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1. PB2442: BLINATUMOMAB REDIRECTS DONOR LYMPHOCYTES AGAINST CD19+ ALL WITHOUT INCREASING THE RISK OF BYSTANDER ALLOREACTIVITY AFTER HAPLOIDENTICAL HEMATOPOIETIC CELL TRANSPLANTATION

Author

Antonella Mancusi, Francesco Zorutti, Loredana Ruggeri, Samanta Bonato, Sara Tricarico, Tiziana Zei, Roberta Iacucci Ostini, Valerio Viglione, Rebecca Sembenico, Valeria Cardinali, Massimo Fabrizio Martelli, Cristina Mecucci, Maria Paola Martelli, Alessandra Carotti, Andrea Velardi, and Antonio Pierini

Subjects
Diseases of the blood and blood-forming organs, RC633-647.5
Published
2023
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3. From Free‐Radical to Radical‐Free: A Paradigm Shift in Light‐Mediated Biofabrication

Author

Riccardo Rizzo, Nika Petelinšek, Angela Bonato, and Marcy Zenobi‐Wong

Subjects
bioprinting, free‐radical, photochemistry, photoclick, reactive oxygen species, thiol‐ene, Science
Abstract

Abstract In recent years, the development of novel photocrosslinking strategies and photoactivatable materials has stimulated widespread use of light‐mediated biofabrication techniques. However, despite great progress toward more efficient and biocompatible photochemical strategies, current photoresins still rely on photoinitiators (PIs) producing radical‐initiating species to trigger the so‐called free‐radical crosslinking/polymerization. In the context of bioprinting, where cells are encapsulated in the bioink, the presence of radicals raises concerns of potential cytotoxicity. In this work, a universal, radical‐free (RF) photocrosslinking strategy to be used for light‐based technologies is presented. Leveraging RF uncaging mechanisms and Michael addition, cell‐laden constructs are photocrosslinked by means of one‐ and two‐photon excitation with high biocompatibility. A hydrophilic coumarin‐based group is used to cage a universal RF photocrosslinker based on 4‐arm‐PEG‐thiol (PEG4SH). Upon light exposure, thiols are uncaged and react with an alkene counterpart to form a hydrogel. RF photocrosslinker is shown to be highly stable, enabling potential for off‐the‐shelf products. While PI‐based systems cause a strong upregulation of reactive oxygen species (ROS)‐associated genes, ROS are not detected in RF photoresins. Finally, optimized RF photoresin is successfully exploited for high resolution two‐photon stereolithography (2P‐SL) using remarkably low polymer concentration (

Published
2023
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7. Dominant VPS16 Pathogenic Variants: Not Only Isolated Dystonia

Author

Monfrini, Edoardo, primary, Avanzino, Laura, additional, Palermo, Giovanni, additional, Bonato, Giulia, additional, Brescia, Gloria, additional, Ceravolo, Roberto, additional, Cantarella, Giovanna, additional, Mandich, Paola, additional, Prokisch, Holger, additional, Storm van's Gravesande, Karin, additional, Straccia, Giulia, additional, Elia, Antonio, additional, Reale, Chiara, additional, Panteghini, Celeste, additional, Zorzi, Giovanna, additional, Eleopra, Roberto, additional, Erro, Roberto, additional, Carecchio, Miryam, additional, Garavaglia, Barbara, additional, Zech, Michael, additional, Romito, Luigi, additional, and Di Fonzo, Alessio, additional

Published
2023
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10. Evaluating the link between predation and pest control services in the mite world

Author

Lise Roy, Adrien Taudière, Julien Papaïx, Rumsais Blatrix, Geoffrey Chiron, Ghais Zriki, Olivier Bonato, and Jean‐Yves Barnagaud

Subjects
animal farming, assemblage dynamics, biological control, ecosystem services, predation, trophic interactions, Ecology, QH540-549.5
Abstract

Abstract Pest regulation by natural enemies has a strong potential to reduce the use of synthetic pesticides in agroecosystems. However, the effective role of predation as an ecosystem service remains largely speculative, especially with minute organisms such as mites. Predatory mites are natural enemies for ectoparasites in livestock farms. We tested for an ecosystem level control of the poultry pest Dermanyssus gallinae by other mites naturally present in manure in poultry farms and investigated differences among farming practices (conventional, free‐range, and organic). We used a multiscale approach involving (a) in vitro behavioral predation experiments, (b) arthropod inventories in henhouses with airborne DNA, and (c) a statistical model of covariations in mite abundances comparing farming practices. Behavioral experiments revealed that three mites are prone to feed on D. gallinae. Accordingly, we observed covariations between the pest and these three taxa only, in airborne DNA at the henhouse level, and in mites sampled from manure. In most situations, covariations in abundances were high in magnitude and their sign was positive. Predation on a pest happens naturally in livestock farms due to predatory mites. However, the complex dynamics of mite trophic network prevents the emergence of a consistent assemblage‐level signal of predation. Based on these results, we suggest perspectives for mite‐based pest control and warn against any possible disruption of ignored services through the application of veterinary drugs or pesticides.

Published
2020
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11. Dystonia‐ataxia syndrome with permanent torsional nystagmus caused by ECHS1 deficiency

Author

Dario Ronchi, Edoardo Monfrini, Sara Bonato, Veronica Mancinelli, Claudia Cinnante, Sabrina Salani, Andreina Bordoni, Patrizia Ciscato, Francesco Fortunato, Marianna Villa, Alessio Di Fonzo, Stefania Corti, Nereo Bresolin, and Giacomo P. Comi

Subjects
Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429
Abstract

Abstract Biallelic mutations in ECHS1, encoding the mitochondrial enoyl‐CoA hydratase, have been associated with mitochondrial encephalopathies with basal ganglia involvement. Here, we describe a novel clinical presentation consisting of dystonia‐ataxia syndrome with hearing loss and a peculiar torsional nystagmus observed in two adult siblings. The presence of a 0.9‐ppm peak at MR spectroscopy analysis suggested the accumulation of branched‐chain amino acids. Exome sequencing in index probands identified two ECHS1 mutations, one of which was novel (p.V82L). ECHS1 protein levels and residual activities were reduced in patients’ fibroblasts. This paper expands the phenotypic spectrum observed in patients with impaired valine catabolism.

