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Your search keyword '"Barbosa, M. M."' showing total 36 results
Start Over Author "Barbosa, M. M." Publisher wiley
36 results on '"Barbosa, M. M."'

34. Supracricoid laryngectomy with CHEP: functional results and outcome.

Author

Lima RA, Freitas EQ, Kligerman J, Dias FL, Barbosa MM, Sa GM, Santos IC, and Farias T

Subjects
Adult, Aged, Carcinoma, Squamous Cell mortality, Disease-Free Survival, Female, Humans, Incidence, Laryngeal Neoplasms mortality, Male, Middle Aged, Neoplasm Staging, Postoperative Complications epidemiology, Treatment Outcome, Carcinoma, Squamous Cell surgery, Cricoid Cartilage surgery, Epiglottis surgery, Glottis surgery, Hyoid Bone surgery, Laryngeal Neoplasms surgery, Laryngectomy methods
Abstract

Objectives: To assess whether supracricoid laryngectomy with cricohiodoepiglottopexy could successfully reach the cure and preserve the voice in glottic laryngeal cancer, we studied 27 patients with T2/T3 squamous cell carcinoma of the larynx treated in our institution with cricohiodoepiglottopexy., Study Design: A retrospective analysis has been carried out between 1995 through 1997. We classified 11 patients as T2N0M0 and 16 patients as T3N0M0. Nineteen patients had bilateral selective lateral neck dissection, 3 patients had unilateral lateral neck dissection, and 5 patients had undissected neck. Survival was analyzed under the Kaplan-Meyer method., Results: Five patients had postoperative complications, 2 were treated with a total laryngectomy. The remaining 25 patients kept the normal airway, swallowing, and speech. None of the patients in the neck dissection group had neck metastasis. Two patients had recurrences, 1 with local recurrence was treated with a total laryngectomy and is alive without disease; the other patient had neck recurrence, was treated with radical neck dissection plus radiotherapy, and is dead of the disease. One patient had a second tumor in oropharynx treated with palliative radiotherapy and is dead of the disease. Three years disease-free survival was 75% for T2 and 79% for T3., Conclusions: This technique is useful in the treatment of selected cases of T3/T2 glottic cancer regarding the extent of disease. The incidence of complications in need of a complete laryngectomy does not compromise the functionality of this technique. The survival is comparable to patients who submitted to total laryngectomy and near-total laryngectomy, regarding the extent of the lesion.

Published
2001
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35. Differential vulnerability of the subiculum and entorhinal cortex of the adult rat to prolonged protein deprivation.

Author

Andrade JP, Madeira MD, and Paula-Barbosa MM

Subjects
Analysis of Variance, Animals, Body Weight physiology, Cell Count, Dendrites ultrastructure, Male, Neurons ultrastructure, Organ Size physiology, Pyramidal Cells ultrastructure, Rats, Rats, Wistar, Entorhinal Cortex physiopathology, Hippocampus physiopathology, Neurons physiology, Protein-Energy Malnutrition physiopathology, Pyramidal Cells physiology
Abstract

Protein deprivation experienced in adult life leads to deficits in the number of hippocampal granule and CA3-CA1 pyramidal cells and to changes in the dendritic domain of granule cells and CA3 pyramids. To obtain a more complete insight into the effects of malnutrition on the limbic system of the adult rat we have analyzed the subiculum and the entorhinal cortex (neuronal layers II, III, and V-VI) in groups of 8-month-old rats fed with a low-protein diet (8% casein) since the age of 2 months and in age-matched control rats. Stereological methods were employed to estimate the total number of neurons in the subiculum and layers II, III, and V-VI of the entorhinal cortex and the volume of the respective cell layers. Moreover, to evaluate whether protein deprivation affects the dendritic domains of the neurons from these regions we have analyzed, in Golgi-impregnated material, the dendritic trees of the pyramidal cells of the subiculum and of the stellate neurons of the entorhinal cortex layer II applying quantitative and metric methods. The volume of the subiculum and the total number of its neurons were reduced in malnourished animals. In these animals we also found marked regressive changes in the apical and basal dendritic trees of the pyramidal subicular neurons. However, the spine density was increased in malnourished rats. No differences in the volume of the neuronal layers of the entorhinal cortex or in the total number of their neurons were found between protein-deprived and control rats, and no alterations were depicted in the dendritic trees of the stellate neurons of layer II. We can thus conclude that the effects of long-term protein deprivation are region specific and that the resulting structural alterations are confined to the three-layered components of the hippocampal region.

Published
1998
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36. Effects of chronic alcohol consumption and withdrawal on the somatostatin-immunoreactive neurons of the rat hippocampal dentate hilus.

Author

Andrade JP, Fernando PM, Madeira MD, Paula-Barbosa MM, Cadete-Leite A, and Zimmer J

Subjects
Animals, Hippocampus cytology, Hippocampus drug effects, Hippocampus pathology, Immunohistochemistry, Male, Neurons cytology, Neurons drug effects, Pyramidal Tracts cytology, Pyramidal Tracts drug effects, Pyramidal Tracts pathology, Rats, Rats, Sprague-Dawley, Reference Values, Somatostatin analysis, Alcohol Withdrawal Delirium pathology, Alcoholism pathology, Ethanol toxicity, Neurons pathology, Somatostatin metabolism
Abstract

Previous studies have demonstrated that the dentate granule and the CA3 pyramidal cells of the rat hippocampal formation are neuronal populations vulnerable to the toxic effects of ethanol. It also has been shown that the resulting alterations do not end after withdrawal from ethanol. As the neurons in the dentate hilus are heavily interconnected with the dentate granule cells, the authors decided to examine the fate of the hilar neurons after chronic alcohol consumption and withdrawal, inasmuch as the hilar somatostatin-immunoreactive (SS-I) neurons were found to be sensitive to cerebral ischemia and to seizures. The following groups of adult rats were studied: (1) alcohol-fed for 6 and 12 months; (2) alcohol-fed for 6 months and then switched to water for a further 6 months; (3) pair-fed controls; and (4) controls fed ad libitum. The authors determined the numerical density of hilar neurons and the number of its SS-I subpopulation. These were found to be significantly reduced in both the alcohol-fed and withdrawal groups when compared with the respective age-matched controls. The consequent loss of the integrative action of the hilar neurons, including the SS-Is, could explain some of the alcohol-related functional deficits as well as their persistence after withdrawal.

Published
1992
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