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305 results on '"Barbaud A"'

1. Cholinergic pruritus treated with omalizumab: Seven cases

Author

Bréhon, Alice, primary, Hamelin, Aurore, additional, Cariou, Claire, additional, Senet, Patricia, additional, Sonigo, Gabrielle, additional, De Risi, Tullia, additional, Barbaud, Annick, additional, Amsler, Emmanuelle, additional, and Soria, Angèle, additional

Published
2024
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2. Allergic contact dermatitis from vitamins: A systematic review

Author

Caterina Foti, Gianfranco Calogiuri, Eustachio Nettis, Aurora De Marco, Luca Stingeni, Katharina Hansel, Danilo Di Bona, Palma Carlucci, Paolo Romita, and Annick Barbaud

Subjects
allergic contact dermatitis, fat‐soluble vitamins, hydro‐soluble vitamins, lymphocyte transformation test, multivitamins, patch test, Medicine
Abstract

Abstract Background and Aims Vitamins are bioactive compounds naturally found in many different types of food and required by the human body for many biological functions and enzymatic activities. Due to their antioxidant properties, certain vitamin derivatives have been synthesized for inclusion in many cosmetics, thus leading to an increasing incidence of allergic contact dermatitis (ACD) cases. Therefore, the present review may be helpful to provide an insight into the sensitizing role of at least certain vitamins and may also offer possible patch test alternatives for definitive diagnosis. Methods This study was conducted in accordance with the Preferred Reporting Items for Systematic reviews and Meta‐Analyses (PRISMA) guidelines. Literature search regarding ACD cases to vitamins was performed using the Medline, PubMed, Scopus, EMBASE, and Google Scholar databases from January 1940 up to June 2021. Results A total of 4494 articles matched the keywords used for the researched. Records removed before screening included 15 duplicate articles and 3429 not eligible articles (e.g., not written in English, studies on animals, not relevant to the topic). A total of 1050 articles underwent the screening phase and 258 were therefore excluded as they were not primary studies. Subsequentially, 792 articles were considered eligible for the review and 688 of them were finally excluded as they did not report the outcome of interest. Therefore, 104 articles were definitely included in the present review. Conclusion ACD to vitamins is still probably an underestimated issue in cosmetology, as many vitamins are considered “natural” and therefore “safe” ingredients. On the contrary, according to current literature, almost all vitamins contained in topical products are able to induce allergic reactions, with the exception of vitamin B2 and vitamin B9. Patch tests are not standardized, thus leading to difficulties in diagnosis.

Published
2022
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4. Hypersensitivity reactions to proton pump inhibitors. An EAACI position paper

Author

Bavbek, Sevim, primary, Kepil Özdemir, Seçil, additional, Bonadonna, Patrizia, additional, Atanaskovic‐Markovic, Marina, additional, Barbaud, Annick, additional, Brockow, Knut, additional, Laguna Martinez, Jose, additional, Nakonechna, Alla, additional, Pagani, Mauro, additional, Arcolacı, Alessandra, additional, Lombardo, Carla, additional, and Torres, Maria J., additional

Published
2023
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6. Risk stratification through extensive allergy work‐up in COVID‐19‐mRNA vaccine allergic reactions

Author

Soria, Angèle, primary, Labella, Marina, additional, Doña, Inmaculada, additional, Nicaise‐Roland, Pascale, additional, Chollet‐Martin, Sylvie, additional, Autegarden, Jean‐Eric, additional, Castagna, Julie, additional, Le Thai, Claire, additional, de Chaisemartin, Luc, additional, Torres, Maria José, additional, and Barbaud, Annick, additional

Published
2023
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7. Characteristics of cutaneous lupus erythematosus in Black patients, association with systemic lupus and response to treatment: A retrospective cohort study of 141 patients

Author

Jaume, Léa, primary, Fayard, Damien, additional, Breillat, Paul, additional, Francès, Camille, additional, Dutheil, Amélie, additional, Barbaud, Annick, additional, Arnaud, Laurent, additional, Mathian, Alexis, additional, Amoura, Zahir, additional, and Chasset, François, additional

Published
2023
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10. Multiple cases of sensitization to an antiseptic containing chlorhexidine digluconate/benzalkonium chloride/benzyl alcohol with different profiles of sensitization in adults and children

Author

Charlotte, Beaumont, Anne-Sophie, Darrigade, Annick, Barbaud, Evelyne, Collet, Nadia, Raison-Peyron, Jean-Luc, Bourrain, Haudrey, Assier, Françoise, Giordano-Labadie, Corina, Bara-Passot, Brigitte, Milpied, Florence, Tétart, Pierre, Armingaud, Florence, Castelain, Lamia, Benkalfate, Claire, Boulard, Juliette, Delaunay, Pascale, Mathelier-Fusade, Catherine, Pecquet, Pauline, Pralong, Dominique, Vital-Durand, Nathalie, Genillier Foin, Marine-Alexia, Lefèvre, Florence, Hacard, Audrey, Nosbaum, Justine, Pasteur, Aude, Valois, Martine, Vigan, Marie-Christine, Ferrier le Bouëdec, Service de dermatologie et allergologie [CHU Tenon], CHU Tenon [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Service de Dermatologie (CHU de Dijon), Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Université de Montpellier (UM), CHU Montpellier, Institut Desbrest de santé publique (IDESP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Service de dermatologie [Mondor], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Henri Mondor-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), CHU Toulouse [Toulouse], CHU Bordeaux [Bordeaux], Service de Dermatologie [Rouen], Hôpital Charles Nicolle [Rouen]-CHU Rouen, Normandie Université (NU)-Normandie Université (NU), Service de pneumologie, allergologie, mucoviscidose pédiatrique [Rouen], CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), Service de dermatologie, hôpital Jacques-Monod, Le Havre, Département d'allergie et d'immunologie clinique [CHU Lyon Sud], Centre Hospitalier Lyon Sud [CHU - HCL] (CHLS), Hospices Civils de Lyon (HCL)-Hospices Civils de Lyon (HCL), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), and Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)

Subjects
recidal-gerda, Adult, Chlorhexidine, contact dermatitis, Dermatology, Allergens, Patch Tests, allergy, benzalkonium chloride, Chlorides, antiseptic, Dermatitis, Allergic Contact, Anti-Infective Agents, Local, Humans, Immunology and Allergy, Benzalkonium Compounds, Child, ComputingMilieux_MISCELLANEOUS, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, Benzyl Alcohols, benzyl alcohol, Retrospective Studies
Abstract

An aqueous antiseptic containing "chlorhexidine digluconate/benzalkonium chloride/benzyl alcohol" (CBB) is widely used in France. The only previous documented study dealing with allergic contact dermatitis (ACD) to this antiseptic is one small case series in children. The French Vigilance Network for Dermatology and Allergy (REVIDAL-GERDA) has collected many cases in the last few years.To evaluate the clinical and sensitization profiles of patients diagnosed with ACD to CBB.We performed a retrospective study of patients with contact dermatitis to CBB and positive tests to CBB and/or at least one of its components. All patients had to be tested with all components of CBB.A total of 102 patients (71 adults and 31 children) were included. The lesions were extensive in 63% of patients and 55% had delayed time to diagnosis. CBB patch tests were positive in 93.8% of cases. The allergen was identified in 97% of patients, mainly benzyl alcohol in adults (81.7%) and chlorhexidine digluconate in children (54.8%). About 32.4% of the patients were sensitized to several components.CBB is a cause of ACD at all ages. The components of the antiseptic should be tested. The sensitization profile seems to be different between adults and children.