Published
2020
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14. Quantification and role of innate lymphoid cell subsets in Chronic Obstructive Pulmonary Disease

Author

Evy E Blomme, Sharen Provoost, Elise G De Smet, Katrien C De Grove, Hannelore P Van Eeckhoutte, Joyceline De Volder, Philip M Hansbro, Matteo Bonato, Marina Saetta, Sara RA Wijnant, Fien Verhamme, Guy F Joos, Ken R Bracke, Guy G Brusselle, and Tania Maes

Subjects
innate lymphoid cells, ILC, COPD, innate inflammation, Immunologic diseases. Allergy, RC581-607
Abstract

Abstract Objectives Innate lymphoid cells (ILCs) secrete cytokines, such as IFN‐γ, IL‐13 and IL‐17, which are linked to chronic obstructive pulmonary disease (COPD). Here, we investigated the role of pulmonary ILCs in COPD pathogenesis. Methods Lung ILC subsets in COPD and control subjects were quantified using flow cytometry and associated with clinical parameters. Tissue localisation of ILC and T‐cell subsets was determined by immunohistochemistry. Mice were exposed to air or cigarette smoke (CS) for 1, 4 or 24 weeks to investigate whether pulmonary ILC numbers and activation are altered and whether they contribute to CS‐induced innate inflammatory responses. Results Quantification of lung ILC subsets demonstrated that ILC1 frequency in the total ILC population was elevated in COPD and was associated with smoking and severity of respiratory symptoms (COPD Assessment Test [CAT] score). All three ILC subsets localised near lymphoid aggregates in COPD. In the COPD mouse model, CS exposure in C57BL/6J mice increased ILC numbers at all time points, with relative increases in ILC1 in bronchoalveolar lavage (BAL) fluid. Importantly, CS exposure induced increases in neutrophils, monocytes and dendritic cells that remained elevated in Rag2/Il2rg‐deficient mice that lack adaptive immune cells and ILCs. However, CS‐induced CXCL1, IL‐6, TNF‐α and IFN‐γ levels were reduced by ILC deficiency. Conclusion The ILC1 subset is increased in COPD patients and correlates with smoking and severity of respiratory symptoms. ILCs also increase upon CS exposure in C57BL/6J mice. In the absence of adaptive immunity, ILCs contribute to CS‐induced pro‐inflammatory mediator release, but are redundant in CS‐induced innate inflammation.

Published
2021
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15. 3D Bioprinting of Macroporous Materials Based on Entangled Hydrogel Microstrands

Author

Benjamin Kessel, Mihyun Lee, Angela Bonato, Yann Tinguely, Enrico Tosoratti, and Marcy Zenobi‐Wong

Subjects
bioinks, cartilage, extrusion bioprinting, microgels, tissue engineering, Science
Abstract

Abstract Hydrogels are excellent mimetics of mammalian extracellular matrices and have found widespread use in tissue engineering. Nanoporosity of monolithic bulk hydrogels, however, limits mass transport of key biomolecules. Microgels used in 3D bioprinting achieve both custom shape and vastly improved permissivity to an array of cell functions, however spherical‐microbead‐based bioinks are challenging to upscale, are inherently isotropic, and require secondary crosslinking. Here, bioinks based on high‐aspect‐ratio hydrogel microstrands are introduced to overcome these limitations. Pre‐crosslinked, bulk hydrogels are deconstructed into microstrands by sizing through a grid with apertures of 40–100 µm. The microstrands are moldable and form a porous, entangled structure, stable in aqueous medium without further crosslinking. Entangled microstrands have rheological properties characteristic of excellent bioinks for extrusion bioprinting. Furthermore, individual microstrands align during extrusion and facilitate the alignment of myotubes. Cells can be placed either inside or outside the hydrogel phase with >90% viability. Chondrocytes co‐printed with the microstrands deposit abundant extracellular matrix, resulting in a modulus increase from 2.7 to 780.2 kPa after 6 weeks of culture. This powerful approach to deconstruct bulk hydrogels into advanced bioinks is both scalable and versatile, representing an important toolbox for 3D bioprinting of architected hydrogels.

Published
2020
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16. Celastrol: A lead compound that inhibits SARS‐CoV‐2 replication, the activity of viral and human cysteine proteases, and virus‐induced IL‐6 secretion

Author

Carlos A. Fuzo, Ronaldo B. Martins, Thais F. C. Fraga‐Silva, Martin K. Amstalden, Thais Canassa De Leo, Juliano P. Souza, Thais M. Lima, Lucia H. Faccioli, Débora Noma Okamoto, Maria Aparecida Juliano, Suzelei C. França, Luiz Juliano, Vania L. D. Bonato, Eurico Arruda, and Marcelo Dias‐Baruffi

Subjects
Molecular Docking Simulation, Interleukin-6, SARS-CoV-2, Drug Discovery, Humans, Protease Inhibitors, Viral Nonstructural Proteins, Pentacyclic Triterpenes, Antiviral Agents, Coronavirus 3C Proteases, COVID-19 Drug Treatment
Abstract

The global emergence of coronavirus disease 2019 (COVID-19) has caused substantial human casualties. Clinical manifestations of this disease vary from asymptomatic to lethal, and the symptomatic form can be associated with cytokine storm and hyperinflammation. In face of the urgent demand for effective drugs to treat COVID-19, we have searched for candidate compounds using in silico approach followed by experimental validation. Here we identified celastrol, a pentacyclic triterpene isolated from Tripterygium wilfordii Hook F, as one of the best compounds out of 39 drug candidates. Celastrol reverted the gene expression signature from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected cells and irreversibly inhibited the recombinant forms of the viral and human cysteine proteases involved in virus invasion, such as M

Published
2022

17. Maytansinol Functionalization: Towards Useful Probes for Studying Microtubule Dynamics

Author

Zlata Boiarska, Helena Pérez‐Peña, Anne‐Catherine Abel, Paola Marzullo, Beatriz Álvarez‐Bernad, Francesca Bonato, Benedetta Santini, Dragos Horvath, Daniel Lucena‐Agell, Francesca Vasile, Maurizio Sironi, J. Fernando Díaz, Andrea E. Prota, Stefano Pieraccini, Daniele Passarella, European Commission, Ministerio de Ciencia e Innovación (España), Boiarska, Zlata, Abel, Anne-Catherine, Marzullo, Paola, Álvarez-Bernad, Beatriz, Bonato, Francesca, Horvath, Dragos, Lucena-Agell, Daniel, Vasile, Francesca, Sironi, Maurizio, Díaz, José Fernando, Prota, Andrea E., Pieraccini, Stefano, and Passarella, D.

Subjects
microtubules, chemical probes, tubulin, maytansinol functionalization, Organic Chemistry, Settore CHIM/06 - Chimica Organica, General Chemistry, maytansinoids, Catalysis
Abstract

11 p.-7 fig.-4 tab. 7 schem., Maytansinoids are a successful class of natural and semisynthetic tubulin binders, known for their potent cytotoxic activity. Their wider application as cytotoxins and chemical probes to study tubulin dynamics has been held back by the complexity of natural product chemistry. Here we report the synthesis of long-chain derivatives and maytansinoid conjugates. We confirmed that bulky substituents do not impact their high activity or the scaffold's binding mode. These encouraging results open new avenues for the design of new maytansine-based probes., This work was supported by the H2020-MSCA-ITN-2019 (860070 TUBINTRAIN), Ministerio de Ciencia e Innovación PID2019-104545RB−I00 (JFD), Proyecto de Investigación en Neurociencia Fundación Tatiana Pérez de Guzmán el Bueno 2020, and by the European Union NextGenerationEU (J.F.D.). Open Access Funding provided by $INSTITUTION within the CRUI-CARE Agreement.

