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3 results on '"Bianca Pane"'

1. Intraplaque Expression of C-Reactive Protein Predicts Cardiovascular Events in Patients with Severe Atherosclerotic Carotid Artery Stenosis

Author

Aldo Bonaventura, François Mach, Aline Roth, Sébastien Lenglet, Fabienne Burger, Karim J. Brandt, Aldo Pende, Maria Bertolotto, Giovanni Spinella, Bianca Pane, Domenico Palombo, Franco Dallegri, Michele Cea, Nicolas Vuilleumier, Fabrizio Montecucco, and Federico Carbone

Subjects
Pathology, RB1-214
Abstract

Serum c-reactive protein (CRP) was suggested for the assessment of intermediate cardiovascular (CV) risk. Here, systemic or intraplaque CRP levels were investigated as predictors of major adverse cardiovascular events (MACEs) in patients with severe carotid stenosis. CRP levels were assessed in the serum and within different portions (upstream and downstream) of carotid plaques of 217 patients undergoing endarterectomy. The association between CRP and intraplaque lipids, collagen, neutrophils, smooth muscle cells (SMC), and macrophage subsets was determined. No correlation between serum CRP and intraplaque biomarkers was observed. In upstream portions, CRP content was directly correlated with intraplaque neutrophils, total macrophages, and M1 macrophages and inversely correlated with SMC content. In downstream portions, intraplaque CRP correlated with M1 and M2 macrophages. According to the cut-off point (CRP > 2.9%) identified by ROC analysis in upstream portions, Kaplan-Meier analysis showed that patients with high CRP levels had a greater rate of MACEs. This risk of MACEs increased independently of age, male gender, serum CRP, and statin use. In conclusion, in patients with severe carotid artery stenosis, high CRP levels within upstream portions of carotid plaques directly and positively correlate with intraplaque inflammatory cells and predict MACEs at an 18-month follow-up period.

Published
2016
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3. Serum lipoprotein (a) predicts acute coronary syndromes in patients with severe carotid stenosis

Author

Aldo Pende, Fabrizio Montecucco, Maria Bertolotto, Fabio Rigamonti, Livia Pisciotta, Stefano Bertolini, Franco Dallegri, Aldo Bonaventura, Bianca Pane, Giovanni Spinella, Federico Carbone, François Mach, Luca Liberale, Aline Roth, Fabienne Burger, and Domenico Palombo

Subjects
Male, cardiovascular risk, medicine.medical_specialty, Acute coronary syndrome, medicine.medical_treatment, Clinical Biochemistry, Aftercare, Pilot Projects, 030204 cardiovascular system & hematology, Biochemistry, Coronary artery disease, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, Humans, Carotid Stenosis, acute coronary syndromes, In patient, Acute Coronary Syndrome, Aged, Endarterectomy, biology, business.industry, General Medicine, Lipoprotein(a), medicine.disease, Plaque, Atherosclerotic, Pathophysiology, Stenosis, Lipoprotein(a), acute coronary syndromes, cardiovascular risk, biology.protein, Cardiology, Female, business, Biomarkers, 030217 neurology & neurosurgery, Lipoprotein
Abstract

Background Different cut-off values of serum lipoprotein (a) [Lp (a)] were recently identified to better stratify cardiovascular risk categories. Both pathophysiological and prognostic values of Lp (a) remain unclear. Materials and methods Here, the prognostic value of Lp (a) and its correlation with intraplaque features were assessed in patients with severe carotid artery stenosis undergoing endarterectomy (n = 180). The cut-off value of 10 mg/dL for serum Lp (a) was selected to predict 24-month follow-up acute coronary syndrome (ACS). In addition, the association between serum Lp (a) and intraplaque lipids, collagen, inflammatory and vascular cells was assessed. Serum Lp (a) levels were measured by nephelometric assay. Results Patients with high Lp (a) had similar comorbidities, medications and laboratory parameters as compared to low Lp (a) levels. At 24-month follow-up, patients with high Lp (a) had more ACS as compared to low levels. Histological parameters within plaques were comparable in the study groups. No significant correlation between Lp (a) serum levels and intraplaque parameters was found, except for a weak positive association with smooth muscle cells in upstream plaque portions. When adjusted for gender, the presence of dyslipidaemia and chronic coronary artery disease, Lp (a) ≥10 mg/dL remained predictive for ACS. Conclusions Lp (a) determination could be a useful tool to predict ACS in patients with severe carotid stenosis.

Published
2018
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