1. Treatment outcome and pattern of failure in hepatoblastoma treated with a consensus protocol in Hong Kong
- Author
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Anthony P. Y. Liu, Alex Wing Kwan Leung, Patrick Ho Yu Chung, Albert C. Y. Chan, C. H. Li, KK Ho, Regina Cheuk-Lam Lo, Edwin Kin Wai Chan, Alan K. S. Chiang, C W Luk, and Janice J. K. Ip
- Subjects
Hepatoblastoma ,Male ,medicine.medical_specialty ,Vincristine ,Consensus ,medicine.medical_treatment ,Disease ,Liver transplantation ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Antineoplastic Combined Chemotherapy Protocols ,medicine ,Humans ,Longitudinal Studies ,Prospective Studies ,Child ,Retrospective Studies ,Patterns of failure ,Chemotherapy ,business.industry ,Liver Neoplasms ,Infant ,Hematology ,medicine.disease ,Combined Modality Therapy ,Liver Transplantation ,Survival Rate ,Regimen ,Treatment Outcome ,Oncology ,Child, Preschool ,030220 oncology & carcinogenesis ,Pediatrics, Perinatology and Child Health ,Risk stratification ,Hong Kong ,Female ,Neoplasm Recurrence, Local ,business ,Follow-Up Studies ,030215 immunology ,medicine.drug - Abstract
Background and aim We reviewed the results and pattern of failure of the consensus HB/HCC 1996 treatment protocol for pediatric hepatoblastoma (HB) in Hong Kong. The role of SIOPEL and Children's Hepatic tumors International Collaboration (CHIC) risk stratification was evaluated. Methods Patients enrolled on the protocol from 1996 to 2014 were included. PRETEXT staging, SIOPEL, and CHIC risk groups were retrospectively assigned. Results Sixty patients were enrolled with median age at diagnosis of 1.1 years and median follow-up time of 6.8 years. Alpha-fetoprotein (AFP) was raised (>100 ng/mL) in 58 (97%) patients. Five (8%) had metastases at presentation and 7 (12%) experienced tumor rupture prior to or during treatment. Twenty-nine patients (48%) received a first-line cisplatin, 5-fluorouracil, and vincristine regimen only while 23 (38%) also had alternative chemotherapeutic agents. Hepatic resection could be performed in 48 (80%) patients. Three (5%) patients underwent upfront liver transplantation. Five-year event-free survival and overall survival rates were 69.2% ± 6.1% and 77.6% ± 5.5% respectively. Among the 16 patients with relapse/progression, 9 had intrahepatic failure only, 5 had distant failure only, and 2 had combined local and distant failure. Predictors of inferior outcome included advanced Evans staging, disease involving both lobes, rupture, low AFP, and suboptimal response to first-line chemotherapy. Assigned in 44 patients, PRETEXT staging, SIOPEL, and CHIC risk groups significantly predicted EFS and OS. Conclusions Although the consensus HB/HCC 1996 protocol led to cure in three-quarters of pediatric HB patients, an upfront risk stratification system is required to identify and improve the outcome of high-risk patients.
- Published
- 2018
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