Published
2023

18. Benefits of a 12 week physical activity programme on muscle and bone health in people living with HIV

Author

Paola Cinque, Laura Galli, Pierluigi Viale, Gaspare Pavei, Giuseppe Banfi, C. Bertocchi, Giampiero Merati, Marco Borderi, Matteo Bonato, Antonio La Torre, Simona Bossolasco, Adriano Lazzarin, Giuseppe Balconi, Bonato, Matteo, Galli, Laura, Bossolasco, Simona, Bertocchi, Cecilia, Balconi, Giuseppe, Borderi, Marco, Viale, Pierluigi, Pavei, Gaspare, Merati, Giampiero, La Torre, Antonio, Lazzarin, Adriano, Banfi, Giuseppe, and Cinque, Paola

Subjects
Gerontology, business.industry, Muscles, QM1-695, Human immunodeficiency virus (HIV), Physical activity, HIV Infections, Diseases of the musculoskeletal system, medicine.disease_cause, Bone health, Exercise Therapy, RC925-935, Bone Density, Physiology (medical), Human anatomy, Medicine, Humans, Orthopedics and Sports Medicine, business, Letter to the Editor, Exercise
Published
2021

21. Intravenous thrombolysis + endovascular thrombectomy versus thrombolysis alone in large vessel occlusion mild stroke: a propensity score matched analysis

Author

Schwarz, Ghil, primary, Bonato, Sara, additional, Lanfranconi, Silvia, additional, Matusevicius, Marius, additional, Ghione, Isabella, additional, Valcamonica, Gloria, additional, Tsivgoulis, Georgios, additional, Paiva Nunes, Ana, additional, Mancuso, Michelangelo, additional, Zini, Andrea, additional, Candelaresi, Paolo, additional, Rand, Viiu‐Marika, additional, Comi, Giacomo P., additional, Mazya, Michael V., additional, and Ahmed, Niaz, additional

Published
2023
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23. Framework for multirisk climate scenarios across system receptors with application to the Metropolitan City of Venice

Author

Sambo, B., Bonato, Marta, Sperotto, A., Torresan, S., Furlan, E., Lambert, J.H., Linkov, I., Critto, A., Sambo, B., Bonato, Marta, Sperotto, A., Torresan, S., Furlan, E., Lambert, J.H., Linkov, I., and Critto, A.

Abstract

Climate change influences the frequency of extreme events that affect both human and natural systems. It requires systemic climate change adaptation to address the complexity of risks across multiple domains and tackle the uncertainties of future scenarios. This paper introduces a multirisk analysis of climate hazard, exposure, vulnerability, and risk severity, specifically designed to hotspot geographic locations and prioritize system receptors that are affected by climate-related extremes. The analysis is demonstrated for the Metropolitan City of Venice. Representative scenarios (RCP4.5 and RCP8.5) of climate threats (i.e., storm surges, pluvial flood, heat waves, and drought) are selected and represented by projections of Regional Climate Models for a 30-year period (2021–2050). A sample of results is as follows. First, an increase in the risk is largely due to drought, pluvial flood, and storm surge, depending on the areas of interest, with the overall situation worsening under the RCP8.5 scenario. Second, particular locations have colocated vulnerable receptors at higher risk, concentrated in the urban centers (e.g., housing, railways, roads) and along the coast (e.g., beaches, wetlands, primary sector). Third, risk communication of potential environmental and socio-economic losses via the multirisk maps is useful to stakeholders and public administration. Fourth, the multirisk maps recommend priorities for future investigation and risk management, such as collection of sensor data, elaboration of mitigations, and adaptation plans at hotspot locations.

Published
2023

24. Antiphospholipid‐Related Chorea: Two Case Reports and Role of Metabolic Imaging

Author

Lisa Lerjefors, Silvia Andretta, Giulia Bonato, Michele Mainardi, Miryam Carecchio, and Angelo Antonini

Subjects
antiphospholipid, PET, Neurology, chorea, Neurology (clinical), MRI
Abstract

Antiphospholipid syndrome (APS) is a complex acquired autoimmune disease with a wide clinical spectrum. Chorea is a rare neurological manifestation of APS.We report two elderly patients with APS-related chorea in whom functional imaging (18F-FDG positron emission tomography, FDG-PET) supported the diagnosis and compare our findings with existing literature.Among 142 clinical cases of antiphospholipid-related chorea found in literature, only 10 had undergone brain metabolic imaging. Striatal hypermetabolism was evident in all cases (6) that underwent FDG-PET cerebral imaging. Cerebral perfusion single photon emission computed tomography (SPECT) was normal in two cases, while the other two presented with basal ganglia hypoperfusion.Brain FDG-PET usually shows striatal hypometabolism in neurodegenerative types of chorea as opposed to striatal hypermetabolism observed in most cases of chorea from reversible etiologies, such as APS-related chorea. When a patient's clinical presentation is not clearly suggestive of either a neurodegenerative or autoimmune chorea, and first-line investigations are normal, FDG-PET may help in the differential diagnosis, especially in the presence of striatal hypermetabolism. SPECT data are less numerous and show either normal scans or basal ganglia hypoperfusion.

Published
2022

25. Forecasting Realized Volatility of International REITs

Author

Oguzhan Cepni, Rangan Gupta, Matteo Bonato, and Christian Pierdzioch

Subjects
Realized variance, Strategy and Management, International data, Interval (mathematics), Management Science and Operations Research, Predictive value, Computer Science Applications, Skewness, Modeling and Simulation, Real estate investment trust, Kurtosis, Econometrics, Economics, Statistics, Probability and Uncertainty, Realized volatility, REITs, Forecasting
Abstract

We use an international dataset on 5-minutes interval intraday data covering nine leading markets and regions to construct measures of realized volatility, realized jumps, realized skewness, and realized kurtosis of returns of international Real Estate Investment Trusts (REITs) over the daily period of September, 2008 to August, 2020. We study out-of-sample the predictive value of realized skewness and realized kurtosis for realized volatility over and above realized jumps, where we also differentiate between measures of ``good" realized volatility and ``bad" realized volatility. We find that realized skewness and realized kurtosis significantly improve forecasting performance at a daily, weekly, and monthly forecast horizon, and that their contribution to forecasting performance outweighs in terms of significance the contribution of realized jumps. Our results have important implications for investors and policymakers.

