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Your search keyword '"Burette, Alain"' showing total 23 results
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23 results on '"Burette, Alain"'

2. Organization of TNIK in dendritic spines

Author

Burette, Alain C., primary, Phend, Kristen D., additional, Burette, Susan, additional, Lin, Qingcong, additional, Liang, Musen, additional, Foltz, Gretchen, additional, Taylor, Noël, additional, Wang, Qi, additional, Brandon, Nicholas J., additional, Bates, Brian, additional, Ehlers, Michael D., additional, and Weinberg, Richard J., additional

Published
2015
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9. Assembly of a β2-adrenergic receptor—GluR1 signalling complex for localized cAMP signalling

Author

Joiner, Mei-ling A, primary, Lisé, Marie-France, additional, Yuen, Eunice Y, additional, Kam, Angel Y F, additional, Zhang, Mingxu, additional, Hall, Duane D, additional, Malik, Zulfiqar A, additional, Qian, Hai, additional, Chen, Yucui, additional, Ulrich, Jason D, additional, Burette, Alain C, additional, Weinberg, Richard J, additional, Law, Ping-Yee, additional, El-Husseini, Alaa, additional, Yan, Zhen, additional, and Hell, Johannes W, additional

Published
2009
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23. Changes in the expression of plasma membrane calcium extrusion systems during the maturation of hippocampal neurons.

Author

Kip SN, Gray NW, Burette A, Canbay A, Weinberg RJ, and Strehler EE

Subjects
Alternative Splicing, Animals, Calcium-Transporting ATPases genetics, Cation Transport Proteins genetics, Cell Membrane metabolism, Cells, Cultured, Male, Neurons cytology, Plasma Membrane Calcium-Transporting ATPases, Protein Isoforms genetics, Protein Isoforms metabolism, RNA, Messenger metabolism, Rats, Rats, Sprague-Dawley, Sodium-Calcium Exchanger genetics, Calcium metabolism, Calcium Signaling physiology, Calcium-Transporting ATPases metabolism, Cation Transport Proteins metabolism, Hippocampus cytology, Neurons physiology, Sodium-Calcium Exchanger metabolism
Abstract

Spatial and temporal control of intracellular calcium signaling is essential for neuronal development and function. The termination of local Ca2+ signaling and the maintenance of basal Ca2+ levels require specific extrusion systems in the plasma membrane. In rat hippocampal neurons (HNs) developing in vitro, transcripts for all isoforms of the plasma membrane Ca2+ pump and the Na/Ca2+ exchanger, and the major nonphotoreceptor Na+/Ca2+,K+ exchangers (NCKX) were strongly upregulated during the second week in culture. Upregulation of plasma membrane calcium ATPases (PMCAs)1, 3, and 4 mRNA coincided with a splice shift from the ubiquitous b-type to the neuron-specific a-type with altered calmodulin regulation. Expression of all PMCA isoforms increased over 5-fold during the first 2 weeks. PMCA immunoreactivity was initially concentrated in the soma and growth cones of developing HNs. As the cells matured, PMCAs concentrated in the dendritic membrane and often colocalized with actin-rich dendritic spines in mature neurons. In the developing rat hippocampal CA1 region, immunohistochemistry confirmed the upregulation of all PMCAs and showed that by the end of the second postnatal week, PMCAs1, 2, and 3 were concentrated in the neuropil, with less intense staining of cell bodies in the pyramidal layer. PMCA4 staining was restricted to a few cells showing intense labeling of the cell periphery and neurites. These results establish that all major Ca2+ extrusion systems are strongly upregulated in HNs during the first 2 weeks of postnatal development. The overall increase in Ca2+ extrusion systems is accompanied by changes in the expression and cellular localization of different isoforms of the Ca2+ pumps and exchangers. The accumulation of PMCAs in dendrites and dendritic spines coincides with the functional maturation in these neurons, suggesting the importance of the proper spatial organization of Ca2+ extrusion systems for synaptic function and development., (Copyright 2005 Wiley-Liss, Inc.)

Published
2006
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