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3 results on '"C. Badulli"'

1. Temporal Variation in Soluble Human Leukocyte Antigen-G (sHLA-G) and Pregnancy-Associated Plasma Protein A (PAPP-A) in Pregnancies Complicated by Gestational Diabetes Mellitus and in Controls

Author

Elisabetta Lovati, Fausta Beneventi, Riccardo Albertini, Elena Locatelli, Giulia Garbin, Arsenio Spinillo, Emilia Genini, C. Badulli, Carmine Tinelli, Miryam Martinetti, Chiara Cavagnoli, and Margherita Simonetta

Subjects
Adult, medicine.medical_specialty, endocrine system diseases, Pregnancy-associated plasma protein A, Immunology, Human leukocyte antigen, Pregnancy, Internal medicine, Retrospective analysis, Humans, Pregnancy-Associated Plasma Protein-A, Immunology and Allergy, Medicine, Prospective Studies, Prospective cohort study, Retrospective Studies, HLA-G Antigens, business.industry, nutritional and metabolic diseases, Obstetrics and Gynecology, medicine.disease, Blood proteins, Gestational diabetes, Diabetes, Gestational, Pregnancy Trimester, First, Endocrinology, Reproductive Medicine, Case-Control Studies, Gestation, Female, business, Biomarkers
Abstract

Problem To target gestational diabetes mellitus (GDM) by means of temporal variation in pregnancy-associated plasma protein A (PAPP-A) and soluble human leukocyte antigen-G (sHLA-G). Method of study Retrospective analysis of PAPP-A and sHLA-G blood levels in historical samples of 112 GDM and 112 controls, drawn at first trimester, and prospective study in 18 GDM and 105 controls collected in triplicate along the pregnancy. Six hundred and sixty-five samples were analyzed. Results Gestational diabetes mellitus had significantly lower first-trimester PAPP-A concentrations than controls (2343 ± 1519 versus 2996 ± 1955 mU/mL, in retrospective brunch and 2490.57 ± 1828.52 versus 3240.84 ± 1930.69 mU/L in prospective one, P

Published
2014
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2. HLAhaplotypes and birth weight variation: is your future going to be light or heavy?

Author

Ilaria Sbarsi, A. De Silvestri, Carmine Tinelli, M. Guarene, Miryam Martinetti, Mariaclara Cuccia, Laura Salvaneschi, C. Badulli, F. Garlaschelli, Annamaria Pasi, Paola Bergamaschi, M. P. Mercati, and Cristina Capittini

Subjects
Male, Birth weight, Immunology, Normal Distribution, Physiology, Human leukocyte antigen, Biochemistry, Nephropathy, Cohort Studies, HLA Antigens, Pregnancy, Diabetes mellitus, Genetics, Birth Weight, Humans, Immunology and Allergy, Medicine, Allele, Polymorphism, Genetic, business.industry, Haplotype, Infant, Newborn, General Medicine, medicine.disease, Low birth weight, Haplotypes, Cord blood, Female, Growth and Development, medicine.symptom, business, Forecasting
Abstract

Birth weight is known to be a direct indicator of perinatal mortality and a clear predictor of adult pathologies too. It has been correlated with several causes of mortality in adulthood: low birth weight with diabetes, nephropathy and cardiovascular diseases and high birth weight with autoimmune diseases and cancer. In genome-wide studies, an extended human leucocyte antigen (HLA) region has been linked to birth weight variation. We focused our attention on the HLA haplotypes marked by HLA-A, HLA-B and HLA-DRB1 polymorphisms in 1206 healthy Caucasian newborns belonging to the Cord Blood Bank of Pavia (Italy) and their mothers, aiming to investigate the association between this restricted HLA region and birth weight variation. In our study, the HLA-B*38;DRB1*13 haplotype showed an ascending trend among centiles addressing to the high foetal weight. The HLA-A*02;B*15 haplotype showed a descending trend among centiles addressing to the low foetal weight. Besides the acknowledged correlation between the HLA-A*02 and HLA-B*15 alleles (as well as low birth weight) and type I diabetes and between the HLA-B*38 and HLA-DRB1*13 alleles (as well as high birth weight) and several autoimmune diseases, we cannot predict if our babies, healthy at birth, will suffer from these pathologies during life. Nevertheless, our data point to the HLA telomeric end for markers linked to the low birth weight and to the HLA centromeric end for markers linked to the high birth weight, thus limiting the region involved in birth weight variation, which still represents a useful predictor of disease risk in adulthood.

Published
2009
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3. Correlation of serum sHLA-G levels with cyst stage in patients with cystic echinococcosis: is it an immune evasion strategy?

Author

Mariconti M, Meroni V, Badulli C, Brunetti E, Tinelli C, De Silvestri A, Tamarozzi F, Genco F, Casulli A, and Martinetti M

Subjects
Adult, Animals, Dendritic Cells immunology, Dendritic Cells parasitology, Echinococcosis blood, Echinococcosis parasitology, Echinococcus genetics, Enzyme-Linked Immunosorbent Assay, Female, HLA-G Antigens blood, Humans, Immune Tolerance, Killer Cells, Natural immunology, Killer Cells, Natural parasitology, Male, Middle Aged, T-Lymphocytes immunology, T-Lymphocytes parasitology, Young Adult, Echinococcosis immunology, Echinococcus growth & development, Echinococcus immunology, HLA-G Antigens immunology, Immune Evasion
Abstract

Patients with cystic echinococcosis (CE) can harbour cysts for years or even decades, apparently without effect of the immune system on the metacestode. Although several immune evasion mechanisms by echinococcal cysts have been described, it is unclear whether the human leucocyte antigen (HLA) system plays a role in the susceptibility or resistance to CE in humans. HLA-G molecules are known to exert a suppressive action on dendritic cells maturation and on natural killer (NK) cells functions, therefore hampering T-cell responses and NK cytolysis. HLA-G plays an important role in immune tolerance, is involved in foetus and in allotransplant tolerance, and may be involved in tumoral and viral immune evasion. In this study, we assessed the presence and levels of soluble HLA-G (sHLA-G) in patients with CE using a commercial ELISA kit to determine whether host's HLA-G may have a role in the course of human CE., (© 2016 John Wiley & Sons Ltd.)

Published
2016
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