Published
2022

27. Maytansinol Functionalization: Towards Useful Probes for Studying Microtubule Dynamics

Author

Boiarska, Zlata, primary, Pérez‐Peña, Helena, additional, Abel, Anne‐Catherine, additional, Marzullo, Paola, additional, Álvarez‐Bernad, Beatriz, additional, Bonato, Francesca, additional, Santini, Benedetta, additional, Horvath, Dragos, additional, Lucena‐Agell, Daniel, additional, Vasile, Francesca, additional, Sironi, Maurizio, additional, Díaz, J. Fernando, additional, Prota, Andrea E., additional, Pieraccini, Stefano, additional, and Passarella, Daniele, additional

Published
2023
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29. Front Cover: Maytansinol Functionalization: Towards Useful Probes for Studying Microtubule Dynamics (Chem. Eur. J. 5/2023)

Author

Boiarska, Zlata, primary, Pérez‐Peña, Helena, additional, Abel, Anne‐Catherine, additional, Marzullo, Paola, additional, Álvarez‐Bernad, Beatriz, additional, Bonato, Francesca, additional, Santini, Benedetta, additional, Horvath, Dragos, additional, Lucena‐Agell, Daniel, additional, Vasile, Francesca, additional, Sironi, Maurizio, additional, Díaz, J. Fernando, additional, Prota, Andrea E., additional, Pieraccini, Stefano, additional, and Passarella, Daniele, additional

Published
2023
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30. Cell death induced by NLRP3–palmitate axis impairs pulmonary damage tolerance and aggravates immunopathology during obesity‐tuberculosis comorbidity

Author

Palma Albornoz, Sandra P, primary, Fraga‐Silva, Thais FC, additional, de Carvalho, Renan VH, additional, Rodrigues, Tamara S, additional, Gembre, Ana Flávia, additional, de Oliveira, Rômulo Silva, additional, de Souza, Fernanda Mesquita, additional, Corrêa, Giseli Furlan, additional, Ramalho, Leandra NZ, additional, Carlos, Daniela, additional, de Almeida, Danilo C, additional, Câmara, Niels OS, additional, Zamboni, Dario S, additional, Takahashi, Viviani Nardini, additional, Sorgi, Carlos A, additional, Faccioli, Lucia H, additional, Medeiros, Alexandra I, additional, Costa, Diego Luís, additional, and Bonato, Vânia LD, additional

Published
2023
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31. Maytansinol Functionalization: Towards Useful Probes for Studying Microtubule Dynamics

Author

Boiarska, Zlata, primary, Pérez‐Peña, Helena, additional, Abel, Anne‐Catherine, additional, Marzullo, Paola, additional, Álvarez‐Bernad, Beatriz, additional, Bonato, Francesca, additional, Santini, Benedetta, additional, Horvath, Dragos, additional, Lucena‐Agell, Daniel, additional, Vasile, Francesca, additional, Sironi, Maurizio, additional, Díaz, J. Fernando, additional, Prota, Andrea E., additional, Pieraccini, Stefano, additional, and Passarella, Daniele, additional

Published
2022
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35. Front Cover: Maytansinol Functionalization: Towards Useful Probes for Studying Microtubule Dynamics (Chem. Eur. J. 5/2023)

Author

Zlata Boiarska, Helena Pérez‐Peña, Anne‐Catherine Abel, Paola Marzullo, Beatriz Álvarez‐Bernad, Francesca Bonato, Benedetta Santini, Dragos Horvath, Daniel Lucena‐Agell, Francesca Vasile, Maurizio Sironi, J. Fernando Díaz, Andrea E. Prota, Stefano Pieraccini, and Daniele Passarella

Subjects
Organic Chemistry, General Chemistry, Catalysis
Published
2023

36. How is working length determination taught? A survey to assess what is recommended in undergraduate Schools of Dentistry in Brazil

Author

Tiago André Fontoura de Melo, Simone Bonato Luisi, Luara Cristina Rech, and Francisco Montagner

Subjects
business.industry, education, Dentistry, Computer-assisted web interviewing, Endodontics, Education, Clinical Practice, Surveys and Questionnaires, Humans, business, Psychology, Education, Dental, General Dentistry, Brazil
Abstract

OBJECTIVE To analyze what are the methods for working length (WLD) determination taught for undergraduate students in Brazilian Dental Schools and the perception of professors about the use of electronic WL determination in the clinical practice. METHODOLOGY An online questionnaire with eighteen closed questions was sent to 209 Schools of Dentistry in Brazil using the Google Forms Platform. The questionnaire was structured to analyze the perception of professors in the department of​endodontics about the method of working length determination taught in undergraduate courses in Dentistry. The data collected in the questionnaires were transferred to an Excel® spreadsheet and analyzed using absolute and relative frequencies. The non-parametric Mann Whitney test was used to compare groups. RESULTS Of the 209 schools contacted, 41 (19.61%) returned answers to the questionnaire. According to professors, electronic working length (WL) determination had a shorter length of time to perform it (P

Published
2021

38. Effects of 16 weeks of pyramidal and polarized training intensity distributions in well‐trained endurance runners

Author

Gabriele Gallo, Matteo Bonato, Luca Filipas, and Roberto Codella

Subjects
Male, Rating of perceived exertion, medicine.medical_specialty, Nutritional Status, Physical Therapy, Sports Therapy and Rehabilitation, Running, Running time, Oxygen Consumption, Physical medicine and rehabilitation, Heart Rate, Periodization, Training intensity, Heart rate, Physical Endurance, medicine, Blood lactate, Humans, Orthopedics and Sports Medicine, Lactic Acid, Training load, Mathematics
Abstract

The aim of this study was to investigate the effects of four different training periodizations, based on two different training intensity distributions during a 16-week training block in well-trained endurance runners. Sixty well-trained male runners were divided into four groups. Each runner completed one of the following 16-week training interventions: a pyramidal periodization (PYR); a polarized periodization (POL); a pyramidal periodization followed by a polarized periodization (PYR → POL); and a polarized periodization followed by a pyramidal periodization (POL → PYR). The PYR and POL groups trained with a pyramidal or polarized distribution for 16 weeks. To allow for the change in periodization for the PYR → POL and POL → PYR groups, the 16-week intervention was split into two 8-week phases, starting with pyramidal or polarized distribution and then switching to the other. The periodization patterns were isolated manipulations of training intensity distribution, while training load was kept constant. Participants were tested pre-, mid- and post-intervention for body mass, velocity at 2 and 4 mmol·L-1 of blood lactate concentration (vBLa2, vBLa4), absolute and relative peak oxygen consumption ( V˙O2peak ) and 5-km running time trial performance. There were significant group × time interactions for relative V˙O2peak (p

Published
2021

40. El Niño, La Niña, and forecastability of the realized variance of agricultural commodity prices: Evidence from a machine learning approach

Author

Matteo Bonato, Oğuzhan Çepni, Rangan Gupta, and Christian Pierdzioch

Subjects
Agricultural commodities, Strategy and Management, Modeling and Simulation, El Niño and La Niña, Realized variance, Random forests, Management Science and Operations Research, Statistics, Probability and Uncertainty, Forecasting, Computer Science Applications
Abstract

We examine the predictive value of El Niño and La Niña weather episodes for the subsequent realized variance of 16 agricultural commodity prices. To this end, we use high-frequency data covering the period from 2009 to 2020 to estimate the realized variance along realized skewness, realized kurtosis, realized jumps, and realized upside and downside tail risks as control variables. Accounting for the impact of the control variables as well as spillover effects from the realized variances of the other agricultural commodities in our sample, we estimate an extended heterogeneous autoregressive (HAR) model by means of random forests to capture in a purely data-driven way potentially nonlinear links between El Niño and La Niña and the subsequent realized variance. We document such nonlinear links, and that El Niño and La Niña increase forecast accuracy, especially at longer forecast horizons, for several of the agricultural commodities that we study in this research.