Published
2022

11. Multiple cases of sensitization to an antiseptic containing chlorhexidine digluconate/benzalkonium chloride/benzyl alcohol with different profiles of sensitization in adults and children.

Author

Beaumont C, Darrigade AS, Barbaud A, Collet E, Raison-Peyron N, Bourrain JL, Assier H, Giordano-Labadie F, Bara-Passot C, Milpied B, Tétart F, Armingaud P, Castelain F, Benkalfate L, Boulard C, Delaunay J, Mathelier-Fusade P, Pecquet C, Pralong P, Vital-Durand D, Genillier Foin N, Lefèvre MA, Hacard F, Nosbaum A, Pasteur J, Valois A, Vigan M, and Ferrier le Bouëdec MC

Subjects
Adult, Allergens, Benzalkonium Compounds, Benzyl Alcohols, Child, Chlorhexidine adverse effects, Chlorhexidine analogs & derivatives, Chlorides, Humans, Patch Tests adverse effects, Retrospective Studies, Anti-Infective Agents, Local adverse effects, Dermatitis, Allergic Contact diagnosis, Dermatitis, Allergic Contact etiology
Abstract

Background: An aqueous antiseptic containing "chlorhexidine digluconate/benzalkonium chloride/benzyl alcohol" (CBB) is widely used in France. The only previous documented study dealing with allergic contact dermatitis (ACD) to this antiseptic is one small case series in children. The French Vigilance Network for Dermatology and Allergy (REVIDAL-GERDA) has collected many cases in the last few years., Objectives: To evaluate the clinical and sensitization profiles of patients diagnosed with ACD to CBB., Methods: We performed a retrospective study of patients with contact dermatitis to CBB and positive tests to CBB and/or at least one of its components. All patients had to be tested with all components of CBB., Results: A total of 102 patients (71 adults and 31 children) were included. The lesions were extensive in 63% of patients and 55% had delayed time to diagnosis. CBB patch tests were positive in 93.8% of cases. The allergen was identified in 97% of patients, mainly benzyl alcohol in adults (81.7%) and chlorhexidine digluconate in children (54.8%). About 32.4% of the patients were sensitized to several components., Conclusion: CBB is a cause of ACD at all ages. The components of the antiseptic should be tested. The sensitization profile seems to be different between adults and children., (© 2022 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)

Published
2022
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13. Allergic contact dermatitis from vitamins: A systematic review

Author

Foti, Caterina, primary, Calogiuri, Gianfranco, additional, Nettis, Eustachio, additional, De Marco, Aurora, additional, Stingeni, Luca, additional, Hansel, Katharina, additional, Di Bona, Danilo, additional, Carlucci, Palma, additional, Romita, Paolo, additional, and Barbaud, Annick, additional

Published
2022
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14. Fixed food eruption to Moringa oleifera.

Author

Amsler E, Mahevas T, Soria A, and Barbaud A

Subjects
Humans, Food, Plant Extracts, Plant Leaves, Moringa oleifera, Dermatitis, Allergic Contact diagnosis, Dermatitis, Allergic Contact etiology
Published
2023
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15. Skin tests in the work-up of cutaneous adverse drug reactions: A review and update.

Author

Barbaud A, Castagna J, and Soria A

Subjects
Humans, Patch Tests, Skin Tests, Acute Generalized Exanthematous Pustulosis diagnosis, Acute Generalized Exanthematous Pustulosis etiology, Dermatitis, Allergic Contact, Drug Hypersensitivity Syndrome diagnosis, Drug Hypersensitivity Syndrome etiology, Stevens-Johnson Syndrome diagnosis, Stevens-Johnson Syndrome etiology
Abstract

Skin tests, including patch tests (PTs), prick tests, and intradermal tests (IDTs), are useful in identifying the culprits of cutaneous adverse drug reactions (CADRs), and determining safer, alternative drugs. PTs have a low sensitivity but are valuable in investigating maculopapular exanthema (MPE), as well as severe CADR, including toxic epidermal necrolysis (TEN), Stevens-Johnson syndrome (SJS), and in particular, acute generalized exanthematous pustulosis (AGEP), and drug reaction with eosinophilia and systemic symptoms (DRESS). To ensure their specificity, at least 10 control tests should be performed. Prick tests are mainly used in the evaluation of immediate-type hypersensitivity and can be performed with all drugs, except opiates. IDTs can be used to explore immediate and delayed-type hypersensitivity, if an injectable form of the drug exists. Except for SJS/TEN, IDTs should be performed by injecting 0.02 mL of the drug. We here provide a practical, up-to-date review on the use of these skin tests in the work-up of CADRs. Numerous negative controls for drug PTs, as well as criteria for the immediate and delayed positivity of prick tests and IDT, are included. It should be emphasized that a negative result never excludes the potential responsibility of a drug in a CADR., (© 2022 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)

Published
2022
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16. Allergies and COVID-19 vaccines : An ENDA/EAACI Position paper

