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2. Characterisation of a Bacterial Galactokinase with High Activity and Broad Substrate Tolerance for Chemoenzymatic Synthesis of 6-Aminogalactose-1-Phosphate and Analogues

Author

Huang, Kun, primary, Parmeggiani, Fabio, additional, Pallister, Edward, additional, Huang, Chuen-Jiuan, additional, Liu, Fang-Fang, additional, Li, Qian, additional, Birmingham, William R., additional, Both, Peter, additional, Thomas, Baptiste, additional, Liu, Li, additional, Voglmeir, Josef, additional, and Flitsch, Sabine L., additional

Published
2018
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10. Nanotechnology in Glycomics: Applications in Diagnostics, Therapy, Imaging, and Separation Processes.

Author

Dosekova E, Filip J, Bertok T, Both P, Kasak P, and Tkac J

Subjects
Animals, Biosensing Techniques, Drug Delivery Systems, Humans, Diagnostic Imaging methods, Glycomics methods, Nanomedicine methods, Nanotechnology methods
Abstract

This review comprehensively covers the most recent achievements (from 2013) in the successful integration of nanomaterials in the field of glycomics. The first part of the paper addresses the beneficial properties of nanomaterials for the construction of biosensors, bioanalytical devices, and protocols for the detection of various analytes, including viruses and whole cells, together with their key characteristics. The second part of the review focuses on the application of nanomaterials integrated with glycans for various biomedical applications, that is, vaccines against viral and bacterial infections and cancer cells, as therapeutic agents, for in vivo imaging and nuclear magnetic resonance imaging, and for selective drug delivery. The final part of the review describes various ways in which glycan enrichment can be effectively done using nanomaterials, molecularly imprinted polymers with polymer thickness controlled at the nanoscale, with a subsequent analysis of glycans by mass spectrometry. A short section describing an active glycoprofiling by microengines (microrockets) is covered as well., (© 2016 Wiley Periodicals, Inc.)

Published
2017
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