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1. Therapeutic potential of a pyridoxal-based vanadium(IV) complex showing selective cytotoxicity for cancer versus healthy cells

Author

Silvana Morello, Maria Strianese, Claudio Pellecchia, Maria Caterina Turco, Anna Basile, and Antonio Mazzone

Subjects
Physiology, Clinical Biochemistry, Cell, Cancer, Cell Biology, Biology, medicine.disease, Molecular biology, Peripheral blood mononuclear cell, chemistry.chemical_compound, medicine.anatomical_structure, chemistry, Biochemistry, Apoptosis, Cell culture, medicine, Tyrosine, Pyridoxal, Intracellular
Abstract

Vanadium compounds can exert anticancer effects, partly due to inhibition of tyrosine phosphatases. Here, we report the effect of N,N'-ethylenebis (pyridoxylideneiminato) vanadium (IV) complex (Pyr2 enV(IV)), that induced 93% and 57% of cell mortality in A375 (human melanoma) and A549 (human lung carcinoma) cells, respectively; the mortality was

Published
2013

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