Author

Barbaud, Annick, Garvey, Lene Heise, Arcolaci, Alessandra, Brockow, Knut, Mori, Francesca, Mayorga, Cristobalina, Bonadonna, Patrizia, Atanaskovic-Markovic, Marina, Moral, Luis, Zanoni, Giovanna, Pagani, Mauro, Soria, Angele, Jost, Maja, Caubet, Jean-Christoph, Carmo, Abreu, Mona, Al-Ahmad, Alvarez-Perea, Alberto, Bavbek, Sevim, Benedetta, Biagioni, Bilo, M. Beatrice, Blanca-Lopez, Natalia, Bogas, Herrera Gador, Buonomo, Alessandro, Calogiuri, Gianfranco, Carli, Giulia, Cernadas, Josefina, Cortellini, Gabriele, Celik, Gulfem, Demir, Semra, Dona, Inmaculada, Dursun, Adile Berna, Eberlein, Bernadette, Faria, Emilia, Fernandes, Bryan, Garcez, Tomaz, Garcia-Nunez, Ignacio, Gawlik, Radoslaw, Gelincik, Asli, Gomes, Eva, Gooi, Jimmy H. C., Grosber, Martine, Gulen, Theo, Hacard, Florence, Hoarau, Cyrille, Janson, Christer, Johnston, Sebastian L., Joerg, Lukas, Ozdemir, Secil Kepil, Klimek, Ludger, Kosnik, Mitja, Kowalski, Marek L., Kuyucu, Semanur, Kvedariene, Violeta, Laguna, Jose Julio, Lombardo, Carla, Marinho, Susana, Merk, Hans, Meucci, Elisa, Morisset, Martine, Munoz-Cano, Rosa, Murzilli, Francesco, Nakonechna, Alla, Popescu, Florin-Dan, Porebski, Grzegorz, Radice, Anna, Regateiro, Frederico S., Rockmann, Heike, Romano, Antonino, Sargur, Ravishankar, Sastre, Joaquin, Hofmeier, Kathrin Scherer, Sedlackova, Lenka, Sobotkova, Marta, Terreehorst, Ingrid, Treudler, Regina, Walusiak-Skorupa, Jolanta, Wedi, Bettina, Wohrl, Stefan, Zidarn, Mihael, Zuberbier, Torsten, Agache, Ioana, Torres, Maria J., Barbaud, Annick, Garvey, Lene Heise, Arcolaci, Alessandra, Brockow, Knut, Mori, Francesca, Mayorga, Cristobalina, Bonadonna, Patrizia, Atanaskovic-Markovic, Marina, Moral, Luis, Zanoni, Giovanna, Pagani, Mauro, Soria, Angele, Jost, Maja, Caubet, Jean-Christoph, Carmo, Abreu, Mona, Al-Ahmad, Alvarez-Perea, Alberto, Bavbek, Sevim, Benedetta, Biagioni, Bilo, M. Beatrice, Blanca-Lopez, Natalia, Bogas, Herrera Gador, Buonomo, Alessandro, Calogiuri, Gianfranco, Carli, Giulia, Cernadas, Josefina, Cortellini, Gabriele, Celik, Gulfem, Demir, Semra, Dona, Inmaculada, Dursun, Adile Berna, Eberlein, Bernadette, Faria, Emilia, Fernandes, Bryan, Garcez, Tomaz, Garcia-Nunez, Ignacio, Gawlik, Radoslaw, Gelincik, Asli, Gomes, Eva, Gooi, Jimmy H. C., Grosber, Martine, Gulen, Theo, Hacard, Florence, Hoarau, Cyrille, Janson, Christer, Johnston, Sebastian L., Joerg, Lukas, Ozdemir, Secil Kepil, Klimek, Ludger, Kosnik, Mitja, Kowalski, Marek L., Kuyucu, Semanur, Kvedariene, Violeta, Laguna, Jose Julio, Lombardo, Carla, Marinho, Susana, Merk, Hans, Meucci, Elisa, Morisset, Martine, Munoz-Cano, Rosa, Murzilli, Francesco, Nakonechna, Alla, Popescu, Florin-Dan, Porebski, Grzegorz, Radice, Anna, Regateiro, Frederico S., Rockmann, Heike, Romano, Antonino, Sargur, Ravishankar, Sastre, Joaquin, Hofmeier, Kathrin Scherer, Sedlackova, Lenka, Sobotkova, Marta, Terreehorst, Ingrid, Treudler, Regina, Walusiak-Skorupa, Jolanta, Wedi, Bettina, Wohrl, Stefan, Zidarn, Mihael, Zuberbier, Torsten, Agache, Ioana, and Torres, Maria J.

Abstract

Background Anaphylaxis, which is rare, has been reported after COVID-19 vaccination, but its management is not standardized. Method Members of the European Network for Drug Allergy and the European Academy of Allergy and Clinical Immunology interested in drug allergy participated in an online questionnaire on pre-vaccination screening and management of allergic reactions to COVID-19 vaccines, and literature was analysed. Results No death due to anaphylaxis to COVID-19 vaccines has been confirmed in scientific literature. Potential allergens, polyethylene glycol (PEG), polysorbate and tromethamine are excipients. The authors propose allergy evaluation of persons with the following histories: 1-anaphylaxis to injectable drug or vaccine containing PEG or derivatives; 2-anaphylaxis to oral/topical PEG containing products; 3-recurrent anaphylaxis of unknown cause; 4-suspected or confirmed allergy to any mRNA vaccine; and 5-confirmed allergy to PEG or derivatives. We recommend a prick-to-prick skin test with the left-over solution in the suspected vaccine vial to avoid waste. Prick test panel should include PEG 4000 or 3500, PEG 2000 and polysorbate 80. The value of in vitro test is arguable. Conclusions These recommendations will lead to a better knowledge of the management and mechanisms involved in anaphylaxis to COVID-19 vaccines and enable more people with history of allergy to be vaccinated.

Published
2022
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17. Hand eczema in glove-wearing patients.

Author

Clément A, Ferrier le Bouëdec MC, Crépy MN, Raison-Peyron N, Tétart F, Marcant P, Pralong P, Valois A, Pasteur J, Assier H, Bernier C, Le Cam MT, Hacard F, Nosbaum A, Giordano Labadie F, Morice C, Leleu C, Milpied B, Darrigade AS, Delaunay J, Barbaud A, Castelain F, Collet E, and Amsler E

Subjects
Humans, Rubber adverse effects, Allergens adverse effects, Patch Tests, Polyvinyl Chloride adverse effects, Gloves, Protective adverse effects, Dermatitis, Allergic Contact diagnosis, Dermatitis, Allergic Contact etiology, Eczema etiology, Hand Dermatoses chemically induced
Abstract

Background: Allergic contact dermatitis to gloves is mostly induced by rubber accelerators. The European baseline series (EBS) appears insufficient to detect glove allergy. Since 2017, it is recommended to use the European rubber series (ERS) and to test the patients' own gloves., Objectives: To investigate the clinical profile of glove-wearing patients with hand eczema (HE) and to evaluate their sensitisation profile to glove allergens and the value of testing the patients' own gloves., Methods: We conducted a French multicentre study of patients evaluated for HE between 2018 and 2020 and tested with the EBS, the ERS and their own gloves in patch tests and semi-open (SO) tests., Results: A total of 279 patients were included; 32.6% of patients had positive tests to their own gloves or to glove allergens. Almost 45% of the sensitisations to glove allergens were detected only by the ERS. Among the patients tested both in patch tests and SO tests with their own gloves with positive results, 28% had positive SO tests only. Polyvinylchloride (PVC) gloves were positive in four patients., Conclusion: Our series confirms the need to test the ERS. All the patients' gloves must also be tested including PVC gloves. SO tests with gloves are useful as a complement to patch tests., (© 2023 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)

Published
2023
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18. Allergic contact dermatitis from essential oil in consumer products: Mode of uses and value of patch tests with an essential oil series. Results of a French study of the DAG (Dermato-Allergology group of the French Society of Dermatology).

