1. Impaired awareness of hypoglycaemia in women with type 1 diabetes in pregnancy: Hypoglycaemia fear, glycaemic and pregnancy outcomes
- Author
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Bahrami, Jasmine, Tomlinson, George, Murphy, Helen R, Feig, Denice S, CONCEPTT Collaborative Group, Murphy, Helen R [0000-0001-6876-8727], Feig, Denice S [0000-0001-8561-7584], and Apollo - University of Cambridge Repository
- Subjects
diabetes mellitus type 1 ,Blood Glucose ,endocrine system diseases ,pregnancy complications ,pregnancy in diabetes ,pregnancy outcomes ,Blood Glucose Self-Monitoring ,Infant, Newborn ,Pregnancy Outcome ,nutritional and metabolic diseases ,Fear ,severe hypoglycaemia ,Hypoglycemia ,Diabetes Mellitus, Type 1 ,Pregnancy ,diabetes mellitus ,Humans ,Female ,hormones, hormone substitutes, and hormone antagonists ,hypoglycaemia - Abstract
Funder: Juvenile Diabetes Research Foundation International; Id: http://dx.doi.org/10.13039/100000901, Funder: Juvenile Diabetes Research Foundation Canada; Id: http://dx.doi.org/10.13039/100009881, AIMS: To examine maternal fear of hypoglycaemia, glycaemia and pregnancy outcomes in women with impaired and normal awareness of hypoglycaemia. METHODS: A pre-planned sub-study of 214 pregnant women with type 1 diabetes who participated in the CONCEPTT trial. Participants completed hypoglycaemia fear surveys (HFS-II) at baseline. Logistic regression and Poisson regression analyses were used to obtain an adjusted estimate for the rate ratio relating awareness to the number of severe hypoglycaemic episodes, and for several neonatal outcomes in relation to the total HFS-II score. The role of continuous glucose monitoring (CGM) use was examined. RESULTS: Overall, 30% of participants reported impaired awareness of hypoglycaemia (n = 64). Women with impaired awareness of hypoglycaemia had more episodes of severe hypoglycaemia (mean 0.44 vs. 0.08, p < 0.001) (12-34 weeks gestation) and scored higher on the HFS-II scale (43.7 vs. 36.0, p 0.008), indicating more fear of hypoglycaemia. They spent more time below range (CGM
- Published
- 2022
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