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4 results on '"Block LH"'

1. Low-dose inhalation therapy with nitric oxide and oxygen--implications for long-term application in patients with COPD and pulmonary hypertension.

Author

Leitner C, Ziesche R, Zimpfer M, Block LH, and Germann P

Subjects
Administration, Inhalation, Blood Pressure drug effects, Cardiac Output drug effects, Humans, Hypertension, Pulmonary drug therapy, Lung blood supply, Lung Diseases, Obstructive drug therapy, Nitric Oxide administration & dosage, Nitric Oxide Synthase metabolism, Oxygen blood, Pulmonary Artery, Stroke Volume drug effects, Vascular Resistance drug effects, Ventricular Function, Right drug effects, Hypertension, Pulmonary therapy, Lung Diseases, Obstructive therapy, Nitric Oxide therapeutic use, Oxygen Inhalation Therapy
Published
1996

2. Regulation of human endothelial nitric oxide synthase by hypoxia and inflammation in human pulmonary arteries--implications for the therapy of pulmonary hypertension in COPD patients.

Author

Ziesche R, Petkov V, Mosgöller W, and Block LH

Subjects
Arteritis pathology, Cell Division, Cell Movement, Cells, Cultured, Down-Regulation, Endothelium, Vascular pathology, Gene Expression Regulation, Enzymologic, Humans, Hypertension, Pulmonary therapy, Hypoxia pathology, Inflammation Mediators physiology, Lung Diseases, Obstructive enzymology, Muscle, Smooth, Vascular enzymology, Muscle, Smooth, Vascular pathology, Nitric Oxide Synthase antagonists & inhibitors, Nitric Oxide Synthase genetics, Pulmonary Artery enzymology, Arteritis metabolism, Endothelium, Vascular enzymology, Hypoxia enzymology, Lung blood supply, Nitric Oxide Synthase metabolism
Published
1996

4. Effects of aspirin on platelet aggregation as a function of dosage and time.

Author

Paccioretti MJ and Block LH

Subjects
Adult, Aspirin administration & dosage, Dose-Response Relationship, Drug, Female, Humans, In Vitro Techniques, Male, Prostaglandin Antagonists pharmacology, Prostaglandins biosynthesis, Regression Analysis, Time Factors, Aspirin pharmacology, Platelet Aggregation drug effects
Abstract

There are reports on the effects of high doses of aspirin on the alteration of platelet aggregation. In our study single doses of aspirin ranging from 81 to 325 mg were given orally to 7 normal subjects. In vitro measurement of platelet aggregation was carried out as a function of time. Based on our data we conclude that low-dose aspirin (81 mg) inhibits platelet aggregation. Both the rate and extent of platelet aggregation are impaired with low-dose aspirin, but neither the rate nor extent of platelet aggregation depends on the size of the dose. Platelet aggregation inhibition by a single dose of aspirin orally (greater than or equal to 81 mg) may be expected to persist for the life of the platelets affected.

Published
1980
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