Author

Barbaud A, Kurihara F, Raison-Peyron N, Milpied B, Valois A, Assier H, Morice C, Manciet JR, Gener G, Giordano-Labadie F, Marcant P, Bernier C, Amsler E, Crepy MN, Tetart F, Soria A, and le Bouëdec MF

Subjects
Humans, Female, Middle Aged, Male, Patch Tests, Oils, Volatile adverse effects, Dermatitis, Allergic Contact diagnosis, Dermatitis, Allergic Contact etiology, Dermatology, Tea Tree Oil adverse effects, Lavandula
Abstract

Objective: To analyse the clinical characteristics and sensitivity of an essential oil patch test series (EOS) in patients sensitized to their own essential oils (EOs)., Method: We analysed the clinical data and patch test results obtained with the European baseline series (BSE) and an EOS, as well as the mode of use of EOs, through a questionnaire included in the patient file., Results: The study included 42 patients (79% women, average age 50 years) with allergic contact dermatitis (ACD), 8 patients required hospitalization. All patients were sensitized to the EO they used, primarily lavender (Lavandula augustifolia, 8000-28-0), tea tree (Melaleuca alternifolia leaf oil, 68647-73-4), ravintsara (Cinnamomum camphora oil, 92201-50-8), and 2 cases were attributed to helichrysum (helichrysum italicum flower absolute, 90045-56-0). 71% had positive patch tests to fragrance mix I or II, 9 only to the EOS and 4 only with their personal EO. Interestingly, 40% of patients did not spontaneously mention the use of EOs, and only 33% received advice on their use at the time of purchase., Conclusion: Patch tests with the BSE, limonene and linalool HP, and oxidized tea tree oil is sufficient to detect most EO-sensitized patients. The most important is to test the patient's own used EOs., (© 2023 The Authors. Contact Dermatitis published by John Wiley & Sons Ltd.)

Published
2023
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20. Occurrence of immediate and delayed hypersensitivity to hexamidine

Author

Flore Kurihara, Angèle Soria, Yannick Chantran, Julie Castagna, Annick Barbaud, Emmanuelle Amsler, and Agathe Le Seac'h

Subjects
Hypersensitivity, Immediate, Male, medicine.medical_specialty, business.industry, Administration, Topical, Hexamidine, Dermatology, Benzamidines, Diagnosis, Differential, chemistry.chemical_compound, Anti-Infective Agents, chemistry, Delayed hypersensitivity, Humans, Immunology and Allergy, Medicine, Hypersensitivity, Delayed, business, Administration, Intranasal, Aged, Skin Tests
Published
2021

22. Allergies and COVID‐19 vaccines: An ENDA/EAACI Position paper

Author

Barbaud, Annick, primary, Garvey, Lene Heise, additional, Arcolaci, Alessandra, additional, Brockow, Knut, additional, Mori, Francesca, additional, Mayorga, Cristobalina, additional, Bonadonna, Patrizia, additional, Atanaskovic‐Markovic, Marina, additional, Moral, Luis, additional, Zanoni, Giovanna, additional, Pagani, Mauro, additional, Soria, Angèle, additional, Jošt, Maja, additional, Caubet, Jean‐Christoph, additional, Carmo, Abreu, additional, Mona, Al‐Ahmad, additional, Alvarez‐Perea, Alberto, additional, Bavbek, Sevim, additional, Benedetta, Biagioni, additional, Bilo, M.Beatrice, additional, Blanca‐López, Natalia, additional, Bogas, Herrera Gádor, additional, Buonomo, Alessandro, additional, Calogiuri, Gianfranco, additional, Carli, Giulia, additional, Cernadas, Josefina, additional, Cortellini, Gabriele, additional, Celik, Gülfem, additional, Demir, Semra, additional, Doña, Inmaculada, additional, Dursun, Adile Berna, additional, Eberlein, Bernadette, additional, Faria, Emilia, additional, Fernandes, Bryan, additional, Garcez, Tomaz, additional, Garcia‐Nunez, Ignacio, additional, Gawlik, Radoslaw, additional, Gelincik, Asli, additional, Gomes, Eva, additional, Gooi, Jimmy H. C., additional, Grosber, Martine, additional, Gülen, Theo, additional, Hacard, Florence, additional, Hoarau, Cyrille, additional, Janson, Christer, additional, Johnston, Sebastian L., additional, Joerg, Lukas, additional, Kepil Özdemir, Seçil, additional, Klimek, Ludger, additional, Košnik, Mitja, additional, Kowalski, Marek L., additional, Kuyucu, Semanur, additional, Kvedariene, Violeta, additional, Laguna, Jose Julio, additional, Lombardo, Carla, additional, Marinho, Susana, additional, Merk, Hans, additional, Meucci, Elisa, additional, Morisset, Martine, additional, Munoz‐Cano, Rosa, additional, Murzilli, Francesco, additional, Nakonechna, Alla, additional, Popescu, Florin‐Dan, additional, Porebski, Grzegorz, additional, Radice, Anna, additional, Regateiro, Frederico S., additional, Röckmann, Heike, additional, Romano, Antonino, additional, Sargur, Ravishankar, additional, Sastre, Joaquin, additional, Scherer Hofmeier, Kathrin, additional, Sedláčková, Lenka, additional, Sobotkova, Marta, additional, Terreehorst, Ingrid, additional, Treudler, Regina, additional, Walusiak‐Skorupa, Jolanta, additional, Wedi, Bettina, additional, Wöhrl, Stefan, additional, Zidarn, Mihael, additional, Zuberbier, Torsten, additional, Agache, Ioana, additional, and Torres, Maria J., additional

Published
2022
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23. Diagnosis and management of the drug hypersensitivity reactions in Coronavirus disease 19: An EAACI Position Paper

Author

Antonino Romano, Knut Brockow, Cristobalina Mayorga, María José Torres, Gülfem Çelik, Aslı Gelincik, Marina Atanaskovic-Markovic, Annick Barbaud, Ozge Soyer, and Inmaculada Doña

Subjects
Drug, medicine.medical_specialty, SARS‐CoV2, medicine.medical_treatment, media_common.quotation_subject, Immunology, desensitization, Review Article, Disease, medicine.disease_cause, Asymptomatic, Drug Hypersensitivity, 030207 dermatology & venereal diseases, 03 medical and health sciences, 0302 clinical medicine, COVID‐19, Pandemic, medicine, Humans, Immunology and Allergy, drug hypersensitivity reactions, Intensive care medicine, Pandemics, Review Articles, Coronavirus, Desensitization (medicine), media_common, SARS-CoV-2, business.industry, Academies and Institutes, COVID-19, 3. Good health, Europe, 030228 respiratory system, Position paper, Differential diagnosis, medicine.symptom, business
Abstract

Coronavirus disease 2019 (COVID‐19), a respiratory tract infection caused by a novel human coronavirus, the severe acute respiratory syndrome coronavirus 2, leads to a wide spectrum of clinical manifestations ranging from asymptomatic cases to patients with mild and severe symptoms, with or without pneumonia. Given the huge influence caused by the overwhelming COVID‐19 pandemic affecting over three million people worldwide, a wide spectrum of drugs is considered for the treatment in the concept of repurposing and off‐label use. There is no knowledge about the diagnosis and clinical management of the drug hypersensitivity reactions that can potentially occur during the disease. This review brings togetherall the published information about the diagnosis and management of drug hypersensitivity reactions due to current and candidate off‐label drugs andhighlights relevant recommendations. Furthermore, it gathers all the dermatologic manifestations reported during the disease for guiding the clinicians to establish a better differential diagnosis of drug hypersensitivity reactionsin the course of the disease.

