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Your search keyword '"Belló-Klein, Adriane"' showing total 19 results
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19 results on '"Belló-Klein, Adriane"'

2. Pterostilbene reduces oxidative stress, prevents hypertrophy and preserves systolic function of right ventricle incor pulmonalemodel

Author

dos Santos Lacerda, Denise, primary, Türck, Patrick, additional, Gazzi de Lima-Seolin, Bruna, additional, Colombo, Rafael, additional, Duarte Ortiz, Vanessa, additional, Poletto Bonetto, Jéssica Hellen, additional, Campos-Carraro, Cristina, additional, Bianchi, Sara Elis, additional, Belló-Klein, Adriane, additional, Linck Bassani, Valquiria, additional, and Sander da Rosa Araujo, Alex, additional

Published
2017
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3. Dietary Supplementation of Ginger and Turmeric Rhizomes Modulates Platelets Ectonucleotidase and Adenosine Deaminase Activities in Normotensive and Hypertensive Rats

Author

Akinyemi, Ayodele Jacob, primary, Thomé, Gustavo Roberto, additional, Morsch, Vera Maria, additional, Bottari, Nathieli B., additional, Baldissarelli, Jucimara, additional, de Oliveira, Lizielle Souza, additional, Goularte, Jeferson Ferraz, additional, Belló-Klein, Adriane, additional, Oboh, Ganiyu, additional, and Schetinger, Maria Rosa Chitolina, additional

Published
2016
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6. Physical training prevents oxidative stress in L‐NAME‐induced hypertension rats

Author

Cardoso, Andréia Machado, primary, Martins, Caroline Curry, additional, Fiorin, Fernando da Silva, additional, Schmatz, Roberta, additional, Abdalla, Fátima Husein, additional, Gutierres, Jessié, additional, Zanini, Daniela, additional, Fiorenza, Amanda Maino, additional, Stefanello, Naiara, additional, Serres, Jonas Daci da Silva, additional, Carvalho, Fabiano, additional, Castro, Verônica Paiva, additional, Mazzanti, Cinthia Melazzo, additional, Royes, Luiz Fernando Freire, additional, Belló‐Klein, Adriane, additional, Goularte, Jeferson Ferraz, additional, Morsch, Vera Maria, additional, Bagatini, Margarete Dulce, additional, and Schetinger, Maria Rosa Chitolina, additional

Published
2012
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7. Time course of hydrogen peroxide-thioredoxin balance and its influence on the intracellular signalling in myocardial infarction

Author

Schenkel, Paulo Cavalheiro, primary, Tavares, Angela Maria Vicente, additional, Fernandes, Rafael Oliveira, additional, Diniz, Gabriela Placoná, additional, Ludke, Ana Raquel Lehenbauer, additional, Ribeiro, Maria Flavia Marques, additional, da Rosa Araujo, Alex Sander, additional, Barreto-Chaves, Maria Luiza, additional, and Belló-Klein, Adriane, additional

Published
2012
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10. Short term STZ‐induced diabetes reduced left ventricular dysfunction and promoted morphometric, immune and antioxidant adaptations after myocardial infarction in rats

Author

Candido, Georgia Orsi, primary, Mendes, Roberta Hack, additional, Rodrigues, Bruno, additional, Rosa, Kaleizu Teodoro, additional, Souza, Leandro Ezequiel, additional, Di Petta, Antonio, additional, Sammoniya, Paulina, additional, Belló‐Klein, Adriane, additional, De Angelis, Kátia, additional, and Irigoyen, Maria Claudia, additional

Published
2010
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19. Pterostilbene reduces oxidative stress, prevents hypertrophy and preserves systolic function of right ventricle in cor pulmonale model.

Author

Dos Santos Lacerda D, Türck P, Gazzi de Lima-Seolin B, Colombo R, Duarte Ortiz V, Poletto Bonetto JH, Campos-Carraro C, Bianchi SE, Belló-Klein A, Linck Bassani V, and Sander da Rosa Araujo A

Subjects
2-Hydroxypropyl-beta-cyclodextrin chemistry, 2-Hydroxypropyl-beta-cyclodextrin pharmacology, Animals, Catalase metabolism, Echocardiography, Glutathione Peroxidase metabolism, Heart Ventricles metabolism, Hypertension, Pulmonary metabolism, Hypertension, Pulmonary pathology, Hypertension, Pulmonary physiopathology, Liver drug effects, Liver pathology, Lung drug effects, Lung pathology, Male, Monocrotaline, NADPH Oxidases metabolism, Oxidative Stress drug effects, Rats, Wistar, Stilbenes chemistry, Stilbenes pharmacology, Superoxide Dismutase metabolism, Systole drug effects, 2-Hydroxypropyl-beta-cyclodextrin therapeutic use, Cardiomegaly prevention & control, Heart Ventricles drug effects, Hypertension, Pulmonary drug therapy, Stilbenes therapeutic use, Ventricular Function drug effects
Abstract

Background and Purpose: In cor pulmonale, the increased afterload imposed on the right ventricle (RV) generates a maladaptive response, impairing the contractile cardiac function. Oxidative mechanisms play an important role in the pathophysiology and progression of this disease. The administration of pterostilbene (PTS), a phytophenol with antioxidant potential, may represent a therapeutic option. In the present study, we evaluated the effect of PTS complexed with hydroxypropyl-β-cyclodextrin (HPβCD) on hypertrophy, contractile function and oxidative parameters in the RV of rats with pulmonary hypertension, induced by the administration of monocrotaline (MCT)., Experimental Approach: The rats received daily doses of the PTS : HPβCD complex at 25, 50 or 100 mg·kg -1 , p.o., for 14 days. The diastolic function, E/A ratio, and systolic function, shortening fraction, fractional area change (FAC) and tricuspid annular plane systolic excursion (TAPSE) of the RV were determined by echocardiography., Key Results: The PTS : HPβCD complex reduced the production of NADPH oxidase-dependent superoxide anions and oxidative stress in the RV of MCT-treated rats in a dose-dependent manner. At higher doses it prevented the reduction in FAC and TAPSE in MCT-treated animals., Conclusions and Implications: The PTS : HPβCD complex prevented the maladaptative remodelling and protected systolic function in the RV of rats with pulmonary hypertension. These cardioprotective mechanisms may be related, in part, to the antioxidant potential of PTS, favoured by the increased p.o. bioavailability promoted by the presence of HPβCD in the complex., (© 2017 The British Pharmacological Society.)

Published
2017
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