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Your search keyword '"Bao-Xi Qu"' showing total 7 results
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7 results on '"Bao-Xi Qu"'

1. P1‐272: A regulatory immune response after DNA vaccination against Aß42

Author

Min Fu, Olaf Stüve, Bao-Xi Qu, Doris Lambracht-Washington, Todd N. Eagar, and Roger N. Rosenberg

Subjects
Psychiatry and Mental health, Cellular and Molecular Neuroscience, Immune system, Developmental Neuroscience, Epidemiology, business.industry, Health Policy, Immunology, Medicine, Neurology (clinical), Geriatrics and Gerontology, business, DNA vaccination
Published
2012

2. IC‐P‐004: PET imaging of Alzheimer's transgenic mice at an early age with F‐18 quinoline

Author

Anjali Gupta, Michael V. L. Bennett, Guiyang Hao, Peter P. Antich, Xiankai Sun, Neil Vasdev, Veera Arora, Srinivas Chiguru, Frederick J. Bonte, Nikolai V Slavine, Padmakar V. Kulkarni, and Bao-Xi Qu

Subjects
Genetically modified mouse, Pathology, medicine.medical_specialty, Epidemiology, business.industry, Health Policy, Quinoline, Pet imaging, Psychiatry and Mental health, Cellular and Molecular Neuroscience, chemistry.chemical_compound, Developmental Neuroscience, chemistry, medicine, Neurology (clinical), Geriatrics and Gerontology, business
Published
2011

3. P1‐322: PET imaging of Alzheimer's transgenic mice at an early age with F‐18 quinoline

Author

Padmakar Kulkarni, Veera Arora, Srinivas Chiguru, Guiyang Hao, Anjali Gupta, Nikolai Slavine, Bao‐Xi Qu, Neil Vasdev, Xiankai Sun, Michael Bennett, Peter Antich, and Frederick Bonte

Subjects
Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Epidemiology, Health Policy, Neurology (clinical), Geriatrics and Gerontology
Published
2011

4. P2‐470: T cell responses after DNA Abeta‐42 trimer immunization in mice indicate the potential for safe immunotherapy for Alzheimer's disease

Author

Olaf Stüve, Roger N. Rosenberg, Min Fu, Todd N. Eagar, Doris Lambracht-Washington, and Bao-Xi Qu

Subjects
Epidemiology, business.industry, Health Policy, medicine.medical_treatment, T cell, Trimer, Immunotherapy, Disease, Virology, Psychiatry and Mental health, Cellular and Molecular Neuroscience, chemistry.chemical_compound, medicine.anatomical_structure, Developmental Neuroscience, Immunization, chemistry, Immunology, medicine, Neurology (clinical), Geriatrics and Gerontology, business, DNA
Published
2011

5. IC‐P‐002: PET imaging of Alzheimer's disease (AD) transgenic mice with F‐18 labeled 8‐hydroxy quinoline

Author

Frederick J. Bonte, Peter P. Antich, Veera Arora, Nikolai V Slavine, Michael Long, Neil Vasdev, Padmakar V. Kulkarni, Guiang Hao, Michael J. Bennett, Xiankai Sun, and Bao-Xi Qu

Subjects
Genetically modified mouse, Epidemiology, Health Policy, Quinoline, Disease, Pet imaging, Molecular biology, Psychiatry and Mental health, Cellular and Molecular Neuroscience, chemistry.chemical_compound, Developmental Neuroscience, chemistry, Neurology (clinical), Geriatrics and Gerontology
Published
2010

6. P3‐241: Abeta42 trimer DNA vaccination is effective and safe as potential therapy for early Alzheimer's disease

Author

Todd N. Eagar, Olaf Stüve, Doris Lambracht-Washington, Bao-Xi Qu, Min Fu, and Roger N. Rosenberg

Subjects
Epidemiology, business.industry, Health Policy, Trimer, Disease, Virology, DNA vaccination, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Immunology, Medicine, Neurology (clinical), Geriatrics and Gerontology, business
Published
2009

7. P2‐355: Trimer Aβ42 gene vaccine elicits a high level of antibody production when delivered with the GAL4‐UAS system and the gene gun

Author

Roger N. Rosenberg, Min Fu, Bao-Xi Qu, and Stephen Albert Johnston

Subjects
Amyloid, biology, Epidemiology, business.industry, Health Policy, Transgene, Gene gun, Antibody opsonization, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Immune system, Developmental Neuroscience, Immunization, In vivo, mental disorders, Immunology, biology.protein, Medicine, Neurology (clinical), Geriatrics and Gerontology, Antibody, business
Abstract

micromolar concentrations. Immunization of young adult mice with hIVIG at 1g/kg i.p. or i.v. resulted in the formation of neutralizing cross-species antibodies as expected, but tolerance developed after both ways of administration in 4-6 weeks. Intraperitoneal administration of hIVIG once weekly for 14 weeks resulted in significant accumulation of human IgG immunoreactivity in the hippocampus of APP/PS1 mice and in some cases opsonization of amyloid plaques. Conclusions: The data suggest that hIVIG contains antibodies that are able to bind Abeta and induce amyloid degradation if provided at high enough concentrations. Development of crossspecies immune response and blood-brain barrier do not prevent testing these effects in transgenic amyloid producing mice also in vivo.

Published
2008

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