Published
2020

24. Mineral oils and waxes in cosmetics: an overview mainly based on the current European regulations and the safety profile of these compounds

Author

B. Chuberre, Elena Araviiskaia, T. Bieber, and Annick Barbaud

Subjects
Acceptable daily intake, Carcinogenesis, Skin Absorption, media_common.quotation_subject, Administration, Oral, Autoimmunity, Cosmetics, Dermatology, 010501 environmental sciences, Administration, Cutaneous, 01 natural sciences, Intestinal absorption, law.invention, 030207 dermatology & venereal diseases, 03 medical and health sciences, 0302 clinical medicine, law, Animals, Humans, Mineral Oil, Medicine, media_common.cataloged_instance, European Union, Food science, European union, Mineral oil, Trade association, 0105 earth and related environmental sciences, media_common, Wax, business.industry, Reproduction, Infectious Diseases, Intestinal Absorption, Mutagenesis, Waxes, visual_art, visual_art.visual_art_medium, Pharmacopoeia, business, medicine.drug
Abstract

Mineral oils and waxes are mixtures of predominantly saturated hydrocarbons consisting of straight-chain, branched and ring structures with carbon chain lengths greater than C14. They have been used for many decades in skin and lip care cosmetic products due to their excellent skin tolerance as well as their high protecting and cleansing performance and broad viscosity options. In contrast to vegetable oils, mineral oils are non-allergenic since they are highly stable and not susceptible to oxidation or rancidity. They have a long history of safe use which is confirmed by clinical and epidemiological data. In Europe, mineral oils are only permitted in cosmetics if compliant with purity specifications on polycyclic aromatic hydrocarbons and safety requirements laid down in the European pharmacopoeia and the EU cosmetics regulation EC/1223/2009. The high quality of these mineral oils is assured by robust quality assurance and a refining/purification process designed to exclude substances with carcinogenic potential and to minimize the presence of mineral oil aromatic hydrocarbons. Given their highly lipophilic properties, mineral oils do not penetrate human skin and, thus, are not systemically bioavailable in the body. Moreover, no significant changes in the skin and no effects on any internal organ system have been reported and attributed to the topical application of refined mineral oils. Regarding potential oral exposure from cosmetic lip care products, Cosmetics Europe, the European trade association for the cosmetics and personal care industry, has advised cosmetic manufacturers to only use mineral oil fractions for which recognized food acceptable daily intake (ADI) values apply. The estimated dose of mineral oils ingested via lip care products contributes to

Published
2019

25. Clinical and histological characteristics during chronic urticaria with dermal neutrophilic infiltrate: Proposal of a diagnostic score

Author

Emmanuelle Amsler, Angèle Soria, Vannina Seta, A. Fajac, Philippe Moguelet, Jean-Benoît Monfort, Alice Brehon, and Annick Barbaud

Subjects
medicine.medical_specialty, Urticaria, Neutrophils, business.industry, Dermatology, Neutrophilic Infiltrate, Infectious Diseases, Humans, Medicine, Chronic Urticaria, Dermatopathology, business, Chronic urticaria, Neutrophilic urticaria
Published
2021

29. Efficacy of tocilizumab in adult H syndrome: a promising therapeutic option

Author

Pierre Hamann, Camille Francès, François Chasset, Annick Barbaud, Tullia de Risi-Pugliese, Philippe Moguelet, Patricia Senet, and Jérémie Delaleu

Subjects
Adult, Oncology, medicine.medical_specialty, Contracture, Interleukin-6, business.industry, MEDLINE, Dermatology, Antibodies, Monoclonal, Humanized, H SYNDROME, chemistry.chemical_compound, Treatment Outcome, Tocilizumab, Text mining, chemistry, Internal medicine, Humans, Medicine, business, Histiocytosis
Published
2021

