8 results on '"Chapman, C. R"'
Search Results
2. The composition of 433 Eros: A mineralogical—chemical synthesis
- Author
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McCoy, T. J., primary, Burbine, T. H., additional, Mcfadden, L. A., additional, Starr, R. D., additional, Gaffey, M. J., additional, Nittler, L. R., additional, Evans, L. G., additional, Izenberg, N., additional, Lucey, P. G., additional, Trombka, J. I., additional, Bell, J. F., additional, Clark, B. E., additional, Clark, P. E., additional, Squyres, S. W., additional, Chapman, C. R., additional, Boynton, W. V., additional, and Veverka, J., additional
- Published
- 2001
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3. Space weathering on Eros: Constraints from albedo and spectral measurements of Psyche crater
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Clark, B. E., primary, Lucey, P., additional, Helfenstein, P., additional, Bell, J. F., additional, Peterson, C., additional, Veverka, J., additional, Mcconnochie, T., additional, Robinson, M. S., additional, Bussey, B., additional, Murchie, S. L., additional, Izenberg, N. I., additional, and Chapman, C. R., additional
- Published
- 2001
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4. PAIN OUT: the making of an international acute pain registry.
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Zaslansky R, Rothaug J, Chapman CR, Bäckström R, Brill S, Fletcher D, Fodor L, Gordon DB, Komann M, Konrad C, Leykin Y, Pogatski-Zahn E, Puig MM, Rawal N, Ullrich K, Volk T, and Meissner W
- Subjects
- Acute Pain diagnosis, Adult, Aged, Aged, 80 and over, Europe, Feasibility Studies, Female, Hospitals, Humans, Male, Middle Aged, Pain, Postoperative diagnosis, Surveys and Questionnaires, Acute Pain therapy, Pain Management, Pain, Postoperative therapy, Registries
- Abstract
Background: About 240 million patients undergo surgery every year, worldwide. Roughly 50% of these patients report clinically significant pain. Numerous barriers impede provision of adequate management. Lack of evidence about appropriateness and effectiveness of interventions is one. A registry can provide such information, eventually facilitating better management. This paper reports the development and feasibility of PAIN OUT, the first international acute pain registry, established with funds from the European Commission, and presents preliminary analysis to illustrate the nature of investigations that registry data make possible., Methods: On the first postoperative day, 6347 adult patients undergoing orthopaedic or general surgery, in 11 medical centres in Europe and Israel, provided Patient Reported Outcomes (PROs) using a validated questionnaire. Clinical data were abstracted from the patient's chart., Results: Feasibility worked well. Over a period of 1 year, surveyors accrued targeted data sets and entered them into an online browser. Collaborators could receive online feedback comparing their findings about PROs against anonymized findings from other centres. Missing data for the majority of variables were low. Despite considerable variability between institutions, a large number of patients were treated according to the generic, evidence-based recommendations we assessed. However, this was not sufficient to result in acceptable outcomes for the majority of patients., Conclusion: The initial development of PAIN OUT has been achieved. From 2013, it continues as a not-for-profit academic project, open to clinicians and researchers worldwide. The International Association for Study of Pain and PAIN OUT will work together to maintain, disseminate and develop the registry., (© 2014 European Pain Federation - EFIC®)
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- 2015
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5. Feasibility of international data collection and feedback on post-operative pain data: proof of concept.
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Zaslansky R, Chapman CR, Rothaug J, Bäckström R, Brill S, Davidson E, Elessi K, Fletcher D, Fodor L, Karanja E, Konrad C, Kopf A, Leykin Y, Lipman A, Puig M, Rawal N, Schug S, Ullrich K, Volk T, and Meissner W
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- Adolescent, Adult, Aged, Aged, 80 and over, Benchmarking, Cooperative Behavior, Databases, Factual, Feasibility Studies, Female, Hospitals, Humans, Male, Middle Aged, Pilot Projects, Quality Assurance, Health Care, Registries, Data Collection methods, Pain Management methods, Pain, Postoperative therapy
- Abstract
Post-operative pain exacts a high toll from patients, families, healthcare professionals and healthcare systems worldwide. PAIN-OUT is a research project funded by the European Union's 7th Framework Program designed to develop effective, evidence-based approaches to improve pain management after surgery, including creating a registry for feedback, benchmarking and decision support. In preparation for PAIN-OUT, we conducted a pilot study to evaluate the feasibility of international data collection with feedback to participating sites. Adult orthopaedic or general surgery patients consented to participate between May and October 2008 at 14 collaborating hospitals in 13 countries. Project staff collected patient-reported outcomes and process data from 688 patients and entered the data into an online database. Project staff in 10 institutions met the enrolment criteria of collecting data from at least 50 patients. The completeness and quality of the data, as assessed by rate of missing data, were acceptable; only 2% of process data and 0.06% of patient-reported outcome data were missing. Participating institutions received access to select items as Web-based feedback comparing their outcomes to those of the other sites, presented anonymously. We achieved proof of concept because staff and patients in all 14 sites cooperated well despite marked differences in cultures, nationalities and languages, and a central database management team was able to provide valuable feedback to all., (© 2011 European Federation of International Association for the Study of Pain Chapters.)
