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46 results on '"Barnhill, Raymond L."'

1. International Skin Imaging Collaboration‐Designated Diagnoses (ISIC‐DX): Consensus terminology for lesion diagnostic labeling

Author

Scope, Alon, primary, Liopyris, Konstantinos, additional, Weber, Jochen, additional, Barnhill, Raymond L., additional, Braun, Ralph P., additional, Curiel‐Lewandrowski, Clara N., additional, Elder, David E., additional, Ferrara, Gerardo, additional, Grant‐Kels, Jane M., additional, Jeunon, Thiago, additional, Lallas, Aimilios, additional, Lin, Jennifer Y., additional, Marchetti, Michael A., additional, Marghoob, Ashfaq A., additional, Navarrete‐Dechent, Cristian, additional, Pellacani, Giovanni, additional, Soyer, Hans Peter, additional, Stratigos, Alexander, additional, Thomas, Luc, additional, Kittler, Harald, additional, Rotemberg, Veronica, additional, and Halpern, Allan C., additional

Published
2024
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9. Complexities of perceived and actual performance in pathology interpretation: A comparison of cutaneous melanocytic skin and breast interpretations

Author

Carney, Patricia A., primary, Frederick, Paul D., additional, Reisch, Lisa M., additional, Titus, Linda, additional, Knezevich, Stevan R., additional, Weinstock, Martin A., additional, Piepkorn, Michael W., additional, Barnhill, Raymond L., additional, Elder, David E., additional, Weaver, Donald L., additional, and Elmore, Joann G., additional

Published
2018
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16. Genetic and morphologic features for melanoma classification

Author

Broekaert, Sigrid M. C., primary, Roy, Ritu, additional, Okamoto, Ichiro, additional, van den Oord, Joost, additional, Bauer, Jürgen, additional, Garbe, Claus, additional, Barnhill, Raymond L., additional, Busam, Klaus J., additional, Cochran, Alistair J., additional, Cook, Martin G., additional, Elder, David E., additional, McCarthy, Stanley W., additional, Mihm, Martin C., additional, Schadendorf, Dirk, additional, Scolyer, Richard A., additional, Spatz, Alan, additional, and Bastian, Boris C., additional

Published
2010
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43. Prognostic modeling of cutaneous melanoma stage I patients using cancer registry data identifies subsets with very-low melanoma mortality.

Author

Eguchi MM, Elder DE, Barnhill RL, Piepkorn MW, Knezevich SR, Elmore JG, and Kerr KF

Subjects
Humans, Prognosis, Routinely Collected Health Data, Registries, Melanoma pathology, Skin Neoplasms pathology
Abstract

Background: Evidence exists that escalating melanoma incidence is due in part to overdiagnosis, the diagnosis of lesions that will not lead to symptoms or death. The authors aimed to characterize subsets of melanoma patients with very-low risk of death that may be contributing to overdiagnosis., Methods: Melanoma patients diagnosed in 2010 and 2011 with stage I lesions ≤1.0 mm thick and negative clinical lymph nodes from the Surveillance, Epidemiology, and End Results database were selected. Classification and regression tree and logistic regression models were developed and validated to identify patients with very-low risk of death from melanoma within 7 years. Logistic models were also used to identify patients at higher risk of death among this group of stage I patients., Results: Compared to an overall 7-year mortality from melanoma of 2.5% in these patients, a subset comprising 25% had a risk below 1%. Younger age at diagnosis and Clark level II were associated with low risk of death in all models. Breslow thickness below 0.4 mm, absence of mitogenicity, absence of ulceration, and female sex were also associated with lower mortality. A small subset of high-risk patients with >20% risk of death was also identified., Conclusion: Patients with very-low risk of dying from melanoma within 7 years of diagnosis were identified. Such cases warrant further study and consensus discussion to develop classification criteria, with the potential to be categorized using an alternative term such as "melanocytic neoplasms of low malignant potential.", Lay Summary: Although melanoma is the most serious skin cancer, most melanoma patients have high chances of survival. There is evidence that some lesions diagnosed as melanoma would never have caused symptoms or death, a phenomenon known as overdiagnosis. In this study, we used cancer registry data to identify a subset of early-stage melanoma patients with almost no melanoma deaths. Using two statistical approaches, we identified patients with <1% risk of dying from melanoma in 7 years. Such patients tended to be younger with minimal invasion into the skin. We also identified a very small patient subset with higher mortality risk., (© 2022 American Cancer Society.)

Published
2023
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44. Characterization of multiple diagnostic terms in melanocytic skin lesion pathology reports.