30. Management of anaphylaxis due to COVID‐19 vaccines in the elderly

Author

Bousquet, Jean, primary, Agache, Ioana, additional, Blain, Hubert, additional, Jutel, Marek, additional, Ventura, Maria Teresa, additional, Worm, Margitta, additional, Del Giacco, Stefano, additional, Benetos, Athanasios, additional, Bilo, Beatrice Maria, additional, Czarlewski, Wienczyslawa, additional, Abdul Latiff, Amir Hamzah, additional, Al‐Ahmad, Mona, additional, Angier, Elizabeth, additional, Annesi‐Maesano, Isabella, additional, Atanaskovic‐Markovic, Marina, additional, Bachert, Claus, additional, Barbaud, Annick, additional, Bedbrook, Anna, additional, Bennoor, Kazi S., additional, Berghea, Elena Camelia, additional, Bindslev‐Jensen, Carsten, additional, Bonini, Sergio, additional, Bosnic‐Anticevich, Sinthia, additional, Brockow, Knut, additional, Brussino, Luisa, additional, Camargos, Paulo, additional, Canonica, G. Walter, additional, Cardona, Victoria, additional, Carreiro‐Martins, Pedro, additional, Carriazo, Ana, additional, Casale, Thomas, additional, Caubet, Jean‐Christoph, additional, Cecchi, Lorenzo, additional, Cherubini, Antonio, additional, Christoff, George, additional, Chu, Derek K., additional, Cruz, Alvaro A., additional, Dokic, Dejan, additional, El‐Gamal†, Yehia, additional, Ebisawa, Motohiro, additional, Eberlein, Bernadette, additional, Farrell, John, additional, Fernandez‐Rivas, Montserrat, additional, Fokkens, Wytske J., additional, Fonseca, Joao A., additional, Gao, Yadong, additional, Gavazzi, Gaëtan, additional, Gawlik, Radoslaw, additional, Gelincik, Asli, additional, Gemicioğlu, Bilun, additional, Gotua, Maia, additional, Guérin, Olivier, additional, Haahtela, Tari, additional, Hoffmann‐Sommergruber, Karin, additional, Hoffmann, Hans Jürgen, additional, Hofmann, Maja, additional, Hrubisko, Martin, additional, Illario, Maddalena, additional, Irani, Carla, additional, Ispayeva, Zhanat, additional, Ivancevich, Juan Carlos, additional, Julge, Kaja, additional, Kaidashev, Igor, additional, Khaitov, Musa, additional, Knol, Edward, additional, Kraxner, Helga, additional, Kuna, Piotr, additional, Kvedariene, Violeta, additional, Lauerma, Antti, additional, Le, Lan T. T., additional, Le Moing, Vincent, additional, Levin, Michael, additional, Louis, Renaud, additional, Lourenco, Olga, additional, Mahler, Vera, additional, Martin, Finbarr C., additional, Matucci, Andrea, additional, Milenkovic, Branislava, additional, Miot, Stéphanie, additional, Montella, Emma, additional, Morais‐Almeida, Mario, additional, Mortz, Charlotte G., additional, Mullol, Joaquim, additional, Namazova‐Baranova, Leyla, additional, Neffen, Hugo, additional, Nekam, Kristof, additional, Niedoszytko, Marek, additional, Odemyr, Mikaëla, additional, O’Hehir, Robyn E., additional, Okamoto, Yoshitaka, additional, Ollert, Markus, additional, Palomares, Oscar, additional, Papadopoulos, Nikolaos G., additional, Panzner, Petr, additional, Passalacqua, Giovanni, additional, Patella, Vincenzo, additional, Petrovic, Mirko, additional, Pfaar, Oliver, additional, Pham‐Thi, Nhân, additional, Plavec, Davor, additional, Popov, Todor A., additional, Recto, Marysia T., additional, Regateiro, Frederico S., additional, Reynes, Jacques, additional, Roller‐Winsberger, Regina E., additional, Rolland, Yves, additional, Romano, Antonino, additional, Rondon, Carmen, additional, Rottem, Menachem, additional, Rouadi, Philip W., additional, Salles, Nathalie, additional, Samolinski, Boleslaw, additional, Santos, Alexandra F., additional, S Sarquis, Faradiba, additional, Sastre, Joaquin, additional, M. G. A. Schols, Jos, additional, Scichilone, Nicola, additional, Sediva, Anna, additional, Shamji, Mohamed H., additional, Sheikh, Aziz, additional, Skypala, Isabel, additional, Smolinska, Sylwia, additional, Sokolowska, Milena, additional, Sousa‐Pinto, Bernardo, additional, Sova, Milan, additional, Stelmach, Rafael, additional, Sturm, Gunter, additional, Suppli Ulrik, Charlotte, additional, Todo‐Bom, Ana Maria, additional, Toppila‐Salmi, Sanna, additional, Tsiligianni, Ioanna, additional, Torres, Maria, additional, Untersmayr, Eva, additional, Urrutia Pereira, Marilyn, additional, Valiulis, Arunas, additional, Vitte, Joana, additional, Vultaggio, Alessandra, additional, Wallace, Dana, additional, Walusiak‐Skorupa, Jolanta, additional, Wang, De‐Yun, additional, Waserman, Susan, additional, Yorgancioglu, Arzu, additional, Yusuf, Osman M., additional, Zernotti, Mario, additional, Zidarn, Mihaela, additional, Chivato, Tomas, additional, Akdis, Cezmi A., additional, Zuberbier, Torsten, additional, and Klimek, Ludger, additional

Published
2021
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31. Low‐dose provocation and skin tests in patients with hypersensitivity to gadolinium‐based contrast agents

Author

Antoine Badaoui, Angèle Soria, H. Gaouar, Camille Francès, Annick Barbaud, and Vannina Seta

Subjects
medicine.medical_specialty, business.industry, Gadolinium, media_common.quotation_subject, Immunology, Provocation test, MEDLINE, chemistry.chemical_element, Retrospective cohort study, 030218 nuclear medicine & medical imaging, Clinical trial, 03 medical and health sciences, 0302 clinical medicine, Text mining, 030228 respiratory system, chemistry, medicine, Immunology and Allergy, Contrast (vision), Observational study, Radiology, business, media_common
Published
2018

32. Allergological workup with half-dose challenge in iodinated contrast media hypersensitivity

Author

J.E. Autegarden, Amandine Vial-Dupuy, Angèle Soria, H. Gaouar, Sylvie Chollet-Martin, Annick Barbaud, Pascale Nicaise-Roland, Nathalie Masson, and Emmanuelle Amsler

Subjects
0301 basic medicine, medicine.medical_specialty, business.industry, Immunology, Iodine Compounds, Contrast Media, Disease Management, Allergens, Dermatology, Drug Hypersensitivity, Iodinated contrast media, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, 030228 respiratory system, Humans, Immunology and Allergy, Medicine, Disease management (health), business, Skin Tests
Published
2018

35. Practice parameters for diagnosing and managing iodinated contrast media hypersensitivity

Author

Torres, María José, primary, Trautmann, Axel, additional, Böhm, Ingrid, additional, Scherer, Kathrin, additional, Barbaud, Annick, additional, Bavbek, Sevim, additional, Bonadonna, Patrizia, additional, Cernadas, Josefina Rodrigues, additional, Chiriac, Anca Mirela, additional, Gaeta, Francesco, additional, Gimenez‐Arnau, Ana M., additional, Kang, Hye‐Ryun, additional, Moreno, Esther, additional, and Brockow, Knut, additional

Published
2021
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36. Sequential Assessment of Cell Cycle S Phase in Flow Cytometry: A Non-Isotopic Method to Measure Lymphocyte Activation In Vitro

Author

Ch. Kohler, M. N. Kolopp‐Sarda, A. De March‐Kennel, A. Barbaud, M. C. Béné, and G. C. Faure

Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282, Cytology, QH573-671
Abstract

Lymphocyte multiplication can be induced in vitro by mitogens or specific antigens, and is usually measured using isotopic methods involving tritiated thymidine. Cellular proliferation can also be analyzed by flow cytometry techniques based on cell cycle analysis through the measurement of DNA content. We applied this method to lymphocytes from 113 individuals, to evaluate lymphocyte proliferation after stimulation in vitro by a mitogen (phytohaemagglutinin, PHA) or a recall antigen (tetanus toxoid), using a kinetic approach with four points sequential measurements of the S and G2 phases over six days of culture. The proportion of cells in S phase after PHA stimulation was significantly higher than in controls overall and as early as on day three of the culture. Activation with a recall antigen significantly induced increasing S phase cell proportions up to day six. These data suggest that flow cytometric assessment of the S phase could be a useful alternative to isotopic methods measuring lymphocyte reactivity in vitro.