Published
2022

42. Celastrol: A lead compound that inhibits SARS‐CoV‐2 replication, the activity of viral and human cysteine proteases, and virus‐induced IL‐6 secretion

Author

Fuzo, Carlos A., primary, Martins, Ronaldo B., additional, Fraga‐Silva, Thais F. C., additional, Amstalden, Martin K., additional, Canassa De Leo, Thais, additional, Souza, Juliano P., additional, Lima, Thais M., additional, Faccioli, Lucia H., additional, Okamoto, Débora Noma, additional, Juliano, Maria Aparecida, additional, França, Suzelei C., additional, Juliano, Luiz, additional, Bonato, Vania L. D., additional, Arruda, Eurico, additional, and Dias‐Baruffi, Marcelo, additional

Published
2022
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43. Use of Machine Learning for the Estimation of Down‐ and Up‐Link Field Exposure in Multi‐Source Indoor WiFi Scenarios

Author

Paolo Ravazzani, Wout Joseph, Marta Parazzini, Silvia Gallucci, David Plets, Gabriella Tognola, Serena Fiocchi, Emma Chiaramello, Marta Bonato, and Luc Martens

Subjects
Technology and Engineering, business.product_category, exposure assessment, Mean squared error, Radio Waves, PREDICTION, Physiology, Computer science, Neural Network, Biophysics, Network, Machine learning, computer.software_genre, Field (computer science), Machine Learning, indoor RF exposure, Position (vector), Humans, Radiology, Nuclear Medicine and imaging, ALGORITHM, Bioelectromagnetics, Research Articles, Neural, Artificial neural network, business.industry, General Medicine, Transmission (telecommunications), Laptop, Neural Networks, Computer, Artificial intelligence, business, computer, Multi-source, Research Article
Abstract

A novel Machine Learning (ML) method based on Neural Networks (NN) is proposed to assess radio-frequency (RF) exposure generated by WiFi sources in indoor scenarios. The aim was to build an NN capable of addressing the complexity and variability of real-life exposure setups, including the effects of not only down-link transmission access points (APs) but also up-link transmission by different sources (e.g. laptop, printers, tablets, and smartphones). The NN was fed with easy to be found data, such as the position and type of WiFi sources (APs, clients, and other users) and the position and material characteristics (e.g. penetration loss) of walls. The NN model was assessed using an additional new layout, distinct from that one used to build and optimize the NN coefficients. The NN model achieved a remarkable field prediction accuracy across exposure conditions in both layouts, with a median prediction error of -0.4 to 0.6 dB and a root mean square error of 2.5-5.1 dB, compared with the target electric field estimated by a deterministic indoor network planner. The proposed approach performs well for the different layouts and is thus generally used to assess RF exposure in indoor scenarios. (c) 2021 The Authors. Bioelectromagnetics published by Wiley Periodicals LLC on behalf of Bioelectromagnetics Society.

Published
2021

44. Detecting Sensitive Mobility Features for Parkinson's Disease Stages Via Machine Learning

Author

Jesse M. Cedarbaum, Theresa Ellis, Paolo Bonato, Lynn Rochester, Elisa Pelosin, Lena Granovsky, Nir Giladi, Michal Melamed, Quincy J. Almeida, Laura Avanzino, Chris J. Hass, Andrea Cereatti, Jamie L. Hamilton, Alice Nieuwboer, Avner Thaler, Mor Ben Or Frank, Bastiaan R. Bloem, Jeffrey M. Hausdorff, Maidan Inbal, Richard Camicioli, Anat Mirelman, Julia C Shirvan, Silvia Del Din, and Ugo Della Croce

Subjects
0301 basic medicine, medicine.medical_specialty, Parkinson's disease, accelerometer, gait, machine learning, wearables, Cross-Sectional Studies, Gait, Humans, Machine Learning, Postural Balance, Time and Motion Studies, Walking, Parkinson Disease, STRIDE, Timed Up and Go test, 03 medical and health sciences, 0302 clinical medicine, Physical medicine and rehabilitation, medicine, business.industry, Cognition, Disorders of movement Donders Center for Medical Neuroscience [Radboudumc 3], medicine.disease, Trunk, Preferred walking speed, 030104 developmental biology, Neurology, Feature (computer vision), Neurology (clinical), business, human activities, 030217 neurology & neurosurgery
Abstract

Contains fulltext : 238527.pdf (Publisher’s version ) (Closed access) BACKGROUND: It is not clear how specific gait measures reflect disease severity across the disease spectrum in Parkinson's disease (PD). OBJECTIVE: To identify the gait and mobility measures that are most sensitive and reflective of PD motor stages and determine the optimal sensor location in each disease stage. METHODS: Cross-sectional wearable-sensor records were collected in 332 patients with PD (Hoehn and Yahr scale I-III) and 100 age-matched healthy controls. Sensors were adhered to the participant's lower back, bilateral ankles, and wrists. Study participants walked in a ~15-meter corridor for 1 minute under two walking conditions: (1) preferred, usual walking speed and (2) walking while engaging in a cognitive task (dual-task). A subgroup (n = 303, 67% PD) also performed the Timed Up and Go test. Multiple machine-learning feature selection and classification algorithms were applied to discriminate between controls and PD and between the different PD severity stages. RESULTS: High discriminatory values were found between motor disease stages with mean sensitivity in the range 72%-83%, specificity 69%-80%, and area under the curve (AUC) 0.76-0.90. Measures from upper-limb sensors best discriminated controls from early PD, turning measures obtained from the trunk sensor were prominent in mid-stage PD, and stride timing and regularity were discriminative in more advanced stages. CONCLUSIONS: Applying machine-learning to multiple, wearable-derived features reveals that different measures of gait and mobility are associated with and discriminate distinct stages of PD. These disparate feature sets can augment the objective monitoring of disease progression and may be useful for cohort selection and power analyses in clinical trials of PD. © 2021 International Parkinson and Movement Disorder Society.

Published
2021

46. Bacterial dynamics of sugarcane silage in the tropics

Author

Luiz Gustavo Nussio, Paula de Almeida Carvalho-Estrada, Gisele Bonato Muraro, Maximiliano Pasetti, and Mateus Castilho Santos

Subjects
Silage, 0303 health sciences, Novosphingobium, Bacteria, biology, 030306 microbiology, food and beverages, Acinetobacter, biology.organism_classification, SILAGEM, Microbiology, Saccharum, 03 medical and health sciences, Burkholderia, Ralstonia, RNA, Ribosomal, 16S, Lactobacillus, Fermentation, Leuconostoc, Food science, Ecology, Evolution, Behavior and Systematics, 030304 developmental biology
Abstract

The objective of this study was to evaluate changes in the bacterial community in sugarcane silage, in distinct soil types along the storage period. We depicted the bacterial community associated with sugarcane, before and after ensiling, through a massive sequencing of the gene 16S rRNA using MiSeq platform. The ensilage process shifted the composition of the bacterial community from the heterofermentative lactic acid bacteria Leuconostoc to bacteria belonging to the genera Acinetobacter, Ralstonia and Novosphingobium. However, this shift did not convey statically significant differences in alfa diversity metrics. In addition, similarity percentage analysis showed that the bacterial Operational Taxonomic Units that were primarily responsible for the observed differences were Leuconostoc, Pseudomonas, Acinetobacter, Ralstonia, Fructobacillus, Novosphingobium, Lactobacillus, Burkholderia and Clostridium sensu stricto 1. The storage period was the most important factor responsible for changes in the bacterial community of silages. Results confirmed that the type of soil did not influence the dissimilarity found among samples.

