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Adult T-cell leukemia-lymphoma (ATL) is one of the most malignant lymphomas with poor prognosis. ATL cells express CC chemokine receptor 4 (CCR4) and mogamulizumab, a monoclonal antibody against CCR4 that exhibits very strong cytotoxicity for ATL cells via antibody-dependent cellular cytotoxicity. Although its effect is dramatic in ATL, serious adverse reactions such as Stevens-Johnson syndrome have been reported. However, these eruptions can appear as therapeutic signs of mogamulizumab. We evaluated the effectiveness of mogamulizumab in five acute-type ATL patients. Peripheral blood (PB) and lymph nodes (LN) were affected in three and four patients, respectively. In PB, complete response (CR) was obtained in all three patients and partial response (PR) was recorded in LN of one patient. In skin lesions, four of five patients manifested CR; in two, the lesions worsened after the start of mogamulizumab treatment and subsequently improved. In these lesions, CD4(+) 8(-) 25(+) ATL cells were replaced by CD3(+) 8(+) cytotoxic T cells. Cutaneous adverse reactions (CAR) developed in two patients with CR; they did not show a relapse of ATL over the course of 9 months. Our findings suggest that mogamulizumab should be continued and surface marker evaluation should be performed even in patients whose skin lesions show aggravation, and that CAR may be a marker for a favorable prognosis.

Communication between an IPv6 host and an IPv4 host requires a name server that makes a mapping between an IPv4 address and an IPv6 address, and a translator that performs IP packet conversion. In this paper, we propose an IPv4–IPv6 bidirectional communication system, implement our proposed method, and present the results of performance evaluation. Our system can provide IPv4 hosts with connectivity to more IPv6 hosts in spite of pooling fewer IPv4 addresses. It is realized by adding a source IPv4 address and a port number to an address mapping with cooperation between a name server and a translator. © 2004 Wiley Periodicals, Inc. Electron Comm Jpn Pt 1, 87(12): 49–59, 2004; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/ecja.10203