Search

Your search keyword '"Bollag W"' showing total 13 results
Start Over Author "Bollag W" Publisher wiley
13 results on '"Bollag W"'

13. Pine oil effects on chemical and thermal injury in mice and cultured mouse dorsal root ganglion neurons.

Author

Clark SP, Bollag WB, Westlund KN, Ma F, Falls G, Xie D, Johnson M, Isales CM, and Bhattacharyya MH

Subjects
Adenosine Triphosphate, Animals, Capsaicin, Cells, Cultured, Dermatitis drug therapy, Disease Models, Animal, Hyperalgesia drug therapy, Male, Mice, Mice, Inbred C57BL, Mice, Inbred ICR, Neurons drug effects, Neurons metabolism, Pain drug therapy, Resins, Plant pharmacology, Skin pathology, Burns drug therapy, Ganglia, Spinal drug effects, Pinus chemistry, Plant Oils pharmacology
Abstract

A commercial resin-based pine oil (PO) derived from Pinus palustris and Pinus elliottii was the major focus of this investigation. Extracts of pine resins, needles, and bark are folk medicines commonly used to treat skin ailments, including burns. The American Burn Association estimates that 500,000 people with burn injuries receive medical treatment each year; one-half of US burn victims are children, most with scald burns. This systematic study was initiated as follow-up to personal anecdotal evidence acquired over more than 10 years by MH Bhattacharyya regarding PO's efficacy for treating burns. The results demonstrate that PO counteracted dermal inflammation in both a mouse ear model of contact irritant-induced dermal inflammation and a second degree scald burn to the mouse paw. Furthermore, PO significantly counteracted the tactile allodynia and soft tissue injury caused by the scald burn. In mouse dorsal root ganglion neuronal cultures, PO added to the medium blocked adenosine triphosphate-activated, but not capsaicin-activated, pain pathways, demonstrating specificity. These results together support the hypothesis that a pine-oil-based treatment can be developed to provide effective in-home care for second degree burns., (Copyright © 2013 John Wiley & Sons, Ltd.)

Published
2014
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results