Published
2021

48. Engineering Inflammation‐Resistant Cartilage: Bridging Gene Therapy and Tissue Engineering

Author

Angela Bonato, Philipp Fisch, Simone Ponta, David Fercher, Mikko Manninen, Daniel Weber, Kari K. Eklund, Goncalo Barreto, and Marcy Zenobi‐Wong

Subjects
Biomaterials, gene editing, inflammation, cartilage tissue engineering, Biomedical Engineering, Pharmaceutical Science
Abstract

Articular cartilage defects caused by traumatic injury rarely heal spontaneously and predispose into post-traumatic osteoarthritis. In the current autologous cell-based treatments the regenerative process is often hampered by the poor regenerative capacity of adult cells and the inflammatory state of the injured joint. The lack of ideal treatment options for cartilage injuries motivated the authors to tissue engineer a cartilage tissue which would be more resistant to inflammation. A clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9 knockout of TGF-beta-activated kinase 1 (TAK1) gene in polydactyly chondrocytes provides multivalent protection against the signals that activate the pro-inflammatory and catabolic NF-kappa B pathway. The TAK1-KO chondrocytes encapsulate into a hyaluronan hydrogel deposit copious cartilage extracellular matrix proteins and facilitate integration onto native cartilage, even under proinflammatory conditions. Furthermore, when implanted in vivo, compared to WT fewer pro-inflammatory M1 macrophages invade the cartilage, likely due to the lower levels of cytokines secreted by the TAK1-KO polydactyly chondrocytes. The engineered cartilage thus represents a new paradigm-shift for the creation of more potent and functional tissues for use in regenerative medicine., Advanced Healthcare Materials, 12 (17), ISSN:2192-2640, ISSN:2192-2659

Published
2023

49. Roflumilast protects against spatial memory impairments and exerts anti‐inflammatory effects after transient global cerebral ischemia

Author

Jos Prickaerts, Humberto Milani, Rúbia Maria Weffort de Oliveira, Patrícia Souza Bonfim de Mendonça, Jéssica Mendes Bonato, Erika Meyer, RS: MHeNs - R3 - Neuroscience, and Psychiatrie & Neuropsychologie

Subjects
Cyclopropanes, Doublecortin Protein, roflumilast, Ischemia, Aminopyridines, Hippocampus, Pharmacology, transient global cerebral ischemia, Brain Ischemia, cognitive deficit, 03 medical and health sciences, 0302 clinical medicine, medicine, Animals, Roflumilast, Neuroinflammation, Spatial Memory, 030304 developmental biology, 0303 health sciences, Glial fibrillary acidic protein, biology, business.industry, General Neuroscience, Neurogenesis, medicine.disease, Rats, Doublecortin, nervous system, Ischemic Attack, Transient, Benzamides, biology.protein, NeuN, phosphodiesterase inhibitor, business, 030217 neurology & neurosurgery, medicine.drug
Abstract

Phosphodiesterase 4 (PDE4) inhibitors have been shown to present beneficial effects in cerebral ischemic injury because of their ability to improve cognition and target different phases and mechanisms of cerebral ischemia, including apoptosis, neurogenesis, angiogenesis, and inflammation. The present study investigated whether repeated treatment with the PDE4 inhibitor roflumilast rescued memory loss and attenuated neuroinflammation in rats following transient global cerebral ischemia (TGCI). TGCI caused memory impairments, neuronal loss (reflected by Neuronal nuclei (NeuN) immunoreactivity), and compensatory neurogenesis (reflected by doublecortin (DCX) immunoreactivity) in the hippocampus. Also, increases in the protein expression of the phosphorylated response element-binding protein (pCREB) and inflammatory markers such as the glial fibrillary acidic protein (GFAP) and ionized calcium-binding adaptor molecule 1 (Iba-1), were detected in the hippocampus in TGCI rats. Repeated treatment with roflumilast (0.003 and 0.01 mg/kg) prevented spatial memory deficits without promoting hippocampal protection in ischemic animals. Roflumilast increased the levels of pCREB, arginase-1, interleukin (IL) 4, and IL-10 in the hippocampus 21 days after TGCI. These data suggest a protective effect of roflumilast against functional sequelae of cerebral ischemia, which might be related to its anti-inflammatory properties.

