1. Neurotrophins and their Trk-receptors in the cerebellum of zebrafish
- Author
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Luciana Castaldo, Annunziata Corteggio, Luigi Avallone, Gennaro Altamura, C. Gatta, Paolo de Girolamo, Carla Lucini, and Livia D'Angelo
- Subjects
0301 basic medicine ,medicine.medical_specialty ,Cerebellum ,animal structures ,Central nervous system ,Danio ,03 medical and health sciences ,0302 clinical medicine ,Neurotrophic factors ,Internal medicine ,medicine ,Zebrafish ,biology ,fungi ,biology.organism_classification ,Cell biology ,030104 developmental biology ,Endocrinology ,medicine.anatomical_structure ,nervous system ,Cerebellar cortex ,Trk receptor ,embryonic structures ,biology.protein ,Animal Science and Zoology ,030217 neurology & neurosurgery ,Developmental Biology ,Neurotrophin - Abstract
Neurotrophins (NTs) and their specific Trk-receptors are key molecules involved in the regulation of survival, proliferation, and differentiation of central nervous system during development and adulthood in vertebrates. In the present survey, we studied the expression and localization of neurotrophins and their Trk-receptors in the cerebellum of teleost fish Danio rerio (zebrafish). Teleostean cerebellum is composed of a valvula, body and vestibulolateral lobe. Valvula and body show the same three-layer structure as cerebellar cortex in mammals. The expression of NTs and Trk-receptors in the whole brain of zebrafish has been studied by Western blotting analysis. By immunohistochemistry, the localization of NTs has been observed mainly in Purkinje cells; TrkA and TrkB-receptors in cells and fibers of granular and molecular layers. TrkC was faintly detected. The occurrence of NTs and Trk-receptors suggests that they could have a synergistic action in the cerebellum of zebrafish. J. Morphol. 277:725-736, 2016. © 2016 Wiley Periodicals, Inc.
- Published
- 2016