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Your search keyword '"Ann E. Kingston"' showing total 6 results
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6 results on '"Ann E. Kingston"'

3. ChemInform Abstract: 2,3′-Disubstituted-2-(2′-carboxycyclopropyl)glycines as Potent and Selective Antagonists of Metabotropic Glutamate Receptors

Author

Darryle D. Schoepp, Angel Mazón, Bryan G. Johnson, Rebecca A. Wright, Ivan Collado, Rosemary Tomlinson, Ann E. Kingston, Concepción Pedregal, Jesús Ezquerra, and Belén Yruretagoyena

Subjects
nervous system, Chemistry, Stereochemistry, Metabotropic glutamate receptor, Glycine, Ic50 values, Antagonist, Alpha (ethology), General Medicine
Abstract

2-(9-Xanthylmethyl)-2-(2′-carboxycyclopropyl) glycine 6e is a novel metabotropic glutamate receptor antagonist. A series of alpha, C-3′ disubstituted (carboxycyclopropyl)glycines 6f-n were prepared. Antagonist activity was observed for all these compounds at group 2 and group 3 mGluRs. Although they were slightly less active on group 2 mGluRs than non C-3′ substituted 6e, the compounds 6f-n were more selective with lesser or no activity on group 1 mGluR subtypes (IC50 values greater than 100μm).

Published
2010
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4. Prospects for Metabotropic Glutamate 1 Receptor Antagonists in the Treatment of Neuropathic Pain

Author

Michael P. Johnson, Jeffrey M. Schkeryantz, and and Ann E. Kingston

Subjects
Analgesics, Chemistry, Analgesic, Antagonist, Glutamate receptor, Pain, Peripheral Nervous System Diseases, General Medicine, Pharmacology, Receptors, Metabotropic Glutamate, Metabotropic receptor, Drug Discovery, Neuropathic pain, Molecular Medicine, Animals, Humans, Receptor
Published
2007
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5. P3–231: Biochemical and histological studies of leucine rich repeat kinase 2 (LRRK2)

Author

Mark Frasier, Ann E. Kingston, Kalpana M. Merchant, Cynthia DeLong, Kelly R. Bales, Linglin Li, John A. Tzaferis, and John W. Ryder

Subjects
Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Biochemistry, Epidemiology, Kinase, Chemistry, Health Policy, Neurology (clinical), Geriatrics and Gerontology, Leucine-rich repeat, LRRK2
Published
2006
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6. P1–007: Alterations in metabotropic and ionotropic glutamate receptor expression in the APP V717F transgenic mouse model of Alzheimer's disease

Author

Theresa A. Day, Michael J. O'Neill, Kelly R. Bales, Ann E. Kingston, Samantha E. Gillard, Viktor Lakics, and Christopher S. Casley

Subjects
Genetically modified mouse, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Metabotropic receptor, Developmental Neuroscience, Epidemiology, Health Policy, Ionotropic glutamate receptor, Neurology (clinical), Disease, Geriatrics and Gerontology, Biology, Cell biology
Published
2006
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