Published
1997
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37. Management of hypersensitivity reactions to Tocilizumab

Author

P. Tétu, Angèle Soria, A. Hamelin, P. Moguelet, and Annick Barbaud

Subjects
030203 arthritis & rheumatology, business.industry, Biopsy, Immunology, Disease Management, Immunoglobulin E, Antibodies, Monoclonal, Humanized, Bioinformatics, Severity of Illness Index, Drug Hypersensitivity, 030207 dermatology & venereal diseases, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Tocilizumab, Text mining, chemistry, Humans, Immunology and Allergy, Medicine, business, Skin Tests
Published
2018

40. What is the optimal duration for a ROAT? The experience of the French Dermatology and Allergology group (DAG).

Author

Amsler E, Assier H, Soria A, Bara C, Ferrier le Bouëdec MC, Barbaud A, Milpied B, Giordano-Labadie F, Pasteur J, Badaoui A, Valois A, Castelain F, Kurihara F, Castagna J, Boulard C, Bernier C, Leleu C, Marcant P, Crépy MN, Tetart F, and Raison-Peyron N

Subjects
Allergens, Dose-Response Relationship, Drug, Humans, Patch Tests methods, Prospective Studies, Dermatitis, Allergic Contact diagnosis, Dermatitis, Allergic Contact etiology, Dermatology
Abstract

Background and Objectives: The repeated open application test (ROAT) is an adjuvant investigation measure to patch testing in the diagnosis of allergic contact dermatitis. ESCD recommends a 15 days duration but its overall duration varies according to publications and patients hardly adhere to prolonged ROAT duration beyond 1 week., Materials and Methods: The Dermatology and Allergy Group of the French Society of Dermatology performed a prospective study with the aim of determining the best duration for the ROAT., Results: A total of 328 ROAT results were collected for topical products, including cosmetics (60%) and topical medications (31.1%). Fifty-nine (18%) ROATs were positive, and 16 (5%) were doubtful. All the positive ROATs occurred within 10 days, with a median time to positivity of 3 days., Conclusion: According to our results, a minimum duration of 10 days is necessary to achieve a positive ROAT to a topical product., (© 2022 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)

Published
2022
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41. Towards a more precise diagnosis of hypersensitivity to beta‐lactams — an EAACI position paper

Author

Romano, Antonino, primary, Atanaskovic‐Markovic, Marina, additional, Barbaud, Annick, additional, Bircher, Andreas J., additional, Brockow, Knut, additional, Caubet, Jean‐Christoph, additional, Celik, Gulfem, additional, Cernadas, Josefina, additional, Chiriac, Anca‐Mirela, additional, Demoly, Pascal, additional, Garvey, Lene H., additional, Mayorga, Cristobalina, additional, Nakonechna, Alla, additional, Whitaker, Paul, additional, and Torres, María José, additional

Published
2020
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45. Synthesis and characterizations of hemiditactic homopolymers derived of poly(3-allyl-3-methylmalic acid): An example of a new class of polymer's ditacticity

Author

Rima Belibel and Christel Barbaud

Subjects
Polypropylene, chemistry.chemical_classification, Materials science, Polymers and Plastics, Organic Chemistry, 02 engineering and technology, Polymer, 010402 general chemistry, 021001 nanoscience & nanotechnology, 01 natural sciences, 0104 chemical sciences, Amorphous solid, Polyester, chemistry.chemical_compound, Crystallinity, Monomer, chemistry, Polymer chemistry, Materials Chemistry, Organic chemistry, Malic acid, 0210 nano-technology, Macromolecule
Abstract

A number of works have been focused on the study of polymers microtacticity and the probability of iso-, syndio-, and atactic arrangement of monomers such as polypropylene and poly(methacrylic esters) before the 1980s. This type of study was fewer in the last four decades despite the importance of stereochemical knowledge of macromolecules in the biomedical field. NMR analysis was the invaluable tool for the study of stereochemistry. This work detailed the synthesis and the physicochemical and microtacticity characterizations of new semicrystalline and amorphous polyesters, poly(3-allyl-3-methylmalic acid) (PAlMMLA) derivatives which are part of the poly(malic acid) family. This polymer is biodegradable and biocompatible. It can also be chemically modified for a possible combination with bioactive molecules. It can be synthesized from chiral product leading a stereoregular and semicrystalline structure. In the case of a racemic starting product, the obtained macromolecular structure is amorphous. Semi-crystalline polyester presented a highly diisotactic structure. © 2017 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2017

Published
2017

46. Airborne allergic contact dermatitis caused by isothiazolinones in water-based paints: a retrospective study of 44 cases

Author

Brigitte Milpied, Angèle Soria, Florence Tetart, Nadia Raison-Peyron, C. Pecquet, Julie Waton, Emmanuelle Amsler, Isabelle Lartigau, Olivier Aerts, Nathalie Genillier, Florence Castelain, F. Giordano-Labadie, Marie Christine Ferrier Le Bouedec, Annick Barbaud, Michèle Debons, Martine Avenel-Audran, Marie-Noëlle Crépy, Claire Bernier, Haudrey Assier, P. Girardin, Evelyne Collet, Dominique Vital-Durand, and P. Pralong

Subjects
Allergy, medicine.medical_specialty, Benzisothiazolinone, business.industry, Patch test, Retrospective cohort study, Methylchloroisothiazolinone, Dermatology, 010501 environmental sciences, medicine.disease, 01 natural sciences, Isothiazolinone, 030207 dermatology & venereal diseases, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, chemistry, Methylisothiazolinone, medicine, Immunology and Allergy, business, Allergic contact dermatitis, 0105 earth and related environmental sciences
Abstract

SummaryBackground Airborne allergic contact dermatitis caused by paints containing isothiazolinones has been recognized as a health hazard. Objectives To collect epidemiological, clinical and patch test data on airborne allergic contact dermatitis caused by isothiazolinone-containing paints in France and Belgium. Methods A descriptive, retrospective study was initiated by the Dermatology and Allergy Group of the French Society of Dermatology, including methylchloroisothiazolinone (MCI)/methylisothiazolinone (MI)- and/or MI-sensitized patients who developed airborne allergic contact dermatitis following exposure to isothiazolinone-containing paint. Results Forty-four cases were identified, with mostly non-occupational exposure (79.5%). Of the patients, 22.5% of also had mucosal symptoms. In several cases, the dermatitis required systemic corticosteroids (27.3%), hospitalization (9.1%), and/or sick leave (20.5%). A median delay of 5.5 weeks was necessary to enable patients to enter a freshly painted room without a flare-up of their dermatitis. Approximately one-fifth of the patients knew that they were allergic to MI and/or MCI/MI before the exposure to paints occurred. Conclusion Our series confirms that airborne allergic contact dermatitis caused by paints containing isothiazolinones is not rare, and may be severe and long-lasting. Better regulation of isothiazolinone concentrations in paints, and their adequate labelling, is urgently needed.