Published
2021

50. NEOTROPICAL FRESHWATER FISHES : A dataset of occurrence and abundance of freshwater fishes in the Neotropics

Author

Tonella, Lívia Helena, primary, Ruaro, Renata, additional, Daga, Vanessa Salete, additional, Garcia, Diego Azevedo Zoccal, additional, Vitorino, Oscar Barroso, additional, Lobato‐de Magalhães, Tatiana, additional, Reis, Roberto Esser, additional, Di Dario, Fabio, additional, Petry, Ana Cristina, additional, Mincarone, Michael Maia, additional, Assis Montag, Luciano Fogaça, additional, Pompeu, Paulo Santos, additional, Teixeira, Adonias Aphoena Martins, additional, Carmassi, Alberto Luciano, additional, Sánchez, Alberto J., additional, Giraldo Pérez, Alejandro, additional, Bono, Alessandra, additional, Datovo, Aléssio, additional, Flecker, Alexander S., additional, Sanches, Alexandra, additional, Godinho, Alexandre Lima, additional, Matthiensen, Alexandre, additional, Peressin, Alexandre, additional, Hilsdorf, Alexandre Wagner Silva, additional, Barufatti, Alexéia, additional, Hirschmann, Alice, additional, Jung, Aline, additional, Cruz‐Ramírez, Allan K., additional, Braga Silva, Alline, additional, Cunico, Almir Manoel, additional, Saldanha Barbosa, Amanda, additional, Barradas, Amauri de Castro, additional, Rêgo, Ana Carolina Lacerda, additional, Franco, Ana Clara Sampaio, additional, Costa, Ana Paula Lula, additional, Vidotto‐Magnoni, Ana Paula, additional, Ferreira, Anderson, additional, Kassner Filho, Anderson, additional, Nobile, André Batista, additional, Magalhães, André Lincoln Barroso, additional, Teixeira da Silva, André, additional, Bialetzki, Andréa, additional, Gomes, Andréa Cristina dos Santos Maroclo, additional, Nobre, Andrezza Bellotto, additional, Casimiro, Armando Cesar Rodrigues, additional, Angulo Sibaja, Arturo, additional, Capelli dos Santos, Arthur Alexandre, additional, Araújo, Átila Rodrigues, additional, Frota, Augusto, additional, Quirino, Bárbara Angélio, additional, Ferreira, Beatriz Moreira, additional, Albuquerque, Bianca Weiss, additional, Meneses, Bruna Arbo, additional, Oliveira, Brunno Tolentino, additional, Torres Parahyba Campos, Bruno Augusto, additional, Gonçalves, Bruno Bastos, additional, Kubiak, Bruno Busnello, additional, Silveira Prudente, Bruno, additional, Gorini de Araujo Passos Pacheco, Bruno, additional, Nakagawa, Bruno Kazuo, additional, Nascimento, Bruno Tayar Marinho, additional, Maia, Calebe, additional, Cantagallo Devids, Camila, additional, Rezende, Carla Ferreira, additional, Muñoz‐Mendoza, Carla, additional, Peres, Carlos A., additional, Sousa Rodrigues Filho, Carlos Alberto, additional, Lucena, Carlos Alberto Santos, additional, Fernandes, Carlos Alexandre, additional, Kasper, Carlos Benhur, additional, DoNascimiento, Carlos, additional, Emidio, Carmino, additional, Carrillo‐Moreno, Carolina, additional, Machado, Carolina, additional, Pera, Carolina, additional, Hartmann, Caroline, additional, Pringle, Catherine M., additional, Leal, Cecília Gontijo, additional, Jézéquel, Céline, additional, Harrod, Chris, additional, Rosa, Clarissa Alves, additional, Quezada‐Romegialli, Claudio, additional, Pott, Crisla Maciel, additional, Larentis, Crislei, additional, Nascimento, Cristiane A. S., additional, Silva Gonçalves, Cristina, additional, Cunha, Cristina Jaques, additional, Pisicchio, Cristina Moreira, additional, Carvalho, Daniel Cardoso, additional, Galiano, Daniel, additional, Gomez‐Uchida, Daniel, additional, Santana, Daniel Oliveira, additional, Salas Johnson, Daniel, additional, Petsch, Danielle Katharine, additional, Freitas, Danielly Torres Hashiguti, additional, Bailly, Dayani, additional, Machado, Débora Ferreira, additional, Carvalho, Débora Reis, additional, Topan, Dhyego Hamilton, additional, Cañas‐Rojas, Diego, additional, Silva, Diego, additional, Freitas‐Souza, Diogo, additional, Lima‐Júnior, Dilermando Pereira, additional, Piscor, Diovani, additional, Moraes, Djalma Pereira, additional, Viana, Douglas, additional, Caetano, Dyego Leonardo Ferraz, additional, Gubiani, Éder André, additional, Okada, Edson K., additional, Amaral, Eduardo Cazuni, additional, Brambilla, Eduardo Meneguzzi, additional, Cunha, Eduardo Ribeiro, additional, Kashiwaqui, Elaine Antoniassi Luiz, additional, Rocha, Elise Amador, additional, Barp, Elisete Ana, additional, Costa Fraga, Elmary, additional, D'Bastiani, Elvira, additional, Zandonà, Eugenia, additional, Dary, Eurizângela Pereira, additional, Benedito, Evanilde, additional, Barba‐Macías, Everardo, additional, Calvache Uvidia, Evelyn Vanessa, additional, Fonseca, Fabiana Luques, additional, Ferreira, Fabiane Silva, additional, Lima, Fábio, additional, Maffei, Fábio, additional, Porto‐Foresti, Fábio, additional, Teresa, Fabrício Barreto, additional, Andrade Frehse, Fabrício, additional, Oliveira, Fagner Júnior M., additional, Silva, Felipe Pessoa, additional, Lima, Felipe Pontieri, additional, Prado, Fernanda Dotti, additional, Jerep, Fernando Camargo, additional, Vieira, Fernando Emmanuel Gonçalves, additional, Gertum Becker, Fernando, additional, Carvalho, Fernando Rogério, additional, Ubaid, Flávio Kulaif, additional, Teixeira, Francisco Keilo, additional, Provenzano Rizzi, Francisco, additional, Severo‐Neto, Francisco, additional, Villamarín, Francisco, additional, Mello, Franco Teixeira, additional, Keppeler, Friedrich Wolfgang, additional, Avila Batista, Gabriel, additional, Menezes Yazbeck, Gabriel, additional, Tesitore, Giancarlo, additional, Salvador, Gilberto Nepomuceno, additional, Soteroruda Brito, Gita Juan, additional, Carmassi, Giulianna Rondineli, additional, Kurchevski, Gregório, additional, Goyenola, Guillermo, additional, Pereira, Hasley Rodrigo, additional, Alvez, Helen Jamille Fernandes Silva, additional, Prado, Helena Alves, additional, Pinho, Henrique Ledo Lopes, additional, Sousa, Híngara Leão, additional, Bornatowski, Hugo, additional, Oliveira Barbosa, Hugo, additional, Tobes, Ibon, additional, Paiva Affonso, Igor, additional, Queiroz, Igor Raposo, additional, Vila, Irma, additional, Negrete, Iván Vinicio Jácome, additional, Prado, Ivo Gavião, additional, Vitule, Jean Ricardo Simões, additional, Figueiredo‐Filho, Jessé, additional, Gonzalez, Jessica Antúnez, additional, Faria Falcão, Jéssica Caroline, additional, Teixeira, Jéssica Vieira, additional, Pincheira‐Ulbrich, Jimmy, additional, Silva, Jislaine Cristina, additional, Araujo Filho, João Antonio, additional, Silva, João Fernando Marques, additional, Genova, João Gabriel, additional, Giovanelli, João Gabriel Ribeiro, additional, Andriola, João Vitor Perin, additional, Alves, Jonatas, additional, Valdiviezo‐Rivera, Jonathan, additional, Brito, Jorge, additional, Botero, Jorge Iván