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Your search keyword '"Arena, Francesca"' showing total 16 results
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16 results on '"Arena, Francesca"'

1. Characterization of immune response against monkeypox virus in cohorts of infected patients, historic and newly vaccinated subjects

Author

Sammartino, Josè Camilla, primary, Cassaniti, Irene, additional, Ferrari, Alessandro, additional, Piralla, Antonio, additional, Bergami, Federica, additional, Arena, Francesca Adua, additional, Paolucci, Stefania, additional, Rovida, Francesca, additional, Lilleri, Daniele, additional, Percivalle, Elena, additional, and Baldanti, Fausto, additional

Published
2023
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2. ELISPOT assays with pp65 peptides or whole HCMV antigen are reliable predictors of immune control of HCMV infection in seropositive kidney transplant recipients

Author

Zavaglio, Federica, primary, Rivela, Francesca, additional, Cassaniti, Irene, additional, Arena, Francesca, additional, Gabanti, Elisa, additional, Asti, Anna L., additional, Lilleri, Daniele, additional, Rampino, Teresa, additional, Baldanti, Fausto, additional, and Gregorini, Marilena, additional

Published
2023
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9. High Relaxivity Supramolecular Adducts Between Human-Liver Fatty-Acid-Binding Protein and Amphiphilic GdIII Complexes: Structural Basis for the Design of Intracellular Targeting MRI Probes

Author

D'Onofrio, Mariapina, primary, Gianolio, Eliana, additional, Ceccon, Alberto, additional, Arena, Francesca, additional, Zanzoni, Serena, additional, Fushman, David, additional, Aime, Silvio, additional, Molinari, Henriette, additional, and Assfalg, Michael, additional

Published
2012
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15. The interaction between iodinated X-ray contrast agents and macrocyclic GBCAs provides a signal enhancement in T 1 -weighted MR images: Insights into the renal excretion pathways of Gd-HPDO3A and iodixanol in healthy mice.

Author

Di Gregorio E, Arena F, Gianolio E, Ferrauto G, and Aime S

Subjects
Animals, Gadolinium, Heterocyclic Compounds, Magnetic Resonance Imaging methods, Mice, Renal Elimination, Tissue Distribution, Triiodobenzoic Acids, X-Rays, Contrast Media chemistry, Organometallic Compounds metabolism
Abstract

Purpose: This work aims to investigate the supramolecular binding interactions that occur between iodinated X-ray contrast agents (CAs) and macrocyclic gadolinium (Gd)-based MRI contrast agents (GBCAs). This study provides some new insights in the renal excretion pathways of the two types of imaging probes., Methods: The water-proton relaxivities (r 1 ) of clinically approved macrocyclic and linear GBCAs have been measured in the presence of different iodinated X-ray contrast agents at different magnetic field strengths in buffer and in serum. The in vivo MRI and X-ray CT of mice injected with either Gd-HPDO3A or a Gd-HPDO3A + iodixanol mixture were then acquired to assess the biodistribution of the two probes., Results: A significant increase in r 1 (up to approximately 200%) was observed for macrocyclic GBCAs when measured in the presence of an excess of iodinated X-ray CAs (1:100 mol:mol) in serum. The co-administration of Gd-HPDO3A and iodixanol in vivo resulted in a marked increase in the signal intensity of the kidney regions in T 1 -weighted MR images. Moreover, the co-presence of the two agents resulted in the extended persistence of the MRI signal enhancement, suggesting that the Gd-HPDO3A/iodixanol adduct was eliminated more slowly than the typical washing out of Gd-HPDO3A., Conclusions: The reported results show that it is possible to detect the co-presence of iodinated agents and macrocyclic GBCAs in contrast-enhanced MR images. The new information may be useful in the design of novel experiments toward improved diagnostic outcomes., (© 2022 The Authors. Magnetic Resonance in Medicine published by Wiley Periodicals LLC on behalf of International Society for Magnetic Resonance in Medicine.)

Published
2022
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16. Photochemical activation of endosomal escape of MRI-Gd-agents in tumor cells.

Author

Gianolio E, Arena F, Strijkers GJ, Nicolay K, Högset A, and Aime S

Subjects
Animals, Carcinoma, Hepatocellular metabolism, Cell Line, Tumor, Contrast Media chemistry, Contrast Media pharmacokinetics, Contrast Media radiation effects, Endosomes radiation effects, Endosomes ultrastructure, Gadolinium, Heterocyclic Compounds chemistry, Image Enhancement methods, Light, Liver Neoplasms metabolism, Organometallic Compounds chemistry, Photochemistry methods, Rats, Staining and Labeling methods, Carcinoma, Hepatocellular pathology, Cell Tracking methods, Endosomes metabolism, Heterocyclic Compounds pharmacokinetics, Liver Neoplasms pathology, Magnetic Resonance Imaging methods, Organometallic Compounds pharmacokinetics
Abstract

Endocytosis is a common internalization pathway for cellular labeling with MRI contrast agents. However, the entrapment of the Gd(III) complexes into endosomes results in a "quenching" of the attainable relaxivity when the number of Gd(III) complexes reaches the number of ca. 1 × 10(9)/cell. Herein we show that the use of the newly developed photochemical internalization technique provides an efficient method for attaining the endosomal escape of GdHPDO3A molecules entrapped by pinocytosis into different kind of cells. Furthermore, it has been found that a new "quenching" limit is observed when the number of Gd-HPDO3A complexes is ca. five times higher than the value observed for the endosome entrapped conditions. The observed behavior is explained in terms of the attainment of the conditions in which the difference in proton relaxation rates between the cytoplasmic and the extracellular compartment is higher than the exchange rate of water molecules across the cellular membrane. The experimental data points have been reproduced by using a properly designed theoretical compartment T(1)-relaxation model., (© 2010 Wiley-Liss, Inc.)

Published
2011
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