1. Mood in Parkinson's disease: From early- to late-stage disease
- Author
-
Ángel Aneiros, Ardura J. González, Nuria Caballol, Jurczynska C. Prieto, C Valero, Víctor Nogueira, Silvia Jesús, Pablo Mir, Lluís Planellas, Padilla F. Carrillo, Caldente J. García, I. Legarda, Losada M. G. Alonso, Itziar Gastón, Moreno J. M. García, Miquel Aguilar, Aymerich L. Valdés, Alonso P. Sánchez, Bartolome C. Cores, Vila B. Solano, Darrian McAfee, Lydia Vela, Aramburu I. González, Pau Pastor, Esther Cubo, Castro E. Suárez, Víctor Puente, Ariztegui N. López, Díaz L. López, Castrillo J. C. Martínez, Fonticoba T. De Deus, Diego Santos-García, Rivera M. A. Ávila, Jaime Kulisevsky, C Borrué, Monica M. Kurtis, S Escalante, Vara J. Hernández, Sauco M. Álvarez, Marina Cosgaya, Manzanares L. López, M Seijo, Iria Cabo, Estrada M. Blázquez, Catalán M. José, Martínez J. Rúiz, and Oriol de Fábregues-Boixar
- Subjects
Male ,medicine.medical_specialty ,Parkinson's disease ,mood ,Disease ,Group B ,s disease ,03 medical and health sciences ,0302 clinical medicine ,Quality of life ,Internal medicine ,Surveys and Questionnaires ,Linear regression ,Medicine ,Humans ,Depression (differential diagnoses) ,Aged ,030214 geriatrics ,business.industry ,Parkinson Disease ,Parkinson&apos ,medicine.disease ,Health Surveys ,Psychiatry and Mental health ,Mood ,Cross-Sectional Studies ,quality of life ,Cohort ,depression ,Quality of Life ,Female ,Geriatrics and Gerontology ,disease duration ,business - Abstract
Background Although depression is known to be frequent in Parkinson's disease (PD), it is unclear how mood can change and/or impact on patient's quality of life (QoL) over time. Our aim was to analyze the frequency of depression, mood related factors and the contribution of mood to a patient's QoL perception in regard to disease duration. Methods PD patients recruited from the COPPADIS cohort from January 2016 to November 2017 were included in this cross-sectional study. Three groups were defined: = 10 years (Group C). Analysis with well-planned linear regression models was conducted to determine how different factors contribute to mood (Beck Depression Inventory-II [BDI-II] as dependent variable), to health-related QoL (39-item Parkinson's Disease Questionnaire [PDQ-39SI] as dependent variable) and to global QoL (European Health Interview Survey - Quality of Life Eight-Item Index [EUROHIS-QOL8] as dependent variable). Results Six hundred and sixty-three PD patients (62.6 +/- 8.9 years old, 59.6% males) were included: Group A, 50.1% (n = 332); Group B, 33.3% (n = 221) and Group C, 16.6% (n = 110). There were no differences between the three groups in terms of the frequency of depressive symptoms nor the frequency of depression type (major vs. minor vs. subthreshold) (p = 0.729). However, the unique percent variance of PDQ-39SI and EUROHIS-QOL8 explained by BDI-II total score was 2 (23.7%) and threefold (26.9%), respectively, in Group C compared to the other two groups. EUROHIS-QOL8 total score provided the highest unique contribution to mood (16.8%). Conclusions Although depression-type frequency does not appear to change over time in PD; the contribution of mood on QoL perception is greater in patients with longer disease duration.
- Published
- 2021