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Start Over Descriptor "Aspergillus insulicola" Publisher wiley
1 results on '"Aspergillus insulicola"'

1. ChemInform Abstract: Azonazine, a Novel Dipeptide from a Hawaiian Marine Sediment-Derived Fungus, Aspergillus insulicola

Author

Tyler A. Johnson, Mitchell S. Crews, Xiao-Jun Yao, Leonard F. Bjeldanes, Marija Draskovic, Karen Tenney, Johann Sohn, Quan-Xiang Wu, Frederick A. Valeriote, and Phillip Crews

Subjects
Dipeptide, Molecular model, biology, Chemistry, Absolute configuration, Sediment, General Medicine, Fungus, biology.organism_classification, chemistry.chemical_compound, Biochemistry, Biological property, Biogenesis, Aspergillus insulicola
Abstract

Azonazine, a unique hexacyclic dipeptide, was isolated from a Hawaiian marine sediment-derived fungus eventually identified as Aspergillus insulicola. Its absolute configuration, 2R,10R,11S,19R, was established using NMR, HRESIMS, and CD data plus insights derived from molecular models. A possible route for its biogenesis is proposed, and biological properties were explored against cancer cell lines and in an NFκB inhibition assay.

Published
2011
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