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4 results on '"B.-J. Wang"'

1. A Method for Multiple Attribute Decision Making Based on the Fusion of Multisource Information

Author

F. W. Zhang, S. H. Xu, B. J. Wang, and Z. J. Wu

Subjects
Mathematics, QA1-939
Abstract

We propose a new method for the multiple attribute decision making problem. In this problem, the decision making information assembles multiple source data. Two main advantages of this proposed approach are that (i) it provides a data fusion technique, which can efficiently deal with the multisource decision making information; (ii) it can produce the degree of credibility of the entire decision making. The proposed method performs very well especially for the scenario that there exists conflict among the multiple source information. Finally, a traffic engineering example is given to illustrate the effect of our method.

Published
2014
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2. SNaPshot reveals high mutation and carrier frequencies of 15 common hearing loss mutants in a Chinese newborn cohort

Author

W. Wang, Q. Zhu, B.-J. Wang, D. Jiang, Y.-H. Liu, Hongxing Li, H.-B. Li, J. Mao, Mingxi Liu, Y. Chen, Y. Ding, Kwong Wai Choy, and Ye Cao

Subjects
Genetics, Mutation, Newborn screening, Hearing loss, Genetic counseling, Biology, Congenital hearing loss, medicine.disease_cause, Cohort, otorhinolaryngologic diseases, medicine, medicine.symptom, Allele, Genotyping, Genetics (clinical)
Abstract

Genetic causes account for more than half of congenital hearing loss cases. The most frequent mutations found in non-syndromic hearing loss patients occur in GJB2 and SLC26A4. Mitochondrial genome mutations are also prevalent. However, the frequency of common hearing loss mutations in the Chinese population has not yet been well estimated. Here, we implemented the SNaPshot genotyping method to investigate the carrier frequency of 15 commonly reported hearing loss mutations in GJB2, SLC26A4 and the mitochondrial genome based on a cohort of 5800 neonates in China. Up to 15.9% (923/5800) of the newborns carry at least one mutant allele. The top three were GJB2-c.109G>A, GJB2-c.235delC, and SLC26A4-c.919A>G, with notably high carrier frequencies of 1/10, 1/53 and 1/62 respectively, and mt-7444G>A with 1/141 was the most frequent allele in the mitochondrial genome. In this cohort, 0.48% (28/5800) of neonates were genetically diagnosed with hearing loss, from which seven cases failed an OAE test. This is the first epidemiological study of non-syndromic hearing loss in Chinese newborns indicating a notably high carrier frequency (1 per 6.3 newborns) among these 15 mutant alleles. Our carrier frequency data also aid in effective risk assessment and genetic counseling for hearing loss patients in the Chinese population.

Published
2014

4. Elimination of hepatitis B virus surface antigen and appearance of neutralizing antibodies in chronically infected patients without viral clearance

Author

Dongliang Yang, X. Li, Michael Roggendorf, Wolfram H. Gerlich, Z.-M. Zhang, X.-P. Zhao, L. Li, Mengji Lu, Dieter Glebe, Z.-H. Zhang, B.-J. Wang, Y. Yang, Corinna M. Bremer, and Yongjun Tian

Subjects
Hepatitis B virus, HBsAg, Hepatology, biology, business.industry, Tupaia, virus diseases, medicine.disease_cause, biology.organism_classification, Virology, digestive system diseases, law.invention, Infectious Diseases, Immune system, HBeAg, law, Immunology, medicine, Recombinant DNA, biology.protein, Seroconversion, Antibody, business
Abstract

Summary. Seroconversion from hepatitis B surface antigen (HBsAg) to antibodies against HBsAg (anti-HBs) usually indicates resolution of hepatitis B virus (HBV) infection. Here, two HBV-infected patients with seroconversion to anti-HBs were found to be persistently positive for HBeAg and HBV DNA. Immunohistology of liver biopsies confirmed the expression of HBV proteins in the liver of one patient. The neutralizing ability of anti-HBs in patient sera was demonstrated by blocking HBV infection of primary tupaia hepatocytes. Analysis of the HBsAg-encoding region of HBV isolates from patients indicated the coexistence of heterogeneous HBV genomes in patients. The majority of recombinant variant HBsAg was reactive in HBsAg assays and was able to bind to anti-HBs. Circulating immune complexes (CIC) of HBsAg in patient sera could be detected by polyethylene glycol precipitation and trypsin digestion. Thus, neutralizing anti-HBs may appear in chronic HBV carriers for long periods but does not necessarily lead to complete viral clearance.

Published
2010

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