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Your search keyword '"Baudouin, C."' showing total 48 results
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48 results on '"Baudouin, C."'

46. Effects of corneal injury on ciliary nerve fibre activity and corneal nociception in mice: A behavioural and electrophysiological study.

Author

Joubert F, Acosta MDC, Gallar J, Fakih D, Sahel JA, Baudouin C, Bodineau L, Mélik Parsadaniantz S, and Réaux-Le Goazigo A

Subjects
Animals, Cornea physiopathology, Male, Mice, Mice, Inbred C57BL, Nerve Fibers physiology, Nociceptors physiology, Sensation, Thermoreceptors physiopathology, Cornea innervation, Corneal Injuries physiopathology, Nociception physiology
Abstract

Background: Ocular surface diseases are among the most frequent ocular pathologies. Ocular pain following corneal injury is frequently observed in clinic. Corneal sensory innervation is supplied by ciliary nerves derived from ophthalmic division of the trigeminal ganglion., Methods & Results: Extracellular activity of the mouse ciliary nerve was first used to investigate the corneal responsiveness to chemical, mechanical and thermal stimulations in order to specifically study the responses of polymodal nociceptors, mechano-nociceptors and cold thermoreceptor in a control cornea. Then, in two models of corneal injury (repeated instillations of 0.02% benzalkonium chloride and corneal scraping), we first measured the corneal sensitivity to chemical (eye-wiping test) and mechanical (von Frey filaments) stimulation. Thereafter, we evaluated whether these corneal injuries modified the spontaneous and chemical stimulation-evoked activity of the ciliary nerve. Both models of injury induced a significant corneal chemical hypersensitivity correlated with an increase of the spontaneous activity of the ciliary nerve and a faster response of the ciliary nerve after a chemical stimulation., Conclusions: Overall, this study provides new insights into the functional aspects of corneal nerve fibre activity in mice after corneal injury. The increase in ciliary nerve activity may thus contribute to the development of ocular pain after corneal damage., Significance: This study highlights the parallel increase in ciliary nerve activity and corneal sensitivity after corneal injury in mice. The strategy of combining ex vivo electrophysiological recordings of the ciliary nerve in mice and corneal sensitivity measurements therefore helps to uncover the functional aspects of corneal pain., (© 2018 European Pain Federation - EFIC®.)

Published
2019
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47. New emollient with topical corticosteroid-sparing effect in treatment of childhood atopic dermatitis: SCORAD and quality of life improvement.

Author

Msika P, De Belilovsky C, Piccardi N, Chebassier N, Baudouin C, and Chadoutaud B

Subjects
Administration, Topical, Child, Preschool, Drug Administration Schedule, Drug Therapy, Combination, Emollients chemistry, Female, Humans, Infant, Male, Parents, Severity of Illness Index, Sunflower Oil, Surveys and Questionnaires, Adrenal Cortex Hormones administration & dosage, Dermatitis, Atopic drug therapy, Dermatitis, Atopic physiopathology, Emollients therapeutic use, Plant Oils chemistry, Quality of Life
Abstract

Emollients are commonly used for their effectiveness on atopic skin, supported by a few clinical studies suggesting their potential role as corticosteroid sparing agents. We investigated the effect of a new natural emollient on corticosteroid sparing and quality of life of young atopic children and their family. Eighty-six patients (4-48 mos) with moderate atopic dermatitis were randomized by 20 pediatricians to five groups for 21 days: corticosteroids (from twice daily to one application every other day) combined or not with the studied cream (twice daily), and evaluated by SCORAD and specific quality of life questionnaires. At the end of the study, all five groups were statistically improved in terms of SCORAD and quality of life index. Thus, application of a topical corticosteroid every other day in addition to the studied cream was as effective as a once or twice daily application of the steroid alone. The studied cream had a significant impact on lichenification, excoriation and quality of life. A twice daily application of a new natural emollient provided a major corticosteroid sparing, improved lichenification and excoriation and improved the quality of life in children and their parents.

Published
2008
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48. Imaging of human brain activity at 0.15 T using fluid attenuated inversion recovery (FLAIR) pulse sequences.

Author

Hajnal JV, Collins AG, White SJ, Pennock JM, Oatridge A, Baudouin CJ, Young IR, and Bydder GM

Subjects
Brain anatomy & histology, Humans, Middle Aged, Photic Stimulation, Brain physiology, Magnetic Resonance Imaging
Abstract

A 3-4% change in signal intensity correlated with visual stimulation was observed in the occipital lobes of three normal volunteers examined with MRI at 0.15 T using fluid attenuated inversion recovery pulse sequences. Similar results were observed at 1.0 T. A double difference technique in which difference images are themselves opposed provided an increase in sensitivity.

Published
1993
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