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- 2012
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6. Patient-controlled analgesic administration. A comparison of steady-state morphine infusions with bolus doses.
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Hill HF, Mackie AM, Coda BA, Iverson K, and Chapman CR
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- Adult, Bone Marrow Transplantation adverse effects, Drug Administration Schedule, Female, Humans, Infusions, Intravenous, Leukemia therapy, Male, Morphine adverse effects, Morphine pharmacokinetics, Mouth Mucosa, Pain, Postoperative etiology, Pain, Postoperative physiopathology, Patient Participation, Self Administration, Stomatitis etiology, Morphine administration & dosage, Pain, Postoperative drug therapy
- Abstract
The authors have shown previously that bone marrow transplant (BMT) patients who self-administered bolus doses of morphine gained equal oral mucositis pain relief while using less drug compared with similar patients receiving morphine by staff-controlled continuous infusion. In a follow-up study they compared the efficacy and side effects of morphine in two groups of marrow transplant patients who controlled their own analgesic administration either by conventional bolus-dose, patient-controlled analgesia (PCA) or by adjusting the rate of continuous morphine infusion to increase or decrease their plasma morphine concentration. Patients controlling their morphine infusion rates (pharmacokinetically based patient-controlled analgesia [PKPCA] group) obtained more relief from oral mucositis pain than did patients using conventional PCA. Patients in the PKPCA group used more morphine than PCA patients and achieved superior pain relief without significant increases in side effects (e.g., nausea, mood changes, sedation). The authors conclude that PKPCA improves the management of prolonged, severe pain in marrow transplant patients and that this approach to patient-controlled analgesia may be useful in other types of persistent pain.
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- 1991
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7. Dose effects of alfentanil in human analgesia.
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Hill H, Walter MH, Saeger L, Sargur M, Sizemore W, and Chapman CR
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- Adult, Alfentanil, Dose-Response Relationship, Drug, Evoked Potentials, Fentanyl metabolism, Half-Life, Humans, In Vitro Techniques, Injections, Intravenous, Kinetics, Male, Pain, Analgesia, Fentanyl analogs & derivatives
- Abstract
Alfentanil, a rapidly acting opioid, was given in subanesthetic doses to 10 subjects in a laboratory setting. Analgesia was assessed from the subjects' responses to painful dental stimulation. A subjective pain report (PR) and brain evoked potential (EP) amplitude were obtained repeatedly before and after injection on each of 4 testing days, on which the following intravenous doses were administered: 0 (saline solution), 5, 10, and 15 micrograms/kg. Significant dose effects were observed for EP amplitude during but not beyond the distributional t1/2 of the drug, but significant effects on the PR extended beyond this time point. Mean volume of distribution, total body clearance, and distribution t1/2 did not differ significantly across the doses of alfentanil. Strong correlations between each effect measure and plasma drug concentration were observed at all doses and were significant at P less than 0.01. The EP scores tracked the distribution of alfentanil very closely, but the correlation between EP amplitude and plasma alfentanil concentration was lower during the elimination phase. In contrast, the PR effects closely tracked the elimination of alfentanil but not its distribution. These findings suggest that EP amplitude and the PR represent two different central effects in opioid analgesia.
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- 1986
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8. Prolonged morphine self-administration and addiction liability. Evaluation of two theories in a bone marrow transplant unit.
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Chapman CR and Hill HF
- Subjects
- Adult, Combined Modality Therapy adverse effects, Drug Administration Schedule, Female, Humans, Male, Mouth Mucosa, Palliative Care psychology, Risk, Stomatitis drug therapy, Stomatitis etiology, Morphine administration & dosage, Morphine Dependence psychology, Pain drug therapy, Self Administration psychology
- Abstract
The technology for patient intravenous self-administration of morphine has been successfully implemented in postoperative and other clinical settings and can be used with terminal patients who experience pain. The question of whether patients who use such instrumentation will be vulnerable to over-medication or development of addiction has not been addressed. This report reviews two competing theories that bear upon this question and tests their predictions about self-administration of morphine for pain relief using data obtained from patients in a bone marrow transplant unit. The first, Opponent Process Theory, predicts escalating drug use and the development of addictive behavior in patients who self-administer morphine. The second, Control Theory, predicts that patients will self-regulate pain effectively by administering morphine without developing problems of medication abuse or addiction. Patients self-administering morphine for 2 weeks were compared to controls who received the drug via routine staff-controlled continuous infusion procedures. Self-administering patients used significantly less morphine than controls and still achieved the same amount of pain control; moreover, they terminated drug use sooner than controls. The predictions based upon Opponent Process Theory were not supported in these marrow transplant patients, but Control Theory accounted well for the outcomes. These results support the assumption that self-administration of opioids in a medical setting does not put patients at risk for over-medication or addiction.
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- 1989
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