Sánchez, additional, Liotta, Jorge, additional, Ramirez, Jorge Luis, additional, Marinho, Jorge Reppold, additional, Birindelli, José Luís Olivan, additional, Novaes, Jorge, additional, Hawes, Joseph E., additional, Ribolli, Josiane, additional, Rivadeneira, Juan Francisco, additional, Schmitter‐Soto, Juan Jacobo, additional, Assis, Juliana Camara, additional, Silva, Juliana Paulo, additional, Santos, Juliana Silveira, additional, Wingert, Juliana, additional, Wojciechowski, Juliana, additional, Bogoni, Juliano André, additional, Ferrer, Juliano, additional, Solórzano, Julio César Jut, additional, Sá‐Oliveira, Júlio César, additional, Vaini, Jussara Oliveira, additional, Silva Ingenito, Leonardo Ferreira, additional, Contreras Palma, Kamila, additional, Orlandi Bonato, Karine, additional, Lima Pereira, Karla Dayane, additional, Santos Sousa, Kassiano, additional, Borja‐Acosta, Kevin Giancarlo, additional, Carneiro, Laís, additional, Faria, Larissa, additional, Oliveira, Leonardo Brito, additional, Resende, Leonardo Cardoso, additional, Oliveira Silva, Leonardo, additional, Rodrigues, Leydiane Nunes, additional, Guarderas Flores, Lida, additional, Martins, Lidiane, additional, Tonini, Lorena, additional, Braga, Lorrana Thaís Máximo Durville, additional, Gomes, Louise Cristina, additional, Fries, Lucas, additional, Silva, Lucas Gonçalves, additional, Jarduli, Lucas Ribeiro, additional, Lima, Luciano Benedito, additional, Gomes Fischer, Luciano, additional, Wolff, Luciano Lazzarini, additional, Santos, Luciano Neves, additional, Bezerra, Luis Artur Valões, additional, Sarmento Soares, Luisa Maria, additional, Manna, Luisa Resende, additional, Duboc, Luiz Fernando, additional, Santos Ribas, Luiz Guilherme, additional, Malabarba, Luiz Roberto, additional, Brito, Marcelo Fulgêncio Guedes, additional, Braga, Marcelo Rennó, additional, Almeida, Marcelo Silva, additional, Sily, Maria Cecília, additional, Barros, Maria Claudene, additional, Nascimento, Maria Histelle Sousa, additional, Souza Delapieve, Maria Laura, additional, Piedade, Maria Teresa Fernandez, additional, Tagliaferro, Marina, additional, Pinna, Mário Cesar Cardoso, additional, Yánez‐Muñoz, Mario H., additional, Orsi, Mário Luís, additional, Rosa, Marlon Ferraz, additional, Bastiani, Marlos, additional, Stefani, Marta Severino, additional, Moreno, Martha Elena Valdez, additional, Carvalho, Mateus Moreira, additional, Kütter, Mateus Tavares, additional, Freitas, Matheus Oliveira, additional, Cañas‐Merino, Mauricio, additional, Cetra, Mauricio, additional, Herrera‐Madrid, Mauricio, additional, Petrucio, Mauricio Mello, additional, Galetti, Mauro, additional, Salcedo, Miguel Ángel, additional, Pascual, Miguel, additional, Ribeiro, Milton Cesar, additional, Abelha, Milza Celi Fedatto, additional, Silva, Mônica Andrade, additional, Araujo, Mônica Pacheco, additional, Dias, Murilo Sversut, additional, Guimaraes Sales, Naiara, additional, Benone, Naraiana Loureiro, additional, Sartor, Natane, additional, Fontoura, Nelson Ferreira, additional, Souza Trigueiro, Nicholas Silvestre, additional, Álvarez‐Pliego, Nicolás, additional, Shibatta, Oscar Akio, additional, Tedesco, Pablo A., additional, Lehmann Albornoz, Pablo Cesar, additional, Santos, Pablo Henrique Fernandes, additional, Freitas, Pâmela Virgolino, additional, Fagundes, Patricia Calegari, additional, Freitas, Patrícia Domingues, additional, Mena‐Valenzuela, Patricio, additional, Tufiño, Paul, additional, Catelani, Paula Araujo, additional, Peixoto, Paula, additional, Ilha, Paulo, additional, Aquino, Pedro De Podestà Uchôa, additional, Gerhard, Pedro, additional, Carvalho, Pedro Hollanda, additional, Jiménez‐Prado, Pedro, additional, Galetti, Pedro Manoel, additional, Borges, Pedro Paulino, additional, Nitschke, Pedro Peixoto, additional, Manoel, Pedro Sartori, additional, Bernardes Perônico, Phamela, additional, Soares, Philip Teles, additional, Piana, Pitágoras Augusto, additional, Oliveira Cunha, Priscila, additional, Plesley, Priscila, additional, Souza, Rafael Couto Rosa, additional, Rosa, Rafael Rogério, additional, El‐Sabaawi, Rana W., additional, Rodrigues, Raoni Rosa, additional, Covain, Raphael, additional, Loures, Raquel Coelho, additional, Braga, Raul Rennó, additional, Ré, Reginaldo, additional, Bigorne, Rémy, additional, Cassemiro Biagioni, Renata, additional, Silvano, Renato Azevedo Matias, additional, Dala‐Corte, Renato Bolson, additional, Martins, Renato Tavares, additional, Rosa, Ricardo, additional, Sartorello, Ricardo, additional, Almeida Nobre, Rodrigo, additional, Bassar, Ronald D., additional, Gurgel‐Lourenço, Ronaldo César, additional, Pinheiro, Ronaldo Fernando Martins, additional, Carneiro, Ronaldo Leal, additional, Florido, Rosa, additional, Mazzoni, Rosana, additional, Silva‐Santos, Rosane, additional, Paula Santos, Rosiane, additional, Delariva, Rosilene Luciana, additional, Hartz, Sandra Maria, additional, Brosse, Sebastien, additional, Althoff, Sérgio Luiz, additional, Nóbrega Marinho Furtado, Shaka, additional, Lima‐Junior, Sidnei Eduardo, additional, Lustosa Costa, Silvia Yasmin, additional, Arrolho, Solange, additional, Auer, Sonya K., additional, Bellay, Sybelle, additional, Fátima Ramos Guimarães, Taís, additional, Francisco, Talitha Mayumi, additional, Mantovano, Tatiane, additional, Gomes, Tatyana, additional, Ramos, Telton Pedro Anselmo, additional, Assis Volpi, Thaís, additional, Emiliano, Thais Moura, additional, Barbosa, Thiago Augusto Pedrosa, additional, Balbi, Thiago José, additional, Silva Campos, Thiago Nascimento, additional, Silva, Thiago Teixeira, additional, Occhi, Thiago Vinícius Trento, additional, Garcia, Thiely Oliveira, additional, Silva Freitas, Tiago Magalhães, additional, Begot, Tiago Octavio, additional, Silveira, Tony Leandro Rezende, additional, Lopes, Ueslei, additional, Schulz, Uwe Horst, additional, Fagundes, Valéria, additional, Batista da Silva, Valéria Flávia, additional, Azevedo‐Santos, Valter M., additional, Ribeiro, Vanessa, additional, Tibúrcio, Vanessa Graciele, additional, Almeida, Vera Lúcia Lescano, additional, Isaac‐Nahum, Victoria J., additional, Abilhoa, Vinicius, additional, Campos, Vinicius Farias, additional, Kütter, Vinicius Tavares, additional, Cionek, Vivian de Mello, additional, Prodocimo, Viviane, additional, Vicentin, Wagner, additional, Martins, Waldney Pereira, additional, Moraes Pires, Walna Micaelle, additional, da Graça, Weferson Júnio, additional, Smith, Welber Senteio, additional, Dáttilo, Wesley, additional, Aguirre Maldonado, Windsor Efren, additional, Gomes Ponce de Carvalho Rocha, Yuri, additional, Súarez, Yzel Rondon, additional, and de Lucena, Zilda Margarete Seixas, additional

Published
2022
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