Author

Chang OH, Elder DE, Barnhill RL, Piepkorn MW, Eguchi MM, Knezevich SR, Lee AC, Moreno RJ, Kerr KF, and Elmore JG

Subjects
Adult, Aged, Biopsy, Female, Humans, Male, Melanocytes pathology, Middle Aged, Terminology as Topic, Pathologists, Skin pathology, Skin Neoplasms classification, Skin Neoplasms diagnosis
Abstract

Background: Histopathologically ambiguous melanocytic lesions lead some pathologists to list multiple diagnostic considerations in the pathology report. The frequency and circumstance of multiple diagnostic considerations remain poorly characterized., Methods: Two hundred and forty skin biopsy samples were interpreted by 187 pathologists (8976 independent diagnoses) and classified according to a diagnostic/treatment stratification (MPATH-Dx)., Results: Multiple diagnoses in different MPATH-Dx classes were used in n = 1320 (14.7%) interpretations, with 97% of pathologists and 91% of cases having at least one such interpretation. Multiple diagnoses were more common for intermediate risk lesions and are associated with greater subjective difficulty and lower confidence. We estimate that 6% of pathology reports for melanocytic lesions in the United States contain two diagnoses of different MPATH-Dx prognostic classes, and 2% of cases are given two diagnoses with significant treatment implications., Conclusions: Difficult melanocytic diagnoses in skin may necessitate multiple diagnostic considerations; however, as patients increasingly access their health records and retrieve pathology reports (as mandated by US law), uncertainty should be expressed unambiguously., (© 2021 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)

Published
2022
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45. Terminology for melanocytic skin lesions and the MPATH-Dx classification schema: A survey of dermatopathologists.

Author

Radick AC, Reisch LM, Shucard HL, Piepkorn MW, Kerr KF, Elder DE, Barnhill RL, Knezevich SR, Oster N, and Elmore JG

Subjects
Adult, Dermatologists statistics & numerical data, Diagnostic Errors statistics & numerical data, Fellowships and Scholarships, Female, Humans, Interdisciplinary Communication, Male, Malpractice statistics & numerical data, Melanoma diagnosis, Melanoma surgery, Middle Aged, Pathologists psychology, Pathologists statistics & numerical data, Physicians, Primary Care statistics & numerical data, Reference Standards, Surveys and Questionnaires statistics & numerical data, Terminology as Topic, Classification methods, Melanocytes pathology, Melanoma classification, Skin Neoplasms pathology
Abstract

Background: Diagnostic terms used in histopathology reports of cutaneous melanocytic lesions are not standardized. We describe dermatopathologists' views regarding diverse diagnostic terminology and the utility of the Melanocytic Pathology Assessment Tool and Hierarchy for Diagnosis (MPATH-Dx) for categorizing melanocytic lesions., Methods: July 2018-2019 survey of board-certified and/or fellowship-trained dermatopathologists with experience interpreting melanocytic lesions., Results: Among 160 participants, 99% reported witnessing different terminology being used for the same melanocytic lesion. Most viewed diverse terminology as confusing to primary care physicians (98%), frustrating to pathologists (83%), requiring more of their time as a consultant (64%), and providing necessary clinical information (52%). Most perceived that adoption of the MPATH-Dx would: improve communication with other pathologists and treating physicians (87%), generally be a change for the better (80%), improve patient care (79%), be acceptable to clinical colleagues (68%), save time in pathology report documentation (53%), and protect from malpractice (51%)., Conclusions: Most dermatopathologists view diverse terminology as contributing to miscommunication with clinicians and patients, adversely impacting patient care. They view the MPATH-Dx as a promising tool to standardize terminology and improve communication. The MPATH-Dx may be a useful supplement to conventional pathology reports. Further revision and refinement are necessary for widespread clinical use., (© 2020 John Wiley & Sons A/S . Published by John Wiley & Sons Ltd.)

Published
2021
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46. The utilization of spitz-related nomenclature in the histological interpretation of cutaneous melanocytic lesions by practicing pathologists: results from the M-Path study.

Author

Zhao G, Lee KC, Peacock S, Reisch LM, Knezevich SR, Elder DE, Piepkorn MW, Elmore JG, and Barnhill RL

Subjects
Humans, Melanoma diagnosis, Nevus, Epithelioid and Spindle Cell diagnosis, Skin Neoplasms diagnosis, Terminology as Topic, Dermatology standards, Melanoma classification, Nevus, Epithelioid and Spindle Cell classification, Pathologists standards, Pathology, Clinical standards, Skin Neoplasms classification
Abstract

Background: Spitz nevi, atypical Spitz tumors and spitzoid melanomas ('spitzoid lesions') represent controversial and poorly understood cutaneous melanocytic lesions that are difficult to diagnose histologically. It is unknown how these terms are used by pathologists., Methods: We describe use of Spitz-related terminology using data from the Melanoma Pathology (M-Path) study database comprising pathologists' interpretations of biopsy slides, a nation-wide study evaluating practicing US pathologists' (N = 187) diagnoses of melanocytic lesions (8976 independent diagnostic assessments on 240 total test cases, with 1 slide per case)., Results: Most pathologists (90%) used the Spitz-related terminology. However, significant variation exists in which specific lesions were diagnosed as spitzoid and in the corresponding treatment recommendations. Recommendations ranged from 'no further treatment' to 'wide excision of 10 mm or greater' with no category capturing more than 50% of responses. For spitzoid melanoma diagnoses, 90% of pathologists recommended excision with ≥10 mm margin. Pathologists report less confidence in diagnosing these lesions compared with other melanocytic proliferations and are more likely to request second opinions and additional clinical information (all p < 0.05)., Conclusions: Spitzoid lesions are often not classified in any standardized way, evoke uncertainty in diagnosis by pathologists, and elicit variability in treatment recommendations., (© 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)

Published
2017
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