were rectified, suggesting that they provide inputs to the non-linear ganglion cells. Visual signalling from the photoreceptors was mediated exclusively through the kainate receptors in the transient OFF bipolar cells, whereas both kainate and AMPA receptors contributed in the other cells. This study demonstrates, for the first time, that parallel visual encoding starts at the OFF bipolar cells in a type-specific manner. Abstract The retina is the entrance to the visual system, which receives various kinds of image signals and forms multiple encoding pathways. The second-order retinal neurons, the bipolar cells, are thought to initiate multiple neural streams by encoding various visual signals in different types of cells. However, the functions of each bipolar cell type have not been fully understood. We investigated whether OFF bipolar cells encode visual signals in a type-dependent manner. We recorded the changes in the bipolar cell voltage in response to two input functions: step and sinusoidal light stimuli. Type 1 and 4 OFF bipolar cells were sustained cells and responded to sinusoidal stimuli over a broad range of frequencies. Type 2 and 3a cells were transient and exhibited band-pass filtering. Type 3b cells were in the middle of these two groups. The distinct temporal responses might be attributed to different types of glutamate receptors. We examined the AMPA and kainate glutamate receptor composition in each bipolar cell type. The light responses in the transient OFF bipolar cells were exclusively mediated by kainate receptors. Although the kainate receptors mediated the light responses in the sustained cells, the AMPA receptors also mediated a portion of the responses in sustained cells. Furthermore, we found that some types of cells were rectified more than other types. Taken together, we found that the OFF bipolar cells encode diverse temporal image signals in a type-dependent manner, confirming that each type of OFF bipolar cell initiates diverse temporal visual processing in parallel.

We might suppose it is not only instrumentally valuable for beliefs to be true, but that it is intrinsically valuable – truth makes a non-derivative, positive contribution to a belief's overall value. Some intrinsic goods are better than others, though, and this article considers the question of how good truth is, compared to other intrinsic goods. I argue that truth is the worst of all intrinsic goods; every other intrinsic good is better than it. I also suggest the best explanation for truth's inferiority is that it is not really an intrinsic good at all. It is intrinsically neutral.

According to a common objection to epistemological naturalism, no empirical, scientific theory of knowledge can be normative in the way epistemological theories need to be. In response, such naturalists as W.V. Quine have claimed naturalized epistemology can be normative by emulating engineering disciplines and addressing the relations of causal efficacy between our cognitive means and ends. This paper evaluates that “engineering reply” and finds it a mixed success. Based on consideration of what it might mean to call a theory “normative,” seven versions of the normativity objection to epistemological naturalism are formulated. The engineering reply alone is sufficient to answer only the four least sophisticated versions. To answer the others, naturalists must draw on more resources than their engineering reply alone provides.

Laurence BonJour has recently proposed a novel and interesting approach to the problem of induction. He grants that it is contingent, and so not a priori, that our patterns of inductive inference are reliable. Nevertheless, he claims, it is necessary and a priori that those patterns are highly likely to be reliable, and that is enough to ground an a priori justification induction. This paper examines an important defect in BonJour's proposal. Once we make sense of the claim that inductive inference is “necessarily highly likely” to be reliable, we find that it is not knowable a priori after all.

© 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited., Background: As gene-targeted therapies are increasingly being developed for Parkinson's disease (PD), identifying and characterizing carriers of specific genetic pathogenic variants is imperative. Only a small fraction of the estimated number of subjects with monogenic PD worldwide are currently represented in the literature and availability of clinical data and clinical trial-ready cohorts is limited. Objective: The objectives are to (1) establish an international cohort of affected and unaffected individuals with PD-linked variants; (2) provide harmonized and quality-controlled clinical characterization data for each included individual; and (3) further promote collaboration of researchers in the field of monogenic PD. Methods: We conducted a worldwide, systematic online survey to collect individual-level data on individuals with PD-linked variants in SNCA, LRRK2, VPS35, PRKN, PINK1, DJ-1, as well as selected pathogenic and risk variants in GBA and corresponding demographic, clinical, and genetic data. All registered cases underwent thorough quality checks, and pathogenicity scoring of the variants and genotype-phenotype relationships were analyzed. Results: We collected 3888 variant carriers for our analyses, reported by 92 centers (42 countries) worldwide. Of the included individuals, 3185 had a diagnosis of PD (ie, 1306 LRRK2, 115 SNCA, 23 VPS35, 429 PRKN, 75 PINK1, 13 DJ-1, and 1224 GBA) and 703 were unaffected (ie, 328 LRRK2, 32 SNCA, 3 VPS35, 1 PRKN, 1 PINK1, and 338 GBA). In total, we identified 269 different pathogenic variants; 1322 individuals in our cohort (34%) were indicated as not previously published. Conclusions: Within the MJFF Global Genetic PD Study Group, we (1) established the largest international cohort of affected and unaffected individuals carrying PD-linked variants; (2) provide harmonized and quality-controlled clinical and genetic data for each included individual; (3) promote collaboration in the field of genetic PD with a view toward clinical and genetic stratification of patients for gene-targeted clinical trials. © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society., Michael J. Fox Foundation for Parkinson's Research. Grant Number: ID 15015.02. NIHR Cambridge Biomedical Research Centre. Grant Number: BRC-1215-20014