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Your search keyword '"Bao-Lai, Xiao"' showing total 2 results
Start Over Author "Bao-Lai, Xiao" Publisher wiley
2 results on '"Bao-Lai, Xiao"'

1. Retracted: Wogonoside promotes apoptosis in gastric cancer AGS and SGC‐7901 cells through induction of mitochondrial dysfunction and endoplasmic reticulum stress

Author

Xiao‐Miao Hu, Jin‐Jian Xiang, Bao‐Lai Xiao, Ying‐Fei Huang, and Jian‐Ping Xie

Subjects
endoplasmic reticulum stress, gastric cancer, mitochondrial dysfunction, wogonoside, Biology (General), QH301-705.5
Abstract

Wogonoside (Wg), a natural flavonoid, has anticancer effects against several human cancers. The purpose of the present study was to investigate the antitumor effects and underlying mechanisms of Wg on gastric cancer (GC) cell lines. We report that Wg treatment inhibited cell viability and induced apoptosis in human GC cell lines AGS and SGC‐7901, and also retarded GC tumor growth in xenograft mice in vivo. We also found that the Wg exerted its antitumor effects against GC cells via induction of reaction oxygen species accumulation, mitochondrial dysfunction, and endoplasmic reticulum stress. Furthermore, C/EBP homologous protein knockdown inhibited apoptosis and increased the viability of Wg‐treated GC cells. Our findings may facilitate the development of novel therapeutic agents for the treatment of GC.

Published
2019
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2. Retracted: Wogonoside promotes apoptosis in gastric cancer AGS and SGC‐7901 cells through induction of mitochondrial dysfunction and endoplasmic reticulum stress

Author

Ying-Fei Huang, Jin-Jian Xiang, Jian-Ping Xie, Bao-Lai Xiao, and Xiao-Miao Hu

Subjects
Male, 0301 basic medicine, Cell Survival, Flavonoid, Mice, Nude, Apoptosis, General Biochemistry, Genetics and Molecular Biology, Mice, 03 medical and health sciences, 0302 clinical medicine, Glucosides, Stomach Neoplasms, In vivo, Cell Line, Tumor, mitochondrial dysfunction, medicine, Animals, Humans, Viability assay, lcsh:QH301-705.5, Research Articles, wogonoside, Cell Proliferation, chemistry.chemical_classification, Mice, Inbred BALB C, Gene knockdown, gastric cancer, Endoplasmic reticulum, Cancer, Endoplasmic Reticulum Stress, medicine.disease, Xenograft Model Antitumor Assays, Mitochondria, 030104 developmental biology, lcsh:Biology (General), chemistry, Cell culture, 030220 oncology & carcinogenesis, Flavanones, Cancer research, Reactive Oxygen Species, Research Article, Signal Transduction
Abstract

Wogonoside (Wg), a natural flavonoid, has anticancer effects against several human cancers. The purpose of the present study was to investigate the antitumor effects and underlying mechanisms of Wg on gastric cancer (GC) cell lines. We report that Wg treatment inhibited cell viability and induced apoptosis in human GC cell lines AGS and SGC‐7901, and also retarded GC tumor growth in xenograft mice in vivo. We also found that the Wg exerted its antitumor effects against GC cells via induction of reaction oxygen species accumulation, mitochondrial dysfunction, and endoplasmic reticulum stress. Furthermore, C/EBP homologous protein knockdown inhibited apoptosis and increased the viability of Wg‐treated GC cells. Our findings may facilitate the development of novel therapeutic agents for the treatment of GC.

Published
2019
Full Text
View/download PDF

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