Published
2017

47. Prurigo pigmentosa induced by ketosis ('keto rash'): a demonstrative case and internet search results

Author

Etty Grynberg-Laloum, Philippe Moguelet, Camille Francès, Pierre Hamann, Patricia Senet, Annick Barbaud, Jérémie Delaleu, Service de dermatologie et allergologie [CHU Tenon], CHU Tenon [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Service d’Anatomopathologie [CHU Tenon], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Tenon [AP-HP], and Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)

Subjects
Prurigo pigmentosa, medicine.medical_specialty, ketosis, MEDLINE, Dermatology, 030207 dermatology & venereal diseases, 03 medical and health sciences, 0302 clinical medicine, Hyperpigmentation, medicine, Humans, 030212 general & internal medicine, ComputingMilieux_MISCELLANEOUS, Internet, business.industry, keto diet, prurigo pigmentosa, Exanthema, medicine.disease, Rash, 3. Good health, Prurigo, Ketosis, medicine.symptom, business, [SDV.MHEP.DERM]Life Sciences [q-bio]/Human health and pathology/Dermatology
Abstract

International audience

Published
2020

48. Histopathological study of six types of adverse cutaneous drug reactions using granulysin expression

Author

François Truchetet, Bernard Cribier, Lucie Germain, Marie Weinborn, Annick Barbaud, and Philippe Beurey

Subjects
Adult, Antigens, Differentiation, T-Lymphocyte, Male, 0301 basic medicine, medicine.medical_specialty, Pathology, Biopsy, Dermatology, Lymphocytic Infiltrate, 030207 dermatology & venereal diseases, 03 medical and health sciences, 0302 clinical medicine, medicine, Humans, Granulysin, Aged, Retrospective Studies, Skin, integumentary system, medicine.diagnostic_test, business.industry, Middle Aged, medicine.disease, Acute generalized exanthematous pustulosis, Immunohistochemistry, Toxic epidermal necrolysis, Drug eruption, 030104 developmental biology, Acute Generalized Exanthematous Pustulosis, Stevens-Johnson Syndrome, Drug Hypersensitivity Syndrome, Female, Histopathology, Drug Eruptions, business, Spongiosis
Abstract

Background Few studies have been published on the histopathology of cutaneous adverse drug reactions (CADR), and most of these lack information on skin allergological tests. The histopathology of drug reaction with eosinophilia and systemic symptoms (DRESS) is also seldom described. The purpose of our study was to examine six types of well-documented CADR (maculopapular exanthema, DRESS, fixed drug eruption, Stevens–Johnson syndrome, toxic epidermal necrolysis [TEN], and acute generalized exanthematous pustulosis) using histopathology and immunohistochemistry to evaluate the expression of granulysin, a key molecule in TEN. Methods We retrospectively included 106 skin biopsies performed in proven cases of CADR (by chronological investigation, single attributable drug, or/and skin tests). All slides were reviewed, and microscopic changes were analyzed using a standardized form. Granulysin expression was studied by immunohistochemistry. Results In DRESS, we observed spongiosis, edema, and basal vacuolization, with rare necrotic keratinocytes and constant lymphocytic infiltrate in the superficial dermis. Eosinophils were often present, and pustules were found in 15% of cases. Necrotic keratinocytes are often absent in maculopapular exanthema. Granulysin was expressed in six types of CADR with a trend toward more intense expression in DRESS and TEN. Conclusion We detailed further about the histopathology of DRESS. Granulysin expression was observed in all CADR with a marked overlap of expression pattern between the six types.

Published
2016

49. First evidence of occupational asthma to argan powder in a cosmetic factory

Author

Isabelle Thaon, Fabrice Herin, Mathias Poussel, Emmanuelle Penven, Christelle Richard, Christophe Paris, S Jacquenet, A. Barbaud, Centre de consultations de pathologies professionnelles [CHRU Nancy] (CCPP), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Interactions Gènes-Risques environnementaux et Effets sur la Santé (INGRES), Université de Lorraine (UL), Epidémiologie et analyses en santé publique : risques, maladies chroniques et handicaps (LEASP), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre de consultations de pathologies professionnelles [CHU Toulouse], CHU Toulouse [Toulouse], Université Fédérale Toulouse Midi-Pyrénées, Genclis SAS, Service de Dermatologie et Allergologie [CHRU Nancy], Développement, Adaptation et Handicap. Régulations cardio-respiratoires et de la motricité (DevAH), and Service des examens de la Fonction respiratoire et de l’aptitude à l’exercice [CHRU Nancy]

Subjects
Adult, Male, Allergy, medicine.medical_specialty, Probable Case, media_common.quotation_subject, Immunology, Occupational disease, Cosmetics, Bronchial Provocation Tests, 03 medical and health sciences, Specific inhalation challenge, 0302 clinical medicine, Risk Factors, Occupational Exposure, medicine, Humans, Immunology and Allergy, Asthma, Occupational, Skin Tests, media_common, Sapotaceae, 030201 allergy, Traditional medicine, business.industry, Allergens, Antigens, Plant, Immunoglobulin E, Middle Aged, medicine.disease, 11s globulin, Elisa inhibition, 3. Good health, Surgery, 030228 respiratory system, Female, business, Occupational asthma, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

International audience; BackgroundArgan is used worldwide in numerous cosmetic products, as this fruit is supposed to have many beneficial properties on health. New cases of allergy can be expected with the growing use of argan. We investigated all workers (9) employed by a cosmetic factory and exposed to argan powder to identify possible allergies related to exposure to argan powder.MethodsPatients were investigated in the occupational disease department and, according to their symptoms, underwent pulmonary function testing, methacholine challenge, specific inhalation challenge to argan powder, skin prick tests, and immunoblotting analysis.ResultsWe report three cases of occupational asthma to argan powder and a probable case of rhinitis. Fifteen argan proteins were recognized by the patients' IgE. Identification of proteins, cross-reactions to nuts, and ELISA inhibition tests suggested that some argan allergens can cross-react in vitro with hazelnut allergens, including 11S globulin and vicilin.ConclusionHigh-level exposure to argan powder should be considered to be a potential cause of IgE-mediated allergy, and workers handling argan powder should be carefully investigated.

Published
2016

50. Synthesis and characterizations of new isotactic homopolyesters, statistical and block copolyesters derived of poly((S )-3,3-dimethylmalic acid) via the lactone route

Author

Imadeddine Azzouz, Rima Belibel, and Christel Barbaud

Subjects
chemistry.chemical_classification, Polymers and Plastics, Chemistry, Organic Chemistry, 02 engineering and technology, Polymer, 010402 general chemistry, 021001 nanoscience & nanotechnology, 01 natural sciences, 0104 chemical sciences, Stereocenter, Polyester, Crystallinity, Tacticity, Polymer chemistry, Materials Chemistry, Copolymer, Side chain, Organic chemistry, 0210 nano-technology, Lactone
Abstract

This article presents the synthesis of a new family of synthetic isotactic polyesters derived from poly((S)-3,3-dimethylmalic acid) (PDMMLA). These polyesters are prepared via the lactone route bearing functionalized groups in its main or side chain. The aim of this work is twofold: metabolism and stereochemistry. First, the synthesis of these new polyesters is chosen to provide biodegradable polyesters biocompatible and bioassimilable by the human body. Next, the molecular chain of this family contains a stereogenic center in the aim to provide 100% isotactic homopolymers and copolymers (statistical and block). Finally, these polymers have been characterized by several analytical techniques: FTIR, 1H and 13C NMR, SEC, DSC, and TGA. The greatest importance will be given to the 13C NMR and DSC to principally confirm the stereoregularity and crystallinity of these stereopolyesters. © 2015 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2016, 54, 1495–1507

Published
2015

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